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Citing the Human Protein Atlas
To cite us, please use:
The Human Protein Atlas
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Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist PH, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Pontén F.
Tissue-based map of the human proteome.
Science 2015 347(6220):1260419.
PubMed: 25613900 DOI: 10.1126/science.1260419
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Uhlen M, Oksvold P, Fagerberg L, Lundberg E, Jonasson K, Forsberg M, Zwahlen M, Kampf C, Wester K, Hober S, Wernerus H, Björling L, Ponten F.
Towards a knowledge-based Human Protein Atlas.
Nat Biotechnol. 2010 28(12):1248-50.
PubMed: 21139605 DOI: 10.1038/nbt1210-1248
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The Cell Atlas
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Thul PJ, Åkesson L, Wiking M, Mahdessian D, Geladaki A, Ait Blal H, Alm T, Asplund A, Björk L, Breckels LM, Bäckström A, Danielsson F, Fagerberg L, Fall J, Gatto L, Gnann C, Hober S, Hjelmare M, Johansson F, Lee S, Lindskog C, Mulder J, Mulvey CM, Nilsson P, Oksvold P, Rockberg J, Schutten R, Schwenk JM, Sivertsson Å, Sjöstedt E, Skogs M, Stadler C, Sullivan DP, Tegel H, Winsnes C, Zhang C, Zwahlen M, Mardinoglu A, Pontén F, von Feilitzen K, Lilley KS, Uhlén M, Lundberg E.
A subcellular map of the human proteome.
Science. 2017 356(6340): eaal3321
PubMed: 28495876 DOI: 10.1126/science.aal3321 Free access:
Abstract,
Full text,
Reprint
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The Pathology Atlas
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Uhlen M, Zhang C, Lee S, Sjöstedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu Z, Edfors F, Sanli K, von Feilitzen K, Oksvold P, Lundberg E, Hober S, Nilsson P, Mattsson J, Schwenk JM, Brunnström H, Glimelius B, Sjöblom T, Edqvist PH, Djureinovic D, Micke P, Lindskog C, Mardinoglu A, Ponten F.
A pathology atlas of the human cancer transcriptome.
Science. 2017 357(6352)
PubMed: 28818916 DOI: 10.1126/science.aan2507
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The original Human Protein Atlas publication
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Uhlén M, Björling E, Agaton C, Szigyarto CA, Amini B, Andersen E, Andersson AC, Angelidou P, Asplund A, Asplund C, Berglund L, Bergström K, Brumer H, Cerjan D, Ekström M, Elobeid A, Eriksson C, Fagerberg L, Falk R, Fall J, Forsberg M, Björklund MG, Gumbel K, Halimi A, Hallin I, Hamsten C, Hansson M, Hedhammar M, Hercules G, Kampf C, Larsson K, Lindskog M, Lodewyckx W, Lund J, Lundeberg J, Magnusson K, Malm E, Nilsson P, Odling J, Oksvold P, Olsson I, Oster E, Ottosson J, Paavilainen L, Persson A, Rimini R, Rockberg J, Runeson M, Sivertsson A, Sköllermo A, Steen J, Stenvall M, Sterky F, Strömberg S, Sundberg M, Tegel H, Tourle S, Wahlund E, Waldén A, Wan J, Wernérus H, Westberg J, Wester K, Wrethagen U, Xu LL, Hober S, Pontén F.
A human protein atlas for normal and cancer tissues based on antibody proteomics.
Mol Cell Proteomics. 2005 4(12):1920-32.
PubMed: 16127175 DOI: 10.1074/mcp.M500279-MCP200
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Publications
| 504 |
Mönnich M, Borgeskov L, Breslin L, Jakobsen L, Rogowski M, Doganli C, Schrøder JM, Mogensen JB, Blinkenkjær L, Harder LM, Lundberg E, Geimer S, Christensen ST, Andersen JS, Larsen LA, Pedersen LB.
CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium.
Cell Rep. 2018 22(10):2584-2592.
PubMed: 29514088 DOI: 10.1016/j.celrep.2018.02.043
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| 503 |
Guala D, Bernhem K, Blal HA, Jans D, Lundberg E, Brismar H, Sonnhammer ELL.
Experimental validation of predicted cancer genes using FRET.
Methods Appl Fluoresc. 2018 6(3):035007.
PubMed: 29570091 DOI: 10.1088/2050-6120/aab932
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| 502 |
Edfors F, Hober A, Linderbäck K, Maddalo G, Azimi A, Sivertsson Å, Tegel H, Hober S, Szigyarto CA, Fagerberg L, von Feilitzen K, Oksvold P, Lindskog C, Forsström B, Uhlen M.
Enhanced validation of antibodies for research applications.
Nat Commun. 2018 9(1):4130.
PubMed: 30297845 DOI: 10.1038/s41467-018-06642-y
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| 501 |
Lovric A, Granér M, Bjornson E, Arif M, Benfeitas R, Nyman K, Ståhlman M, Pentikäinen MO, Lundbom J, Hakkarainen A, Sirén R, Nieminen MS, Lundbom N, Lauerma K, Taskinen MR, Mardinoglu A, Boren J.
Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome.
Sci Rep. 2018 8(1):14200.
PubMed: 30242179 DOI: 10.1038/s41598-018-31865-w
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| 500 |
Sjöstedt E, Sivertsson Å, Hikmet Noraddin F, Katona B, Näsström Å, Vuu J, Kesti D, Oksvold P, Edqvist PH, Olsson I, Uhlén M, Lindskog C.
Integration of transcriptomics and antibody-based proteomics for exploration of proteins expressed in specialized tissues.
J Proteome Res. 2018 Epub ahead of print
PubMed: 30272454 DOI: 10.1021/acs.jproteome.8b00406
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| 499 |
Lee S, Zhang C, Arif M, Liu Z, Benfeitas R, Bidkhori G, Deshmukh S, Al Shobky M, Lovric A, Boren J, Nielsen J, Uhlen M, Mardinoglu A.
TCSBN: a database of tissue and cancer specific biological networks.
Nucleic Acids Res. 2018 46(D1):D595-D600.
PubMed: 29069445 DOI: 10.1093/nar/gkx994
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| 498 |
Mardinoglu A, Uhlen M, Borén J.
Broad Views of Non-alcoholic Fatty Liver Disease.
Cell Syst. 2018 6(1):7-9.
PubMed: 29401451 DOI: 10.1016/j.cels.2018.01.004
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| 497 |
Mardinoglu A, Wu H, Bjornson E, Zhang C, Hakkarainen A, Räsänen SM, Lee S, Mancina RM, Bergentall M, Pietiläinen KH, Söderlund S, Matikainen N, Ståhlman M, Bergh PO, Adiels M, Piening BD, Granér M, Lundbom N, Williams KJ, Romeo S, Nielsen J, Snyder M, Uhlén M, Bergström G, Perkins R, Marschall HU, Bäckhed F, Taskinen MR, Borén J.
An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.
Cell Metab. 2018 27(3):559-571.e5.
PubMed: 29456073 DOI: 10.1016/j.cmet.2018.01.005
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| 496 |
Karnevi E, Dror LB, Mardinoglu A, Elebro J, Heby M, Olofsson SE, Nodin B, Eberhard J, Gallagher W, Uhlén M, Jirström K.
Translational study reveals a two-faced role of RBM3 in pancreatic cancer and suggests its potential value as a biomarker for improved patient stratification.
Oncotarget. 2018 9(5):6188-6200.
PubMed: 29464064 DOI: 10.18632/oncotarget.23486
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| 495 |
Azimi A, Caramuta S, Seashore-Ludlow B, Boström J, Robinson JL, Edfors F, Tuominen R, Kemper K, Krijgsman O, Peeper DS, Nielsen J, Hansson J, Egyhazi Brage S, Altun M, Uhlen M, Maddalo G.
Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.
Mol Syst Biol. 2018 14(3):e7858.
PubMed: 29507054
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| 494 |
Lee CY, Wang D, Wilhelm M, Zolg DP, Schmidt T, Schnatbaum K, Reimer U, Pontén F, Uhlén M, Hahne H, Kuster B.
Mining the Human Tissue Proteome for Protein Citrullination.
Mol Cell Proteomics. 2018 17(7):1378-1391.
