Tight junctions are cell-cell contacts formed at the apical-most part of the lateral membrane between polarized cells and are important players in maintaining the homeostasis and the integrity of epithelia and endothelia. Claudin-3 is one of the central components in tight junction complexes...Read more

In a publication in Cancers a comprehensive mass spectrometry strategy was used to profile blood plasma samples from a large pan-cancer cohort including 15 different cancer types. Differential expression analysis and machine learning was then used to identify a potential biomarker panel able to correctly diagnose multiple myeloma...Read more

In the past decade, we have seen an increasing number of large-scale bioimage initiatives. These efforts have generated a rich source of histology images, covering a plethora of organs and tissues in the human body, which should ultimately come together to form a reference map of the human body...Read more

In this movie light-sheet microscopy has been used to visualize muscle fibers and alpha motor neurons in muscle and Eva Hedlund, professor in Neurobiology at the Karolinska Institute, explains how these muscles function and how they are affected by the neurodegenerative disease amyotrophic lateral sclerosis (ALS)...Read more