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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
TCGA (cancer tissue):
Expressed in all
HPA (cell line):
Cell line enhanced (HHSteC)
HPA (normal tissue):
Expressed in all
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expression normal tissuei
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Nuclear expression in fractions of cells in most tissues.
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability descriptioni
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining mainly consistent with RNA expression data.
Reliability score - normal tissuesi
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from.
Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
For each cancer, color-coded bars indicate the percentage of patients (maximum 12 patients) with high and medium protein expression level. The cancer types are color-coded according to which type of normal organ the cancer originates from. Low or not detected protein expression results in a white bar. Mouse-over function shows details about expression level and normal tissue of origin. The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies.
Moderate to strong nuclear staining in a fraction of cells seen in most cancers. Prostate, testis and liver cancers were mostly negative.
Varying fractions of tumor cells in most cancer tissues showed moderate to strong nuclear and cytoplasmic positivity. Lymphomas were negative.
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
CDKN1A-001
CDKN1A-002
CDKN1A-201
CDKN1A-202
CDKN1A-203
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0004860 [protein kinase inhibitor activity] GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007265 [Ras protein signal transduction] GO:0007346 [regulation of mitotic cell cycle] GO:0008285 [negative regulation of cell proliferation] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016604 [nuclear body] GO:0019912 [cyclin-dependent protein kinase activating kinase activity] GO:0030308 [negative regulation of cell growth] GO:0031625 [ubiquitin protein ligase binding] GO:0031668 [cellular response to extracellular stimulus] GO:0034198 [cellular response to amino acid starvation] GO:0042326 [negative regulation of phosphorylation] GO:0043234 [protein complex] GO:0045860 [positive regulation of protein kinase activity] GO:0046872 [metal ion binding] GO:0048146 [positive regulation of fibroblast proliferation] GO:0050821 [protein stabilization] GO:0070557 [PCNA-p21 complex] GO:0071479 [cellular response to ionizing radiation] GO:0071493 [cellular response to UV-B] GO:0072331 [signal transduction by p53 class mediator] GO:0090398 [cellular senescence] GO:0090400 [stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1904031 [positive regulation of cyclin-dependent protein kinase activity] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0004860 [protein kinase inhibitor activity] GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007265 [Ras protein signal transduction] GO:0007346 [regulation of mitotic cell cycle] GO:0008285 [negative regulation of cell proliferation] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016604 [nuclear body] GO:0019912 [cyclin-dependent protein kinase activating kinase activity] GO:0030308 [negative regulation of cell growth] GO:0031625 [ubiquitin protein ligase binding] GO:0031668 [cellular response to extracellular stimulus] GO:0034198 [cellular response to amino acid starvation] GO:0042326 [negative regulation of phosphorylation] GO:0043234 [protein complex] GO:0045860 [positive regulation of protein kinase activity] GO:0046872 [metal ion binding] GO:0048146 [positive regulation of fibroblast proliferation] GO:0050821 [protein stabilization] GO:0070557 [PCNA-p21 complex] GO:0071479 [cellular response to ionizing radiation] GO:0071493 [cellular response to UV-B] GO:0072331 [signal transduction by p53 class mediator] GO:0090398 [cellular senescence] GO:0090400 [stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1904031 [positive regulation of cyclin-dependent protein kinase activity] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0004860 [protein kinase inhibitor activity] GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007265 [Ras protein signal transduction] GO:0007346 [regulation of mitotic cell cycle] GO:0008285 [negative regulation of cell proliferation] GO:0009411 [response to UV] GO:0009636 [response to toxic substance] GO:0010033 [response to organic substance] GO:0010165 [response to X-ray] GO:0010243 [response to organonitrogen compound] GO:0010629 [negative regulation of gene expression] GO:0010942 [positive regulation of cell