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Show complete data for human cells assay. The location(s) are highlighted in the illustration on the right.
Localized to the plasma membrane & cytosol.
RNA cell categoryi
The cell lines in the Human Protein Atlas have been analyzed by RNA-seq to estimate the transcript abundance of each protein-coding gene. The RNA-seq data was then used to classify all genes according to their cell line-specific expression into one of six different categories, defined based on the total set of all TPM values in all analyzed cell lines.
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Main locationi
The main location is characterized by presence in all tested cell lines and/or increased intensity compared to other locations. It is highlighted in the illustration to the right. If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively.
Localized to the Plasma membrane (enhanced), Cytosol (enhanced)
DATA RELIABILITY
Reliability scorei
A reliability score is set for all genes and indicates the level of reliability of the analyzed protein expression pattern based on available protein/RNA/gene characterization data. The reliability of the annotated protein expression data is also scored depending on similarity in immunostaining patterns and consistency with available experimental gene/protein characterization data in the UniProtKB/Swiss-Prot database.
Below is an overview of RNA expression data generated in the HPA project. The analyzed cell lines are divided into 12 color-coded groups according to the organ they were obtained from. By clicking the toolbars in the top right corner it is possible to sort the cell lines in the chart by different criteria: the organ and the origin that the cell line was obtained from, the category of the cell line according to cellosaurus, alphabetically or by descending RNA expression. Detailed information about a specific cell line can be accessed by hovering over the corresponding bar in the chart. The RNA-sequencing results generated in the HPA are reported as number of Transcripts per Kilobase Million (TPM). In the Human Protein Atlas a TPM value of 1.0 is defined as a treshhold for expression of the corresponding protein.
The cell lines in the Human Protein Atlas have been analyzed by RNA-seq to estimate the transcript abundance of each protein-coding gene. The RNA-seq data was then used to classify all genes according to their cell line-specific expression into one of six different categories, defined based on the total set of all TPM values in all analyzed cell lines.
Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
Cell lines sorted alphabetically.
HUMAN CELLSi
The "human cells" section gives an overview about the subcellular location of the protein of interest obtained by indirect immunofluorescence microscopy, an antibody-based protein-visualization technique. The immunofluorescent analysis is carried out in three different cell lines, one of them always being U-2 OS. A selection of immunofluorescent images is displayed below. Three different organelle probes are displayed as different channels in the multicolor images - nucleus stained in blue, microtubules in red and ER in yellow. The antibody staining targeting the protein of interest is shown in green. By using the toggle channel buttons, the different channels can be turned on and off. For the selection of the images to compare, use the checkboxes next to the images at the bottom. Three images can be compared at a time. All images are clickable for an enlarged view. The selected image will appear in large size and miniature images with all other staining results for this gene will be listed at the top left of the image. The selected miniature image has an orange overlay. For cell structure reference, visit the cell dictionary.
Summaryi
Summary of the immunofluorescent analysis in all studied cell lines with all tested antibodies.
Localized to the plasma membrane & cytosol.
Main locationi
The main location is characterized by presence in all tested cell lines and/or increased intensity compared to other locations.
Plasma membrane (enhanced), Cytosol (enhanced)
Toggle channelsi
Three different organelle probes are displayed as different channels in the multicolor images - nucleus stained in blue, microtubules in red and ER in yellow. The antibody staining targeting the protein of interest is shown in green. By using the "toggle channels"-buttons, the different channels can be turned on and off. The intensity toggle shows the pixel intensity range in 16 different colors for the selected channel. The object toggle shows the computational segmentation of the cells used for further analysis in the HPA project. For samples where cell cycle dependency for the protein is suggested according to a correlation assay the predicted cell cycle position of each cell is displayed when using the object toggle.
Low
High
G1
S
G2
M
N/A
Thumbnaili
Representative images for the assay. Three images can be compared at the same time. To change which images to compare, use the checkboxes next to the images below. All images are clickable for an enlarged view. The selected image will appear in large size and miniature images with all other staining results for this gene will be listed at the top left of the image. The selected miniature image has an orange overlay.
