Changes in metabolic pathways are frequently seen in cancer cells, and mutations in certain metabolic genes may even play a direct role in cancer development and progression. One gene for which this is true is the multi-localizing gene fumarate hydratase...Read more

Cancer-associated protein fetal and adult testis expressed 1 (gene: FATE1) is mapped to reproductive supporting cells in normal testis tissue using multiplex immunohistochemistry (mIHC/IF)...Read more

This month, the expression of beta-cell-associated transcription factor PDX1 within the endocrine pancreas is displayed through multiplex immunohistochemistry (mIHC/IF)...Read more

Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disorder associated with high morbidity and early mortality. Rapidly progressive cell death of upper and lower motor neurons in the brain as well as in the spinal cord leads to loss of voluntary muscle control. Within a few years of diagnosis, patients lose the ability to move, speak, eat and breath without mechanical support. There is no cure for ALS, with current treatments merely aiming at slowing disease progression and improving symptoms...Read more

The multiplex tissue image of this month showcases the spatial expression pattern of acinar cell-regulating basic helix-loop-helix family member a15 (gene: BHLHA15) in exocrine glandular structures of the salivary gland...Read more