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Show complete data for human cells assay. The location(s) are highlighted in the illustration on the right.
Localized to the nucleus & vesicles.
RNA cell categoryi
The cell lines in the Human Protein Atlas have been analyzed by RNA-seq to estimate the transcript abundance of each protein-coding gene. The RNA-seq data was then used to classify all genes according to their cell line-specific expression into one of six different categories, defined based on the total set of all TPM values in all analyzed cell lines.
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Main locationi
The main location is characterized by presence in all tested cell lines and/or increased intensity compared to other locations. It is highlighted in the illustration to the right. If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively.
Localized to the Nucleus (enhanced), Vesicles (enhanced)
DATA RELIABILITY
Reliability scorei
A reliability score is set for all genes and indicates the level of reliability of the analyzed protein expression pattern based on available protein/RNA/gene characterization data. The reliability of the annotated protein expression data is also scored depending on similarity in immunostaining patterns and consistency with available experimental gene/protein characterization data in the UniProtKB/Swiss-Prot database.
Below is an overview of RNA expression data generated in the HPA project. The analyzed cell lines are divided into 12 color-coded groups according to the organ they were obtained from. By clicking the toolbars in the top right corner it is possible to sort the cell lines in the chart by different criteria: the organ and the origin that the cell line was obtained from, the category of the cell line according to cellosaurus, alphabetically or by descending RNA expression. Detailed information about a specific cell line can be accessed by hovering over the corresponding bar in the chart. The RNA-sequencing results generated in the HPA are reported as number of Transcripts per Kilobase Million (TPM). In the Human Protein Atlas a TPM value of 1.0 is defined as a treshhold for expression of the corresponding protein.
The cell lines in the Human Protein Atlas have been analyzed by RNA-seq to estimate the transcript abundance of each protein-coding gene. The RNA-seq data was then used to classify all genes according to their cell line-specific expression into one of six different categories, defined based on the total set of all TPM values in all analyzed cell lines.
Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
Cell lines sorted alphabetically.
HUMAN CELLSi
The "human cells" section gives an overview about the subcellular location of the protein of interest obtained by indirect immunofluorescence microscopy, an antibody-based protein-visualization technique. The immunofluorescent analysis is carried out in three different cell lines, one of them always being U-2 OS. A selection of immunofluorescent images is displayed below. Three different organelle probes are displayed as different channels in the multicolor images - nucleus stained in blue, microtubules in red and ER in yellow. The antibody staining targeting the protein of interest is shown in green. By using the toggle channel buttons, the different channels can be turned on and off. For the selection of the images to compare, use the checkboxes next to the images at the bottom. Three images can be compared at a time. All images are clickable for an enlarged view. The selected image will appear in large size and miniature images with all other staining results for this gene will be listed at the top left of the image. The selected miniature image has an orange overlay. For cell structure reference, visit the cell dictionary.
Summaryi
Summary of the immunofluorescent analysis in all studied cell lines with all tested antibodies.
Localized to the nucleus & vesicles.
Main locationi
The main location is characterized by presence in all tested cell lines and/or increased intensity compared to other locations.
Nucleus (enhanced), Vesicles (enhanced)
Toggle channelsi
Three different organelle probes are displayed as different channels in the multicolor images - nucleus stained in blue, microtubules in red and ER in yellow. The antibody staining targeting the protein of interest is shown in green. By using the "toggle channels"-buttons, the different channels can be turned on and off. The intensity toggle shows the pixel intensity range in 16 different colors for the selected channel. The object toggle shows the computational segmentation of the cells used for further analysis in the HPA project. For samples where cell cycle dependency for the protein is suggested according to a correlation assay the predicted cell cycle position of each cell is displayed when using the object toggle.
Low
High
G1
S
G2
M
N/A
Thumbnaili
Representative images for the assay. Three images can be compared at the same time. To change which images to compare, use the checkboxes next to the images below. All images are clickable for an enlarged view. The selected image will appear in large size and miniature images with all other staining results for this gene will be listed at the top left of the image. The selected miniature image has an orange overlay.
Antibodyi
Antibody used for analysis. Clicking the antibody ID links to the antibody validation page.
Cell linei
Cell line used for analysis. Read more about the cell lines in the Human Protein Atlas.
Locationi
Location(s) annotated in the corresponding cell line.
Single-cell variationi
As the images in the Cell Atlas provide single cell resolution, variations in protein expression patterns from cell to cell can be observed. A single-cell variation can either be observed in the intensity of the immunofluorescent signal or in the spatial distribution pattern of the protein. This column contains information about whether and for which of the annotated locations a single-cell variation pattern was manually annotated.
