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Show complete data for human cells assay. The location(s) are highlighted in the illustration on the right.
Mainly localized to the plasma membrane. In addition localized to the cytosol.
RNA cell categoryi
The cell lines in the Human Protein Atlas have been analyzed by RNA-seq to estimate the transcript abundance of each protein-coding gene. The RNA-seq data was then used to classify all genes according to their cell line-specific expression into one of six different categories, defined based on the total set of all TPM values in all analyzed cell lines.
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Main locationi
The main location is characterized by presence in all tested cell lines and/or increased intensity compared to other locations. It is highlighted in the illustration to the right. If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively.
Localized to the Plasma membrane (enhanced)
Additional locationi
Additional locations are characterized by either a markedly lower staining intensity than the main location, or that it is only observed in a subset of the cell lines. They are highlighted in the illustration to the right. If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively.
In addition localized to the Cytosol (enhanced)
DATA RELIABILITY
Reliability scorei
A reliability score is set for all genes and indicates the level of reliability of the analyzed protein expression pattern based on available protein/RNA/gene characterization data. The reliability of the annotated protein expression data is also scored depending on similarity in immunostaining patterns and consistency with available experimental gene/protein characterization data in the UniProtKB/Swiss-Prot database.
Below is an overview of RNA expression data generated in the HPA project. The analyzed cell lines are divided into 12 color-coded groups according to the organ they were obtained from. By clicking the toolbars in the top right corner it is possible to sort the cell lines in the chart by different criteria: the organ and the origin that the cell line was obtained from, the category of the cell line according to cellosaurus, alphabetically or by descending RNA expression. Detailed information about a specific cell line can be accessed by hovering over the corresponding bar in the chart. The RNA-sequencing results generated in the HPA are reported as number of Transcripts per Kilobase Million (TPM). In the Human Protein Atlas a TPM value of 1.0 is defined as a treshhold for expression of the corresponding protein.
The cell lines in the Human Protein Atlas have been analyzed by RNA-seq to estimate the transcript abundance of each protein-coding gene. The RNA-seq data was then used to classify all genes according to their cell line-specific expression into one of six different categories, defined based on the total set of all TPM values in all analyzed cell lines.
Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
Cell lines sorted alphabetically.
HUMAN CELLSi
The "human cells" section gives an overview about the subcellular location of the protein of interest obtained by indirect immunofluorescence microscopy, an antibody-based protein-visualization technique. The immunofluorescent analysis is carried out in three different cell lines, one of them always being U-2 OS. A selection of immunofluorescent images is displayed below. Three different organelle probes are displayed as different channels in the multicolor images - nucleus stained in blue, microtubules in red and ER in yellow. The antibody staining targeting the protein of interest is shown in green. By using the toggle channel buttons, the different channels can be turned on and off. For the selection of the images to compare, use the checkboxes next to the images at the bottom. Three images can be compared at a time. All images are clickable for an enlarged view. The selected image will appear in large size and miniature images with all other staining results for this gene will be listed at the top left of the image. The selected miniature image has an orange overlay. For cell structure reference, visit the cell dictionary.
Summaryi
Summary of the immunofluorescent analysis in all studied cell lines with all tested antibodies.
Mainly localized to the plasma membrane. In addition localized to the cytosol.
Main locationi
The main location is characterized by presence in all tested cell lines and/or increased intensity compared to other locations.
Plasma membrane (enhanced)
Additional locationi
Additional locations are characterized by either a markedly lower staining intensity than the main location, or that it is only observed in a subset of the cell lines.
Cytosol (enhanced)
Toggle channelsi
Three different organelle probes are displayed as different channels in the multicolor images - nucleus stained in blue, microtubules in red and ER in yellow. The antibody staining targeting the protein of interest is shown in green. By using the "toggle channels"-buttons, the different channels can be turned on and off. The intensity toggle shows the pixel intensity range in 16 different colors for the selected channel. The object toggle shows the computational segmentation of the cells used for further analysis in the HPA project. For samples where cell cycle dependency for the protein is suggested according to a correlation assay the predicted cell cycle position of each cell is displayed when using the object toggle.
