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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for data imported from The Genotype-Tissue Expression project (GTEX), FANTOM5 Consortium (FANTOM5) and internally generated Human Protein Atlas (HPA) data.
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expressioni
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
High expression in CNS and peripheral nerves, as well as subsets of cells in bone marrow.
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability descriptioni
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability scorei
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Below is an overview of RNA and protein expression data generated in the Human Protein Atlas project. Analyzed tissues are divided into color-coded groups according to which functional features they have in common. For each group, a list of included tissues is accessed by clicking on group name, group symbol, RNA bar, or protein bar. Subsequent selection of a particular tissue in this list links to the image data page.
Images of selected tissues give a visual summary of the protein expression profile furthest to the right.
The gray human body provides links to a histology dictionary when clicking on any part of the figure.
RNA expression (TPM)i
RNA-seq results generated in HPA are reported as number of transcripts per million (TPM). Each bar represents the highest expression score found in a particular group of tissues. The assay is described more in detail in Assays & Annotation.
Protein expression (score)i
Each bar represents the highest expression score found in a particular group of tissues. Protein expression scores are based on a best estimate of the "true" protein expression from a knowledge-based annotation, described more in detail under Assays & annotation. For genes where more than one antibody has been used, a collective score is set displaying the estimated true protein expression.
Protein expression data is shown for each of the 44 tissues. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. Mouse-over function shows protein score for analyzed cell types in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation.
For genes with available protein data for which a knowledge-based annotation gave inconclusive results, no protein expression data is displayed in the protein expression data overview. However, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Organ
Expression
Alphabetical
RNA EXPRESSION OVERVIEWi
RNA expression overview shows RNA-data from three different sources: Internally generated Human Protein Atlas (HPA) RNA-seq data, RNA-seq data from the Genotype-Tissue Expression (GTEx) project and CAGE data from FANTOM5 project. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.
HPA dataseti
HPA dataset RNA-seq tissue data is reported as mean TPM (transcripts per million), corresponding to mean values of the different individual samples from each tissue. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar. The RNA-seq assay is described in detail in Assays & Annotation.
RNA tissue category HPA HPA RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (bone marrow, cerebral cortex)
GTEx dataseti
GTEx dataset RNA-seq data is reported as median RPKM (reads per kilobase per million mapped reads), generated by the Genotype-Tissue Expression (GTEx) project. More information can be found in Assays & Annotation.
RNA tissue category GTEx GTEx RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
FANTOM5 dataset Tissue data obtained through Cap Analysis of Gene Expression (CAGE) are reported as Tags Per Million, generated by the FANTOM5 project. More information can be found in Assays & Annotation.
RNA tissue category FANTOM5 FANTOM5 RNA tissue category (category description) is calculated based on gene expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
SNCA (HGNC Symbol)
Synonyms
alpha-synuclein, NACP, PARK1, PARK4, PD1
Description
Synuclein alpha (HGNC Symbol)
Entrez gene summary
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030544 [Hsp70 protein binding] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045202 [synapse] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0046872 [metal ion binding] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0070840 [dynein complex binding] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0098794 [postsynapse] GO:0099512 [supramolecular fiber] GO:1901215 [negative regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:1904715 [negative regulation of chaperone-mediated autophagy] GO:1905606 [regulation of presynapse assembly]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030544 [Hsp70 protein binding] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045202 [synapse] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0046872 [metal ion binding] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0070840 [dynein complex binding] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0098794 [postsynapse] GO:0099512 [supramolecular fiber] GO:1901215 [negative regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:1904715 [negative regulation of chaperone-mediated autophagy] GO:1905606 [regulation of presynapse assembly]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0001933 [negative regulation of protein phosphorylation] GO:0001956 [positive regulation of neurotransmitter secretion] GO:0001963 [synaptic transmission, dopaminergic] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005640 [nuclear outer membrane] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005791 [rough endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005840 [ribosome] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006631 [fatty acid metabolic process] GO:0006638 [neutral lipid metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007006 [mitochondrial membrane organization] GO:0007268 [chemical synaptic transmission] GO:0007568 [aging] GO:0008017 [microtubule binding] GO:0008021 [synaptic vesicle] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0008344 [adult locomotory behavior] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014048 [regulation of glutamate secretion] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030544 [Hsp70 protein binding] GO:0030659 [cytoplasmic vesicle membrane] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0040012 [regulation of locomotion] GO:0042220 [response to