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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for data imported from The Genotype-Tissue Expression project (GTEX), FANTOM5 Consortium (FANTOM5) and internally generated Human Protein Atlas (HPA) data.
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expressioni
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Cytoplasmic and nuclear expression in several tissues.
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability descriptioni
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining mainly not consistent with RNA expression data.
Reliability scorei
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Below is an overview of RNA and protein expression data generated in the Human Protein Atlas project. Analyzed tissues are divided into color-coded groups according to which functional features they have in common. For each group, a list of included tissues is accessed by clicking on group name, group symbol, RNA bar, or protein bar. Subsequent selection of a particular tissue in this list links to the image data page.
Images of selected tissues give a visual summary of the protein expression profile furthest to the right.
The gray human body provides links to a histology dictionary when clicking on any part of the figure.
RNA expression (TPM)i
RNA-seq results generated in HPA are reported as number of transcripts per million (TPM). Each bar represents the highest expression score found in a particular group of tissues. The assay is described more in detail in Assays & Annotation.
Protein expression (score)i
Each bar represents the highest expression score found in a particular group of tissues. Protein expression scores are based on a best estimate of the "true" protein expression from a knowledge-based annotation, described more in detail under Assays & annotation. For genes where more than one antibody has been used, a collective score is set displaying the estimated true protein expression.
Protein expression data is shown for each of the 44 tissues. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. Mouse-over function shows protein score for analyzed cell types in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation.
For genes with available protein data for which a knowledge-based annotation gave inconclusive results, no protein expression data is displayed in the protein expression data overview. However, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Organ
Expression
Alphabetical
RNA EXPRESSION OVERVIEWi
RNA expression overview shows RNA-data from three different sources: Internally generated Human Protein Atlas (HPA) RNA-seq data, RNA-seq data from the Genotype-Tissue Expression (GTEx) project and CAGE data from FANTOM5 project. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.
HPA dataseti
HPA dataset RNA-seq tissue data is reported as mean TPM (transcripts per million), corresponding to mean values of the different individual samples from each tissue. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar. The RNA-seq assay is described in detail in Assays & Annotation.
RNA tissue category HPA HPA RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
GTEx dataset RNA-seq data is reported as median RPKM (reads per kilobase per million mapped reads), generated by the Genotype-Tissue Expression (GTEx) project. More information can be found in Assays & Annotation.
RNA tissue category GTEx GTEx RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
FANTOM5 dataset Tissue data obtained through Cap Analysis of Gene Expression (CAGE) are reported as Tags Per Million, generated by the FANTOM5 project. More information can be found in Assays & Annotation.
RNA tissue category FANTOM5 FANTOM5 RNA tissue category (category description) is calculated based on gene expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
PPARG-001
PPARG-002
PPARG-003
PPARG-004
PPARG-005
PPARG-007
PPARG-009
PPARG-013
PPARG-015
PPARG-017
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Nuclear receptors Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001890 [placenta development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003707 [steroid hormone receptor activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0004955 [prostaglandin receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006629 [lipid metabolic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007584 [response to nutrient] GO:0008134 [transcription factor binding] GO:0008144 [drug binding] GO:0008217 [regulation of blood pressure] GO:0008270 [zinc ion binding] GO:0010742 [macrophage derived foam cell differentiation] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010871 [negative regulation of receptor biosynthetic process] GO:0010887 [negative regulation of cholesterol storage] GO:0010891 [negative regulation of sequestering of triglyceride] GO:0015909 [long-chain fatty acid transport] GO:0019899 [enzyme binding] GO:0030224 [monocyte differentiation] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0030522 [intracellular receptor signaling pathway] GO:0030855 [epithelial cell differentiation] GO:0032526 [response to retinoic acid] GO:0032869 [cellular response to insulin stimulus] GO:0033613 [activating transcription factor binding] GO:0033993 [response to lipid] GO:0035357 [peroxisome proliferator activated receptor signaling pathway] GO:0042593 [glucose homeostasis] GO:0042752 [regulation of circadian rhythm] GO:0042802 [identical protein binding] GO:0042953 [lipoprotein transport] GO:0043231 [intracellular membrane-bounded organelle] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045165 [cell fate commitment] GO:0045600 [positive regulation of fat cell differentiation] GO:0045713 [low-density lipoprotein particle receptor biosynthetic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046965 [retinoid X receptor binding] GO:0048469 [cell maturation] GO:0048511 [rhythmic process] GO:0048662 [negative regulation of smooth muscle cell proliferation] GO:0050544 [arachidonic acid binding] GO:0050872 [white fat cell differentiation] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051393 [alpha-actinin binding] GO:0055088 [lipid homeostasis] GO:0055098 [response to low-density lipoprotein particle] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0060694 [regulation of cholesterol transporter activity] GO:0060850 [regulation of transcription involved in cell fate commitment] GO:0090575 [RNA polymerase II transcription factor complex]
