Multiplex immunohistochemistry (mIHC/IF) reveals nuclear expression of the protein Shugoshin 1 (gene: SGO1) in pachytene/diplotene spermatocytes - the early cell states of developing sperm cells...Read more

GDF11, or Growth Differentiation Factor 11, rose to fame as a promising anti-aging molecule in 2013 when repletion in mice was shown to result in an age-related decline and reversal of cardiac hypertrophy (Loffredo, 2013). Subsequent studies further announced abilities to regenerate skeletal muscle and revascularize the brain (Sinha, 2014; Katsimpardi, 2014). In 2022, the biopharmaceutical company Elevian raised $58 million for GDF11 research, prompting a New York Times article titled "Can a 'Magic' Protein Slow the Aging Process?"..Read more

Our cells contain tiny molecular clocks that control a multitude of physiological and behavioral processes according to the circadian rhythm. Governed by a central clock, residing in the suprachiasmic nucleus of the brain, peripheral clocks are present in almost all tissues and organs (Hastings et al., 2003). They are, though able to persist in the absence of environmental cues, driven by the 24-hour patterns of light and temperature produced by the earth´s rotation, and periodically regulate functions such as body temperature, blood pressure, circulating hormones and metabolism (Mazzoccoli et al., 2012)...Read more

Tripartite motif-containing protein 73 (gene: TRIM73) is a protein whose expression at the protein level was unveiled only recently by a team affiliated with the Human Protein Atlas. Multiplex immunohistochemistry allowed them to confirm its cell-type specific localization in the ovary, thus significantly advancing our understanding of both TRIM73 and the ovary proteome...Read more

How can sperm swim? The outer dense fiber of sperm tails 4 (gene: ODF4) is one of the proteins thought to be important for sperm tail movement that propels the sperm forward. Multiplex immunohistochemistry technique enabled us to examine the expression of this protein during sperm development (spermatogenesis) in more detail than ever before...Read more