Mitochondria are well known as the energy factories of human cells, but their roles extend well beyond ATP production, with multiple links to other cellular functions continuously being discovered. As can be seen in the subcellular resource of the HPA, the positioning of mitochondria within cells is variable, both between cell types and from cell-to-cell. This arrangement is not random, but rather regulated and highly dynamic. In fact, their proximity and direct interactions with other organelles can regulate cellular processes in these compartments...Read more

In this edition of multiplex tissue image of the month, the expression pattern of ciliogenesis-activating transcription factor FOXJ1 is contrasted with chromatin-regulating protein HMGN3 in fallopian tube...Read more

In a recent study published in Nature it was discovered that the polyamine spermine acts as a chelator of intracellular iron and thus as a suppressor of ferroptosis. Spermine is a polyamine metabolite that is essential for cellular homeostasis, with known roles ranging from DNA stabilization and RNA processing to protein synthesis and ion channel regulation. Dysregulation of spermine metabolism is implicated in various malignant, neurodegenerative and inflammatory diseases...Read more