Among the about 20,000 genes in the human proteome there are still many rather unknown but potentially interesting proteins that deserve some extra attention. Here we will focus on C10orf53, a gene specifically expressed in the testis...Read more

The brain is a high energy consuming tissue that needs a continuous supply of energy substrates from the circulation for optimal neurological function. Astrocytes are important for regulating the relationship between energy consumption and dynamic neuronal activity in the brain and are mainly involved in processes used for efficient transfer of energy substrates to neurons. Changes in astrocyte energy metabolism could therefore potentially disrupt essential neuronal processes, and this cell type has also been shown to undergo structural and biochemical changes in Alzheimer's disease (AD). Here the cell type distribution and cellular levels of the brain enzyme CKB, which is crucial for energy homeostasis and known to have decreased activity in AD, has been investigated to identify changes associated with neurodegenerative processes...Read more

Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the first and rate-limiting step in the kynurenine pathway, which converts the essential amino acid tryptophan into kynurenine and other metabolites (Ball, 2014). This enzymatic activity exerts significant immunoregulatory effects, which has made it an attractive target for immunotherapy research...Read more

The difference in spatial distributions of two aquaporin proteins in the cells of collecting ducts in the kidney is illuminated through multiplex immunohistochemistry (mIHC/IF)...Read more