death] GO:0014070 [response to organic cyclic compound] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016604 [nuclear body] GO:0019912 [cyclin-dependent protein kinase activating kinase activity] GO:0030308 [negative regulation of cell growth] GO:0030332 [cyclin binding] GO:0030890 [positive regulation of B cell proliferation] GO:0031100 [animal organ regeneration] GO:0031625 [ubiquitin protein ligase binding] GO:0031668 [cellular response to extracellular stimulus] GO:0032403 [protein complex binding] GO:0033158 [regulation of protein import into nucleus, translocation] GO:0034198 [cellular response to amino acid starvation] GO:0034605 [cellular response to heat] GO:0042326 [negative regulation of phosphorylation] GO:0042493 [response to drug] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0043066 [negative regulation of apoptotic process] GO:0043068 [positive regulation of programmed cell death] GO:0043234 [protein complex] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045860 [positive regulation of protein kinase activity] GO:0046685 [response to arsenic-containing substance] GO:0046872 [metal ion binding] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048471 [perinuclear region of cytoplasm] GO:0050821 [protein stabilization] GO:0051384 [response to glucocorticoid] GO:0051412 [response to corticosterone] GO:0051726 [regulation of cell cycle] GO:0055093 [response to hyperoxia] GO:0060574 [intestinal epithelial cell maturation] GO:0070557 [PCNA-p21 complex] GO:0071479 [cellular response to ionizing radiation] GO:0071480 [cellular response to gamma radiation] GO:0071493 [cellular response to UV-B] GO:0071850 [mitotic cell cycle arrest] GO:0072331 [signal transduction by p53 class mediator] GO:0090398 [cellular senescence] GO:0090399 [replicative senescence] GO:0090400 [stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1904031 [positive regulation of cyclin-dependent protein kinase activity] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] GO:2000278 [regulation of DNA biosynthetic process] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0004860 [protein kinase inhibitor activity] GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007265 [Ras protein signal transduction] GO:0007346 [regulation of mitotic cell cycle] GO:0008285 [negative regulation of cell proliferation] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016604 [nuclear body] GO:0019912 [cyclin-dependent protein kinase activating kinase activity] GO:0030308 [negative regulation of cell growth] GO:0031625 [ubiquitin protein ligase binding] GO:0031668 [cellular response to extracellular stimulus] GO:0034198 [cellular response to amino acid starvation] GO:0042326 [negative regulation of phosphorylation] GO:0043234 [protein complex] GO:0045860 [positive regulation of protein kinase activity] GO:0046872 [metal ion binding] GO:0048146 [positive regulation of fibroblast proliferation] GO:0050821 [protein stabilization] GO:0070557 [PCNA-p21 complex] GO:0071479 [cellular response to ionizing radiation] GO:0071493 [cellular response to UV-B] GO:0072331 [signal transduction by p53 class mediator] GO:0090398 [cellular senescence] GO:0090400 [stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1904031 [positive regulation of cyclin-dependent protein kinase activity] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0004860 [protein kinase inhibitor activity] GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007265 [Ras protein signal transduction] GO:0007346 [regulation of mitotic cell cycle] GO:0008285 [negative regulation of cell proliferation] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016604 [nuclear body] GO:0019912 [cyclin-dependent protein kinase activating kinase activity] GO:0030308 [negative regulation of cell growth] GO:0031625 [ubiquitin protein ligase binding] GO:0031668 [cellular response to extracellular stimulus] GO:0034198 [cellular response to amino acid starvation] GO:0042326 [negative regulation of phosphorylation] GO:0043234 [protein complex] GO:0045860 [positive regulation of protein kinase activity] GO:0046872 [metal ion binding] GO:0048146 [positive regulation of fibroblast proliferation] GO:0050821 [protein stabilization] GO:0070557 [PCNA-p21 complex] GO:0071479 [cellular response to ionizing radiation] GO:0071493 [cellular response to UV-B] GO:0072331 [signal transduction by p53 class mediator] GO:0090398 [cellular senescence] GO:0090400 [stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1904031 [positive regulation of cyclin-dependent protein kinase activity] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
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