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SRC
GENERAL INFORMATION
Gene namei SRC
Gene descriptioni SRC proto-oncogene, non-receptor tyrosine kinase
Protein classi Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted localizationi Intracellular
Number of transcriptsi 4
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HUMAN PROTEIN ATLAS INFORMATION
RNA tissue categoryi
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all
Protein evidencei Evidence at protein level
Protein expressioni Cytoplasmic and membranous expression in several tissues.

IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability
descriptioni		 Antibody staining mainly not consistent with RNA expression data.
Reliability scorei
Approved
Antibodiesi HPA030875 , CAB004023
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RNA AND PROTEIN EXPRESSION SUMMARYi
RNA expression (TPM)i Protein expression (score)i
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis
PROTEIN EXPRESSION OVERVIEWi
Organ
Expression
Alphabetical
RNA EXPRESSION OVERVIEWi
HPA dataseti
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataseti
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataseti
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GENE INFORMATIONi
Gene name SRC (HGNC Symbol)
Synonyms ASV, c-src, SRC1
Description SRC proto-oncogene, non-receptor tyrosine kinase (HGNC Symbol)
Entrez gene summary This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome 20
Cytoband q11.23
Chromosome location (bp) 37344685 - 37406050
Protein evidence Evidence at protein level (all genes)
Ensembl ENSG00000197122 (version 88.38)
Entrez gene 6714
UniProt P12931 (UniProt - Evidence at protein level)
neXtProt NX_P12931
Antibodypedia SRC antibodies
PROTEIN BROWSERi
SRC-001
SRC-002
SRC-005
SRC-201
PROTEIN INFORMATIONi
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
SRC-001
ENSP00000362680
ENST00000373578
P12931 [Direct mapping]
Proto-oncogene tyrosine-protein kinase Src
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002102 [podosome]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002376 [immune system process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005080 [protein kinase C binding]
GO:0005102 [receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0007417 [central nervous system development]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0009612 [response to mechanical stimulus]
GO:0009615 [response to virus]
GO:0010447 [response to acidic pH]
GO:0010628 [positive regulation of gene expression]
GO:0010632 [regulation of epithelial cell migration]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010641 [positive regulation of platelet-derived growth factor receptor signaling pathway]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0010954 [positive regulation of protein processing]
GO:0014069 [postsynaptic density]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016477 [cell migration]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0020037 [heme binding]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030168 [platelet activation]
GO:0030331 [estrogen receptor binding]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0030900 [forebrain development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031648 [protein destabilization]
GO:0031667 [response to nutrient levels]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0032148 [activation of protein kinase B activity]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032403 [protein complex binding]
GO:0032463 [negative regulation of protein homooligomerization]
GO:0032587 [ruffle membrane]
GO:0032869 [cellular response to insulin stimulus]
GO:0033146 [regulation of intracellular estrogen receptor signaling pathway]
GO:0033625 [positive regulation of integrin activation]
GO:0034332 [adherens junction organization]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035556 [intracellular signal transduction]
GO:0035635 [entry of bacterium into host cell]
GO:0036035 [osteoclast development]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038128 [ERBB2 signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042169 [SH2 domain binding]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0043005 [neuron projection]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043114 [regulation of vascular permeability]
GO:0043149 [stress fiber assembly]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043393 [regulation of protein binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0044325 [ion channel binding]
GO:0045056 [transcytosis]
GO:0045087 [innate immune response]
GO:0045124 [regulation of bone resorption]
GO:0045296 [cadherin binding]
GO:0045453 [bone resorption]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045785 [positive regulation of cell adhesion]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048477 [oogenesis]
GO:0050715 [positive regulation of cytokine secretion]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050839 [cell adhesion molecule binding]
GO:0050847 [progesterone receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0051219 [phosphoprotein binding]
GO:0051222 [positive regulation of protein transport]
GO:0051385 [response to mineralocorticoid]
GO:0051427 [hormone receptor binding]
GO:0051602 [response to electrical stimulus]
GO:0051726 [regulation of cell cycle]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051902 [negative regulation of mitochondrial depolarization]
GO:0051974 [negative regulation of telomerase activity]
GO:0060065 [uterus development]
GO:0060444 [branching involved in mammary gland duct morphogenesis]
GO:0060491 [regulation of cell projection assembly]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070542 [response to fatty acid]
GO:0070555 [response to interleukin-1]
GO:0070851 [growth factor receptor binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071393 [cellular response to progesterone stimulus]
GO:0071398 [cellular response to fatty acid]
GO:0071456 [cellular response to hypoxia]
GO:0071498 [cellular response to fluid shear stress]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0071801 [regulation of podosome assembly]
GO:0071803 [positive regulation of podosome assembly]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097110 [scaffold protein binding]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1902533 [positive regulation of intracellular signal transduction]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
GO:2000573 [positive regulation of DNA biosynthetic process]
GO:2000641 [regulation of early endosome to late endosome transport]
GO:2000811 [negative regulation of anoikis]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001286 [regulation of caveolin-mediated endocytosis]
Show all
 536 aa
59.8 kDa 		No 0
SRC-002
ENSP00000362668
ENST00000373567
P12931 [Direct mapping]
Proto-oncogene tyrosine-protein kinase Src