Nuclear receptors Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001890 [placenta development] GO:0002674 [negative regulation of acute inflammatory response] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003707 [steroid hormone receptor activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0004955 [prostaglandin receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006629 [lipid metabolic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007507 [heart development] GO:0007584 [response to nutrient] GO:0008134 [transcription factor binding] GO:0008144 [drug binding] GO:0008217 [regulation of blood pressure] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0009409 [response to cold] GO:0009612 [response to mechanical stimulus] GO:0010033 [response to organic substance] GO:0010742 [macrophage derived foam cell differentiation] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010871 [negative regulation of receptor biosynthetic process] GO:0010887 [negative regulation of cholesterol storage] GO:0010891 [negative regulation of sequestering of triglyceride] GO:0014070 [response to organic cyclic compound] GO:0015909 [long-chain fatty acid transport] GO:0019216 [regulation of lipid metabolic process] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0019903 [protein phosphatase binding] GO:0030224 [monocyte differentiation] GO:0030308 [negative regulation of cell growth] GO:0030331 [estrogen receptor binding] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0030855 [epithelial cell differentiation] GO:0031000 [response to caffeine] GO:0031100 [animal organ regeneration] GO:0032526 [response to retinoic acid] GO:0032869 [cellular response to insulin stimulus] GO:0032966 [negative regulation of collagen biosynthetic process] GO:0033189 [response to vitamin A] GO:0033613 [activating transcription factor binding] GO:0033993 [response to lipid] GO:0035357 [peroxisome proliferator activated receptor signaling pathway] GO:0035902 [response to immobilization stress] GO:0042493 [response to drug] GO:0042593 [glucose homeostasis] GO:0042594 [response to starvation] GO:0042752 [regulation of circadian rhythm] GO:0042802 [identical protein binding] GO:0042953 [lipoprotein transport] GO:0043065 [positive regulation of apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0043627 [response to estrogen] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045165 [cell fate commitment] GO:0045598 [regulation of fat cell differentiation] GO:0045600 [positive regulation of fat cell differentiation] GO:0045713 [low-density lipoprotein particle receptor biosynthetic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046321 [positive regulation of fatty acid oxidation] GO:0046872 [metal ion binding] GO:0046965 [retinoid X receptor binding] GO:0048469 [cell maturation] GO:0048471 [perinuclear region of cytoplasm] GO:0048511 [rhythmic process] GO:0048662 [negative regulation of smooth muscle cell proliferation] GO:0048714 [positive regulation of oligodendrocyte differentiation] GO:0050544 [arachidonic acid binding] GO:0050872 [white fat cell differentiation] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051393 [alpha-actinin binding] GO:0051974 [negative regulation of telomerase activity] GO:0055088 [lipid homeostasis] GO:0055098 [response to low-density lipoprotein particle] GO:0060100 [positive regulation of phagocytosis, engulfment] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0060694 [regulation of cholesterol transporter activity] GO:0060850 [regulation of transcription involved in cell fate commitment] GO:0071300 [cellular response to retinoic acid] GO:0071306 [cellular response to vitamin E] GO:0071379 [cellular response to prostaglandin stimulus] GO:0071380 [cellular response to prostaglandin E stimulus] GO:0071455 [cellular response to hyperoxia] GO:0090575 [RNA polymerase II transcription factor complex] GO:1901558 [response to metformin] GO:2000230 [negative regulation of pancreatic stellate cell proliferation]
Nuclear receptors Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001890 [placenta development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003707 [steroid hormone receptor activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0004955 [prostaglandin receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006629 [lipid metabolic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007584 [response to nutrient] GO:0008134 [transcription factor binding] GO:0008144 [drug binding] GO:0008217 [regulation of blood pressure] GO:0008270 [zinc ion binding] GO:0010742 [macrophage derived foam cell differentiation] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010871 [negative regulation of receptor biosynthetic process] GO:0010887 [negative regulation of cholesterol storage] GO:0010891 [negative regulation of sequestering of triglyceride] GO:0015909 [long-chain fatty acid transport] GO:0019899 [enzyme binding] GO:0030224 [monocyte differentiation] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0030522 [intracellular receptor signaling pathway] GO:0030855 [epithelial cell differentiation] GO:0032526 [response to retinoic acid] GO:0032869 [cellular response to insulin stimulus] GO:0033613 [activating transcription factor binding] GO:0033993 [response to lipid] GO:0035357 [peroxisome proliferator activated receptor signaling pathway] GO:0042593 [glucose homeostasis] GO:0042752 [regulation of circadian rhythm] GO:0042802 [identical protein binding] GO:0042953 [lipoprotein transport] GO:0043231 [intracellular membrane-bounded organelle] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045165 [cell fate commitment] GO:0045600 [positive regulation of fat cell differentiation] GO:0045713 [low-density lipoprotein particle receptor biosynthetic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046965 [retinoid X receptor binding] GO:0048469 [cell maturation] GO:0048511 [rhythmic process] GO:0048662 [negative regulation of smooth muscle cell proliferation] GO:0050544 [arachidonic acid binding] GO:0050872 [white fat cell differentiation] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051393 [alpha-actinin binding] GO:0055088 [lipid homeostasis] GO:0055098 [response to low-density lipoprotein particle] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0060694 [regulation of cholesterol transporter activity] GO:0060850 [regulation of transcription involved in cell fate commitment] GO:0090575 [RNA polymerase II transcription factor complex]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0030522 [intracellular receptor signaling pathway]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003707 [steroid hormone receptor activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0030522 [intracellular receptor signaling pathway] GO:0043231 [intracellular membrane-bounded organelle] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding]