PubMed: 29610271 DOI: 10.1074/mcp.RA118.000696
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| 493 |
Mardinoglu A, Boren J, Smith U, Uhlen M, Nielsen J.
Systems biology in hepatology: approaches and applications.
Nat Rev Gastroenterol Hepatol. 2018 15(6):365-377.
PubMed: 29686404 DOI: 10.1038/s41575-018-0007-8
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| 492 |
Turanli B, Grøtli M, Boren J, Nielsen J, Uhlen M, Arga KY, Mardinoglu A.
Drug Repositioning for Effective Prostate Cancer Treatment.
Front Physiol. 2018 9():500.
PubMed: 29867548 DOI: 10.3389/fphys.2018.00500
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| 491 |
Zhang MD, Su J, Adori C, Cinquina V, Malenczyk K, Girach F, Peng C, Ernfors P, Löw P, Borgius L, Kiehn O, Watanabe M, Uhlén M, Mitsios N, Mulder J, Harkany T, Hökfelt T.
Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity.
J Clin Invest. 2018 128(9):3757-3768.
PubMed: 29893745 DOI: 10.1172/JCI120913
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| 490 |
Rosario D, Benfeitas R, Bidkhori G, Zhang C, Uhlen M, Shoaie S, Mardinoglu A.
Understanding the Representative Gut Microbiota Dysbiosis in Metformin-Treated Type 2 Diabetes Patients Using Genome-Scale Metabolic Modeling.
Front Physiol. 2018 9():775.
PubMed: 29988585 DOI: 10.3389/fphys.2018.00775
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| 489 |
Bidkhori G, Benfeitas R, Elmas E, Kararoudi MN, Arif M, Uhlen M, Nielsen J, Mardinoglu A.
Metabolic Network-Based Identification and Prioritization of Anticancer Targets Based on Expression Data in Hepatocellular Carcinoma.
Front Physiol. 2018 9():916.
PubMed: 30065658 DOI: 10.3389/fphys.2018.00916
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| 488 |
Matic LP, Jesus Iglesias M, Vesterlund M, Lengquist M, Hong MG, Saieed S, Sanchez-Rivera L, Berg M, Razuvaev A, Kronqvist M, Lund K, Caidahl K, Gillgren P, Pontén F, Uhlén M, Schwenk JM, Hansson GK, Paulsson-Berne G, Fagman E, Roy J, Hultgren R, Bergström G, Lehtiö J, Odeberg J, Hedin U.
Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage.
JACC Basic Transl Sci. 2018 3(4):464-480.
PubMed: 30175270 DOI: 10.1016/j.jacbts.2018.04.001
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| 487 |
Dusart P, Fagerberg L, Perisic L, Civelek M, Struck E, Hedin U, Uhlén M, Trégouët DA, Renné T, Odeberg J, Butler LM.
A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein.
Sci Rep. 2018 8(1):14668.
PubMed: 30279450 DOI: 10.1038/s41598-018-32859-4
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| 486 |
O'Hagan S, Wright Muelas M, Day PJ, Lundberg E, Kell DB.
GeneGini: Assessment via the Gini Coefficient of Reference "Housekeeping" Genes and Diverse Human Transporter Expression Profiles.
Cell Syst. 2018 6(2):230-244.e1.
PubMed: 29428416 DOI: 10.1016/j.cels.2018.01.003
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| 485 |
Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B.
How many human proteoforms are there?
Nat Chem Biol. 2018 14(3):206-214.
PubMed: 29443976 DOI: 10.1038/nchembio.2576
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| 484 |
Sullivan DP, Winsnes CF, Åkesson L, Hjelmare M, Wiking M, Schutten R, Campbell L, Leifsson H, Rhodes S, Nordgren A, Smith K, Revaz B, Finnbogason B, Szantner A, Lundberg E.
Deep learning is combined with massive-scale citizen science to improve large-scale image classification.
Nat Biotechnol. 2018 36(9):820-828.
PubMed: 30125267 DOI: 10.1038/nbt.4225
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| 483 |
Danielsson F, Fasterius E, Sullivan D, Hases L, Sanli K, Zhang C, Mardinoglu A, Al-Khalili C, Huss M, Uhlén M, Williams C, Lundberg E.
Transcriptome profiling of the interconnection of pathways involved in malignant transformation and response to hypoxia.
Oncotarget. 2018 9(28):19730-19744.
PubMed: 29731978 DOI: 10.18632/oncotarget.24808
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| 482 |
Sullivan DP, Lundberg E.
Seeing More: A Future of Augmented Microscopy.
Cell. 2018 173(3):546-548.
PubMed: 29677507 DOI: 10.1016/j.cell.2018.04.003
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| 481 |
Carreras-Puigvert J, Zitnik M, Jemth AS, Carter M, Unterlass JE, Hallström B, Loseva O, Karem Z, Calderón-Montaño JM, Lindskog C, Edqvist PH, Matuszewski DJ, Ait Blal H, Berntsson RPA, Häggblad M, Martens U, Studham M, Lundgren B, Wählby C, Sonnhammer ELL, Lundberg E, Stenmark P, Zupan B, Helleday T.
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family.
Nat Commun. 2017 8(1):1541.
PubMed: 29142246 DOI: 10.1038/s41467-017-01642-w
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| 480 |
Boström J, Sramkova Z, Salašová A, Johard H, Mahdessian D, Fedr R, Marks C, Medalová J, Souček K, Lundberg E, Linnarsson S, Bryja V, Sekyrova P, Altun M, Andäng M.
Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells.
PLoS One. 2017 12(12):e0188772.
PubMed: 29228002 DOI: 10.1371/journal.pone.0188772
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| 479 |
Feizi A, Gatto F, Uhlen M, Nielsen J.
Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome.
NPJ Syst Biol Appl. 2017 3():22.
PubMed: 28845240 DOI: 10.1038/s41540-017-0021-4
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| 478 |
Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell P, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, Enard W, Farmer A, Fugger L, Göttgens B, Hacohen N, Haniffa M, Hemberg M, Kim S, Klenerman P, Kriegstein A, Lein E, Linnarsson S, Lundberg E, Lundeberg J, Majumder P, Marioni JC, Merad M, Mhlanga M, Nawijn M, Netea M, Nolan G, Pe'er D, Phillipakis A, Ponting CP, Quake S, Reik W, Rozenblatt-Rosen O, Sanes J, Satija R, Schumacher TN, Shalek A, Shapiro E, Sharma P, Shin JW, Stegle O, Stratton M, Stubbington MJT, Theis FJ, Uhlen M, van Oudenaarden A, Wagner A, Watt F, Weissman J, Wold B, Xavier R, Yosef N, Human Cell Atlas Meeting Participants.
The Human Cell Atlas.
Elife. 2017 6():.
PubMed: 29206104 DOI: 10.7554/eLife.27041
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| 477 |
Birse KD, Romas LM, Guthrie BL, Nilsson P, Bosire R, Kiarie J, Farquhar C, Broliden K, Burgener AD.
Genital Injury Signatures and Microbiome Alterations Associated With Depot Medroxyprogesterone Acetate Usage and Intravaginal Drying Practices.
J Infect Dis. 2017 215(4):590-598.
PubMed: 28011908 DOI: 10.1093/infdis/jiw590
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| 476 |
Svedberg G, Jeong Y, Na H, Jang J, Nilsson P, Kwon S, Gantelius J, Svahn HA.
Towards encoded particles for highly multiplexed colorimetric point of care autoantibody detection.
Lab Chip. 2017 17(3):549-556.
PubMed: 28102419 DOI: 10.1039/c6lc01358a
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| 475 |
Checa A, Idborg H, Zandian A, Sar DG, Surowiec I, Trygg J, Svenungsson E, Jakobsson PJ, Nilsson P, Gunnarsson I, Wheelock CE.
Dysregulations in circulating sphingolipids associate with disease activity indices in female patients with systemic lupus erythematosus: a cross-sectional study.
Lupus. 2017 26(10):1023-1033.
PubMed: 28134039 DOI: 10.1177/0961203316686707
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| 474 |
Ch'ng JH, Sirel M, Zandian A, Del Pilar Quintana M, Chun Leung Chan S, Moll K, Tellgren-Roth A, Nilsson I, Nilsson P, Qundos U, Wahlgren M.
