News Articles

The roles of vaccine-induced SARS-CoV-2 NAbs and T cells in protection and disease


In a study published in Molecular Therapy researchers from KTH among others have generated several different DNA vaccines selectively activating neutralizing antibodies (Nabs) and/or T cells and used them in different animal models to study their individual roles in the protection against severe SARS-CoV-2...Read more

A multi-omics strategy to discover and validate missing proteins in the ovary


In a publication in Journal of Proteome Research transcriptomics and spatial proteomics were used to investigate and validate the expression of so-called missing proteins in the human ovary...Read more

The role of trypsin in bottom-up proteomics moving towards clinical application


The impact of different trypsins on commonly used bottom-up proteomics workflows were investigated across a range of sample types in a publication in Analytical Chemistry. Besides the type of trypsin, different protease concentrations, sample matrices, instrument acquisition techniques, and protease storage times were investigated...Read more

A proteomics strategy to assess the reliability of biomarkers for Duchenne muscular dystrophy


In a publication in Clinical Proteomics a novel orthogonal strategy based on affinity proteomics and mass spectrometry was used for analytical validation of biomarkers in longitudinally collected serum samples from Duchenne muscular dystrophy (DMD) patients...Read more

The plasma proteome signature of multiple myeloma


In a publication in Cancers a comprehensive mass spectrometry strategy was used to profile blood plasma samples from a large pan-cancer cohort including 15 different cancer types. Differential expression analysis and machine learning was then used to identify a potential biomarker panel able to correctly diagnose multiple myeloma...Read more