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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
TCGA (cancer tissue):
Mixed
HPA (cell line):
Cell line enhanced (AF22)
HPA (normal tissue):
Tissue enhanced (testis)
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expression normal tissuei
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
External characterization data and paired antibodies with high similarity supports the antibody staining pattern.
Reliability score - normal tissuesi
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from.
Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
For each cancer, color-coded bars indicate the percentage of patients (maximum 12 patients) with high and medium protein expression level. The cancer types are color-coded according to which type of normal organ the cancer originates from. Low or not detected protein expression results in a white bar. Mouse-over function shows details about expression level and normal tissue of origin. The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies.
Most cancer tissues showed weak to moderate nuclear positivity. A few thyroid and pancreatic cancer were strongly stained.
Several cases of most cancers showed weak to moderate nuclear positivity. Strong staining was observed in a few testis, urothelial, stomach, pancreatic and liver cancers.
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
HMGA2 (HGNC Symbol)
Synonyms
BABL, HMGIC, LIPO
Description
High mobility group AT-hook 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
HMGA2-001
HMGA2-003
HMGA2-005
HMGA2-006
HMGA2-008
HMGA2-011
HMGA2-013
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P52926 [Direct mapping] High mobility group protein HMGI-C
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Predicted intracellular proteins Plasma proteins Transcription factors beta-Sheet binding to DNA Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000228 [nuclear chromosome] GO:0000785 [chromatin] GO:0000975 [regulatory region DNA binding] GO:0000989 [transcription factor activity, transcription factor binding] GO:0001047 [core promoter binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001837 [epithelial to mesenchymal transition] GO:0002062 [chondrocyte differentiation] GO:0003131 [mesodermal-endodermal cell signaling] GO:0003677 [DNA binding] GO:0003680 [AT DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0004677 [DNA-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006284 [base-excision repair] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007049 [cell cycle] GO:0007067 [mitotic nuclear division] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0007275 [multicellular organism development] GO:0008134 [transcription factor binding] GO:0008301 [DNA binding, bending] GO:0009615 [response to virus] GO:0010564 [regulation of cell cycle process] GO:0010628 [positive regulation of gene expression] GO:0030261 [chromosome condensation] GO:0031052 [chromosome breakage] GO:0031492 [nucleosomal DNA binding] GO:0031507 [heterochromatin assembly] GO:0032993 [protein-DNA complex] GO:0035497 [cAMP response element binding] GO:0035500 [MH2 domain binding] GO:0035501 [MH1 domain binding] GO:0035978 [histone H2A-S139 phosphorylation] GO:0035985 [senescence-associated heterochromatin focus] GO:0035986 [senescence-associated heterochromatin focus assembly] GO:0035987 [endodermal cell differentiation] GO:0035988 [chondrocyte proliferation] GO:0040008 [regulation of growth] GO:0042769 [DNA damage response, detection of DNA damage] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043392 [negative regulation of DNA binding] GO:0043922 [negative regulation by host of viral transcription] GO:0045444 [fat cell differentiation] GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046332 [SMAD binding] GO:0048333 [mesodermal cell differentiation] GO:0048762 [mesenchymal cell differentiation] GO:0048863 [stem cell differentiation] GO:0051301 [cell division] GO:0051575 [5'-deoxyribose-5-phosphate lyase activity] GO:0070742 [C2H2 zinc finger domain binding] GO:0071141 [SMAD protein complex] GO:0071158 [positive regulation of cell cycle arrest] GO:0090402 [oncogene-induced cell senescence] GO:2000036 [regulation of stem cell population maintenance] GO:2000648 [positive regulation of stem cell proliferation] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2000685 [positive regulation of cellular response to X-ray] GO:2000774 [positive regulation of cellular senescence] GO:2001022 [positive regulation of response to DNA damage stimulus] GO:2001033 [negative regulation of double-strand break repair via nonhomologous end joining] GO:2001038 [regulation of cellular response to drug]
F5H6H0 [Direct mapping] High mobility group protein HMGI-C