Low
High
G1
S
G2
M
N/A
Thumbnaili
Representative images for the assay. Three images can be compared at the same time. To change which images to compare, use the checkboxes next to the images below. All images are clickable for an enlarged view. The selected image will appear in large size and miniature images with all other staining results for this gene will be listed at the top left of the image. The selected miniature image has an orange overlay.
Antibodyi
Antibody used for analysis. Clicking the antibody ID links to the antibody validation page.
Cell linei
Cell line used for analysis. Read more about the cell lines in the Human Protein Atlas.
Locationi
Location(s) annotated in the corresponding cell line.
Single-cell variationi
As the images in the Cell Atlas provide single cell resolution, variations in protein expression patterns from cell to cell can be observed. A single-cell variation can either be observed in the intensity of the immunofluorescent signal or in the spatial distribution pattern of the protein. This column contains information about whether and for which of the annotated locations a single-cell variation pattern was manually annotated.
Cell cycle dependent variationi
A likely cause for single-cell variation in the immunofluorescent images is cell cycle dependency. This column contains information about whether the manually observed cell-to-cell variation pattern correlates with cell cycle progression.
For the genes where the mouse and human genes are orthologues, the mouse cell line NIH 3T3 is also stained. The main subcellular location of the encoded proteins and any additional locations are reported as well as staining characteristics, staining intensity and validation score. Example images are shown below. To change which images to compare, use the checkboxes next to the images at the bottom. Three images can be compared at a time. All images are clickable for an enlarged view. The selected image will appear in large size and miniature images with all other staining results for this gene will be listed at the top left of the image. The selected miniature image has an orange overlay. For cell structure reference, visit the cell dictionary.
Main locationi
The main location is characterized by a higher intensity compared to other locations observed.
Three different organelle probes are displayed as different channels in the multicolor images - nucleus stained in blue, microtubules in red and ER in yellow. The HPA-antibody staining targeting the protein of interest is shown in green. By using the "toggle channels"-buttons, the different channels can be turned on and off. The intensity toggle shows the pixel intensity range in 16 different colors for the selected channel. The object toggle shows the computational segmentation of the cells used for further analysis in the HPA project. For samples where cell cycle dependency for the protein is suggested according to a correlation assay the predicted cell cycle position of each cell is displayed when using the object toggle.
Low
High
G1
S
G2
M
N/A
Thumbnaili
Representative images for the assay. Three images can be compared at the same time. To change which images to compare, use the checkboxes next to the images below. All images are clickable for an enlarged view. The selected image will appear in large size and miniature images with all other staining results for this gene will be listed at the top left of the image. The selected miniature image has an orange overlay.
Antibodyi
Antibody used for analysis. Clicking the antibody ID links to the antibody validation page.
Cell linei
Cell line used for analysis. Read more about the cell lines in the Human Protein Atlas.
Locationi
Location(s) annotated in the corresponding cell line.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
SRC-001
SRC-002
SRC-005
SRC-201
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding] GO:0002102 [podosome] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002376 [immune system process] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005080 [protein kinase C binding] GO:0005102 [receptor binding] GO:0005158 [insulin receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005884 [actin filament] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007411 [axon guidance] GO:0007417 [central nervous system development] GO:0008022 [protein C-terminus binding] GO:0008283 [cell proliferation] GO:0009612 [response to mechanical stimulus] GO:0009615 [response to virus] GO:0010447 [response to acidic pH] GO:0010628 [positive regulation of gene expression] GO:0010632 [regulation of epithelial cell migration] GO:0010634 [positive regulation of epithelial cell migration] GO:0010641 [positive regulation of platelet-derived growth factor receptor signaling pathway] GO:0010907 [positive regulation of glucose metabolic process] GO:0010954 [positive regulation of protein processing] GO:0014069 [postsynaptic density] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016337 [single organismal cell-cell adhesion] GO:0016477 [cell migration] GO:0016740 [transferase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019901 [protein kinase binding] GO:0019904 [protein domain specific binding] GO:0020037 [heme binding] GO:0022407 [regulation of cell-cell adhesion] GO:0030168 [platelet activation] GO:0030331 [estrogen receptor binding] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0030900 [forebrain development] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0031667 [response to nutrient levels] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032148 [activation of protein kinase B activity] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032403 [protein