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PTK2B
GENERAL INFORMATION
Gene namei PTK2B
Gene descriptioni Protein tyrosine kinase 2 beta
Protein classi Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted localizationi Intracellular
Number of transcriptsi 9
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HUMAN PROTEIN ATLAS INFORMATION
RNA categoryi
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (REH)
HPA (normal tissue):Expressed in all
Protein evidencei Evidence at protein level
Protein expression
normal tissuei		 Cytoplasmic and nuclear expression at variable levels in most cell types, expressed mainly in the brain and lymphoid tissue.

IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability
descriptioni		 Antibody staining mainly consistent with RNA expression data.
Reliability score -
normal tissuesi
Approved
Antibodiesi HPA026091 , HPA026276 , CAB003850
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PROGNOSTIC SUMMARYi
Prognostic marker in cervical cancer (favourable) and thyroid cancer (favourable).
Cervical cancer p<0.001
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEWi
TCGA dataseti
RNA cancer category: Expressed in all
PROTEIN EXPRESSIONi
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer
PROTEIN EXPRESSION SUMMARYi
Organ
Expression
Alphabetical
HPA026091
HPA026276
CAB003850
GENE INFORMATIONi
Gene name PTK2B (HGNC Symbol)
Synonyms CADTK, CAKB, FAK2, PTK, PYK2, RAFTK
Description Protein tyrosine kinase 2 beta (HGNC Symbol)
Entrez gene summary This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome 8
Cytoband p21.2
Chromosome location (bp) 27311482 - 27459391
Protein evidence Evidence at protein level (all genes)
Ensembl ENSG00000120899 (version 88.38)
Entrez gene 2185
UniProt Q14289 (UniProt - Evidence at protein level)
neXtProt NX_Q14289
Antibodypedia PTK2B antibodies
PROTEIN BROWSERi
PTK2B-001
PTK2B-002
PTK2B-007
PTK2B-009
PTK2B-010
PTK2B-011
PTK2B-014
PTK2B-015
PTK2B-201
PROTEIN INFORMATIONi
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
PTK2B-001
ENSP00000332816
ENST00000346049
Q14289 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0002250 [adaptive immune response]
GO:0002315 [marginal zone B cell differentiation]
GO:0002376 [immune system process]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0006968 [cellular defense response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010758 [regulation of macrophage chemotaxis]
GO:0010976 [positive regulation of neuron projection development]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030335 [positive regulation of cell migration]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030500 [regulation of bone mineralization]
GO:0030502 [negative regulation of bone mineralization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032960 [regulation of inositol trisphosphate biosynthetic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042976 [activation of Janus kinase activity]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045453 [bone resorption]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060291 [long-term synaptic potentiation]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071300 [cellular response to retinoic acid]
GO:0097440 [apical dendrite]
GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000538 [positive regulation of B cell chemotaxis]
Show all
 1009 aa
115.9 kDa 		No 0
PTK2B-002
ENSP00000427931
ENST00000517339
Q14289 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0002250 [adaptive immune response]
GO:0002315 [marginal zone B cell differentiation]
GO:0002376 [immune system process]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0006968 [cellular defense response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010758 [regulation of macrophage chemotaxis]
GO:0010976 [positive regulation of neuron projection development]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030335 [positive regulation of cell migration]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030500 [regulation of bone mineralization]
GO:0030502 [negative regulation of bone mineralization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032960 [regulation of inositol trisphosphate biosynthetic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042976 [activation of Janus kinase activity]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045453 [bone resorption]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060291 [long-term synaptic potentiation]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071300 [cellular response to retinoic acid]
GO:0097440 [apical dendrite]
GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000538 [positive regulation of B cell chemotaxis]
Show all
 967 aa
111.2 kDa 		No 0
PTK2B-007
ENSP00000416174
ENST00000412793
C9JHV9 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005856 [cytoskeleton]
GO:0007165 [signal transduction]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030500 [regulation of bone mineralization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042127 [regulation of cell proliferation]
GO:0045765 [regulation of angiogenesis]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 213 aa
24.9 kDa 		No 0
PTK2B-009
ENSP00000380638
ENST00000397501
Q14289 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0000302 [response to reactive oxygen species]
GO:0001525 [angiogenesis]
GO:0001556 [oocyte maturation]
GO:0001666 [response to hypoxia]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0002250 [adaptive immune response]
GO:0002315 [marginal zone B cell differentiation]
GO:0002376 [immune system process]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0006968 [cellular defense response]
GO:0006970 [response to osmotic stress]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009612 [response to mechanical stimulus]
GO:0009725 [response to hormone]
GO:0009749 [response to glucose]
GO:0010226 [response to lithium ion]