Cell cycle dependent variationi
A likely cause for single-cell variation in the immunofluorescent images is cell cycle dependency. This column contains information about whether the manually observed cell-to-cell variation pattern correlates with cell cycle progression.
For the genes where the mouse and human genes are orthologues, the mouse cell line NIH 3T3 is also stained. The main subcellular location of the encoded proteins and any additional locations are reported as well as staining characteristics, staining intensity and validation score. Example images are shown below. To change which images to compare, use the checkboxes next to the images at the bottom. Three images can be compared at a time. All images are clickable for an enlarged view. The selected image will appear in large size and miniature images with all other staining results for this gene will be listed at the top left of the image. The selected miniature image has an orange overlay. For cell structure reference, visit the cell dictionary.
Main locationi
The main location is characterized by a higher intensity compared to other locations observed.
Three different organelle probes are displayed as different channels in the multicolor images - nucleus stained in blue, microtubules in red and ER in yellow. The HPA-antibody staining targeting the protein of interest is shown in green. By using the "toggle channels"-buttons, the different channels can be turned on and off. The intensity toggle shows the pixel intensity range in 16 different colors for the selected channel. The object toggle shows the computational segmentation of the cells used for further analysis in the HPA project. For samples where cell cycle dependency for the protein is suggested according to a correlation assay the predicted cell cycle position of each cell is displayed when using the object toggle.
Low
High
G1
S
G2
M
N/A
Thumbnaili
Representative images for the assay. Three images can be compared at the same time. To change which images to compare, use the checkboxes next to the images below. All images are clickable for an enlarged view. The selected image will appear in large size and miniature images with all other staining results for this gene will be listed at the top left of the image. The selected miniature image has an orange overlay.
Antibodyi
Antibody used for analysis. Clicking the antibody ID links to the antibody validation page.
Cell linei
Cell line used for analysis. Read more about the cell lines in the Human Protein Atlas.
Locationi
Location(s) annotated in the corresponding cell line.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
PPARG-001
PPARG-002
PPARG-003
PPARG-004
PPARG-005
PPARG-007
PPARG-009
PPARG-013
PPARG-015
PPARG-017
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Nuclear receptors Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001890 [placenta development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003707 [steroid hormone receptor activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0004955 [prostaglandin receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006629 [lipid metabolic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007584 [response to nutrient] GO:0008134 [transcription factor binding] GO:0008144 [drug binding] GO:0008217 [regulation of blood pressure] GO:0008270 [zinc ion binding] GO:0010742 [macrophage derived foam cell differentiation] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010871 [negative regulation of receptor biosynthetic process] GO:0010887 [negative regulation of cholesterol storage] GO:0010891 [negative regulation of sequestering of triglyceride] GO:0015909 [long-chain fatty acid transport] GO:0019899 [enzyme binding] GO:0030224 [monocyte differentiation] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0030522 [intracellular receptor signaling pathway] GO:0030855 [epithelial cell differentiation] GO:0032526 [response to retinoic acid] GO:0032869 [cellular response to insulin stimulus] GO:0033613 [activating transcription factor binding] GO:0033993 [response to lipid] GO:0035357 [peroxisome proliferator activated receptor signaling pathway] GO:0042593 [glucose homeostasis] GO:0042752 [regulation of circadian rhythm] GO:0042802 [identical protein binding] GO:0042953 [lipoprotein transport] GO:0043231 [intracellular membrane-bounded organelle] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045165 [cell fate commitment] GO:0045600 [positive regulation of fat cell differentiation] GO:0045713 [low-density lipoprotein particle receptor biosynthetic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046965 [retinoid X receptor binding] GO:0048469 [cell maturation] GO:0048511 [rhythmic process] GO:0048662 [negative regulation of smooth muscle cell proliferation] GO:0050544 [arachidonic acid binding] GO:0050872 [white fat cell differentiation] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051393 [alpha-actinin binding] GO:0055088 [lipid homeostasis] GO:0055098 [response to low-density lipoprotein particle] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0060694 [regulation of cholesterol transporter activity] GO:0060850 [regulation of transcription involved in cell fate commitment] GO:0090575 [RNA polymerase II transcription factor complex]
