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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
TCGA (cancer tissue):
Tissue enriched (melanoma)
HPA (cell line):
Cell line enhanced (HEL, HUVEC TERT2, SK-MEL-30, TIME)
HPA (normal tissue):
Group enriched (bone marrow, cerebral cortex)
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expression normal tissuei
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
High expression in CNS and peripheral nerves, as well as subsets of cells in bone marrow.
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability descriptioni
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score - normal tissuesi
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEWi
RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from.
Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
For each cancer, color-coded bars indicate the percentage of patients (maximum 12 patients) with high and medium protein expression level. The cancer types are color-coded according to which type of normal organ the cancer originates from. Low or not detected protein expression results in a white bar. Mouse-over function shows details about expression level and normal tissue of origin. The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies.
Cancer cells were mainly negative. A few cases of melanoma showed moderate to strong granular cytoplasmic staining.
Several cases of melanoma displayed strong cytoplasmic staining. Remaining cancer tissues were negative.
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
SNCA (HGNC Symbol)
Synonyms
alpha-synuclein, NACP, PARK1, PARK4, PD1
Description
Synuclein alpha (HGNC Symbol)
Entrez gene summary
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030544 [Hsp70 protein binding] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045202 [synapse] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0046872 [metal ion binding] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0070840 [dynein complex binding] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0098794 [postsynapse] GO:0099512 [supramolecular fiber] GO:1901215 [negative regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:1904715 [negative regulation of chaperone-mediated autophagy] GO:1905606 [regulation of presynapse assembly]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030544 [Hsp70 protein binding] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045202 [synapse] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0046872 [metal ion binding] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0070840 [dynein complex binding] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0098794 [postsynapse] GO:0099512 [supramolecular fiber] GO:1901215 [negative regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:1904715 [negative regulation of chaperone-mediated autophagy] GO:1905606 [regulation of presynapse assembly]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0001933 [negative regulation of protein phosphorylation] GO:0001956 [positive regulation of neurotransmitter secretion] GO:0001963 [synaptic transmission, dopaminergic] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005640 [nuclear outer membrane] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005791 [rough endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005840 [ribosome] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006631 [fatty acid metabolic process] GO:0006638 [neutral lipid metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007006 [mitochondrial membrane organization] GO:0007268 [chemical synaptic transmission] GO:0007568 [aging] GO:0008017 [microtubule binding] GO:0008021 [synaptic vesicle] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0008344 [adult locomotory behavior] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014048 [regulation of glutamate secretion] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030544 [Hsp70 protein binding] GO:0030659 [cytoplasmic vesicle membrane] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0040012 [regulation of locomotion] GO:0042220 [response to cocaine] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042417 [dopamine metabolic process] GO:0042493 [response to drug] GO:0042775 [mitochondrial ATP synthesis coupled electron transport] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043025 [neuronal cell body] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043030 [regulation of macrophage activation] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043195 [terminal bouton] GO:0043231 [intracellular membrane-bounded organelle] GO:0043274 [phospholipase binding] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043679 [axon terminus] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0044344 [cellular response to fibroblast growth factor stimulus] GO:0045202 [synapse] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0045963 [negative regulation of dopamine metabolic process] GO:0046872 [metal ion binding] GO:0046928 [regulation of neurotransmitter secretion] GO:0047485 [protein N-terminus binding] GO:0048148 [behavioral response to cocaine] GO:0048156 [tau protein binding] GO:0048168 [regulation of neuronal synaptic plasticity] GO:0048169 [regulation of long-term neuronal synaptic plasticity] GO:0048471 [perinuclear region of cytoplasm] GO:0048487 [beta-tubulin binding] GO:0048488 [synaptic vesicle endocytosis] GO:0048489 [synaptic vesicle transport] GO:0050806 [positive regulation of synaptic transmission] GO:0050808 [synapse organization] GO:0050812 [regulation of acyl-CoA biosynthetic process] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060079 [excitatory postsynaptic potential] GO:0060291 [long-term synaptic potentiation] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0061024 [membrane organization] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0070840 [dynein complex binding] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0098794 [postsynapse] GO:0099512 [supramolecular fiber] GO:1901214 [regulation of neuron death] GO:1901215 [negative regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:1904715 [negative regulation of chaperone-mediated autophagy] GO:1905606 [regulation of presynapse assembly] GO:2000377 [regulation of reactive oxygen species metabolic process]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030544 [Hsp70 protein binding] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045202 [synapse] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0046872 [metal ion binding] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0070840 [dynein complex binding] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0098794 [postsynapse] GO:0099512 [supramolecular fiber] GO:1901215 [negative regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:1904715 [negative regulation of chaperone-mediated autophagy] GO:1905606 [regulation of presynapse assembly]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030544 [Hsp70 protein binding] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045202 [synapse] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0046872 [metal ion binding] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0070840 [dynein complex binding] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0098794 [postsynapse] GO:0099512 [supramolecular fiber] GO:1901215 [negative regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:1904715 [negative regulation of chaperone-mediated autophagy] GO:1905606 [regulation of presynapse assembly]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030544 [Hsp70 protein binding] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045202 [synapse] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0046872 [metal ion binding] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0070840 [dynein complex binding] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0098794 [postsynapse] GO:0099512 [supramolecular fiber] GO:1901215 [negative regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:1904715 [negative regulation of chaperone-mediated autophagy] GO:1905606 [regulation of presynapse assembly]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030544 [Hsp70 protein binding] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045202 [synapse] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0046872 [metal ion binding] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0070840 [dynein complex binding] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0098794 [postsynapse] GO:0099512 [supramolecular fiber] GO:1901215 [negative regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:1904715 [negative regulation of chaperone-mediated autophagy] GO:1905606 [regulation of presynapse assembly]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030544 [Hsp70 protein binding] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045202 [synapse] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0046872 [metal ion binding] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0070840 [dynein complex binding] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0098794 [postsynapse] GO:0099512 [supramolecular fiber] GO:1901215 [negative regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:1904715 [negative regulation of chaperone-mediated autophagy] GO:1905606 [regulation of presynapse assembly]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030544 [Hsp70 protein binding] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045202 [synapse] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0046872 [metal ion binding] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0070840 [dynein complex binding] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0098794 [postsynapse] GO:0099512 [supramolecular fiber] GO:1901215 [negative regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:1904715 [negative regulation of chaperone-mediated autophagy] GO:1905606 [regulation of presynapse assembly]
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000287 [magnesium ion binding] GO:0001774 [microglial cell activation] GO:0001921 [positive regulation of receptor recycling] GO:0005507 [copper ion binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008198 [ferrous iron binding] GO:0008270 [zinc ion binding] GO:0010040 [response to iron(II) ion] GO:0010517 [regulation of phospholipase activity] GO:0010642 [negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0014059 [regulation of dopamine secretion] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016491 [oxidoreductase activity] GO:0019894 [kinesin binding] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030426 [growth cone] GO:0030544 [Hsp70 protein binding] GO:0031092 [platelet alpha granule membrane] GO:0031115 [negative regulation of microtubule polymerization] GO:0031623 [receptor internalization] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032410 [negative regulation of transporter activity] GO:0032496 [response to lipopolysaccharide] GO:0032769 [negative regulation of monooxygenase activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034341 [response to interferon-gamma] GO:0034599 [cellular response to oxidative stress] GO:0035067 [negative regulation of histone acetylation] GO:0042393 [histone binding] GO:0042416 [dopamine biosynthetic process] GO:0042802 [identical protein binding] GO:0043014 [alpha-tubulin binding] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044267 [cellular protein metabolic process] GO:0045202 [synapse] GO:0045807 [positive regulation of endocytosis] GO:0045920 [negative regulation of exocytosis] GO:0046872 [metal ion binding] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0051219 [phosphoprotein binding] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051585 [negative regulation of dopamine uptake involved in synaptic transmission] GO:0051612 [negative regulation of serotonin uptake] GO:0051622 [negative regulation of norepinephrine uptake] GO:0055114 [oxidation-reduction process] GO:0060732 [positive regulation of inositol phosphate biosynthetic process] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0070555 [response to interleukin-1] GO:0070840 [dynein complex binding] GO:0071280 [cellular response to copper ion] GO:0071872 [cellular response to epinephrine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0098794 [postsynapse] GO:0099512 [supramolecular fiber] GO:1901215 [negative regulation of neuron death] GO:1902957 [negative regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903284 [positive regulation of glutathione peroxidase activity] GO:1903285 [positive regulation of hydrogen peroxide catabolic process] GO:1903421 [regulation of synaptic vesicle recycling] GO:1903426 [regulation of reactive oxygen species biosynthetic process] GO:1904715 [negative regulation of chaperone-mediated autophagy] GO:1905606 [regulation of presynapse assembly]