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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for data imported from The Genotype-Tissue Expression project (GTEX), FANTOM5 Consortium (FANTOM5) and internally generated Human Protein Atlas (HPA) data.
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Reliability scorei
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Below is an overview of RNA and protein expression data generated in the Human Protein Atlas project. Analyzed tissues are divided into color-coded groups according to which functional features they have in common. For each group, a list of included tissues is accessed by clicking on group name, group symbol, RNA bar, or protein bar. Subsequent selection of a particular tissue in this list links to the image data page.
Images of selected tissues give a visual summary of the protein expression profile furthest to the right.
The gray human body provides links to a histology dictionary when clicking on any part of the figure.
RNA expression (TPM)i
RNA-seq results generated in HPA are reported as number of transcripts per million (TPM). Each bar represents the highest expression score found in a particular group of tissues. The assay is described more in detail in Assays & Annotation.
Protein expression (score)i
Each bar represents the highest expression score found in a particular group of tissues. Protein expression scores are based on a best estimate of the "true" protein expression from a knowledge-based annotation, described more in detail under Assays & annotation. For genes where more than one antibody has been used, a collective score is set displaying the estimated true protein expression.
Protein expression data is shown for each of the 44 tissues. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. Mouse-over function shows protein score for analyzed cell types in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation.
For genes with available protein data for which a knowledge-based annotation gave inconclusive results, no protein expression data is displayed in the protein expression data overview. However, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Pending normal tissue annotation.
RNA EXPRESSION OVERVIEWi
RNA expression overview shows RNA-data from three different sources: Internally generated Human Protein Atlas (HPA) RNA-seq data, RNA-seq data from the Genotype-Tissue Expression (GTEx) project and CAGE data from FANTOM5 project. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.
HPA dataseti
HPA dataset RNA-seq tissue data is reported as mean TPM (transcripts per million), corresponding to mean values of the different individual samples from each tissue. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar. The RNA-seq assay is described in detail in Assays & Annotation.
RNA tissue category HPA HPA RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataseti
GTEx dataset RNA-seq data is reported as median RPKM (reads per kilobase per million mapped reads), generated by the Genotype-Tissue Expression (GTEx) project. More information can be found in Assays & Annotation.
RNA tissue category GTEx GTEx RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataseti
FANTOM5 dataset Tissue data obtained through Cap Analysis of Gene Expression (CAGE) are reported as Tags Per Million, generated by the FANTOM5 project. More information can be found in Assays & Annotation.
RNA tissue category FANTOM5 FANTOM5 RNA tissue category (category description) is calculated based on gene expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
XBP1 (HGNC Symbol)
Synonyms
XBP2
Description
X-box binding protein 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
XBP1-001
XBP1-003
XBP1-006
XBP1-007
XBP1-201
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P17861 [Direct mapping] X-box-binding protein 1 X-box-binding protein 1, cytoplasmic form X-box-binding protein 1, luminal form A0A024R1F0 [Target identity:100%; Query identity:100%] X-box binding protein 1, isoform CRA_b
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MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Ezkurdia et al 2014)
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001047 [core promoter binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001158 [enhancer sequence-specific DNA binding] GO:0001525 [angiogenesis] GO:0001889 [liver development] GO:0001935 [endothelial cell proliferation] GO:0002070 [epithelial cell maturation] GO:0002639 [positive regulation of immunoglobulin production] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005623 [cell] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006629 [lipid metabolic process] GO:0006633 [fatty acid biosynthetic process] GO:0006810 [transport] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0006955 [immune response] GO:0006986 [response to unfolded protein] GO:0006990 [positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response] GO:0007275 [multicellular organism development] GO:0007517 [muscle organ development] GO:0008284 [positive regulation of cell proliferation] GO:0010506 [regulation of autophagy] GO:0010832 [negative regulation of myotube differentiation] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0031017 [exocrine pancreas development] GO:0031648 [protein destabilization] GO:0031670 [cellular response to nutrient] GO:0032869 [cellular response to insulin stimulus] GO:0035356 [cellular triglyceride homeostasis] GO:0035470 [positive regulation of vascular wound healing] GO:0036498 [IRE1-mediated unfolded protein response] GO:0036500 [ATF6-mediated unfolded protein response] GO:0042149 [cellular response to glucose starvation] GO:0042593 [glucose homeostasis] GO:0042632 [cholesterol homeostasis] GO:0043066 [negative regulation of apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0045348 [positive regulation of MHC class II biosynthetic process] GO:0045579 [positive regulation of B cell differentiation] GO:0045582 [positive regulation of T cell differentiation] GO:0045600 [positive regulation of fat cell differentiation] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048666 [neuron development] GO:0051024 [positive regulation of immunoglobulin secretion] GO:0055089 [fatty acid homeostasis] GO:0055092 [sterol homeostasis] GO:0060612 [adipose tissue development] GO:0060691 [epithelial cell maturation involved in salivary gland development] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0071222 [cellular response to lipopolysaccharide] GO:0071230 [cellular response to amino acid stimulus] GO:0071332 [cellular response to fructose stimulus] GO:0071333 [cellular response to glucose stimulus] GO:0071353 [cellular response to interleukin-4] GO:0071375 [cellular response to peptide hormone stimulus] GO:1900100 [positive regulation of plasma cell differentiation] GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response] GO:1901800 [positive regulation of proteasomal protein catabolic process] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903489 [positive regulation of lactation] GO:1990418 [response to insulin-like growth factor stimulus] GO:2000347 [positive regulation of hepatocyte proliferation] GO:2000778 [positive regulation of interleukin-6 secretion]