Nuclear receptors Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001890 [placenta development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003707 [steroid hormone receptor activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0004955 [prostaglandin receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006629 [lipid metabolic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007584 [response to nutrient] GO:0008134 [transcription factor binding] GO:0008144 [drug binding] GO:0008217 [regulation of blood pressure] GO:0008270 [zinc ion binding] GO:0010742 [macrophage derived foam cell differentiation] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010871 [negative regulation of receptor biosynthetic process] GO:0010887 [negative regulation of cholesterol storage] GO:0010891 [negative regulation of sequestering of triglyceride] GO:0015909 [long-chain fatty acid transport] GO:0019899 [enzyme binding] GO:0030224 [monocyte differentiation] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0030522 [intracellular receptor signaling pathway] GO:0030855 [epithelial cell differentiation] GO:0032526 [response to retinoic acid] GO:0032869 [cellular response to insulin stimulus] GO:0033613 [activating transcription factor binding] GO:0033993 [response to lipid] GO:0035357 [peroxisome proliferator activated receptor signaling pathway] GO:0042593 [glucose homeostasis] GO:0042752 [regulation of circadian rhythm] GO:0042802 [identical protein binding] GO:0042953 [lipoprotein transport] GO:0043231 [intracellular membrane-bounded organelle] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045165 [cell fate commitment] GO:0045600 [positive regulation of fat cell differentiation] GO:0045713 [low-density lipoprotein particle receptor biosynthetic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046965 [retinoid X receptor binding] GO:0048469 [cell maturation] GO:0048511 [rhythmic process] GO:0048662 [negative regulation of smooth muscle cell proliferation] GO:0050544 [arachidonic acid binding] GO:0050872 [white fat cell differentiation] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051393 [alpha-actinin binding] GO:0055088 [lipid homeostasis] GO:0055098 [response to low-density lipoprotein particle] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0060694 [regulation of cholesterol transporter activity] GO:0060850 [regulation of transcription involved in cell fate commitment] GO:0090575 [RNA polymerase II transcription factor complex]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0030522 [intracellular receptor signaling pathway] GO:0043231 [intracellular membrane-bounded organelle] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding]
Nuclear receptors Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001890 [placenta development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003707 [steroid hormone receptor activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0004955 [prostaglandin receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006629 [lipid metabolic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007584 [response to nutrient] GO:0008134 [transcription factor binding] GO:0008144 [drug binding] GO:0008217 [regulation of blood pressure] GO:0008270 [zinc ion binding] GO:0010742 [macrophage derived foam cell differentiation] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010871 [negative regulation of receptor biosynthetic process] GO:0010887 [negative regulation of cholesterol storage] GO:0010891 [negative regulation of sequestering of triglyceride] GO:0015909 [long-chain fatty acid transport] GO:0019899 [enzyme binding] GO:0030224 [monocyte differentiation] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0030522 [intracellular receptor signaling pathway] GO:0030855 [epithelial cell differentiation] GO:0032526 [response to retinoic acid] GO:0032869 [cellular response to insulin stimulus] GO:0033613 [activating transcription factor binding] GO:0033993 [response to lipid] GO:0035357 [peroxisome proliferator activated receptor signaling pathway] GO:0042593 [glucose homeostasis] GO:0042752 [regulation of circadian rhythm] GO:0042802 [identical protein binding] GO:0042953 [lipoprotein transport] GO:0043231 [intracellular membrane-bounded organelle] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045165 [cell fate commitment] GO:0045600 [positive regulation of fat cell differentiation] GO:0045713 [low-density lipoprotein particle receptor biosynthetic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046965 [retinoid X receptor binding] GO:0048469 [cell maturation] GO:0048511 [rhythmic process] GO:0048662 [negative regulation of smooth muscle cell proliferation] GO:0050544 [arachidonic acid binding] GO:0050872 [white fat cell differentiation] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051393 [alpha-actinin binding] GO:0055088 [lipid homeostasis] GO:0055098 [response to low-density lipoprotein particle] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0060694 [regulation of cholesterol transporter activity] GO:0060850 [regulation of transcription involved in cell fate commitment] GO:0090575 [RNA polymerase II transcription factor complex]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0030522 [intracellular receptor signaling pathway] GO:0043231 [intracellular membrane-bounded organelle] GO:0043565 [sequence-specific DNA binding]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0030522 [intracellular receptor signaling pathway]
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