complex binding] GO:0032463 [negative regulation of protein homooligomerization] GO:0032587 [ruffle membrane] GO:0032869 [cellular response to insulin stimulus] GO:0033146 [regulation of intracellular estrogen receptor signaling pathway] GO:0033625 [positive regulation of integrin activation] GO:0034332 [adherens junction organization] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0034614 [cellular response to reactive oxygen species] GO:0035556 [intracellular signal transduction] GO:0035635 [entry of bacterium into host cell] GO:0036035 [osteoclast development] GO:0036120 [cellular response to platelet-derived growth factor stimulus] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0038128 [ERBB2 signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0042493 [response to drug] GO:0042542 [response to hydrogen peroxide] GO:0043005 [neuron projection] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043114 [regulation of vascular permeability] GO:0043149 [stress fiber assembly] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043393 [regulation of protein binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0044325 [ion channel binding] GO:0045056 [transcytosis] GO:0045087 [innate immune response] GO:0045124 [regulation of bone resorption] GO:0045296 [cadherin binding] GO:0045453 [bone resorption] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045785 [positive regulation of cell adhesion] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046628 [positive regulation of insulin receptor signaling pathway] GO:0046777 [protein autophosphorylation] GO:0046875 [ephrin receptor binding] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0048477 [oogenesis] GO:0050715 [positive regulation of cytokine secretion] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050839 [cell adhesion molecule binding] GO:0050847 [progesterone receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051057 [positive regulation of small GTPase mediated signal transduction] GO:0051219 [phosphoprotein binding] GO:0051222 [positive regulation of protein transport] GO:0051385 [response to mineralocorticoid] GO:0051427 [hormone receptor binding] GO:0051602 [response to electrical stimulus] GO:0051726 [regulation of cell cycle] GO:0051895 [negative regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051902 [negative regulation of mitochondrial depolarization] GO:0051974 [negative regulation of telomerase activity] GO:0060065 [uterus development] GO:0060444 [branching involved in mammary gland duct morphogenesis] GO:0060491 [regulation of cell projection assembly] GO:0070062 [extracellular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070542 [response to fatty acid] GO:0070555 [response to interleukin-1] GO:0070851 [growth factor receptor binding] GO:0071222 [cellular response to lipopolysaccharide] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071393 [cellular response to progesterone stimulus] GO:0071398 [cellular response to fatty acid] GO:0071456 [cellular response to hypoxia] GO:0071498 [cellular response to fluid shear stress] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:0071801 [regulation of podosome assembly] GO:0071803 [positive regulation of podosome assembly] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0086098 [angiotensin-activated signaling pathway involved in heart process] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0097110 [scaffold protein binding] GO:1900182 [positive regulation of protein localization to nucleus] GO:1902533 [positive regulation of intracellular signal transduction] GO:2000394 [positive regulation of lamellipodium morphogenesis] GO:2000573 [positive regulation of DNA biosynthetic process] GO:2000641 [regulation of early endosome to late endosome transport] GO:2000811 [negative regulation of anoikis] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001286 [regulation of caveolin-mediated endocytosis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002376 [immune system process] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005102 [receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007411 [axon guidance] GO:0007417 [central nervous system development] GO:0010632 [regulation of epithelial cell migration] GO:0010634 [positive regulation of epithelial cell migration] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0020037 [heme binding] GO:0022407 [regulation of cell-cell adhesion] GO:0030168 [platelet activation] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032463 [negative regulation of protein homooligomerization] GO:0033625 [positive regulation of integrin activation] GO:0035556 [intracellular signal transduction] GO:0035635 [entry of bacterium into host cell] GO:0036035 [osteoclast development] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0038128 [ERBB2 signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043114 [regulation of vascular permeability] GO:0043149 [stress fiber assembly] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0045124 [regulation of bone resorption] GO:0045296 [cadherin binding] GO:0045453 [bone resorption] GO:0046777 [protein autophosphorylation] GO:0046875 [ephrin receptor binding] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050847 [progesterone receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051057 [positive regulation of small GTPase mediated signal transduction] GO:0051219 [phosphoprotein binding] GO:0051427 [hormone receptor binding] GO:0051726 [regulation of cell cycle] GO:0051895 [negative regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051902 [negative regulation of mitochondrial depolarization] GO:0051974 [negative regulation of telomerase