Epitopes of anti-RIFIN antibodies and characterization of rif-expressing Plasmodium falciparum parasites by RNA sequencing.
Sci Rep. 2017 7():43190.
PubMed: 28233866 DOI: 10.1038/srep43190
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| 473 |
Sierra-Sánchez Á, Garrido-Martín D, Lourido L, González-González M, Díez P, Ruiz-Romero C, Sjöber R, Droste C, De Las Rivas J, Nilsson P, Blanco F, Fuentes M.
Screening and Validation of Novel Biomarkers in Osteoarticular Pathologies by Comprehensive Combination of Protein Array Technologies.
J Proteome Res. 2017 16(5):1890-1899.
PubMed: 28379711 DOI: 10.1021/acs.jproteome.6b00980
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| 472 |
Ge C, Tong D, Liang B, Lönnblom E, Schneider N, Hagert C, Viljanen J, Ayoglu B, Stawikowska R, Nilsson P, Fields GB, Skogh T, Kastbom A, Kihlberg J, Burkhardt H, Dobritzsch D, Holmdahl R.
Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
JCI Insight. 2017 2(13):.
PubMed: 28679953 DOI: 10.1172/jci.insight.93688
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| 471 |
Skogs M, Stadler C, Schutten R, Hjelmare M, Gnann C, Björk L, Poser I, Hyman A, Uhlén M, Lundberg E.
Antibody Validation in Bioimaging Applications Based on Endogenous Expression of Tagged Proteins.
J Proteome Res. 2017 16(1):147-155.
PubMed: 27723985 DOI: 10.1021/acs.jproteome.6b00821
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| 470 |
Alkasalias T, Alexeyenko A, Hennig K, Danielsson F, Lebbink RJ, Fielden M, Turunen SP, Lehti K, Kashuba V, Madapura HS, Bozoky B, Lundberg E, Balland M, Guvén H, Klein G, Gad AK, Pavlova T.
RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo.
Proc Natl Acad Sci U S A. 2017 114(8):E1413-E1421.
PubMed: 28174275 DOI: 10.1073/pnas.1621161114
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| 469 |
Omenn GS, Lane L, Lundberg EK, Overall CM, Deutsch EW.
Progress on the HUPO Draft Human Proteome: 2017 Metrics of the Human Proteome Project.
J Proteome Res. 2017 Epub ahead of print
PubMed: 28853897 DOI: 10.1021/acs.jproteome.7b00375
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| 468 |
Ly T, Whigham A, Clarke R, Brenes-Murillo AJ, Estes B, Madhessian D, Lundberg E, Wadsworth P, Lamond AI.
Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS.
Elife. 2017 6():.
PubMed: 29052541 DOI: 10.7554/eLife.27574
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| 467 |
Brunnström H, Johansson A, Westbom-Fremer S, Backman M, Djureinovic D, Patthey A, Isaksson-Mettävainio M, Gulyas M, Micke P.
PD-L1 immunohistochemistry in clinical diagnostics of lung cancer: inter-pathologist variability is higher than assay variability.
Mod Pathol. 2017 30(10):1411-1421.
PubMed: 28664936 DOI: 10.1038/modpathol.2017.59
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| 466 |
Jedlinski A, Garvin S, Johansson AC, Edqvist PH, Ponten F, Roberg K.
Cetuximab sensitivity of head and neck squamous cell carcinoma xenografts is associated with treatment-induced reduction in EGFR, pEGFR, and pSrc.
J Oral Pathol Med. 2017 46(9):717-724.
PubMed: 28036101 DOI: 10.1111/jop.12545
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| 465 |
Gremel G, Djureinovic D, Niinivirta M, Laird A, Ljungqvist O, Johannesson H, Bergman J, Edqvist PH, Navani S, Khan N, Patil T, Sivertsson Å, Uhlén M, Harrison DJ, Ullenhag GJ, Stewart GD, Pontén F.
A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma.
BMC Cancer. 2017 17(1):9.
PubMed: 28052770 DOI: 10.1186/s12885-016-3030-6
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| 464 |
Niinivirta M, Enblad G, Edqvist PH, Pontén F, Dragomir A, Ullenhag GJ.
Tumoral cubilin is a predictive marker for treatment of renal cancer patients with sunitinib and sorafenib.
J Cancer Res Clin Oncol. 2017 143(6):961-970.
PubMed: 28260162 DOI: 10.1007/s00432-017-2365-y
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| 463 |
Grinberg M, Djureinovic D, Brunnström HR, Mattsson JS, Edlund K, Hengstler JG, La Fleur L, Ekman S, Koyi H, Branden E, Ståhle E, Jirström K, Tracy DK, Pontén F, Botling J, Rahnenführer J, Micke P.
Reaching the limits of prognostication in non-small cell lung cancer: an optimized biomarker panel fails to outperform clinical parameters.
Mod Pathol. 2017 30(7):964-977.
PubMed: 28281552 DOI: 10.1038/modpathol.2017.14
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| 462 |
Bondeson ML, Ericson K, Gudmundsson S, Ameur A, Pontén F, Wesström J, Frykholm C, Wilbe M.
A nonsense mutation in CEP55 defines a new locus for a Meckel-like syndrome, an autosomal recessive lethal fetal ciliopathy.
Clin Genet. 2017 92(5):510-516.
PubMed: 28295209 DOI: 10.1111/cge.13012
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| 461 |
Roy A, Attarha S, Weishaupt H, Edqvist PH, Swartling FJ, Bergqvist M, Siebzehnrubl FA, Smits A, Pontén F, Tchougounova E.
Serglycin as a potential biomarker for glioma: association of serglycin expression, extent of mast cell recruitment and glioblastoma progression.
Oncotarget. 2017 8(15):24815-24827.
PubMed: 28445977 DOI: 10.18632/oncotarget.15820
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| 460 |
Roy A, Libard S, Weishaupt H, Gustavsson I, Uhrbom L, Hesselager G, Swartling FJ, Pontén F, Alafuzoff I, Tchougounova E.
Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential.
Front Oncol. 2017 7():115.
PubMed: 28626727 DOI: 10.3389/fonc.2017.00115
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| 459 |
Casar-Borota O, Botling J, Granberg D, Stigare J, Wikström J, Boldt HB, Kristensen BW, Pontén F, Trouillas J.
Serotonin, ATRX, and DAXX Expression in Pituitary Adenomas: Markers in the Differential Diagnosis of Neuroendocrine Tumors of the Sellar Region.
Am J Surg Pathol. 2017 41(9):1238-1246.
PubMed: 28719461 DOI: 10.1097/PAS.0000000000000908
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| 458 |
Siesing C, Sorbye H, Dragomir A, Pfeiffer P, Qvortrup C, Pontén F, Jirström K, Glimelius B, Eberhard J.
High RBM3 expression is associated with an improved survival and oxaliplatin response in patients with metastatic colorectal cancer.
PLoS One. 2017 12(8):e0182512.
PubMed: 28800641 DOI: 10.1371/journal.pone.0182512
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| 457 |
Dos Remedios CG, Lal SP, Li A, McNamara J, Keogh A, Macdonald PS, Cooke R, Ehler E, Knöll R, Marston SB, Stelzer J, Granzier H, Bezzina C, van Dijk S, De Man F, Stienen GJM, Odeberg J, Pontén F, Linke W, van der Velden J.
The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease.
Biophys Rev. 2017 Epub ahead of print
PubMed: 28808947 DOI: 10.1007/s12551-017-0305-3
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| 456 |
Fredholm H, Magnusson K, Lindström LS, Tobin NP, Lindman H, Bergh J, Holmberg L, Pontén F, Frisell J, Fredriksson I.
Breast cancer in young women and prognosis: How important are proliferation markers?
Eur J Cancer. 2017 84():278-289.
PubMed: 28844016 DOI: 10.1016/j.ejca.2017.07.044
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| 455 |
Zieba A, Ponten F, Uhlén M, Landegren U.
In situ protein detection with enhanced specificity using DNA-conjugated antibodies and proximity ligation.
Mod Pathol. 2017 Epub ahead of print
PubMed: 28937142 DOI: 10.1038/modpathol.2017.102
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| 454 |
Sjöstedt E, Bollerslev J, Mulder J, Lindskog C, Pontén F, Casar-Borota O.