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002376 [immune system process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005102 [receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0007417 [central nervous system development]
GO:0010632 [regulation of epithelial cell migration]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0020037 [heme binding]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030168 [platelet activation]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032463 [negative regulation of protein homooligomerization]
GO:0033625 [positive regulation of integrin activation]
GO:0035556 [intracellular signal transduction]
GO:0035635 [entry of bacterium into host cell]
GO:0036035 [osteoclast development]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038128 [ERBB2 signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042169 [SH2 domain binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043114 [regulation of vascular permeability]
GO:0043149 [stress fiber assembly]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0045124 [regulation of bone resorption]
GO:0045296 [cadherin binding]
GO:0045453 [bone resorption]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050847 [progesterone receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0051219 [phosphoprotein binding]
GO:0051427 [hormone receptor binding]
GO:0051726 [regulation of cell cycle]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051902 [negative regulation of mitochondrial depolarization]
GO:0051974 [negative regulation of telomerase activity]
GO:0070062 [extracellular exosome]
GO:0070555 [response to interleukin-1]
GO:0070851 [growth factor receptor binding]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071393 [cellular response to progesterone stimulus]
GO:0071801 [regulation of podosome assembly]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0097110 [scaffold protein binding]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
GO:2000641 [regulation of early endosome to late endosome transport]
GO:2000811 [negative regulation of anoikis]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001286 [regulation of caveolin-mediated endocytosis]
Show all
 536 aa
59.8 kDa 		No 0
SRC-005
ENSP00000362659
ENST00000373558
P12931 [Direct mapping]
Proto-oncogene tyrosine-protein kinase Src
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002376 [immune system process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005102 [receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0007417 [central nervous system development]
GO:0010632 [regulation of epithelial cell migration]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0020037 [heme binding]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030168 [platelet activation]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032463 [negative regulation of protein homooligomerization]
GO:0033625 [positive regulation of integrin activation]
GO:0035556 [intracellular signal transduction]
GO:0035635 [entry of bacterium into host cell]
GO:0036035 [osteoclast development]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038128 [ERBB2 signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042169 [SH2 domain binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043114 [regulation of vascular permeability]
GO:0043149 [stress fiber assembly]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0045124 [regulation of bone resorption]
GO:0045296 [cadherin binding]
GO:0045453 [bone resorption]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050847 [progesterone receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0051219 [phosphoprotein binding]
GO:0051427 [hormone receptor binding]
GO:0051726 [regulation of cell cycle]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051902 [negative regulation of mitochondrial depolarization]
GO:0051974 [negative regulation of telomerase activity]
GO:0070062 [extracellular exosome]
GO:0070555 [response to interleukin-1]
GO:0070851 [growth factor receptor binding]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071393 [cellular response to progesterone stimulus]
GO:0071801 [regulation of podosome assembly]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0097110 [scaffold protein binding]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
GO:2000641 [regulation of early endosome to late endosome transport]
GO:2000811 [negative regulation of anoikis]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001286 [regulation of caveolin-mediated endocytosis]
Show all
 542 aa
60.6 kDa 		No 0
SRC-201
ENSP00000350941
ENST00000358208
P12931 [Direct mapping]
Proto-oncogene tyrosine-protein kinase Src
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002376 [immune system process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005102 [receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007411 [axon guidance]
GO:0007417 [central nervous system development]
GO:0010632 [regulation of epithelial cell migration]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0020037 [heme binding]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030168 [platelet activation]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032463 [negative regulation of protein homooligomerization]
GO:0033625 [positive regulation of integrin activation]
GO:0035556 [intracellular signal transduction]
GO:0035635 [entry of bacterium into host cell]
GO:0036035 [osteoclast development]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038128 [ERBB2 signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042169 [SH2 domain binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043114 [regulation of vascular permeability]
GO:0043149 [stress fiber assembly]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0045124 [regulation of bone resorption]
GO:0045296 [cadherin binding]
GO:0045453 [bone resorption]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050847 [progesterone receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0051219 [phosphoprotein binding]
GO:0051427 [hormone receptor binding]
GO:0051726 [regulation of cell cycle]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051902 [negative regulation of mitochondrial depolarization]
GO:0051974 [negative regulation of telomerase activity]
GO:0070062 [extracellular exosome]
GO:0070555 [response to interleukin-1]
GO:0070851 [growth factor receptor binding]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071393 [cellular response to progesterone stimulus]
GO:0071801 [regulation of podosome assembly]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0097110 [scaffold protein binding]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
GO:2000641 [regulation of early endosome to late endosome transport]
GO:2000811 [negative regulation of anoikis]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001286 [regulation of caveolin-mediated endocytosis]
Show all
 536 aa
59.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.