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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for data imported from The Genotype-Tissue Expression project (GTEX), FANTOM5 Consortium (FANTOM5) and internally generated Human Protein Atlas (HPA) data.
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expressioni
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Cytoplasmic and nuclear expression at variable levels in most cell types, expressed mainly in the brain and lymphoid tissue.
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability descriptioni
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining mainly consistent with RNA expression data.
Reliability scorei
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Below is an overview of RNA and protein expression data generated in the Human Protein Atlas project. Analyzed tissues are divided into color-coded groups according to which functional features they have in common. For each group, a list of included tissues is accessed by clicking on group name, group symbol, RNA bar, or protein bar. Subsequent selection of a particular tissue in this list links to the image data page.
Images of selected tissues give a visual summary of the protein expression profile furthest to the right.
The gray human body provides links to a histology dictionary when clicking on any part of the figure.
RNA expression (TPM)i
RNA-seq results generated in HPA are reported as number of transcripts per million (TPM). Each bar represents the highest expression score found in a particular group of tissues. The assay is described more in detail in Assays & Annotation.
Protein expression (score)i
Each bar represents the highest expression score found in a particular group of tissues. Protein expression scores are based on a best estimate of the "true" protein expression from a knowledge-based annotation, described more in detail under Assays & annotation. For genes where more than one antibody has been used, a collective score is set displaying the estimated true protein expression.
Protein expression data is shown for each of the 44 tissues. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. Mouse-over function shows protein score for analyzed cell types in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation.
For genes with available protein data for which a knowledge-based annotation gave inconclusive results, no protein expression data is displayed in the protein expression data overview. However, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Organ
Expression
Alphabetical
RNA EXPRESSION OVERVIEWi
RNA expression overview shows RNA-data from three different sources: Internally generated Human Protein Atlas (HPA) RNA-seq data, RNA-seq data from the Genotype-Tissue Expression (GTEx) project and CAGE data from FANTOM5 project. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.
HPA dataseti
HPA dataset RNA-seq tissue data is reported as mean TPM (transcripts per million), corresponding to mean values of the different individual samples from each tissue. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar. The RNA-seq assay is described in detail in Assays & Annotation.
RNA tissue category HPA HPA RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataseti
GTEx dataset RNA-seq data is reported as median RPKM (reads per kilobase per million mapped reads), generated by the Genotype-Tissue Expression (GTEx) project. More information can be found in Assays & Annotation.
RNA tissue category GTEx GTEx RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataseti
FANTOM5 dataset Tissue data obtained through Cap Analysis of Gene Expression (CAGE) are reported as Tags Per Million, generated by the FANTOM5 project. More information can be found in Assays & Annotation.
RNA tissue category FANTOM5 FANTOM5 RNA tissue category (category description) is calculated based on gene expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
PTK2B (HGNC Symbol)
Synonyms
CADTK, CAKB, FAK2, PTK, PYK2, RAFTK
Description
Protein tyrosine kinase 2 beta (HGNC Symbol)
Entrez gene summary
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
PTK2B-001
PTK2B-002
PTK2B-007
PTK2B-009
PTK2B-010
PTK2B-011
PTK2B-014
PTK2B-015
PTK2B-201
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0001525 [angiogenesis] GO:0001954 [positive regulation of cell-matrix adhesion] GO:0002040 [sprouting angiogenesis] GO:0002250 [adaptive immune response] GO:0002315 [marginal zone B cell differentiation] GO:0002376 [immune system process] GO:0002688 [regulation of leukocyte chemotaxis] GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0004972 [NMDA glutamate receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006461 [protein complex assembly] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006950 [response to stress] GO:0006968 [cellular defense response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0010595 [positive regulation of endothelial cell migration] GO:0010758 [regulation of macrophage chemotaxis] GO:0010976 [positive regulation of neuron projection development] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0017146 [NMDA selective glutamate receptor complex] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030027 [lamellipodium] GO:0030054 [cell junction] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0030335 [positive regulation of cell migration] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0030500 [regulation of bone mineralization] GO:0030502 [negative regulation of bone mineralization] GO:0030838 [positive regulation of actin filament polymerization] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0032960 [regulation of inositol trisphosphate biosynthetic process] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0042976 [activation of Janus kinase activity] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0043066 [negative regulation of apoptotic process] GO:0043267 [negative regulation of potassium