A specific antibody to detect transcription factor T-Pit: a reliable marker of corticotroph cell differentiation and a tool to improve the classification of pituitary neuroendocrine tumours.
Acta Neuropathol. 2017 Epub ahead of print
PubMed: 28823042 DOI: 10.1007/s00401-017-1768-9
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| 453 |
Carapito C, Duek P, Macron C, Seffals M, Rondel K, Delalande F, Lindskog C, Fréour T, Vandenbrouck Y, Lane L, Pineau C.
Validating Missing Proteins in Human Sperm Cells by Targeted Mass-Spectrometry- and Antibody-based Methods.
J Proteome Res. 2017 Epub ahead of print
PubMed: 28891297 DOI: 10.1021/acs.jproteome.7b00374
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Protein Sci. 2017 Epub ahead of print
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Guo J, Grow EJ, Yi C, Mlcochova H, Maher GJ, Lindskog C, Murphy PJ, Wike CL, Carrell DT, Goriely A, Hotaling JM, Cairns BR.
Chromatin and Single-Cell RNA-Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during Human Spermatogonial Stem Cell Development.
Cell Stem Cell. 2017 21(4):533-546.e6.
PubMed: 28985528 DOI: 10.1016/j.stem.2017.09.003
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Bosley J, Boren C, Lee S, Grøtli M, Nielsen J, Uhlen M, Boren J, Mardinoglu A.
Improving the economics of NASH/NAFLD treatment through the use of systems biology.
Drug Discov Today. 2017 22(10):1532-1538.
PubMed: 28736156 DOI: 10.1016/j.drudis.2017.07.005
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Liu Z, Que S, Mardinoglu A.
Rediscussion on linearity between fibrosis stages and mortality risk in nonalcoholic fatty liver disease patients.
Hepatology. 2017 66(4):1357-1358.
PubMed: 28727167 DOI: 10.1002/hep.29390
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Liu Z, Que S, Zhou L, Zheng S, Romeo S, Mardinoglu A, Valenti L.
The effect of the TM6SF2 E167K variant on liver steatosis and fibrosis in patients with chronic hepatitis C: a meta-analysis.
Sci Rep. 2017 7(1):9273.
PubMed: 28839198 DOI: 10.1038/s41598-017-09548-9
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Lee S, Zhang C, Liu Z, Klevstig M, Mukhopadhyay B, Bergentall M, Cinar R, Ståhlman M, Sikanic N, Park JK, Deshmukh S, Harzandi AM, Kuijpers T, Grøtli M, Elsässer SJ, Piening BD, Snyder M, Smith U, Nielsen J, Bäckhed F, Kunos G, Uhlen M, Boren J, Mardinoglu A.
Network analyses identify liver-specific targets for treating liver diseases.
Mol Syst Biol. 2017 13(8):938.
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Mardinoglu A, Stančáková A, Lotta LA, Kuusisto J, Boren J, Blüher M, Wareham NJ, Ferrannini E, Groop PH, Laakso M, Langenberg C, Smith U.
Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease.
Cell Metab. 2017 26(2):281-283.
PubMed: 28768165 DOI: 10.1016/j.cmet.2017.07.006
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Benfeitas R, Uhlen M, Nielsen J, Mardinoglu A.
New Challenges to Study Heterogeneity in Cancer Redox Metabolism.
Front Cell Dev Biol. 2017 5():65.
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Mardinoglu A, Borén J.
AUP1 (Ancient Ubiquitous Protein 1): A Molecular Link Between Hepatic Lipid Mobilization and VLDL Secretion.
Arterioscler Thromb Vasc Biol. 2017 37(4):609-610.
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Mardinoglu A, Bjornson E, Zhang C, Klevstig M, Söderlund S, Ståhlman M, Adiels M, Hakkarainen A, Lundbom N, Kilicarslan M, Hallström BM, Lundbom J, Vergès B, Barrett PH, Watts GF, Serlie MJ, Nielsen J, Uhlén M, Smith U, Marschall HU, Taskinen MR, Boren J.
Personal model-assisted identification of NAD(+) and glutathione metabolism as intervention target in NAFLD.
Mol Syst Biol. 2017 13(3):916.
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Nilsson A, Mardinoglu A, Nielsen J.
Predicting growth of the healthy infant using a genome scale metabolic model.
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Schwenk JM, Omenn GS, Sun Z, Campbell DS, Baker MS, Overall CM, Aebersold R, Moritz RL, Deutsch EW.
The Human Plasma Proteome Draft of 2017: Building on the Human Plasma PeptideAtlas from Mass Spectrometry and Complementary Assays.
J Proteome Res. 2017 Epub ahead of print
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Untargeted screening for novel autoantibodies with prognostic value in first-episode psychosis.
Transl Psychiatry. 2017 7(7):e1177.
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U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.
Acta Oncol. 2017 ():1-8.
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Affinity Proteomics Exploration of Melanoma Identifies Proteins in Serum with Associations to T-Stage and Recurrence.
Transl Oncol. 2017 10(3):385-395.
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A Preliminary Report: Radical Surgery and Stem Cell Transplantation for the Treatment of Patients With Pancreatic Cancer.
J Immunother. 2017 Epub ahead of print
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Sci Rep. 2017 7(1):137.
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Whole-Proteome Peptide Microarrays for Profiling Autoantibody Repertoires within Multiple Sclerosis and Narcolepsy.
J Proteome Res. 2017 16(3):1300-1314.
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A pathology atlas of the human cancer transcriptome.
Science. 2017 357(6352)
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The endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFR.
J Cell Biol. 2016 215(4):543-558.
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Mass spectrometric analysis of synaptosomal membrane preparations for the determination of brain receptors, transporters and channels.
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The Impact of the Fourth Edition of the WHO Classification of Lung Tumours on Histological Classification of Resected Pulmonary NSCCs.
J Thorac Oncol. 2016 11(6):862-72.
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Mol Syst Biol. 2016 12(10):883.
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The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene.
Sci Transl Med. 2016 8(369):369ra177.
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Ten Berge JC, van Rosmalen J, Vermeer J, Hellström C, Lindskog C, Nilsson P, Qundos U, Rothova A, Schreurs MW.
Serum Autoantibody Profiling of Patients with Paraneoplastic and Non-Paraneoplastic Autoimmune Retinopathy.
PLoS One. 2016 11(12):e0167909.
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Editorial: The Impact of Systems Medicine on Human Health and Disease.
Front Physiol. 2016 7():552.
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mSystems. 2016 1(6):.
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ANLN is a prognostic biomarker independent of Ki-67 and essential for cell cycle progression in primary breast cancer.
BMC Cancer. 2016 16(1):904.
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The human adrenal gland proteome defined by transcriptomics and antibody-based profiling.
Endocrinology. 2016 ():en20161758.
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An automated method measures variability in P-glycoprotein and ABCG2 densities across brain regions and brain matter.
J Cereb Blood Flow Metab. 2016 Epub ahead of print
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Increased Levels of Extracellular Microvesicle Markers and Decreased Levels of Endocytic/Exocytic Proteins in the Alzheimer's Disease Brain.
J Alzheimers Dis. 2016 54(4):1671-1686.
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Protein profiling in serum after traumatic brain injury in rats reveals potential injury markers.
Behav Brain Res. 2016 Epub ahead of print
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Antigen arrays for profiling autoantibody repertoires.
Bioanalysis. 2016 8(10):1105-26.
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Key players in neurodegenerative disorders in focus-New insights into the proteomic profile of Alzheimer's disease, schizophrenia, ALS, and multiple sclerosis-24th HUPO BPP Workshop: September 29, 2015, Vancouver, Canada.
Proteomics. 2016 16(7):1047-50.
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Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease.
PLoS One. 2016 11(3):e0150672.
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Confounding Effects of Metformin on the Human Gut Microbiome in Type 2 Diabetes.
Cell Metab. 2016 23(1):10-2.
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Personalized Cardiovascular Disease Prediction and Treatment-A Review of Existing Strategies and Novel Systems Medicine Tools.
Front Physiol. 2016 7():2.
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Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q in hepatocellular carcinoma metabolism.
