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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for data imported from The Genotype-Tissue Expression project (GTEX), FANTOM5 Consortium (FANTOM5) and internally generated Human Protein Atlas (HPA) data.
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expressioni
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Cytoplasmic and nuclear expression in most tissues.
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability descriptioni
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining mainly consistent with RNA expression data.
Reliability scorei
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Below is an overview of RNA and protein expression data generated in the Human Protein Atlas project. Analyzed tissues are divided into color-coded groups according to which functional features they have in common. For each group, a list of included tissues is accessed by clicking on group name, group symbol, RNA bar, or protein bar. Subsequent selection of a particular tissue in this list links to the image data page.
Images of selected tissues give a visual summary of the protein expression profile furthest to the right.
The gray human body provides links to a histology dictionary when clicking on any part of the figure.
RNA expression (TPM)i
RNA-seq results generated in HPA are reported as number of transcripts per million (TPM). Each bar represents the highest expression score found in a particular group of tissues. The assay is described more in detail in Assays & Annotation.
Protein expression (score)i
Each bar represents the highest expression score found in a particular group of tissues. Protein expression scores are based on a best estimate of the "true" protein expression from a knowledge-based annotation, described more in detail under Assays & annotation. For genes where more than one antibody has been used, a collective score is set displaying the estimated true protein expression.
Protein expression data is shown for each of the 44 tissues. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. Mouse-over function shows protein score for analyzed cell types in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation.
For genes with available protein data for which a knowledge-based annotation gave inconclusive results, no protein expression data is displayed in the protein expression data overview. However, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Organ
Expression
Alphabetical
RNA EXPRESSION OVERVIEWi
RNA expression overview shows RNA-data from three different sources: Internally generated Human Protein Atlas (HPA) RNA-seq data, RNA-seq data from the Genotype-Tissue Expression (GTEx) project and CAGE data from FANTOM5 project. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.
HPA dataseti
HPA dataset RNA-seq tissue data is reported as mean TPM (transcripts per million), corresponding to mean values of the different individual samples from each tissue. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar. The RNA-seq assay is described in detail in Assays & Annotation.
RNA tissue category HPA HPA RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataseti
GTEx dataset RNA-seq data is reported as median RPKM (reads per kilobase per million mapped reads), generated by the Genotype-Tissue Expression (GTEx) project. More information can be found in Assays & Annotation.
RNA tissue category GTEx GTEx RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataseti
FANTOM5 dataset Tissue data obtained through Cap Analysis of Gene Expression (CAGE) are reported as Tags Per Million, generated by the FANTOM5 project. More information can be found in Assays & Annotation.
RNA tissue category FANTOM5 FANTOM5 RNA tissue category (category description) is calculated based on gene expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
PARK7 (HGNC Symbol)
Synonyms
DJ-1, DJ1
Description
Parkinsonism associated deglycase (HGNC Symbol)
Entrez gene summary
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
PARK7-001
PARK7-002
PARK7-003
PARK7-004
PARK7-005
PARK7-006
PARK7-010
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q99497 [Direct mapping] Protein deglycase DJ-1 V9HWC2 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 67p
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Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0002866 [positive regulation of acute inflammatory response to antigenic stimulus] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0005102 [receptor binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0006469 [negative regulation of protein kinase activity] GO:0006508 [proteolysis] GO:0006517 [protein deglycosylation] GO:0006914 [autophagy] GO:0006954 [inflammatory response] GO:0007005 [mitochondrion organization] GO:0007265 [Ras protein signal transduction] GO:0007338 [single fertilization] GO:0008134 [transcription factor binding] GO:0008233 [peptidase activity] GO:0009438 [methylglyoxal metabolic process] GO:0010273 [detoxification of copper ion] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016020 [membrane] GO:0016532 [superoxide dismutase copper chaperone activity] GO:0016605 [PML body] GO:0016684 [oxidoreductase activity, acting on peroxide as acceptor] GO:0016787 [hydrolase activity] GO:0019249 [lactate biosynthetic process] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019955 [cytokine binding] GO:0030424 [axon] GO:0031397 [negative regulation of protein ubiquitination] GO:0032091 [negative regulation of protein binding] GO:0032148 [activation of protein kinase B activity] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032757 [positive regulation of interleukin-8 production] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0033234 [negative regulation of protein sumoylation] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034599 [cellular response to oxidative stress] GO:0036470 [tyrosine 3-monooxygenase activator activity] GO:0036471 [cellular response to glyoxal] GO:0036478 [L-dopa decarboxylase activator activity] GO:0036524 [protein deglycase activity] GO:0036525 [protein deglycation] GO:0036526 [peptidyl-cysteine deglycation] GO:0036527 [peptidyl-arginine deglycation] GO:0036528 [peptidyl-lysine deglycation] GO:0036529 [protein deglycation, glyoxal removal] GO:0036530 [protein deglycation, methylglyoxal removal] GO:0036531 [glutathione deglycation] GO:0042743 [hydrogen peroxide metabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043523 [regulation of neuron apoptotic process] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044388 [small protein activating enzyme binding] GO:0044390 [ubiquitin-like protein conjugating enzyme binding] GO:0045121 [membrane raft] GO:0045296 [cadherin binding] GO:0045340 [mercury ion binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046295 [glycolate biosynthetic process] GO:0046826 [negative regulation of protein export from nucleus] GO:0048471 [perinuclear region of cytoplasm] GO:0050681 [androgen receptor binding] GO:0050727 [regulation of inflammatory response] GO:0050787 [detoxification of mercury ion] GO:0050821 [protein stabilization] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051444 [negative regulation of ubiquitin-protein transferase activity] GO:0051881 [regulation of mitochondrial membrane potential] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060548 [negative regulation of cell death] GO:0060765 [regulation of androgen receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0070301 [cellular response to hydrogen peroxide] GO:0070491 [repressing transcription factor binding] GO:0090073 [positive regulation of protein homodimerization activity] GO:0097110 [scaffold protein binding] GO:0098793 [presynapse] GO:0098869 [cellular oxidant detoxification] GO:1900182 [positive regulation of protein localization to nucleus] GO:1901215 [negative regulation of neuron death] GO:1901671 [positive regulation of superoxide dismutase activity] GO:1901984 [negative regulation of protein acetylation] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1902903 [regulation of supramolecular fiber organization] GO:1902958 [positive regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903073 [negative regulation of death-inducing signaling complex assembly] GO:1903094 [negative regulation of protein K48-linked deubiquitination] GO:1903122 [negative regulation of TRAIL-activated apoptotic signaling pathway] GO:1903135 [cupric ion binding] GO:1903136 [cuprous ion binding] GO:1903168 [positive regulation of pyrroline-5-carboxylate reductase activity] GO:1903178 [positive regulation of tyrosine 3-monooxygenase activity] GO:1903181 [positive regulation of dopamine biosynthetic process] GO:1903189 [glyoxal metabolic process] GO:1903197 [positive regulation of L-dopa biosynthetic process] GO:1903200 [positive regulation of L-dopa decarboxylase activity] GO:1903202 [negative regulation of oxidative stress-induced cell death] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:1903208 [negative regulation of hydrogen peroxide-induced neuron death] GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway] GO:1903384 [negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway] GO:1903599 [positive regulation of mitophagy] GO:1905259 [negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway] GO:1990381 [ubiquitin-specific protease binding] GO:2000157 [negative regulation of ubiquitin-specific protease activity] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2000825 [positive regulation of androgen receptor activity] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
The Human Protein Atlas project is funded
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