P17861 [Direct mapping] X-box-binding protein 1 X-box-binding protein 1, cytoplasmic form X-box-binding protein 1, luminal form
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SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Ezkurdia et al 2014)
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001047 [core promoter binding] GO:0001158 [enhancer sequence-specific DNA binding] GO:0001525 [angiogenesis] GO:0001889 [liver development] GO:0002639 [positive regulation of immunoglobulin production] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006629 [lipid metabolic process] GO:0006633 [fatty acid biosynthetic process] GO:0006810 [transport] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0006955 [immune response] GO:0006986 [response to unfolded protein] GO:0006990 [positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response] GO:0007275 [multicellular organism development] GO:0007517 [muscle organ development] GO:0008284 [positive regulation of cell proliferation] GO:0010832 [negative regulation of myotube differentiation] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0031670 [cellular response to nutrient] GO:0032869 [cellular response to insulin stimulus] GO:0035356 [cellular triglyceride homeostasis] GO:0035470 [positive regulation of vascular wound healing] GO:0036498 [IRE1-mediated unfolded protein response] GO:0036500 [ATF6-mediated unfolded protein response] GO:0042149 [cellular response to glucose starvation] GO:0042632 [cholesterol homeostasis] GO:0043066 [negative regulation of apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0045348 [positive regulation of MHC class II biosynthetic process] GO:0045579 [positive regulation of B cell differentiation] GO:0045582 [positive regulation of T cell differentiation] GO:0045600 [positive regulation of fat cell differentiation] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048666 [neuron development] GO:0051024 [positive regulation of immunoglobulin secretion] GO:0055089 [fatty acid homeostasis] GO:0055092 [sterol homeostasis] GO:0060612 [adipose tissue development] GO:0071222 [cellular response to lipopolysaccharide] GO:0071230 [cellular response to amino acid stimulus] GO:0071332 [cellular response to fructose stimulus] GO:0071333 [cellular response to glucose stimulus] GO:0071353 [cellular response to interleukin-4] GO:0071375 [cellular response to peptide hormone stimulus] GO:1900100 [positive regulation of plasma cell differentiation] GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903489 [positive regulation of lactation] GO:1990418 [response to insulin-like growth factor stimulus] GO:2000347 [positive regulation of hepatocyte proliferation] GO:2000778 [positive regulation of interleukin-6 secretion]
P17861 [Direct mapping] X-box-binding protein 1 X-box-binding protein 1, cytoplasmic form X-box-binding protein 1, luminal form
Show all
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001047 [core promoter binding] GO:0001158 [enhancer sequence-specific DNA binding] GO:0001525 [angiogenesis] GO:0001889 [liver development] GO:0002639 [positive regulation of immunoglobulin production] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006629 [lipid metabolic process] GO:0006633 [fatty acid biosynthetic process] GO:0006810 [transport] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0006955 [immune response] GO:0006986 [response to unfolded protein] GO:0006990 [positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response] GO:0007275 [multicellular organism development] GO:0007517 [muscle organ development] GO:0008284 [positive regulation of cell proliferation] GO:0010832 [negative regulation of myotube differentiation] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0030335 [positive regulation of cell migration] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0031670 [cellular response to nutrient] GO:0032869 [cellular response to insulin stimulus] GO:0035356 [cellular triglyceride homeostasis] GO:0035470 [positive regulation of vascular wound healing] GO:0036498 [IRE1-mediated unfolded protein response] GO:0036500 [ATF6-mediated unfolded protein response] GO:0042149 [cellular response to glucose starvation] GO:0042632 [cholesterol homeostasis] GO:0043066 [negative regulation of apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0045348 [positive regulation of MHC class II biosynthetic process] GO:0045579 [positive regulation of B cell differentiation] GO:0045582 [positive regulation of T cell differentiation] GO:0045600 [positive regulation of fat cell differentiation] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048666 [neuron development] GO:0051024 [positive regulation of immunoglobulin secretion] GO:0055089 [fatty acid homeostasis] GO:0055092 [sterol homeostasis] GO:0060612 [adipose tissue development] GO:0071222 [cellular response to lipopolysaccharide] GO:0071230 [cellular response to amino acid stimulus] GO:0071332 [cellular response to fructose stimulus] GO:0071333 [cellular response to glucose stimulus] GO:0071353 [cellular response to interleukin-4] GO:0071375 [cellular response to peptide hormone stimulus] GO:1900100 [positive regulation of plasma cell differentiation] GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903489 [positive regulation of lactation] GO:1990418 [response to insulin-like growth factor stimulus] GO:2000347 [positive regulation of hepatocyte proliferation] GO:2000778 [positive regulation of interleukin-6 secretion]
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