Mol Biosyst. 2016 12(5):1496-506.
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Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis.
Nucleic Acids Res. 2016 44(12):5529-39.
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Investigating the Combinatory Effects of Biological Networks on Gene Co-expression.
Front Physiol. 2016 7():160.
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ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid metabolism.
Biochim Biophys Acta. 2016 1861(11):1643-1651.
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Mitochondria-related transcriptional signature is downregulated in adipocytes in obesity: a study of young healthy MZ twins.
Diabetologia. 2016 Epub ahead of print
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J Transl Med. 2016 14(1):128.
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Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance.
Cell Metab. 2016 24(1):172-84.
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Liver: Phenotypic and genetic variance: a systems approach to the liver.
Nat Rev Gastroenterol Hepatol. 2016 13(8):439-40.
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Eur J Haematol. 2016 Epub ahead of print
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Front Neuroanat. 2016 10():77.
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Blokzijl A, Friedman M, Pontén F, Landegren U.
Profiling protein expression and interactions: proximity ligation as a tool for personalized medicine.
J Intern Med. 2010 268(3):232-45.
PubMed: 20695973 DOI: 10.1111/j.1365-2796.2010.02256.x
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Ryan D, Rafferty M, Hegarty S, O'Leary P, Faller W, Gremel G, Bergqvist M, Agnarsdottir M, Strömberg S, Kampf C, Pontén F, Millikan RC, Dervan PA, Gallagher WM.
Topoisomerase I amplification in melanoma is associated with more advanced tumours and poor prognosis.
Pigment Cell Melanoma Res. 2010 23(4):542-53.
PubMed: 20465595 DOI: 10.1111/j.1755-148X.2010.00720.x
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Brennan DJ, Brändstedt J, Rexhepaj E, Foley M, Pontén F, Uhlén M, Gallagher WM, O'Connor DP, O'Herlihy C, Jirstrom K.
Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer.
BMC Cancer. 2010 10:125.
PubMed: 20359358 DOI: 10.1186/1471-2407-10-125
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Nord H, Segersten U, Sandgren J, Wester K, Busch C, Menzel U, Komorowski J, Dumanski JP, Malmström PU, Díaz de Ståhl T.
Focal amplifications are associated with high grade and recurrences in stage Ta bladder carcinoma.
Int J Cancer. 2010 126(6):1390-402.
PubMed: 19821490 DOI: 10.1002/ijc.24954
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Borsics T, Lundberg E, Geerts D, Koomoa DL, Koster J, Wester K, Bachmann AS.
Subcellular distribution and expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in malignant glioma: Influence on cell survival and migration.
Cancer Sci. 2010 101(7):1624-31.
PubMed: 20412121 DOI: 10.1111/j.1349-7006.2010.01570.x
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Lundberg E, Uhlén M.
Creation of an antibody-based subcellular protein atlas.
Proteomics. 2010 10(22):3984-96.
PubMed: 20648481 DOI: 10.1002/pmic.201000125
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Schwenk JM, Igel U, Neiman M, Langen H, Becker C, Bjartell A, Ponten F, Wiklund F, Grönberg H, Nilsson P, Uhlen M.
Toward next generation plasma profiling via heat-induced epitope retrieval and array-based assays.
Mol Cell Proteomics. 2010 9(11):2497-507.
PubMed: 20682762 DOI: 10.1074/mcp.M110.001560
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Rockberg J, Löfblom J, Hjelm B, Ståhl S, Uhlén M.
Epitope mapping using gram-positive surface display.
Curr Protoc Immunol. 2010 Chapter 9:Unit9.9.
PubMed: 20814943 DOI: 10.1002/0471142735.im0909s90
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Tassidis H, Brokken LJ, Jirström K, Ehrnström R, Pontén F, Ulmert D, Bjartell A, Härkönen P, Wingren AG.
Immunohistochemical detection of tyrosine phosphatase SHP-1 predicts outcome after radical prostatectomy for localized prostate cancer.
Int J Cancer. 2010 126(10):2296-307.
PubMed: 19795453 DOI: 10.1002/ijc.24917
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Holgersson G, Ekman S, Reizenstein J, Bergqvist M, Pontén F, Uhlén M, Magnusson K, Jonnalagadda P, Asplund A, Strömberg S, Linder A, Blomquist E, Liljeholm M, Lödén B, Hellström K, Bergström S.
Molecular profiling using tissue microarrays as a tool to identify predictive biomarkers in laryngeal cancer treated with radiotherapy.
Cancer Genomics Proteomics 2010 7(1):1-7.
PubMed: 20181625
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Tegel H, Tourle S, Ottosson J, Persson A.
Increased levels of recombinant human proteins with the Escherichia coli strain Rosetta(DE3).
Protein Expr Purif. 2010 69(2):159-67.
PubMed: 19733669 DOI: 10.1016/j.pep.2009.08.017
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Fagerberg L, Jonasson K, von Heijne G, Uhlén M, Berglund L.
Prediction of the human membrane proteome.
Proteomics. 2010 10(6):1141-9.
PubMed: 20175080 DOI: 10.1002/pmic.200900258
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Schwenk JM, Igel U, Kato BS, Nicholson G, Karpe F, Uhlén M, Nilsson P.
Comparative protein profiling of serum and plasma using an antibody suspension bead array approach.
Proteomics. 2010 10(3):532-40.
PubMed: 19953555 DOI: 10.1002/pmic.200900657
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Stadler C, Skogs M, Brismar H, Uhlén M, Lundberg E.
A single fixation protocol for proteome-wide immunofluorescence localization studies.
J Proteomics. 2010 73(6):1067-78.
PubMed: 19896565 DOI: 10.1016/j.jprot.2009.10.012
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Gloriam DE, Orchard S, Bertinetti D, Björling E, Bongcam-Rudloff E, Borrebaeck CA, Bourbeillon J, Bradbury AR, de Daruvar A, Dübel S, Frank R, Gibson TJ, Gold L, Haslam N, Herberg FW, Hiltke T, Hoheisel JD, Kerrien S, Koegl M, Konthur Z, Korn B, Landegren U, Montecchi-Palazzi L, Palcy S, Rodriguez H, Schweinsberg S, Sievert V, Stoevesandt O, Taussig MJ, Ueffing M, Uhlén M, van der Maarel S, Wingren C, Woollard P, Sherman DJ, Hermjakob H.
A community standard format for the representation of protein affinity reagents.
Mol Cell Proteomics. 2010 9(1):1-10.
PubMed: 19674966 DOI: 10.1074/mcp.M900185-MCP200
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Szigyarto CA, Sibbons P, Williams G, Uhlen M, Metcalfe SM.
The E3 ligase axotrophin/MARCH-7: protein expression profiling of human tissues reveals links to adult stem cells.
J Histochem Cytochem. 2010 58(4):301-8.
PubMed: 19901269 DOI: 10.1369/jhc.2009.954420
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Hjelm B, Fernández CD, Löfblom J, Ståhl S, Johannesson H, Rockberg J, Uhlén M.
Exploring epitopes of antibodies toward the human tryptophanyl-tRNA synthetase.
N Biotechnol. 2010 27(2):129-37.
PubMed: 19913117 DOI: 10.1016/j.nbt.2009.11.001
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Paavilainen L, Edvinsson A, Asplund A, Hober S, Kampf C, Pontén F, Wester K.
The impact of tissue fixatives on morphology and antibody-based protein profiling in tissues and cells.
J Histochem Cytochem. 2010 58(3):237-46.
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Tchougounova E, Jiang Y, Bråsäter D, Lindberg N, Kastemar M, Asplund A, Westermark B, Uhrbom L.
Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence.
Oncogene. 2009 28(12):1537-48.
PubMed: 19219070 DOI: 10.1038/onc.2009.9
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Oberg F, Haseeb A, Ahnfelt M, Pontén F, Westermark B, El-Obeid A.
Herbal melanin activates TLR4/NF-kappaB signaling pathway.
Phytomedicine. 2009 16(5):477-84.
