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Mapping the GPCR-RAMP interactome

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G-protein coupled receptors (GPCRs) are a large family of cell surface receptors important for activating cellular responses. They are activated by many types of signals like light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters and are involved in a wide range of diseases which have made them important drug targets. Receptor activity-modifying proteins (RAMPs) form complexes with the GPCRs and may regulate their cellular trafficking and pharmacology...Read more