Nuclear receptors Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001890 [placenta development] GO:0002674 [negative regulation of acute inflammatory response] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003707 [steroid hormone receptor activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0004955 [prostaglandin receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006629 [lipid metabolic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007507 [heart development] GO:0007584 [response to nutrient] GO:0008134 [transcription factor binding] GO:0008144 [drug binding] GO:0008217 [regulation of blood pressure] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0009409 [response to cold] GO:0009612 [response to mechanical stimulus] GO:0010033 [response to organic substance] GO:0010742 [macrophage derived foam cell differentiation] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010871 [negative regulation of receptor biosynthetic process] GO:0010887 [negative regulation of cholesterol storage] GO:0010891 [negative regulation of sequestering of triglyceride] GO:0014070 [response to organic cyclic compound] GO:0015909 [long-chain fatty acid transport] GO:0019216 [regulation of lipid metabolic process] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0019903 [protein phosphatase binding] GO:0030224 [monocyte differentiation] GO:0030308 [negative regulation of cell growth] GO:0030331 [estrogen receptor binding] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0030855 [epithelial cell differentiation] GO:0031000 [response to caffeine] GO:0031100 [animal organ regeneration] GO:0032526 [response to retinoic acid] GO:0032869 [cellular response to insulin stimulus] GO:0032966 [negative regulation of collagen biosynthetic process] GO:0033189 [response to vitamin A] GO:0033613 [activating transcription factor binding] GO:0033993 [response to lipid] GO:0035357 [peroxisome proliferator activated receptor signaling pathway] GO:0035902 [response to immobilization stress] GO:0042493 [response to drug] GO:0042593 [glucose homeostasis] GO:0042594 [response to starvation] GO:0042752 [regulation of circadian rhythm] GO:0042802 [identical protein binding] GO:0042953 [lipoprotein transport] GO:0043065 [positive regulation of apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0043627 [response to estrogen] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045165 [cell fate commitment] GO:0045598 [regulation of fat cell differentiation] GO:0045600 [positive regulation of fat cell differentiation] GO:0045713 [low-density lipoprotein particle receptor biosynthetic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046321 [positive regulation of fatty acid oxidation] GO:0046872 [metal ion binding] GO:0046965 [retinoid X receptor binding] GO:0048469 [cell maturation] GO:0048471 [perinuclear region of cytoplasm] GO:0048511 [rhythmic process] GO:0048662 [negative regulation of smooth muscle cell proliferation] GO:0048714 [positive regulation of oligodendrocyte differentiation] GO:0050544 [arachidonic acid binding] GO:0050872 [white fat cell differentiation] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051393 [alpha-actinin binding] GO:0051974 [negative regulation of telomerase activity] GO:0055088 [lipid homeostasis] GO:0055098 [response to low-density lipoprotein particle] GO:0060100 [positive regulation of phagocytosis, engulfment] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0060694 [regulation of cholesterol transporter activity] GO:0060850 [regulation of transcription involved in cell fate commitment] GO:0071300 [cellular response to retinoic acid] GO:0071306 [cellular response to vitamin E] GO:0071379 [cellular response to prostaglandin stimulus] GO:0071380 [cellular response to prostaglandin E stimulus] GO:0071455 [cellular response to hyperoxia] GO:0090575 [RNA polymerase II transcription factor complex] GO:1901558 [response to metformin] GO:2000230 [negative regulation of pancreatic stellate cell proliferation]
Nuclear receptors Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001890 [placenta development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003707 [steroid hormone receptor activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0004955 [prostaglandin receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006629 [lipid metabolic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007584 [response to nutrient] GO:0008134 [transcription factor binding] GO:0008144 [drug binding] GO:0008217 [regulation of blood pressure] GO:0008270 [zinc ion binding] GO:0010742 [macrophage derived foam cell differentiation] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010871 [negative regulation of receptor biosynthetic process] GO:0010887 [negative regulation of cholesterol storage] GO:0010891 [negative regulation of sequestering of triglyceride] GO:0015909 [long-chain fatty acid transport] GO:0019899 [enzyme binding] GO:0030224 [monocyte differentiation] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0030522 [intracellular receptor signaling pathway] GO:0030855 [epithelial cell differentiation] GO:0032526 [response to retinoic acid] GO:0032869 [cellular response to insulin stimulus] GO:0033613 [activating transcription factor binding] GO:0033993 [response to lipid] GO:0035357 [peroxisome proliferator activated receptor signaling pathway] GO:0042593 [glucose homeostasis] GO:0042752 [regulation of circadian rhythm] GO:0042802 [identical protein binding] GO:0042953 [lipoprotein transport] GO:0043231 [intracellular membrane-bounded organelle] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045165 [cell fate commitment] GO:0045600 [positive regulation of fat cell differentiation] GO:0045713 [low-density lipoprotein particle receptor biosynthetic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046965 [retinoid X receptor binding] GO:0048469 [cell maturation] GO:0048511 [rhythmic process] GO:0048662 [negative regulation of smooth muscle cell proliferation] GO:0050544 [arachidonic acid binding] GO:0050872 [white fat cell differentiation] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051393 [alpha-actinin binding] GO:0055088 [lipid homeostasis] GO:0055098 [response to low-density lipoprotein particle] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0060694 [regulation of cholesterol transporter activity] GO:0060850 [regulation of transcription involved in cell fate commitment] GO:0090575 [RNA polymerase II transcription factor complex]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0030522 [intracellular receptor signaling pathway]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003707 [steroid hormone receptor activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0030522 [intracellular receptor signaling pathway] GO:0043231 [intracellular membrane-bounded organelle] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding]