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000228 [nuclear chromosome] GO:0000785 [chromatin] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003680 [AT DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007283 [spermatogenesis] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0008584 [male gonad development] GO:0010564 [regulation of cell cycle process] GO:0010628 [positive regulation of gene expression] GO:0019899 [enzyme binding] GO:0021846 [cell proliferation in forebrain] GO:0021983 [pituitary gland development] GO:0030178 [negative regulation of Wnt signaling pathway] GO:0030325 [adrenal gland development] GO:0033144 [negative regulation of intracellular steroid hormone receptor signaling pathway] GO:0035019 [somatic stem cell population maintenance] GO:0040018 [positive regulation of multicellular organism growth] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046426 [negative regulation of JAK-STAT cascade] GO:0048712 [negative regulation of astrocyte differentiation] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060123 [regulation of growth hormone secretion] GO:0060428 [lung epithelium development] GO:0060441 [epithelial tube branching involved in lung morphogenesis] GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis] GO:0060612 [adipose tissue development] GO:0060613 [fat pad development] GO:0090276 [regulation of peptide hormone secretion] GO:2000648 [positive regulation of stem cell proliferation]
P52926 [Direct mapping] High mobility group protein HMGI-C
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Predicted intracellular proteins Plasma proteins Transcription factors beta-Sheet binding to DNA Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000228 [nuclear chromosome] GO:0000785 [chromatin] GO:0000975 [regulatory region DNA binding] GO:0000989 [transcription factor activity, transcription factor binding] GO:0001047 [core promoter binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001837 [epithelial to mesenchymal transition] GO:0002062 [chondrocyte differentiation] GO:0003131 [mesodermal-endodermal cell signaling] GO:0003677 [DNA binding] GO:0003680 [AT DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0004677 [DNA-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006284 [base-excision repair] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007049 [cell cycle] GO:0007067 [mitotic nuclear division] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0007275 [multicellular organism development] GO:0008134 [transcription factor binding] GO:0008301 [DNA binding, bending] GO:0009615 [response to virus] GO:0010564 [regulation of cell cycle process] GO:0010628 [positive regulation of gene expression] GO:0030261 [chromosome condensation] GO:0031052 [chromosome breakage] GO:0031492 [nucleosomal DNA binding] GO:0031507 [heterochromatin assembly] GO:0032993 [protein-DNA complex] GO:0035497 [cAMP response element binding] GO:0035500 [MH2 domain binding] GO:0035501 [MH1 domain binding] GO:0035978 [histone H2A-S139 phosphorylation] GO:0035985 [senescence-associated heterochromatin focus] GO:0035986 [senescence-associated heterochromatin focus assembly] GO:0035987 [endodermal cell differentiation] GO:0035988 [chondrocyte proliferation] GO:0040008 [regulation of growth] GO:0042769 [DNA damage response, detection of DNA damage] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043392 [negative regulation of DNA binding] GO:0043922 [negative regulation by host of viral transcription] GO:0045444 [fat cell differentiation] GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046332 [SMAD binding] GO:0048333 [mesodermal cell differentiation] GO:0048762 [mesenchymal cell differentiation] GO:0048863 [stem cell differentiation] GO:0051301 [cell division] GO:0051575 [5'-deoxyribose-5-phosphate lyase activity] GO:0070742 [C2H2 zinc finger domain binding] GO:0071141 [SMAD protein complex] GO:0071158 [positive regulation of cell cycle arrest] GO:0090402 [oncogene-induced cell senescence] GO:2000036 [regulation of stem cell population maintenance] GO:2000648 [positive regulation of stem cell proliferation] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2000685 [positive regulation of cellular response to X-ray] GO:2000774 [positive regulation of cellular senescence] GO:2001022 [positive regulation of response to DNA damage stimulus] GO:2001033 [negative regulation of double-strand break repair via nonhomologous end joining] GO:2001038 [regulation of cellular response to drug]
P52926 [Direct mapping] High mobility group protein HMGI-C
Show all
Predicted intracellular proteins Plasma proteins Transcription factors beta-Sheet binding to DNA Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000228 [nuclear chromosome] GO:0000785 [chromatin] GO:0000975 [regulatory region DNA binding] GO:0000989 [transcription factor activity, transcription factor binding] GO:0001047 [core promoter binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001837 [epithelial to mesenchymal transition] GO:0002062 [chondrocyte differentiation] GO:0003131 [mesodermal-endodermal cell signaling] GO:0003677 [DNA binding] GO:0003680 [AT DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0004677 [DNA-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006284 [base-excision repair] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007049 [cell cycle] GO:0007067 [mitotic nuclear division] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0007275 [multicellular organism development] GO:0008134 [transcription factor binding] GO:0008301 [DNA binding, bending] GO:0009615 [response to virus] GO:0010564 [regulation of cell cycle process] GO:0010628 [positive regulation of gene expression] GO:0030261 [chromosome condensation] GO:0031052 [chromosome breakage] GO:0031492 [nucleosomal DNA binding] GO:0031507 [heterochromatin assembly] GO:0032993 [protein-DNA complex] GO:0035497 [cAMP response element binding] GO:0035500 [MH2 domain binding] GO:0035501 [MH1 domain binding] GO:0035978 [histone H2A-S139 phosphorylation] GO:0035985 [senescence-associated heterochromatin focus] GO:0035986 [senescence-associated heterochromatin focus assembly] GO:0035987 [endodermal cell differentiation] GO:0035988 [chondrocyte proliferation] GO:0040008 [regulation of growth] GO:0042769 [DNA damage response, detection of DNA damage] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043392 [negative regulation of DNA binding] GO:0043922 [negative regulation by host of viral transcription] GO:0045444 [fat cell differentiation] GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046332 [SMAD binding] GO:0048333 [mesodermal cell differentiation] GO:0048762 [mesenchymal cell differentiation] GO:0048863 [stem cell differentiation] GO:0051301 [cell division] GO:0051575 [5'-deoxyribose-5-phosphate lyase activity] GO:0070742 [C2H2 zinc finger domain binding] GO:0071141 [SMAD protein complex] GO:0071158 [positive regulation of cell cycle arrest] GO:0090402 [oncogene-induced cell senescence] GO:2000036 [regulation of stem cell population maintenance] GO:2000648 [positive regulation of stem cell proliferation] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2000685 [positive regulation of cellular response to X-ray] GO:2000774 [positive regulation of cellular senescence] GO:2001022 [positive regulation of response to DNA damage stimulus] GO:2001033 [negative regulation of double-strand break repair via nonhomologous end joining] GO:2001038 [regulation of cellular response to drug]
P52926 [Direct mapping] High mobility group protein HMGI-C
Show all
Predicted intracellular proteins Plasma proteins Transcription factors beta-Sheet binding to DNA Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000228 [nuclear chromosome] GO:0000785 [chromatin] GO:0000975 [regulatory region DNA binding] GO:0000989 [transcription factor activity, transcription factor binding] GO:0001047 [core promoter binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001837 [epithelial to mesenchymal transition] GO:0002062 [chondrocyte differentiation] GO:0003131 [mesodermal-endodermal cell signaling] GO:0003677 [DNA binding] GO:0003680 [AT DNA binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0004677 [DNA-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006284 [base-excision repair] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007049 [cell cycle] GO:0007067 [mitotic nuclear division] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0007275 [multicellular organism development] GO:0008134 [transcription factor binding] GO:0008301 [DNA binding, bending] GO:0009615 [response to virus] GO:0010564 [regulation of cell cycle process] GO:0010628 [positive regulation of gene expression] GO:0030261 [chromosome condensation] GO:0031052 [chromosome breakage] GO:0031492 [nucleosomal DNA binding] GO:0031507 [heterochromatin assembly] GO:0032993 [protein-DNA complex] GO:0035497 [cAMP response element binding] GO:0035500 [MH2 domain binding] GO:0035501 [MH1 domain binding] GO:0035978 [histone H2A-S139 phosphorylation] GO:0035985 [senescence-associated heterochromatin focus] GO:0035986 [senescence-associated heterochromatin focus assembly] GO:0035987 [endodermal cell differentiation] GO:0035988 [chondrocyte proliferation] GO:0040008 [regulation of growth] GO:0042769 [DNA damage response, detection of DNA damage] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043392 [negative regulation of DNA binding] GO:0043922 [negative regulation by host of viral transcription] GO:0045444 [fat cell differentiation] GO:0045869 [negative regulation of single stranded viral RNA replication via double stranded DNA intermediate] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046332 [SMAD binding] GO:0048333 [mesodermal cell differentiation] GO:0048762 [mesenchymal cell differentiation] GO:0048863 [stem cell differentiation] GO:0051301 [cell division] GO:0051575 [5'-deoxyribose-5-phosphate lyase activity] GO:0070742 [C2H2 zinc finger domain binding] GO:0071141 [SMAD protein complex] GO:0071158 [positive regulation of cell cycle arrest] GO:0090402 [oncogene-induced cell senescence] GO:2000036 [regulation of stem cell population maintenance] GO:2000648 [positive regulation of stem cell proliferation] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2000685 [positive regulation of cellular response to X-ray] GO:2000774 [positive regulation of cellular senescence] GO:2001022 [positive regulation of response to DNA damage stimulus] GO:2001033 [negative regulation of double-strand break repair via nonhomologous end joining] GO:2001038 [regulation of cellular response to drug]
F5H2U8 [Direct mapping] High mobility group protein HMGI-C
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
F5H2A4 [Direct mapping] High mobility group protein HMGI-C
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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