PubMed: 19103478 DOI: 10.1016/j.phymed.2008.10.008
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Apweiler R, Aslanidis C, Deufel T, Gerstner A, Hansen J, Hochstrasser D, Kellner R, Kubicek M, Lottspeich F, Maser E, Mewes HW, Meyer HE, Müllner S, Mutter W, Neumaier M, Nollau P, Nothwang HG, Ponten F, Radbruch A, Reinert K, Rothe G, Stockinger H, Tárnok A, Taussig MJ, Thiel A, Thiery J, Ueffing M, Valet G, Vandekerckhove J, Wagener C, Wagner O, Schmitz G.
Approaching clinical proteomics: current state and future fields of application in cellular proteomics.
Cytometry A. 2009 75(10):816-32.
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Leja J, Essaghir A, Essand M, Wester K, Oberg K, Tötterman TH, Lloyd R, Vasmatzis G, Demoulin JB, Giandomenico V.
Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas.
Mod Pathol. 2009 22(2):261-72.
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Qu M, Aronica E, Boer K, Fällmar D, Kumlien E, Nistér M, Wester K, Pontén F, Smits A.
DLG3/SAP102 protein expression in malformations of cortical development: a study of human epileptic cortex by tissue microarray.
Epilepsy Res. 2009 84(1):33-41.
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Newberg JY, Li J, Rao A, Pontén F, Uhlén M, Lundberg E, Murphy RF.
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Proc IEEE Int Symp Biomed Imaging. 2009 5193229:1023-1026.
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Gaber A, Johansson M, Stenman UH, Hotakainen K, Pontén F, Glimelius B, Bjartell A, Jirström K, Birgisson H.
High expression of tumour-associated trypsin inhibitor correlates with liver metastasis and poor prognosis in colorectal cancer.
Br J Cancer. 2009 100(10):1540-8.
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Paulsson J, Sjöblom T, Micke P, Pontén F, Landberg G, Heldin CH, Bergh J, Brennan DJ, Jirström K, Ostman A.
Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer.
Am J Pathol. 2009 175(1):334-41.
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Apweiler R, Aslanidis C, Deufel T, Gerstner A, Hansen J, Hochstrasser D, Kellner R, Kubicek M, Lottspeich F, Maser E, Mewes HW, Meyer HE, Müllner S, Mutter W, Neumaier M, Nollau P, Nothwang HG, Ponten F, Radbruch A, Reinert K, Rothe G, Stockinger H, Tarnok A, Taussig MJ, Thiel A, Thiery J, Ueffing M, Valet G, Vandekerckhove J, Verhuven W, Wagener C, Wagner O, Schmitz G.
Approaching clinical proteomics: current state and future fields of application in fluid proteomics.
Clin Chem Lab Med. 2009 47(6):724-44.
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The prognostic significance of tryptophanyl-tRNA synthetase in colorectal cancer.
Cancer Epidemiol Biomarkers Prev. 2009 18(11):2949-56.
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ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth.
PLoS Biol. 2009 7(12):e1000256.
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J Proteomics 2009 73(2):252-66.
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Detection and analysis of low-abundance cell-surface biomarkers using enzymatic amplification in microfluidic droplets.
Angew Chem Int Ed Engl. 2009 48(14):2518-21.
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Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008).
Mol Oncol. 2009 3(1):9-17.
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Discovery of epitopes for targeting the human epidermal growth factor receptor 2 (HER2) with antibodies.
Mol Oncol. 2009 3(3):238-47.
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Correlations between RNA and protein expression profiles in 23 human cell lines.
BMC Genomics. 2009 10:365.
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Nuclear expression of the RNA-binding protein RBM3 is associated with an improved clinical outcome in breast cancer.
Mod Pathol. 2009 22(12):1564-74.
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Endogenous gene and protein expression of drug-transporting proteins in cell lines routinely used in drug discovery programs.
Drug Metab Dispos. 2009 37(12):2275-83.
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Control of iron homeostasis by an iron-regulated ubiquitin ligase.
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Secretagogin is a Ca2+-binding protein specifying subpopulations of telencephalic neurons.
Proc Natl Acad Sci U S A. 2009 106(52):22492-7.
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A novel strategy based on histological protein profiling in-silico for identifying potential biomarkers in urinary bladder cancer.
BJU Int. 2009 104(11):1780-5.
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A global view of protein expression in human cells, tissues, and organs.
Mol Syst Biol. 2009 5:337.
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Protein Sci. 2009 18(11):2346-55.
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Recommendations from the 2008 International Summit on Proteomics Data Release and Sharing Policy: the Amsterdam principles.
J Proteome Res. 2009 8(7):3689-92.
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Pulmonary autoimmunity as a feature of autoimmune polyendocrine syndrome type 1 and identification of KCNRG as a bronchial autoantigen.
Proc Natl Acad Sci U S A. 2009 106(11):4396-401.
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Selective expression of Syntaxin-7 protein in benign melanocytes and malignant melanoma.
J Proteome Res. 2009 8(4):1639-46.
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Intercalated discs: multiple proteins perform multiple functions in non-failing and failing human hearts.
Biophys Rev 2009 1:43-49.
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Extensive expression of craniofacial related homeobox genes in canine mammary sarcomas.
Breast Cancer Res Treat. 2009 118(2):333-43.
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Tissue profiling of the mammalian central nervous system using human antibody-based proteomics.
Mol Cell Proteomics. 2009 8(7):1612-22.
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Characterization of PrEST-based antibodies towards human Cytokeratin-17.
J Immunol Methods. 2009 342(1-2):20-32.
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J Chromatogr A. 2009 1216(20):4457-64.
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Biotechnol Appl Biochem. 2009 52(Pt 2):159-66.
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Neurosci Lett. 2008 436(2):171-6.
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The protein expression of TRP-1 and galectin-1 in cutaneous malignant melanomas.
Cancer Genomics Proteomics 2008 5(6):293-300.
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Borgquist S, Djerbi S, Pontén F, Anagnostaki L, Goldman M, Gaber A, Manjer J, Landberg G, Jirström K.
HMG-CoA reductase expression in breast cancer is associated with a less aggressive phenotype and influenced by anthropometric factors.
Int J Cancer. 2008 123(5):1146-53.
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Breast Cancer Res. 2008 10(5):R79.
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Expression profiling of microdissected cell populations selected from basal cells in normal epidermis and basal cell carcinoma.
Br J Dermatol. 2008 158(3):527-38.
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Genome Biol. 2008 9(11):325.
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A pilot project to generate affinity reagents to human proteins.
Nat Methods. 2008 5(10):854-5.
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J Pathol. 2008 216(4):387-93.
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Nat Methods. 2008 5(12):1039-45.
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A genecentric Human Protein Atlas for expression profiles based on antibodies.
Mol Cell Proteomics. 2008 7(10):2019-27.
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Mol Cell Proteomics. 2008 7(10):2028-37.
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J Mol Recognit. 2008 22(2):57-64.
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The correlation between cellular size and protein expression levels - normalization for global protein profiling.
J Proteomics. 2008 71(4):448-60.
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J Proteome Res. 2008 7(8):3168-79.
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A whole-genome bioinformatics approach to selection of antigens for systematic antibody generation.
Proteomics. 2008 8(14):2832-9.
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Biotechniques. 2008 44(5):649-54.
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Evaluation of monospecific antibodies: a comparison study with commercial analogs using immunohistochemistry on tissue microarrays.
Appl Immunohistochem Mol Morphol. 2008 16(5):493-502.
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The epitope space of the human proteome.
Protein Sci. 2008 17(4):606-13.
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Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H.
Toward a confocal subcellular atlas of the human proteome.
Mol Cell Proteomics. 2008 7(3):499-508.
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Björling E, Lindskog C, Oksvold P, Linné J, Kampf C, Hober S, Uhlén M, Pontén F.
A web-based tool for in silico biomarker discovery based on tissue-specific protein profiles in normal and cancer tissues.
Mol Cell Proteomics. 2008 7(5):825-44.
PubMed: 17913849 DOI: 10.1074/mcp.M700411-MCP200
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| 39 |
Hober S, Uhlén M.
Human protein atlas and the use of microarray technologies.
Curr Opin Biotechnol. 2008 19(1):30-5.