activity] GO:0070062 [extracellular exosome] GO:0070555 [response to interleukin-1] GO:0070851 [growth factor receptor binding] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071393 [cellular response to progesterone stimulus] GO:0071801 [regulation of podosome assembly] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0086098 [angiotensin-activated signaling pathway involved in heart process] GO:0097110 [scaffold protein binding] GO:2000394 [positive regulation of lamellipodium morphogenesis] GO:2000641 [regulation of early endosome to late endosome transport] GO:2000811 [negative regulation of anoikis] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001286 [regulation of caveolin-mediated endocytosis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002376 [immune system process] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005102 [receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007411 [axon guidance] GO:0007417 [central nervous system development] GO:0010632 [regulation of epithelial cell migration] GO:0010634 [positive regulation of epithelial cell migration] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0020037 [heme binding] GO:0022407 [regulation of cell-cell adhesion] GO:0030168 [platelet activation] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032463 [negative regulation of protein homooligomerization] GO:0033625 [positive regulation of integrin activation] GO:0035556 [intracellular signal transduction] GO:0035635 [entry of bacterium into host cell] GO:0036035 [osteoclast development] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0038128 [ERBB2 signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043114 [regulation of vascular permeability] GO:0043149 [stress fiber assembly] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0045124 [regulation of bone resorption] GO:0045296 [cadherin binding] GO:0045453 [bone resorption] GO:0046777 [protein autophosphorylation] GO:0046875 [ephrin receptor binding] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050847 [progesterone receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051057 [positive regulation of small GTPase mediated signal transduction] GO:0051219 [phosphoprotein binding] GO:0051427 [hormone receptor binding] GO:0051726 [regulation of cell cycle] GO:0051895 [negative regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051902 [negative regulation of mitochondrial depolarization] GO:0051974 [negative regulation of telomerase activity] GO:0070062 [extracellular exosome] GO:0070555 [response to interleukin-1] GO:0070851 [growth factor receptor binding] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071393 [cellular response to progesterone stimulus] GO:0071801 [regulation of podosome assembly] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0086098 [angiotensin-activated signaling pathway involved in heart process] GO:0097110 [scaffold protein binding] GO:2000394 [positive regulation of lamellipodium morphogenesis] GO:2000641 [regulation of early endosome to late endosome transport] GO:2000811 [negative regulation of anoikis] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001286 [regulation of caveolin-mediated endocytosis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002376 [immune system process] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005102 [receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007411 [axon guidance] GO:0007417 [central nervous system development] GO:0010632 [regulation of epithelial cell migration] GO:0010634 [positive regulation of epithelial cell migration] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0020037 [heme binding] GO:0022407 [regulation of cell-cell adhesion] GO:0030168 [platelet activation] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032463 [negative regulation of protein homooligomerization] GO:0033625 [positive regulation of integrin activation] GO:0035556 [intracellular signal transduction] GO:0035635 [entry of bacterium into host cell] GO:0036035 [osteoclast development] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0038128 [ERBB2 signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043114 [regulation of vascular permeability] GO:0043149 [stress fiber assembly] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0045124 [regulation of bone resorption] GO:0045296 [cadherin binding] GO:0045453 [bone resorption] GO:0046777 [protein autophosphorylation] GO:0046875 [ephrin receptor binding] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050847 [progesterone receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051057 [positive regulation of small GTPase mediated signal transduction] GO:0051219 [phosphoprotein binding] GO:0051427 [hormone receptor binding] GO:0051726 [regulation of cell cycle] GO:0051895 [negative regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051902 [negative regulation of mitochondrial depolarization] GO:0051974 [negative regulation of telomerase activity] GO:0070062 [extracellular exosome] GO:0070555 [response to interleukin-1] GO:0070851 [growth factor receptor binding] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071393 [cellular response to progesterone stimulus] GO:0071801 [regulation of podosome assembly] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0086098 [angiotensin-activated signaling pathway involved in heart process] GO:0097110 [scaffold protein binding] GO:2000394 [positive regulation of lamellipodium morphogenesis] GO:2000641 [regulation of early endosome to late endosome transport] GO:2000811 [negative regulation of anoikis] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001286 [regulation of caveolin-mediated endocytosis]