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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
TCGA (cancer tissue):
Expressed in all
HPA (cell line):
Mixed
HPA (normal tissue):
Mixed
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expression normal tissuei
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Cytoplasmic and membranous expression in several tissues.
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability descriptioni
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining mainly not consistent with RNA expression data.
Reliability score - normal tissuesi
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from.
Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
For each cancer, color-coded bars indicate the percentage of patients (maximum 12 patients) with high and medium protein expression level. The cancer types are color-coded according to which type of normal organ the cancer originates from. Low or not detected protein expression results in a white bar. Mouse-over function shows details about expression level and normal tissue of origin. The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies.
Several cases of cervical, skin, pancreatic, urothelial, head and neck cancers displayed moderate to strong cytoplasmic and membranous positivity. Many cases of colorectal, lung and stomach cancers along with rare ovarian, testis, liver cancers and carcinoid showed moderate positivity. Remaining cancer tissues were weakly stained or negative.
Colorectal, prostate, urothelial, gastric, pancreatic and liver cancers showed moderate to strong cytoplasmic positivity. Remaining cancers were weakly stained or negative.
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
SRC-001
SRC-002
SRC-005
SRC-201
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding] GO:0002102 [podosome] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002376 [immune system process] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005080 [protein kinase C binding] GO:0005102 [receptor binding] GO:0005158 [insulin receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005884 [actin filament] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007411 [axon guidance] GO:0007417 [central nervous system development] GO:0008022 [protein C-terminus binding] GO:0008283 [cell proliferation] GO:0009612 [response to mechanical stimulus] GO:0009615 [response to virus] GO:0010447 [response to acidic pH] GO:0010628 [positive regulation of gene expression] GO:0010632 [regulation of epithelial cell migration] GO:0010634 [positive regulation of epithelial cell migration] GO:0010641 [positive regulation of platelet-derived growth factor receptor signaling pathway] GO:0010907 [positive regulation of glucose metabolic process] GO:0010954 [positive regulation of protein processing] GO:0014069 [postsynaptic density] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016337 [single organismal cell-cell adhesion] GO:0016477 [cell migration] GO:0016740 [transferase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019901 [protein kinase binding] GO:0019904 [protein domain specific binding] GO:0020037 [heme binding] GO:0022407 [regulation of cell-cell adhesion] GO:0030168 [platelet activation] GO:0030331 [estrogen receptor binding] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0030900 [forebrain development] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0031667 [response to nutrient levels] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032148 [activation of protein kinase B activity] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032403 [protein complex binding] GO:0032463 [negative regulation of protein homooligomerization] GO:0032587 [ruffle membrane] GO:0032869 [cellular response to insulin stimulus] GO:0033146 [regulation of intracellular estrogen receptor signaling pathway] GO:0033625 [positive regulation of integrin activation] GO:0034332 [adherens junction organization] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0034614 [cellular response to reactive oxygen species] GO:0035556 [intracellular signal transduction] GO:0035635 [entry of bacterium into host cell] GO:0036035 [osteoclast development] GO:0036120 [cellular response to platelet-derived growth factor stimulus] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0038128 [ERBB2 signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0042493 [response to drug] GO:0042542 [response to hydrogen peroxide] GO:0043005 [neuron projection] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043114 [regulation of vascular permeability] GO:0043149 [stress fiber assembly] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043393 [regulation of protein binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0044325 [ion channel binding] GO:0045056 [transcytosis] GO:0045087 [innate immune response] GO:0045124 [regulation of bone resorption] GO:0045296 [cadherin binding] GO:0045453 [bone resorption] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045785 [positive regulation of cell adhesion] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046628 [positive regulation of insulin receptor signaling pathway] GO:0046777 [protein autophosphorylation] GO:0046875 [ephrin receptor binding] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0048477 [oogenesis] GO:0050715 [positive regulation of cytokine secretion] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050839 [cell adhesion molecule binding] GO:0050847 [progesterone receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051057 [positive regulation of small GTPase mediated signal transduction] GO:0051219 [phosphoprotein binding] GO:0051222 [positive regulation of protein transport] GO:0051385 [response to mineralocorticoid] GO:0051427 [hormone receptor binding] GO:0051602 [response to electrical stimulus] GO:0051726 [regulation of cell cycle] GO:0051895 [negative regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051902 [negative regulation of mitochondrial depolarization] GO:0051974 [negative regulation of telomerase activity] GO:0060065 [uterus development] GO:0060444 [branching involved in mammary gland duct morphogenesis] GO:0060491 [regulation of cell projection assembly] GO:0070062 [extracellular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070542 [response to fatty acid] GO:0070555 [response to interleukin-1] GO:0070851 [growth factor receptor binding] GO:0071222 [cellular response to lipopolysaccharide] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071393 [cellular response to progesterone stimulus] GO:0071398 [cellular response to fatty acid] GO:0071456 [cellular response to hypoxia] GO:0071498 [cellular response to fluid shear stress] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:0071801 [regulation of podosome assembly] GO:0071803 [positive regulation of podosome assembly] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0086098 [angiotensin-activated signaling pathway involved in heart process] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0097110 [scaffold protein binding] GO:1900182 [positive regulation of protein localization to nucleus] GO:1902533 [positive regulation of intracellular signal transduction] GO:2000394 [positive regulation of lamellipodium morphogenesis] GO:2000573 [positive regulation of DNA biosynthetic process] GO:2000641 [regulation of early endosome to late endosome transport] GO:2000811 [negative regulation of anoikis] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001286 [regulation of caveolin-mediated endocytosis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002376 [immune system process] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005102 [receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007411 [axon guidance] GO:0007417 [central nervous system development] GO:0010632 [regulation of epithelial cell migration] GO:0010634 [positive regulation of epithelial cell migration] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0020037 [heme binding] GO:0022407 [regulation of cell-cell adhesion] GO:0030168 [platelet activation] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032463 [negative regulation of protein homooligomerization] GO:0033625 [positive regulation of integrin activation] GO:0035556 [intracellular signal transduction] GO:0035635 [entry of bacterium into host cell] GO:0036035 [osteoclast development] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0038128 [ERBB2 signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043114 [regulation of vascular permeability] GO:0043149 [stress fiber assembly] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0045124 [regulation of bone resorption] GO:0045296 [cadherin binding] GO:0045453 [bone resorption] GO:0046777 [protein autophosphorylation] GO:0046875 [ephrin receptor binding] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050847 [progesterone receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051057 [positive regulation of small GTPase mediated signal transduction] GO:0051219 [phosphoprotein binding] GO:0051427 [hormone receptor binding] GO:0051726 [regulation of cell cycle] GO:0051895 [negative regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051902 [negative regulation of mitochondrial depolarization] GO:0051974 [negative regulation of telomerase activity] GO:0070062 [extracellular exosome] GO:0070555 [response to interleukin-1] GO:0070851 [growth factor receptor binding] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071393 [cellular response to progesterone stimulus] GO:0071801 [regulation of podosome assembly] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0086098 [angiotensin-activated signaling pathway involved in heart process] GO:0097110 [scaffold protein binding] GO:2000394 [positive regulation of lamellipodium morphogenesis] GO:2000641 [regulation of early endosome to late endosome transport] GO:2000811 [negative regulation of anoikis] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001286 [regulation of caveolin-mediated endocytosis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002376 [immune system process] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005102 [receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007411 [axon guidance] GO:0007417 [central nervous system development] GO:0010632 [regulation of epithelial cell migration] GO:0010634 [positive regulation of epithelial cell migration] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0020037 [heme binding] GO:0022407 [regulation of cell-cell adhesion] GO:0030168 [platelet activation] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032463 [negative regulation of protein homooligomerization] GO:0033625 [positive regulation of integrin activation] GO:0035556 [intracellular signal transduction] GO:0035635 [entry of bacterium into host cell] GO:0036035 [osteoclast development] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0038128 [ERBB2 signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043114 [regulation of vascular permeability] GO:0043149 [stress fiber assembly] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0045124 [regulation of bone resorption] GO:0045296 [cadherin binding] GO:0045453 [bone resorption] GO:0046777 [protein autophosphorylation] GO:0046875 [ephrin receptor binding] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050847 [progesterone receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051057 [positive regulation of small GTPase mediated signal transduction] GO:0051219 [phosphoprotein binding] GO:0051427 [hormone receptor binding] GO:0051726 [regulation of cell cycle] GO:0051895 [negative regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051902 [negative regulation of mitochondrial depolarization] GO:0051974 [negative regulation of telomerase activity] GO:0070062 [extracellular exosome] GO:0070555 [response to interleukin-1] GO:0070851 [growth factor receptor binding] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071393 [cellular response to progesterone stimulus] GO:0071801 [regulation of podosome assembly] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0086098 [angiotensin-activated signaling pathway involved in heart process] GO:0097110 [scaffold protein binding] GO:2000394 [positive regulation of lamellipodium morphogenesis] GO:2000641 [regulation of early endosome to late endosome transport] GO:2000811 [negative regulation of anoikis] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001286 [regulation of caveolin-mediated endocytosis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002376 [immune system process] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005102 [receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005901 [caveola] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007411 [axon guidance] GO:0007417 [central nervous system development] GO:0010632 [regulation of epithelial cell migration] GO:0010634 [positive regulation of epithelial cell migration] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0020037 [heme binding] GO:0022407 [regulation of cell-cell adhesion] GO:0030168 [platelet activation] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0032211 [negative regulation of telomere maintenance via telomerase] GO:0032463 [negative regulation of protein homooligomerization] GO:0033625 [positive regulation of integrin activation] GO:0035556 [intracellular signal transduction] GO:0035635 [entry of bacterium into host cell] GO:0036035 [osteoclast development] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0038128 [ERBB2 signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043114 [regulation of vascular permeability] GO:0043149 [stress fiber assembly] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0045124 [regulation of bone resorption] GO:0045296 [cadherin binding] GO:0045453 [bone resorption] GO:0046777 [protein autophosphorylation] GO:0046875 [ephrin receptor binding] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050847 [progesterone receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051057 [positive regulation of small GTPase mediated signal transduction] GO:0051219 [phosphoprotein binding] GO:0051427 [hormone receptor binding] GO:0051726 [regulation of cell cycle] GO:0051895 [negative regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051902 [negative regulation of mitochondrial depolarization] GO:0051974 [negative regulation of telomerase activity] GO:0070062 [extracellular exosome] GO:0070555 [response to interleukin-1] GO:0070851 [growth factor receptor binding] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071393 [cellular response to progesterone stimulus] GO:0071801 [regulation of podosome assembly] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0086098 [angiotensin-activated signaling pathway involved in heart process] GO:0097110 [scaffold protein binding] GO:2000394 [positive regulation of lamellipodium morphogenesis] GO:2000641 [regulation of early endosome to late endosome transport] GO:2000811 [negative regulation of anoikis] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001286 [regulation of caveolin-mediated endocytosis]