PubMed: 18187316 DOI: 10.1016/j.copbio.2007.11.006
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| 38 |
Mathivanan S, Ahmed M, Ahn NG, Alexandre H, Amanchy R, Andrews PC, Bader JS, Balgley BM, Bantscheff M, Bennett KL, Björling E, Blagoev B, Bose R, Brahmachari SK, Burlingame AS, Bustelo XR, Cagney G, Cantin GT, Cardasis HL, Celis JE, Chaerkady R, Chu F, Cole PA, Costello CE, Cotter RJ, Crockett D, DeLany JP, De Marzo AM, DeSouza LV, Deutsch EW, Dransfield E, Drewes G, Droit A, Dunn MJ, Elenitoba-Johnson K, Ewing RM, Van Eyk J, Faca V, Falkner J, Fang X, Fenselau C, Figeys D, Gagné P, Gelfi C, Gevaert K, Gimble JM, Gnad F, Goel R, Gromov P, Hanash SM, Hancock WS, Harsha HC, Hart G, Hays F, He F, Hebbar P, Helsens K, Hermeking H, Hide W, Hjernø K, Hochstrasser DF, Hofmann O, Horn DM, Hruban RH, Ibarrola N, James P, Jensen ON, Jensen PH, Jung P, Kandasamy K, Kheterpal I, Kikuno RF, Korf U, Körner R, Kuster B, Kwon MS, Lee HJ, Lee YJ, Lefevre M, Lehvaslaiho M, Lescuyer P, Levander F, Lim MS, Löbke C, Loo JA, Mann M, Martens L, Martinez-Heredia J, McComb M, McRedmond J, Mehrle A, Menon R, Miller CA, Mischak H, Mohan SS, Mohmood R, Molina H, Moran MF, Morgan JD, Moritz R, Morzel M, Muddiman DC, Nalli A, Navarro JD, Neubert TA, Ohara O, Oliva R, Omenn GS, Oyama M, Paik YK, Pennington K, Pepperkok R, Periaswamy B, Petricoin EF, Poirier GG, Prasad TS, Purvine SO, Rahiman BA, Ramachandran P, Ramachandra YL, Rice RH, Rick J, Ronnholm RH, Salonen J, Sanchez JC, Sayd T, Seshi B, Shankari K, Sheng SJ, Shetty V, Shivakumar K, Simpson RJ, Sirdeshmukh R, Siu KW, Smith JC, Smith RD, States DJ, Sugano S, Sullivan M, Superti-Furga G, Takatalo M, Thongboonkerd V, Trinidad JC, Uhlen M, Vandekerckhove J, Vasilescu J, Veenstra TD, Vidal-Taboada JM, Vihinen M, Wait R, Wang X, Wiemann S, Wu B, Xu T, Yates JR, Zhong J, Zhou M, Zhu Y, Zurbig P, Pandey A.
Human Proteinpedia enables sharing of human protein data.
Nat Biotechnol. 2008 26(2):164-7.
PubMed: 18259167 DOI: 10.1038/nbt0208-164
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| 37 |
Nestor M, Ekberg T, Dring J, van Dongen GA, Wester K, Tolmachev V, Anniko M.
Quantification of CD44v6 and EGFR expression in head and neck squamous cell carcinomas using a single-dose radioimmunoassay.
Tumour Biol. 2007 28(5):253-63.
PubMed: 17992053 DOI: 10.1159/000110898
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| 36 |
Sundqvist G, Stenvall M, Berglund H, Ottosson J, Brumer H.
A general, robust method for the quality control of intact proteins using LC-ESI-MS.
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 852(1-2):188-94.
PubMed: 17267305 DOI: 10.1016/j.jchromb.2007.01.011
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| 35 |
Alm T, Steen J, Ottosson J, Hober S.
High-throughput protein purification under denaturating conditions by the use of cation exchange chromatography.
Biotechnol J. 2007 2(6):709-16.
PubMed: 17492715 DOI: 10.1002/biot.200700060
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| 34 |
Renberg B, Nordin J, Merca A, Uhlén M, Feldwisch J, Nygren PA, Karlström AE.
Affibody molecules in protein capture microarrays: evaluation of multidomain ligands and different detection formats.
J Proteome Res. 2007 6(1):171-9.
PubMed: 17203961 DOI: 10.1021/pr060316r
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| 33 |
Mulder J, Wernérus H, Shi TJ, Pontén F, Hober S, Uhlén M, Hökfelt T.
Systematically generated antibodies against human gene products: high throughput screening on sections from the rat nervous system.
Neuroscience. 2007 146(4):1689-703.
PubMed: 17478047 DOI: 10.1016/j.neuroscience.2007.02.054
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| 32 |
Orchard S, Heck A, Uhlen M, Ping P.
Publication Committee meeting. HUPO 5th annual World Congress. Long Beach, CA, USA 30 October 2006.
Proteomics. 2007 7(7):1009-11.
PubMed: 17340644 DOI: 10.1002/pmic.200700015
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| 31 |
Falk R, Ramström M, Ståhl S, Hober S.
Approaches for systematic proteome exploration.
Biomol Eng. 2007 24(2):155-68.
PubMed: 17376740 DOI: 10.1016/j.bioeng.2007.01.001
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| 30 |
Strömberg S, Björklund MG, Asplund C, Sköllermo A, Persson A, Wester K, Kampf C, Nilsson P, Andersson AC, Uhlen M, Kononen J, Ponten F, Asplund A.
A high-throughput strategy for protein profiling in cell microarrays using automated image analysis.
Proteomics. 2007 7(13):2142-50.
PubMed: 17549799 DOI: 10.1002/pmic.200700199
|
| 29 |
Uhlen M.
Mapping the human proteome using antibodies
Mol Cell Proteomics 2007 6(8):1455-6.
PubMed: 17703056
|
| 28 |
Bengtsson S, Krogh M, Szigyarto CA, Uhlen M, Schedvins K, Silfverswärd C, Linder S, Auer G, Alaiya A, James P.
Large-scale proteomics analysis of human ovarian cancer for biomarkers.
J Proteome Res. 2007 6(4):1440-50.
PubMed: 17315909 DOI: 10.1021/pr060593y
|
| 27 |
Lofblom J, Kronqvist N, Uhlen M, Stahl S, Wernerus H.
Optimization of electroporation-mediated transformation: Staphylococcus carnosus as model organism.
J Appl Microbiol 2007 102(3):736-47.
PubMed: 17309623 DOI: 10.1111/j.1365-2672.2006.03127.x
|
| 26 |
Lerner M, Corcoran M, Cepeda D, Nielsen ML, Zubarev R, Pontén F, Uhlén M, Hober S, Grandér D, Sangfelt O.
The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD.
Mol Biol Cell. 2007 18(5):1670-82.
PubMed: 17314412 DOI: 10.1091/mbc.E06-03-0248
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| 25 |
Lundberg E, Sundberg M, Gräslund T, Uhlén M, Svahn HA.
A novel method for reproducible fluorescent labeling of small amounts of antibodies on solid phase.
J Immunol Methods. 2007 322(1-2):40-9.
PubMed: 17383674 DOI: 10.1016/j.jim.2007.01.023
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| 24 |
Patrakka J, Xiao Z, Nukui M, Takemoto M, He L, Oddsson A, Perisic L, Kaukinen A, Szigyarto CA, Uhlén M, Jalanko H, Betsholtz C, Tryggvason K.
Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik.
J Am Soc Nephrol. 2007 18(3):689-97.
PubMed: 17251388 DOI: 10.1681/ASN.2006060675
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| 23 |
Taussig MJ, Stoevesandt O, Borrebaeck CA, Bradbury AR, Cahill D, Cambillau C, de Daruvar A, Dubel S, Eichler J, Frank R, Gibson TJ, Gloriam D, Gold L, Herberg FW, Hermjakob H, Hoheisel JD, Joos TO, Kallioniemi O, Koegll M, Konthur Z, Korn B, Kremmer E, Krobitsch S, Landegren U, van der Maarel S, McCafferty J, Muyldermans S, Nygren PA, Palcy S, Pluckthun A, Polic B, Przybylski M, Saviranta P, Sawyer A, Sherman DJ, Skerra A, Templin M, Ueffing M, Uhlen M.
ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome.
Nature Methods 2007 4(1):13-7.
PubMed: 17195019 DOI: 10.1038/nmeth0107-13
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| 22 |
Schwenk JM, Lindberg J, Sundberg M, Uhlén M, Nilsson P.
