In 2021, Trey Idekers team at UCLA in collaboration with Emma Lundbergs team at KTH and Stanford presented a new way of creating hierarchical maps of subcellular protein organization by integrating data from immunofluorescence images from the HPA with protein interaction data. The resulting cell map was referred to as the multi-scale integrated cell (MuSIC 1.0). Four years later, the same team has now released the next version of such a multimodal cell map, again accompanied by a prestigious publication in Nature...Read more

Among the about 20,000 genes giving rise to the human proteome there are still many rather unknown but potentially interesting genes that deserve some extra attention. Here we will focus on C19orf67, a gene with low evidence but specific and consistent expression detected in the testis across different datasets...Read more

In a publication in the journal Neuron a group of scientists including Jan Mulder, an HPA-related researcher, have used Stereo-seq, in combination with single-nucleus RNA sequencing data to create a 3-D atlas showing the cell-type distribution across the whole mouse brain. The spatial distributions of diverse cell types and lncRNAs in adult brain as well as the spatiotemporal profile of gene expression during brain development were investigated...Read more

KTH professor Mathias Uhlén, founder of the Human Protein Atlas, was interviewed in GenomeWeb about the new Alpha Cell project, an effort with the aim to map and model cellular components and processes...Read more

Calcium release activated channel regulator 2A (gene: CRACR2A) displays a diverse expression pattern in the salivary gland...Read more