A comprehensive characterization of blood proteome profiles in cancer patients can contribute to a better understanding of the disease etiology, resulting in earlier diagnosis, risk stratification and better monitoring of the different cancer subtypes. In an article in Nature Communications, next generation protein profiling has been used to explore the proteome signature in blood across patients representing many of the major cancer types...Read more

In a publication in the US-based journal Cell an international collaboration, involving researchers from the Human Protein Atlas, is described. A newly developed large-field-of-view spatial transcriptome method has been used to map the cellular and molecular organization of the macaque cerebral cortex...Read more

In this image of the month we highlight the protein barttin, encoded by the BSND gene, which is involved in the development of Bartter Syndrome. Barttin facilitates reabsorption of chloride in the loops of Henle in the kidneys and secretion of potassium in the stria vascularis of the inner ear (Estévez et al, 2001 ). More recently barttin has also been found to be expressed in the salivary ducts (Shinmura et al, 2018)...Read more

In this interview in GEN Biotechnology KTH professor Mathias Uhlén describes how his professional journey started out with protein production and engineering, continued in technology development for the Human Genome Project (HGP), before reaching its final destination in proteomics after the completion of the HGP...Read more