Antibodyi
Antibody used for analysis. Clicking the antibody ID links to the antibody validation page.
Cell linei
Cell line used for analysis. Read more about the cell lines in the Human Protein Atlas.
Locationi
Location(s) annotated in the corresponding cell line.
Single-cell variationi
As the images in the Cell Atlas provide single cell resolution, variations in protein expression patterns from cell to cell can be observed. A single-cell variation can either be observed in the intensity of the immunofluorescent signal or in the spatial distribution pattern of the protein. This column contains information about whether and for which of the annotated locations a single-cell variation pattern was manually annotated.
Cell cycle dependent variationi
A likely cause for single-cell variation in the immunofluorescent images is cell cycle dependency. This column contains information about whether the manually observed cell-to-cell variation pattern correlates with cell cycle progression.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
PTK2B (HGNC Symbol)
Synonyms
CADTK, CAKB, FAK2, PTK, PYK2, RAFTK
Description
Protein tyrosine kinase 2 beta (HGNC Symbol)
Entrez gene summary
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
PTK2B-001
PTK2B-002
PTK2B-007
PTK2B-009
PTK2B-010
PTK2B-011
PTK2B-014
PTK2B-015
PTK2B-201
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0001525 [angiogenesis] GO:0001954 [positive regulation of cell-matrix adhesion] GO:0002040 [sprouting angiogenesis] GO:0002250 [adaptive immune response] GO:0002315 [marginal zone B cell differentiation] GO:0002376 [immune system process] GO:0002688 [regulation of leukocyte chemotaxis] GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0004972 [NMDA glutamate receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006461 [protein complex assembly] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006950 [response to stress] GO:0006968 [cellular defense response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0010595 [positive regulation of endothelial cell migration] GO:0010758 [regulation of macrophage chemotaxis] GO:0010976 [positive regulation of neuron projection development] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0017146 [NMDA selective glutamate receptor complex] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030027 [lamellipodium] GO:0030054 [cell junction] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0030335 [positive regulation of cell migration] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0030500 [regulation of bone mineralization] GO:0030502 [negative regulation of bone mineralization] GO:0030838 [positive regulation of actin filament polymerization] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0032960 [regulation of inositol trisphosphate biosynthetic process] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0042976 [activation of Janus kinase activity] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0043066 [negative regulation of apoptotic process] GO:0043267 [negative regulation of potassium ion transport] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0044297 [cell body] GO:0045087 [innate immune response] GO:0045453 [bone resorption] GO:0045638 [negative regulation of myeloid cell differentiation] GO:0045765 [regulation of angiogenesis] GO:0045860 [positive regulation of protein kinase activity] GO:0046330 [positive regulation of JNK cascade] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0051279 [regulation of release of sequestered calcium ion into cytosol] GO:0051968 [positive regulation of synaptic transmission, glutamatergic] GO:0060291 [long-term synaptic potentiation] GO:0070098 [chemokine-mediated signaling pathway] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071300 [cellular response to retinoic acid] GO:0097440 [apical dendrite] GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000114 [regulation of establishment of cell polarity] GO:2000249 [regulation of actin cytoskeleton reorganization] GO:2000310 [regulation of NMDA receptor activity] GO:2000463 [positive regulation of excitatory postsynaptic potential] GO:2000538 [positive regulation of B cell chemotaxis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0001525 [angiogenesis] GO:0001954 [positive regulation of cell-matrix adhesion] GO:0002040 [sprouting angiogenesis] GO:0002250 [adaptive immune response] GO:0002315 [marginal zone B cell differentiation] GO:0002376 [immune system process] GO:0002688 [regulation of leukocyte chemotaxis] GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0004972 [NMDA glutamate receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006461 [protein complex assembly] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006950 [response to stress] GO:0006968 [cellular defense response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0010595 [positive regulation of endothelial cell migration] GO:0010758 [regulation of macrophage chemotaxis] GO:0010976 [positive regulation of neuron projection development] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0017146 [NMDA selective glutamate receptor complex] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030027 [lamellipodium] GO:0030054 [cell junction] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0030335 [positive regulation of cell migration] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0030500 [regulation of bone mineralization] GO:0030502 [negative regulation of bone mineralization] GO:0030838 [positive regulation of actin filament polymerization] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0032960 [regulation of inositol trisphosphate biosynthetic process] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0042976 [activation of Janus kinase activity] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0043066 [negative regulation of apoptotic process] GO:0043267 [negative regulation of potassium ion transport] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0044297 [cell body] GO:0045087 [innate immune response] GO:0045453 [bone resorption] GO:0045638 [negative regulation of myeloid cell differentiation] GO:0045765 [regulation of angiogenesis] GO:0045860 [positive regulation of protein kinase activity] GO:0046330 [positive regulation of JNK cascade] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0051279 [regulation of release of sequestered calcium ion into cytosol] GO:0051968 [positive regulation of synaptic transmission, glutamatergic] GO:0060291 [long-term synaptic potentiation] GO:0070098 [chemokine-mediated signaling pathway] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071300 [cellular response to retinoic acid] GO:0097440 [apical dendrite] GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000114 [regulation of establishment of cell polarity] GO:2000249 [regulation of actin cytoskeleton reorganization] GO:2000310 [regulation of NMDA receptor activity] GO:2000463 [positive regulation of excitatory postsynaptic potential] GO:2000538 [positive regulation of B cell chemotaxis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0000302 [response to reactive oxygen species] GO:0001525 [angiogenesis] GO:0001556 [oocyte maturation] GO:0001666 [response to hypoxia] GO:0001954 [positive regulation of cell-matrix adhesion] GO:0002040 [sprouting angiogenesis] GO:0002250 [adaptive immune response] GO:0002315 [marginal zone B cell differentiation] GO:0002376 [immune system process] GO:0002688 [regulation of leukocyte chemotaxis] GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0004972 [NMDA glutamate receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006461 [protein complex assembly] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006950 [response to stress] GO:0006968 [cellular defense response] GO:0006970 [response to osmotic stress] GO:0007015 [actin filament organization] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007229 [integrin-mediated signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0009612 [response to mechanical stimulus] GO:0009725 [response to hormone] GO:0009749 [response to glucose] GO:0010226 [response to lithium ion] GO:0010243 [response to organonitrogen compound] GO:0010595 [positive regulation of endothelial cell migration] GO:0010656 [negative regulation of muscle cell apoptotic process] GO:0010752 [regulation of cGMP-mediated signaling] GO:0010758 [regulation of macrophage chemotaxis] GO:0010976 [positive regulation of neuron projection development] GO:0014009 [glial cell proliferation] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0017146 [NMDA selective glutamate receptor complex] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0030027 [lamellipodium] GO:0030054 [cell junction] GO:0030154 [cell differentiation] GO:0030155 [regulation of cell adhesion] GO:0030279 [negative regulation of ossification] GO:0030307 [positive regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0030335 [positive regulation of cell migration] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0030500 [regulation of bone mineralization] GO:0030502 [negative regulation of bone mineralization] GO:0030826 [regulation of cGMP biosynthetic process] GO:0030838 [positive regulation of actin filament polymerization] GO:0031175 [neuron projection development] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032403 [protein complex binding] GO:0032960 [regulation of inositol trisphosphate biosynthetic process] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0035902 [response to immobilization stress] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0042220 [response to cocaine] GO:0042493 [response to drug] GO:0042542 [response to hydrogen peroxide] GO:0042976 [activation of Janus kinase activity] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0043066 [negative regulation of apoptotic process] GO:0043149 [stress fiber assembly] GO:0043197 [dendritic spine] GO:0043267 [negative regulation of potassium ion transport] GO:0043423 [3-phosphoinositide-dependent protein kinase binding] GO:0043507 [positive regulation of JUN kinase