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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for data imported from The Genotype-Tissue Expression project (GTEX), FANTOM5 Consortium (FANTOM5) and internally generated Human Protein Atlas (HPA) data.
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expressioni
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
External characterization data and paired antibodies with high similarity supports the antibody staining pattern.
Reliability scorei
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Below is an overview of RNA and protein expression data generated in the Human Protein Atlas project. Analyzed tissues are divided into color-coded groups according to which functional features they have in common. For each group, a list of included tissues is accessed by clicking on group name, group symbol, RNA bar, or protein bar. Subsequent selection of a particular tissue in this list links to the image data page.
Images of selected tissues give a visual summary of the protein expression profile furthest to the right.
The gray human body provides links to a histology dictionary when clicking on any part of the figure.
RNA expression (TPM)i
RNA-seq results generated in HPA are reported as number of transcripts per million (TPM). Each bar represents the highest expression score found in a particular group of tissues. The assay is described more in detail in Assays & Annotation.
Protein expression (score)i
Each bar represents the highest expression score found in a particular group of tissues. Protein expression scores are based on a best estimate of the "true" protein expression from a knowledge-based annotation, described more in detail under Assays & annotation. For genes where more than one antibody has been used, a collective score is set displaying the estimated true protein expression.
Protein expression data is shown for each of the 44 tissues. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. Mouse-over function shows protein score for analyzed cell types in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation.
For genes with available protein data for which a knowledge-based annotation gave inconclusive results, no protein expression data is displayed in the protein expression data overview. However, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Organ
Expression
Alphabetical
RNA EXPRESSION OVERVIEWi
RNA expression overview shows RNA-data from three different sources: Internally generated Human Protein Atlas (HPA) RNA-seq data, RNA-seq data from the Genotype-Tissue Expression (GTEx) project and CAGE data from FANTOM5 project. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.
HPA dataseti
HPA dataset RNA-seq tissue data is reported as mean TPM (transcripts per million), corresponding to mean values of the different individual samples from each tissue. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar. The RNA-seq assay is described in detail in Assays & Annotation.
RNA tissue category HPA HPA RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataseti
GTEx dataset RNA-seq data is reported as median RPKM (reads per kilobase per million mapped reads), generated by the Genotype-Tissue Expression (GTEx) project. More information can be found in Assays & Annotation.
RNA tissue category GTEx GTEx RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataseti
FANTOM5 dataset Tissue data obtained through Cap Analysis of Gene Expression (CAGE) are reported as Tags Per Million, generated by the FANTOM5 project. More information can be found in Assays & Annotation.
RNA tissue category FANTOM5 FANTOM5 RNA tissue category (category description) is calculated based on gene expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
HMGA2 (HGNC Symbol)
Synonyms
BABL, HMGIC, LIPO
Description
High mobility group AT-hook 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
HMGA2-001
HMGA2-003
HMGA2-005
HMGA2-006
HMGA2-008
HMGA2-011
HMGA2-013
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P52926 [Direct mapping] High mobility group protein HMGI-C
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Predicted intracellular proteins Plasma proteins Transcription factors beta-Sheet binding to DNA Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000228 [nuclear chromosome] GO:0000785 [chromatin] GO:0000975 [regulatory region DNA binding] GO:0000989 [transcription factor activity, transcription factor binding] GO:0001047 [core promoter binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001837 [epithelial to mesenchymal transition] GO:0002062 [chondrocyte differentiation] GO:0003131 [mesodermal-endodermal cell signaling] GO:0003677 [DNA binding] GO:0003680 [AT DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0004677 [DNA-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006284 [base-excision repair] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007049 [cell cycle] GO:0007067 [mitotic nuclear division] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0007275 [multicellular organism development] GO:0008134 [transcription factor binding] GO:0008301 [DNA binding, bending] GO:0009615 [response to virus] GO:0010564 [regulation of cell cycle process] GO:0010628 [positive regulation of gene expression] GO:0030261 [chromosome condensation] GO:0031052 [chromosome breakage] GO:0031492 [nucleosomal DNA binding] GO:0031507 [heterochromatin assembly] GO:0032993 [protein-DNA complex] GO:0035497 [cAMP response element binding] GO:0035500 [MH2 domain binding] GO:0035501 [MH1 domain binding] GO:0035978 [histone H2A-S139 phosphorylation] GO:0035985 [senescence-associated heterochromatin focus] GO:0035986 [senescence-associated heterochromatin focus assembly] GO:0035987 [endodermal cell differentiation] GO:0035988 [chondrocyte proliferation] GO:0040008 [regulation of growth] GO:0042769 [DNA damage response, detection of DNA damage] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043392 [negative regulation of DNA binding] GO:0043922 [negative regulation by host of viral transcription] GO:0045444 [fat cell differentiation] GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046332 [SMAD binding] GO:0048333 [mesodermal cell differentiation] GO:0048762 [mesenchymal cell differentiation] GO:0048863 [stem cell differentiation] GO:0051301 [cell division] GO:0051575 [5'-deoxyribose-5-phosphate lyase activity] GO:0070742 [C2H2 zinc finger domain binding] GO:0071141 [SMAD protein complex] GO:0071158 [positive regulation of cell cycle arrest] GO:0090402 [oncogene-induced cell senescence] GO:2000036 [regulation of stem cell population maintenance] GO:2000648 [positive regulation of stem cell proliferation] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2000685 [positive regulation of cellular response to X-ray] GO:2000774 [positive regulation of cellular senescence] GO:2001022 [positive regulation of response to DNA damage stimulus] GO:2001033 [negative regulation of double-strand break repair via nonhomologous end joining] GO:2001038 [regulation of cellular response to drug]
F5H6H0 [Direct mapping] High mobility group protein HMGI-C
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000228 [nuclear chromosome] GO:0000785 [chromatin] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003680 [AT DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007283 [spermatogenesis] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0008584 [male gonad development] GO:0010564 [regulation of cell cycle process] GO:0010628 [positive regulation of gene expression] GO:0019899 [enzyme binding] GO:0021846 [cell proliferation in forebrain] GO:0021983 [pituitary gland development] GO:0030178 [negative regulation of Wnt signaling pathway] GO:0030325 [adrenal gland development] GO:0033144 [negative regulation of intracellular steroid hormone receptor signaling pathway] GO:0035019 [somatic stem cell population maintenance] GO:0040018 [positive regulation of multicellular organism growth] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046426 [negative regulation of JAK-STAT cascade] GO:0048712 [negative regulation of astrocyte differentiation] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060123 [regulation of growth hormone secretion] GO:0060428 [lung epithelium development] GO:0060441 [epithelial tube branching involved in lung morphogenesis] GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis] GO:0060612 [adipose tissue development] GO:0060613 [fat pad development] GO:0090276 [regulation of peptide hormone secretion] GO:2000648 [positive regulation of stem cell proliferation]
P52926 [Direct mapping] High mobility group protein HMGI-C
Show all
Predicted intracellular proteins Plasma proteins Transcription factors beta-Sheet binding to DNA Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000228 [nuclear chromosome] GO:0000785 [chromatin] GO:0000975 [regulatory region DNA binding] GO:0000989 [transcription factor activity, transcription factor binding] GO:0001047 [core promoter binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001837 [epithelial to mesenchymal transition] GO:0002062 [chondrocyte differentiation] GO:0003131 [mesodermal-endodermal cell signaling] GO:0003677 [DNA binding] GO:0003680 [AT DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0004677 [DNA-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006284 [base-excision repair] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007049 [cell cycle] GO:0007067 [mitotic nuclear division] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0007275 [multicellular organism development] GO:0008134 [transcription factor binding] GO:0008301 [DNA binding, bending] GO:0009615 [response to virus] GO:0010564 [regulation of cell cycle process] GO:0010628 [positive regulation of gene expression] GO:0030261 [chromosome condensation] GO:0031052 [chromosome breakage] GO:0031492 [nucleosomal DNA binding] GO:0031507 [heterochromatin assembly] GO:0032993 [protein-DNA complex] GO:0035497 [cAMP response element binding] GO:0035500 [MH2 domain binding] GO:0035501 [MH1 domain binding] GO:0035978 [histone H2A-S139 phosphorylation] GO:0035985 [senescence-associated heterochromatin focus] GO:0035986 [senescence-associated heterochromatin focus assembly] GO:0035987 [endodermal cell differentiation] GO:0035988 [chondrocyte proliferation] GO:0040008 [regulation of growth] GO:0042769 [DNA damage response, detection of DNA damage] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043392 [negative regulation of DNA binding] GO:0043922 [negative regulation by host of viral transcription] GO:0045444 [fat cell differentiation] GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046332 [SMAD binding] GO:0048333 [mesodermal cell differentiation] GO:0048762 [mesenchymal cell differentiation] GO:0048863 [stem cell differentiation] GO:0051301 [cell division] GO:0051575 [5'-deoxyribose-5-phosphate lyase activity] GO:0070742 [C2H2 zinc finger domain binding] GO:0071141 [SMAD protein complex] GO:0071158 [positive regulation of cell cycle arrest] GO:0090402 [oncogene-induced cell senescence] GO:2000036 [regulation of stem cell population maintenance] GO:2000648 [positive regulation of stem cell proliferation] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2000685 [positive regulation of cellular response to X-ray] GO:2000774 [positive regulation of cellular senescence] GO:2001022 [positive regulation of response to DNA damage stimulus] GO:2001033 [negative regulation of double-strand break repair via nonhomologous end joining] GO:2001038 [regulation of cellular response to drug]
P52926 [Direct mapping] High mobility group protein HMGI-C
Show all