cocaine] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042417 [dopamine metabolic process] GO:0042493 [response to drug] GO:0042775 [mitochondrial ATP synthesis coupled electron transport] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043025 [neuronal cell body] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043030 [regulation of macrophage activation] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043195 [terminal bouton] GO:0043231 [intracellular membrane-bounded organelle] GO:0043274 [phospholipase binding] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043679 [axon terminus] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0045202 [synapse] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0045963 [negative regulation of dopamine metabolic process] GO:0046872 [metal ion binding] GO:0046928 [regulation of neurotransmitter secretion] GO:0047485 [protein N-terminus binding] GO:0048148 [behavioral response to cocaine] GO:0048156 [tau protein binding] GO:0048168 [regulation of neuronal synaptic plasticity] GO:0048169 [regulation of long-term neuronal synaptic plasticity] GO:0048471 [perinuclear region of cytoplasm] GO:0048487 [beta-tubulin binding] GO:0048488 [synaptic vesicle endocytosis] GO:0048489 [synaptic vesicle transport] GO:0050806 [positive regulation of synaptic transmission] GO:0050808 [synapse organization] GO:0050812 [regulation of acyl-CoA biosynthetic process] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060079 [excitatory postsynaptic potential] GO:0060291 [long-term synaptic potentiation] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0061024 [membrane organization] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0070840 [dynein complex binding] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0098794 [postsynapse] GO:0099512 [supramolecular fiber] GO:1901214 [regulation of neuron death] GO:1901215 [negative regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:1904715 [negative regulation of chaperone-mediated autophagy] GO:1905606 [regulation of presynapse assembly] GO:2000377 [regulation of reactive oxygen species metabolic process]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030544 [Hsp70 protein binding] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045202 [synapse] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0046872 [metal ion binding] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0070840 [dynein complex binding] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0098794 [postsynapse] GO:0099512 [supramolecular fiber] GO:1901215 [negative regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:1904715 [negative regulation of chaperone-mediated autophagy] GO:1905606 [regulation of presynapse assembly]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030544 [Hsp70 protein binding] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045202 [synapse] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0046872 [metal ion binding] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0070840 [dynein complex binding] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0098794 [postsynapse] GO:0099512 [supramolecular fiber] GO:1901215 [negative regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:1904715 [negative regulation of chaperone-mediated autophagy] GO:1905606 [regulation of presynapse assembly]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030544 [Hsp70 protein binding] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045202 [synapse] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0046872 [metal ion binding] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0070840 [dynein complex binding] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0098794 [postsynapse] GO:0099512 [supramolecular fiber] GO:1901215 [negative regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:1904715 [negative regulation of chaperone-mediated autophagy] GO:1905606 [regulation of presynapse assembly]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030544 [Hsp70 protein binding] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045202 [synapse] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0046872 [metal ion binding] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0070840 [dynein complex binding] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0098794 [postsynapse] GO:0099512 [supramolecular fiber] GO:1901215 [negative regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:1904715 [negative regulation of chaperone-mediated autophagy] GO:1905606 [regulation of presynapse assembly]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030544 [Hsp70 protein binding] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045202 [synapse] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0046872 [metal ion binding] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0070840 [dynein complex binding] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0098794 [postsynapse] GO:0099512 [supramolecular fiber] GO:1901215 [negative regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:1904715 [negative regulation of chaperone-mediated autophagy] GO:1905606 [regulation of presynapse assembly]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030544 [Hsp70 protein binding] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045202 [synapse] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0046872 [metal ion binding] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0070840 [dynein complex binding] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0098794 [postsynapse] GO:0099512 [supramolecular fiber] GO:1901215 [negative regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:1904715 [negative regulation of chaperone-mediated autophagy] GO:1905606 [regulation of presynapse assembly]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030544 [Hsp70 protein binding] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045202 [synapse] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0046872 [metal ion binding] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0070840 [dynein complex binding] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0098794 [postsynapse] GO:0099512 [supramolecular fiber] GO:1901215 [negative regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:1904715 [negative regulation of chaperone-mediated autophagy] GO:1905606 [regulation of presynapse assembly]
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