Nuclear receptors Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001890 [placenta development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003707 [steroid hormone receptor activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0004955 [prostaglandin receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006629 [lipid metabolic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007584 [response to nutrient] GO:0008134 [transcription factor binding] GO:0008144 [drug binding] GO:0008217 [regulation of blood pressure] GO:0008270 [zinc ion binding] GO:0010742 [macrophage derived foam cell differentiation] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010871 [negative regulation of receptor biosynthetic process] GO:0010887 [negative regulation of cholesterol storage] GO:0010891 [negative regulation of sequestering of triglyceride] GO:0015909 [long-chain fatty acid transport] GO:0019899 [enzyme binding] GO:0030224 [monocyte differentiation] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0030522 [intracellular receptor signaling pathway] GO:0030855 [epithelial cell differentiation] GO:0032526 [response to retinoic acid] GO:0032869 [cellular response to insulin stimulus] GO:0033613 [activating transcription factor binding] GO:0033993 [response to lipid] GO:0035357 [peroxisome proliferator activated receptor signaling pathway] GO:0042593 [glucose homeostasis] GO:0042752 [regulation of circadian rhythm] GO:0042802 [identical protein binding] GO:0042953 [lipoprotein transport] GO:0043231 [intracellular membrane-bounded organelle] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045165 [cell fate commitment] GO:0045600 [positive regulation of fat cell differentiation] GO:0045713 [low-density lipoprotein particle receptor biosynthetic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046965 [retinoid X receptor binding] GO:0048469 [cell maturation] GO:0048511 [rhythmic process] GO:0048662 [negative regulation of smooth muscle cell proliferation] GO:0050544 [arachidonic acid binding] GO:0050872 [white fat cell differentiation] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051393 [alpha-actinin binding] GO:0055088 [lipid homeostasis] GO:0055098 [response to low-density lipoprotein particle] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0060694 [regulation of cholesterol transporter activity] GO:0060850 [regulation of transcription involved in cell fate commitment] GO:0090575 [RNA polymerase II transcription factor complex]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0030522 [intracellular receptor signaling pathway] GO:0043231 [intracellular membrane-bounded organelle] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding]
Nuclear receptors Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001890 [placenta development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003707 [steroid hormone receptor activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0004955 [prostaglandin receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006629 [lipid metabolic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007584 [response to nutrient] GO:0008134 [transcription factor binding] GO:0008144 [drug binding] GO:0008217 [regulation of blood pressure] GO:0008270 [zinc ion binding] GO:0010742 [macrophage derived foam cell differentiation] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010871 [negative regulation of receptor biosynthetic process] GO:0010887 [negative regulation of cholesterol storage] GO:0010891 [negative regulation of sequestering of triglyceride] GO:0015909 [long-chain fatty acid transport] GO:0019899 [enzyme binding] GO:0030224 [monocyte differentiation] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0030522 [intracellular receptor signaling pathway] GO:0030855 [epithelial cell differentiation] GO:0032526 [response to retinoic acid] GO:0032869 [cellular response to insulin stimulus] GO:0033613 [activating transcription factor binding] GO:0033993 [response to lipid] GO:0035357 [peroxisome proliferator activated receptor signaling pathway] GO:0042593 [glucose homeostasis] GO:0042752 [regulation of circadian rhythm] GO:0042802 [identical protein binding] GO:0042953 [lipoprotein transport] GO:0043231 [intracellular membrane-bounded organelle] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045165 [cell fate commitment] GO:0045600 [positive regulation of fat cell differentiation] GO:0045713 [low-density lipoprotein particle receptor biosynthetic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0046965 [retinoid X receptor binding] GO:0048469 [cell maturation] GO:0048511 [rhythmic process] GO:0048662 [negative regulation of smooth muscle cell proliferation] GO:0050544 [arachidonic acid binding] GO:0050872 [white fat cell differentiation] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051393 [alpha-actinin binding] GO:0055088 [lipid homeostasis] GO:0055098 [response to low-density lipoprotein particle] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0060694 [regulation of cholesterol transporter activity] GO:0060850 [regulation of transcription involved in cell fate commitment] GO:0090575 [RNA polymerase II transcription factor complex]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0030522 [intracellular receptor signaling pathway] GO:0043231 [intracellular membrane-bounded organelle] GO:0043565 [sequence-specific DNA binding]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0030522 [intracellular receptor signaling pathway]
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