Determination of binding specificities in highly multiplexed bead-based assays for antibody proteomics.
Mol Cell Proteomics. 2007 6(1):125-32.
PubMed: 17060675 DOI: 10.1074/mcp.T600035-MCP200
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| 21 |
Söderberg O, Gullberg M, Jarvius M, Ridderstråle K, Leuchowius KJ, Jarvius J, Wester K, Hydbring P, Bahram F, Larsson LG, Landegren U.
Direct observation of individual endogenous protein complexes in situ by proximity ligation.
Nat Methods. 2006 3(12):995-1000.
PubMed: 17072308 DOI: 10.1038/nmeth947
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| 20 |
Steen J, Uhlén M, Hober S, Ottosson J.
High-throughput protein purification using an automated set-up for high-yield affinity chromatography.
Protein Expr Purif. 2006 46(2):173-8.
PubMed: 16483795 DOI: 10.1016/j.pep.2005.12.010
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| 19 |
Andrade J, Berglund L, Uhlén M, Odeberg J.
Using Grid technology for computationally intensive applied bioinformatics analyses.
In Silico Biol. 2006 6(6):495-504.
PubMed: 17518760
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| 18 |
Persson A, Hober S, Uhlén M.
A human protein atlas based on antibody proteomics.
Curr Opin Mol Ther. 2006 8(3):185-90.
PubMed: 16774037
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| 17 |
Ek S, Andréasson U, Hober S, Kampf C, Pontén F, Uhlén M, Merz H, Borrebaeck CA.
From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies.
Mol Cell Proteomics. 2006 5(6):1072-81.
PubMed: 16524965 DOI: 10.1074/mcp.M600077-MCP200
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| 16 |
Eriksson C, Agaton C, Kånge R, Sundberg M, Nilsson P, Ek B, Uhlén M, Gustafsson M, Hober S.
Microfluidic analysis of antibody specificity in a compact disk format.
J Proteome Res. 2006 5(7):1568-74.
PubMed: 16823963 DOI: 10.1021/pr050447c
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| 15 |
Haab BB, Paulovich AG, Anderson NL, Clark AM, Downing GJ, Hermjakob H, Labaer J, Uhlen M.
A reagent resource to identify proteins and peptides of interest for the cancer community: a workshop report.
Mol Cell Proteomics. 2006 5(10):1996-2007.
PubMed: 16867976 DOI: 10.1074/mcp.T600020-MCP200
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| 14 |
Larsson K, Wester K, Nilsson P, Uhlén M, Hober S, Wernérus H.
Multiplexed PrEST immunization for high-throughput affinity proteomics.
J Immunol Methods. 2006 315(1-2):110-20.
PubMed: 16949094 DOI: 10.1016/j.jim.2006.07.014
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| 13 |
Andersson AC, Strömberg S, Bäckvall H, Kampf C, Uhlen M, Wester K, Pontén F.
Analysis of protein expression in cell microarrays: a tool for antibody-based proteomics.
J Histochem Cytochem. 2006 54(12):1413-23.
PubMed: 16957166 DOI: 10.1369/jhc.6A7001.2006
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| 12 |
Rada-Iglesias A, Wallerman O, Koch C, Ameur A, Enroth S, Clelland G, Wester K, Wilcox S, Dovey OM, Ellis PD, Wraight VL, James K, Andrews R, Langford C, Dhami P, Carter N, Vetrie D, Pontén F, Komorowski J, Dunham I, Wadelius C.
Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays.
Hum Mol Genet. 2005 14(22):3435-47.
PubMed: 16221759 DOI: 10.1093/hmg/ddi378
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| 11 |
Janzi M, Odling J, Pan-Hammarström Q, Sundberg M, Lundeberg J, Uhlén M, Hammarström L, Nilsson P.
Serum microarrays for large scale screening of protein levels.
Mol Cell Proteomics. 2005 4(12):1942-7.
PubMed: 16131484 DOI: 10.1074/mcp.M500213-MCP200
|
| 10 |
Nilsson P, Paavilainen L, Larsson K, Odling J, Sundberg M, Andersson AC, Kampf C, Persson A, Al-Khalili Szigyarto C, Ottosson J, Björling E, Hober S, Wernérus H, Wester K, Pontén F, Uhlen M.
Towards a human proteome atlas: high-throughput generation of mono-specific antibodies for tissue profiling.
Proteomics. 2005 5(17):4327-37.
PubMed: 16237735 DOI: 10.1002/pmic.200500072
|
| 9 |
Hedhammar M, Stenvall M, Lönneborg R, Nord O, Sjölin O, Brismar H, Uhlén M, Ottosson J, Hober S.
A novel flow cytometry-based method for analysis of expression levels in Escherichia coli, giving information about precipitated and soluble protein.
J Biotechnol. 2005 119(2):133-46.
PubMed: 15996784 DOI: 10.1016/j.jbiotec.2005.03.024
|
| 8 |
Stenvall M, Steen J, Uhlén M, Hober S, Ottosson J.
High-throughput solubility assay for purified recombinant protein immunogens.
Biochim Biophys Acta. 2005 1752(1):6-10.
PubMed: 16084133 DOI: 10.1016/j.bbapap.2005.07.002
|
| 7 |
Uhlén M, Björling E, Agaton C, Szigyarto CA, Amini B, Andersen E, Andersson AC, Angelidou P, Asplund A, Asplund C, Berglund L, Bergström K, Brumer H, Cerjan D, Ekström M, Elobeid A, Eriksson C, Fagerberg L, Falk R, Fall J, Forsberg M, Björklund MG, Gumbel K, Halimi A, Hallin I, Hamsten C, Hansson M, Hedhammar M, Hercules G, Kampf C, Larsson K, Lindskog M, Lodewyckx W, Lund J, Lundeberg J, Magnusson K, Malm E, Nilsson P, Odling J, Oksvold P, Olsson I, Oster E, Ottosson J, Paavilainen L, Persson A, Rimini R, Rockberg J, Runeson M, Sivertsson A, Sköllermo A, Steen J, Stenvall M, Sterky F, Strömberg S, Sundberg M, Tegel H, Tourle S, Wahlund E, Waldén A, Wan J, Wernérus H, Westberg J, Wester K, Wrethagen U, Xu LL, Hober S, Pontén F.
A human protein atlas for normal and cancer tissues based on antibody proteomics.
Mol Cell Proteomics. 2005 4(12):1920-32.
PubMed: 16127175 DOI: 10.1074/mcp.M500279-MCP200
|
| 6 |
Lindskog M, Rockberg J, Uhlen M, Sterky F.
Selection of protein epitopes for antibody production
Biotechniques 2005 38(5):723-7.
PubMed: 15945371
|
| 5 |
Uhlen M, Ponten F.
Antibody-based proteomics for human tissue profiling.
Mol Cell Proteomics. 2005 4(4):384-93.
PubMed: 15695805 DOI: 10.1074/mcp.R500009-MCP200
|
| 4 |
Kampf C, Andersson A-C, Wester K, Björling E, Uhlen M, Ponten F
Antibody-based tissue profiling as a tool in clinical proteomics
Clin. Proteomics 2004 1(3-4):285-300.
DOI: 10.1385/CP:1:3-4:285
|
| 3 |
Agaton C, Uhlén M, Hober S.
Genome-based proteomics.
Electrophoresis. 2004 25(9):1280-8.
PubMed: 15174050 DOI: 10.1002/elps.200405846
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| 2 |
Agaton C, Falk R, Hoiden Guthenberg I, Gostring L, Uhlen M, Hober S.
Selective enrichment of monospecific polyclonal antibodies for antibody-based proteomics efforts.
J Chromatogr A 2004 16;1043(1):33-40.
PubMed: 15317410
|
| 1 |
Agaton C, Galli J, Höidén Guthenberg I, Janzon L, Hansson M, Asplund A, Brundell E, Lindberg S, Ruthberg I, Wester K, Wurtz D, Höög C, Lundeberg J, Ståhl S, Pontén F, Uhlén M.
Affinity proteomics for systematic protein profiling of chromosome 21 gene products in human tissues.
Mol Cell Proteomics. 2003 2(6):405-14.
PubMed: 12796447 DOI: 10.1074/mcp.M300022-MCP200
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