Predicted intracellular proteins Plasma proteins Transcription factors beta-Sheet binding to DNA Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000228 [nuclear chromosome] GO:0000785 [chromatin] GO:0000975 [regulatory region DNA binding] GO:0000989 [transcription factor activity, transcription factor binding] GO:0001047 [core promoter binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001837 [epithelial to mesenchymal transition] GO:0002062 [chondrocyte differentiation] GO:0003131 [mesodermal-endodermal cell signaling] GO:0003677 [DNA binding] GO:0003680 [AT DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0004677 [DNA-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006284 [base-excision repair] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007049 [cell cycle] GO:0007067 [mitotic nuclear division] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0007275 [multicellular organism development] GO:0008134 [transcription factor binding] GO:0008301 [DNA binding, bending] GO:0009615 [response to virus] GO:0010564 [regulation of cell cycle process] GO:0010628 [positive regulation of gene expression] GO:0030261 [chromosome condensation] GO:0031052 [chromosome breakage] GO:0031492 [nucleosomal DNA binding] GO:0031507 [heterochromatin assembly] GO:0032993 [protein-DNA complex] GO:0035497 [cAMP response element binding] GO:0035500 [MH2 domain binding] GO:0035501 [MH1 domain binding] GO:0035978 [histone H2A-S139 phosphorylation] GO:0035985 [senescence-associated heterochromatin focus] GO:0035986 [senescence-associated heterochromatin focus assembly] GO:0035987 [endodermal cell differentiation] GO:0035988 [chondrocyte proliferation] GO:0040008 [regulation of growth] GO:0042769 [DNA damage response, detection of DNA damage] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043392 [negative regulation of DNA binding] GO:0043922 [negative regulation by host of viral transcription] GO:0045444 [fat cell differentiation] GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046332 [SMAD binding] GO:0048333 [mesodermal cell differentiation] GO:0048762 [mesenchymal cell differentiation] GO:0048863 [stem cell differentiation] GO:0051301 [cell division] GO:0051575 [5'-deoxyribose-5-phosphate lyase activity] GO:0070742 [C2H2 zinc finger domain binding] GO:0071141 [SMAD protein complex] GO:0071158 [positive regulation of cell cycle arrest] GO:0090402 [oncogene-induced cell senescence] GO:2000036 [regulation of stem cell population maintenance] GO:2000648 [positive regulation of stem cell proliferation] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2000685 [positive regulation of cellular response to X-ray] GO:2000774 [positive regulation of cellular senescence] GO:2001022 [positive regulation of response to DNA damage stimulus] GO:2001033 [negative regulation of double-strand break repair via nonhomologous end joining] GO:2001038 [regulation of cellular response to drug]
P52926 [Direct mapping] High mobility group protein HMGI-C
Show all
Predicted intracellular proteins Plasma proteins Transcription factors beta-Sheet binding to DNA Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000228 [nuclear chromosome] GO:0000785 [chromatin] GO:0000975 [regulatory region DNA binding] GO:0000989 [transcription factor activity, transcription factor binding] GO:0001047 [core promoter binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001837 [epithelial to mesenchymal transition] GO:0002062 [chondrocyte differentiation] GO:0003131 [mesodermal-endodermal cell signaling] GO:0003677 [DNA binding] GO:0003680 [AT DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0004677 [DNA-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006284 [base-excision repair] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007049 [cell cycle] GO:0007067 [mitotic nuclear division] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0007275 [multicellular organism development] GO:0008134 [transcription factor binding] GO:0008301 [DNA binding, bending] GO:0009615 [response to virus] GO:0010564 [regulation of cell cycle process] GO:0010628 [positive regulation of gene expression] GO:0030261 [chromosome condensation] GO:0031052 [chromosome breakage] GO:0031492 [nucleosomal DNA binding] GO:0031507 [heterochromatin assembly] GO:0032993 [protein-DNA complex] GO:0035497 [cAMP response element binding] GO:0035500 [MH2 domain binding] GO:0035501 [MH1 domain binding] GO:0035978 [histone H2A-S139 phosphorylation] GO:0035985 [senescence-associated heterochromatin focus] GO:0035986 [senescence-associated heterochromatin focus assembly] GO:0035987 [endodermal cell differentiation] GO:0035988 [chondrocyte proliferation] GO:0040008 [regulation of growth] GO:0042769 [DNA damage response, detection of DNA damage] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043392 [negative regulation of DNA binding] GO:0043922 [negative regulation by host of viral transcription] GO:0045444 [fat cell differentiation] GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046332 [SMAD binding] GO:0048333 [mesodermal cell differentiation] GO:0048762 [mesenchymal cell differentiation] GO:0048863 [stem cell differentiation] GO:0051301 [cell division] GO:0051575 [5'-deoxyribose-5-phosphate lyase activity] GO:0070742 [C2H2 zinc finger domain binding] GO:0071141 [SMAD protein complex] GO:0071158 [positive regulation of cell cycle arrest] GO:0090402 [oncogene-induced cell senescence] GO:2000036 [regulation of stem cell population maintenance] GO:2000648 [positive regulation of stem cell proliferation] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2000685 [positive regulation of cellular response to X-ray] GO:2000774 [positive regulation of cellular senescence] GO:2001022 [positive regulation of response to DNA damage stimulus] GO:2001033 [negative regulation of double-strand break repair via nonhomologous end joining] GO:2001038 [regulation of cellular response to drug]
F5H2U8 [Direct mapping] High mobility group protein HMGI-C
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
F5H2A4 [Direct mapping] High mobility group protein HMGI-C
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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