News Articles

A multi-omics strategy to discover and validate missing proteins in the ovary


In a publication in Journal of Proteome Research transcriptomics and spatial proteomics were used to investigate and validate the expression of so-called missing proteins in the human ovary...Read more

Image of the month - PF4 in platelets

News image of the month jan 2024 PL4 small intestine 3.JPG

Platelet factor 4 (gene: PF4) is a chemokine expressed by platelets (thrombocytes) - blood cell fragments that play a key role during blood clotting. Although its normal physiological role is not completely understood, PF4 is implicated in antimicrobial activity and life-threatening thrombosis caused by adenovirus vector covid-19 vaccines...Read more

The dual face of p63: A tumor suppressor or an oncogene?

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The p63 protein belongs to the p53 family of transcription factors and is considered a master regulator of stem cell maintenance and differentiation of epithelial tissues as well as a central player in oocyte fate determination. For years the role of p63 in cancer has been a subject of debate, as there are p63 isoforms with oncogenic functions while others have a tumor suppressive role...Read more

LRIT2 - a Gene Doe of the retina

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In this post we want to draw some attention to one of the rather unknown but interesting genes that we have encountered, the LRIT2 gene specifically expressed in retina...Read more

The role of trypsin in bottom-up proteomics moving towards clinical application


The impact of different trypsins on commonly used bottom-up proteomics workflows were investigated across a range of sample types in a publication in Analytical Chemistry. Besides the type of trypsin, different protease concentrations, sample matrices, instrument acquisition techniques, and protease storage times were investigated...Read more