ion transport] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0044297 [cell body] GO:0045087 [innate immune response] GO:0045453 [bone resorption] GO:0045638 [negative regulation of myeloid cell differentiation] GO:0045765 [regulation of angiogenesis] GO:0045860 [positive regulation of protein kinase activity] GO:0046330 [positive regulation of JNK cascade] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0051279 [regulation of release of sequestered calcium ion into cytosol] GO:0051968 [positive regulation of synaptic transmission, glutamatergic] GO:0060291 [long-term synaptic potentiation] GO:0070098 [chemokine-mediated signaling pathway] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071300 [cellular response to retinoic acid] GO:0097440 [apical dendrite] GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000114 [regulation of establishment of cell polarity] GO:2000249 [regulation of actin cytoskeleton reorganization] GO:2000310 [regulation of NMDA receptor activity] GO:2000463 [positive regulation of excitatory postsynaptic potential] GO:2000538 [positive regulation of B cell chemotaxis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0001525 [angiogenesis] GO:0001954 [positive regulation of cell-matrix adhesion] GO:0002040 [sprouting angiogenesis] GO:0002250 [adaptive immune response] GO:0002315 [marginal zone B cell differentiation] GO:0002376 [immune system process] GO:0002688 [regulation of leukocyte chemotaxis] GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0004972 [NMDA glutamate receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006461 [protein complex assembly] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006950 [response to stress] GO:0006968 [cellular defense response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0010595 [positive regulation of endothelial cell migration] GO:0010758 [regulation of macrophage chemotaxis] GO:0010976 [positive regulation of neuron projection development] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0017146 [NMDA selective glutamate receptor complex] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030027 [lamellipodium] GO:0030054 [cell junction] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0030335 [positive regulation of cell migration] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0030500 [regulation of bone mineralization] GO:0030502 [negative regulation of bone mineralization] GO:0030838 [positive regulation of actin filament polymerization] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0032960 [regulation of inositol trisphosphate biosynthetic process] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0042976 [activation of Janus kinase activity] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0043066 [negative regulation of apoptotic process] GO:0043267 [negative regulation of potassium ion transport] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0044297 [cell body] GO:0045087 [innate immune response] GO:0045453 [bone resorption] GO:0045638 [negative regulation of myeloid cell differentiation] GO:0045765 [regulation of angiogenesis] GO:0045860 [positive regulation of protein kinase activity] GO:0046330 [positive regulation of JNK cascade] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0051279 [regulation of release of sequestered calcium ion into cytosol] GO:0051968 [positive regulation of synaptic transmission, glutamatergic] GO:0060291 [long-term synaptic potentiation] GO:0070098 [chemokine-mediated signaling pathway] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071300 [cellular response to retinoic acid] GO:0097440 [apical dendrite] GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000114 [regulation of establishment of cell polarity] GO:2000249 [regulation of actin cytoskeleton reorganization] GO:2000310 [regulation of NMDA receptor activity] GO:2000463 [positive regulation of excitatory postsynaptic potential] GO:2000538 [positive regulation of B cell chemotaxis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0000302 [response to reactive oxygen species] GO:0001525 [angiogenesis] GO:0001556 [oocyte maturation] GO:0001666 [response to hypoxia] GO:0001954 [positive regulation of cell-matrix adhesion] GO:0002040 [sprouting angiogenesis] GO:0002250 [adaptive immune response] GO:0002315 [marginal zone B cell differentiation] GO:0002376 [immune system process] GO:0002688 [regulation of leukocyte chemotaxis] GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0004972 [NMDA glutamate receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006461 [protein complex assembly] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006950 [response to stress] GO:0006968 [cellular defense response] GO:0006970 [response to osmotic stress] GO:0007015 [actin filament organization] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007229 [integrin-mediated signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0009612 [response to mechanical stimulus] GO:0009725 [response to hormone] GO:0009749 [response to glucose] GO:0010226 [response to lithium ion] GO:0010243 [response to organonitrogen compound] GO:0010595 [positive regulation of endothelial cell migration] GO:0010656 [negative regulation of muscle cell apoptotic process] GO:0010752 [regulation of cGMP-mediated signaling] GO:0010758 [regulation of macrophage chemotaxis] GO:0010976 [positive regulation of neuron projection development] GO:0014009 [glial cell proliferation] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0017146 [NMDA selective glutamate receptor complex] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0030027 [lamellipodium] GO:0030054 [cell junction] GO:0030154 [cell differentiation] GO:0030155 [regulation of cell adhesion] GO:0030279 [negative regulation of ossification] GO:0030307 [positive regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0030335 [positive regulation of cell migration] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0030500 [regulation of bone mineralization] GO:0030502 [negative regulation of bone mineralization] GO:0030826 [regulation of cGMP biosynthetic process] GO:0030838 [positive regulation of actin filament polymerization] GO:0031175 [neuron projection development] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032403 [protein complex binding] GO:0032960 [regulation of inositol trisphosphate biosynthetic process] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0035902 [response to immobilization stress] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0042220 [response to cocaine] GO:0042493 [response to drug] GO:0042542 [response to hydrogen peroxide] GO:0042976 [activation of Janus kinase activity] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0043066 [negative regulation of apoptotic process] GO:0043149 [stress fiber assembly] GO:0043197 [dendritic spine] GO:0043267 [negative regulation of potassium ion transport] GO:0043423 [3-phosphoinositide-dependent protein kinase binding] GO:0043507 [positive regulation of JUN kinase activity] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043534 [blood vessel endothelial cell migration] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0044297 [cell body] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045428 [regulation of nitric oxide biosynthetic process] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045453 [bone resorption] GO:0045471 [response to ethanol] GO:0045638 [negative regulation of myeloid cell differentiation] GO:0045727 [positive regulation of translation] GO:0045765 [regulation of angiogenesis] GO:0045766 [positive regulation of angiogenesis] GO:0045860 [positive regulation of protein kinase activity] GO:0046330 [positive regulation of JNK cascade] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048041 [focal adhesion assembly] GO:0048471 [perinuclear region of cytoplasm] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050848 [regulation of calcium-mediated signaling] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051279 [regulation of release of sequestered calcium ion into cytosol] GO:0051591 [response to cAMP] GO:0051592 [response to calcium ion] GO:0051968 [positive regulation of synaptic transmission, glutamatergic] GO:0060291 [long-term synaptic potentiation] GO:0060292 [long term synaptic depression] GO:0070098 [chemokine-mediated signaling pathway] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071300 [cellular response to retinoic acid] GO:0071498 [cellular response to fluid shear stress] GO:0090630 [activation of GTPase activity] GO:0097440 [apical dendrite] GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000114 [regulation of establishment of cell polarity] GO:2000249 [regulation of actin cytoskeleton reorganization] GO:2000310 [regulation of NMDA receptor activity] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2000463 [positive regulation of excitatory postsynaptic potential] GO:2000538 [positive regulation of B cell chemotaxis] GO:2000573 [positive regulation of DNA biosynthetic process]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0001525 [angiogenesis] GO:0001954 [positive regulation of cell-matrix adhesion] GO:0002040 [sprouting angiogenesis] GO:0002250 [adaptive immune response] GO:0002315 [marginal zone B cell differentiation] GO:0002376 [immune system process] GO:0002688 [regulation of leukocyte chemotaxis] GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0004972 [NMDA glutamate receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006461 [protein complex assembly] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006950 [response to stress] GO:0006968 [cellular defense response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0010595 [positive regulation of endothelial cell migration] GO:0010758 [regulation of macrophage chemotaxis] GO:0010976 [positive regulation of neuron projection development] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0017146 [NMDA selective glutamate receptor complex] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030027 [lamellipodium] GO:0030054 [cell junction] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0030335 [positive regulation of cell migration] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0030500 [regulation of bone mineralization] GO:0030502 [negative regulation of bone mineralization] GO:0030838 [positive regulation of actin filament polymerization] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0032960 [regulation of inositol trisphosphate biosynthetic process] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0042976 [activation of Janus kinase activity] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0043066 [negative regulation of apoptotic process] GO:0043267 [negative regulation of potassium ion transport] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0044297 [cell body] GO:0045087 [innate immune response] GO:0045453 [bone resorption] GO:0045638 [negative regulation of myeloid cell differentiation] GO:0045765 [regulation of angiogenesis] GO:0045860 [positive regulation of protein kinase activity] GO:0046330 [positive regulation of JNK cascade] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0051279 [regulation of release of sequestered calcium ion into cytosol] GO:0051968 [positive regulation of synaptic transmission, glutamatergic] GO:0060291 [long-term synaptic potentiation] GO:0070098 [chemokine-mediated signaling pathway] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071300 [cellular response to retinoic acid] GO:0097440 [apical dendrite] GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000114 [regulation of establishment of cell polarity] GO:2000249 [regulation of actin cytoskeleton reorganization] GO:2000310 [regulation of NMDA receptor activity] GO:2000463 [positive regulation of excitatory postsynaptic potential] GO:2000538 [positive regulation of B cell chemotaxis]
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