GO:0010243 [response to organonitrogen compound]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010656 [negative regulation of muscle cell apoptotic process]
GO:0010752 [regulation of cGMP-mediated signaling]
GO:0010758 [regulation of macrophage chemotaxis]
GO:0010976 [positive regulation of neuron projection development]
GO:0014009 [glial cell proliferation]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030279 [negative regulation of ossification]
GO:0030307 [positive regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030500 [regulation of bone mineralization]
GO:0030502 [negative regulation of bone mineralization]
GO:0030826 [regulation of cGMP biosynthetic process]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031175 [neuron projection development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032403 [protein complex binding]
GO:0032960 [regulation of inositol trisphosphate biosynthetic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035902 [response to immobilization stress]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042220 [response to cocaine]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0042976 [activation of Janus kinase activity]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043149 [stress fiber assembly]
GO:0043197 [dendritic spine]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043423 [3-phosphoinositide-dependent protein kinase binding]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043534 [blood vessel endothelial cell migration]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045428 [regulation of nitric oxide biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045453 [bone resorption]
GO:0045471 [response to ethanol]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045727 [positive regulation of translation]
GO:0045765 [regulation of angiogenesis]
GO:0045766 [positive regulation of angiogenesis]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050848 [regulation of calcium-mediated signaling]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0051591 [response to cAMP]
GO:0051592 [response to calcium ion]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060291 [long-term synaptic potentiation]
GO:0060292 [long term synaptic depression]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071300 [cellular response to retinoic acid]
GO:0071498 [cellular response to fluid shear stress]
GO:0090630 [activation of GTPase activity]
GO:0097440 [apical dendrite]
GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000538 [positive regulation of B cell chemotaxis]
GO:2000573 [positive regulation of DNA biosynthetic process]
Show all
 1009 aa
115.9 kDa 		No 0
PTK2B-010
ENSP00000429694
ENST00000522338
E5RHL2 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0007165 [signal transduction]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030500 [regulation of bone mineralization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042127 [regulation of cell proliferation]
GO:0045765 [regulation of angiogenesis]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 68 aa
7.6 kDa 		No 0
PTK2B-011
ENSP00000428837
ENST00000519512
H0YB74 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005856 [cytoskeleton]
GO:0007165 [signal transduction]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030500 [regulation of bone mineralization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042127 [regulation of cell proliferation]
GO:0045765 [regulation of angiogenesis]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 194 aa
21.7 kDa 		No 0
PTK2B-014
ENSP00000430404
ENST00000521164
E5RK84 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0007165 [signal transduction]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030500 [regulation of bone mineralization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042127 [regulation of cell proliferation]
GO:0045765 [regulation of angiogenesis]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 103 aa
11.6 kDa 		No 0
PTK2B-015
ENSP00000428271
ENST00000522517
E5RJ77 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005856 [cytoskeleton]
GO:0007165 [signal transduction]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030500 [regulation of bone mineralization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042127 [regulation of cell proliferation]
GO:0045765 [regulation of angiogenesis]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 184 aa
21.5 kDa 		No 0
PTK2B-201
ENSP00000391995
ENST00000420218
Q14289 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0002250 [adaptive immune response]
GO:0002315 [marginal zone B cell differentiation]
GO:0002376 [immune system process]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006461 [protein complex assembly]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006950 [response to stress]
GO:0006968 [cellular defense response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010758 [regulation of macrophage chemotaxis]
GO:0010976 [positive regulation of neuron projection development]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030335 [positive regulation of cell migration]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030500 [regulation of bone mineralization]
GO:0030502 [negative regulation of bone mineralization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032960 [regulation of inositol trisphosphate biosynthetic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0042976 [activation of Janus kinase activity]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045453 [bone resorption]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060291 [long-term synaptic potentiation]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071300 [cellular response to retinoic acid]
GO:0097440 [apical dendrite]
GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000538 [positive regulation of B cell chemotaxis]
Show all
 967 aa
111.2 kDa 		No 0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.