activity] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043534 [blood vessel endothelial cell migration] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0044297 [cell body] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045428 [regulation of nitric oxide biosynthetic process] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045453 [bone resorption] GO:0045471 [response to ethanol] GO:0045638 [negative regulation of myeloid cell differentiation] GO:0045727 [positive regulation of translation] GO:0045765 [regulation of angiogenesis] GO:0045766 [positive regulation of angiogenesis] GO:0045860 [positive regulation of protein kinase activity] GO:0046330 [positive regulation of JNK cascade] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048041 [focal adhesion assembly] GO:0048471 [perinuclear region of cytoplasm] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050848 [regulation of calcium-mediated signaling] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051279 [regulation of release of sequestered calcium ion into cytosol] GO:0051591 [response to cAMP] GO:0051592 [response to calcium ion] GO:0051968 [positive regulation of synaptic transmission, glutamatergic] GO:0060291 [long-term synaptic potentiation] GO:0060292 [long term synaptic depression] GO:0070098 [chemokine-mediated signaling pathway] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071300 [cellular response to retinoic acid] GO:0071498 [cellular response to fluid shear stress] GO:0090630 [activation of GTPase activity] GO:0097440 [apical dendrite] GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000114 [regulation of establishment of cell polarity] GO:2000249 [regulation of actin cytoskeleton reorganization] GO:2000310 [regulation of NMDA receptor activity] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2000463 [positive regulation of excitatory postsynaptic potential] GO:2000538 [positive regulation of B cell chemotaxis] GO:2000573 [positive regulation of DNA biosynthetic process]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0001525 [angiogenesis] GO:0001954 [positive regulation of cell-matrix adhesion] GO:0002040 [sprouting angiogenesis] GO:0002250 [adaptive immune response] GO:0002315 [marginal zone B cell differentiation] GO:0002376 [immune system process] GO:0002688 [regulation of leukocyte chemotaxis] GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0004972 [NMDA glutamate receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006461 [protein complex assembly] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006950 [response to stress] GO:0006968 [cellular defense response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0010595 [positive regulation of endothelial cell migration] GO:0010758 [regulation of macrophage chemotaxis] GO:0010976 [positive regulation of neuron projection development] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0017146 [NMDA selective glutamate receptor complex] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030027 [lamellipodium] GO:0030054 [cell junction] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0030335 [positive regulation of cell migration] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0030500 [regulation of bone mineralization] GO:0030502 [negative regulation of bone mineralization] GO:0030838 [positive regulation of actin filament polymerization] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0032960 [regulation of inositol trisphosphate biosynthetic process] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0035235 [ionotropic glutamate receptor signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0042976 [activation of Janus kinase activity] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0043066 [negative regulation of apoptotic process] GO:0043267 [negative regulation of potassium ion transport] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0044297 [cell body] GO:0045087 [innate immune response] GO:0045453 [bone resorption] GO:0045638 [negative regulation of myeloid cell differentiation] GO:0045765 [regulation of angiogenesis] GO:0045860 [positive regulation of protein kinase activity] GO:0046330 [positive regulation of JNK cascade] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0051279 [regulation of release of sequestered calcium ion into cytosol] GO:0051968 [positive regulation of synaptic transmission, glutamatergic] GO:0060291 [long-term synaptic potentiation] GO:0070098 [chemokine-mediated signaling pathway] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071300 [cellular response to retinoic acid] GO:0097440 [apical dendrite] GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000114 [regulation of establishment of cell polarity] GO:2000249 [regulation of actin cytoskeleton reorganization] GO:2000310 [regulation of NMDA receptor activity] GO:2000463 [positive regulation of excitatory postsynaptic potential] GO:2000538 [positive regulation of B cell chemotaxis]
The Human Protein Atlas project is funded
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