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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
TCGA (cancer tissue):
Expressed in all
HPA (cell line):
Expressed in all
HPA (normal tissue):
Expressed in all
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expression normal tissuei
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining mainly consistent with RNA expression data.
Reliability score - normal tissuesi
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEWi
RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from.
Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
For each cancer, color-coded bars indicate the percentage of patients (maximum 12 patients) with high and medium protein expression level. The cancer types are color-coded according to which type of normal organ the cancer originates from. Low or not detected protein expression results in a white bar. Mouse-over function shows details about expression level and normal tissue of origin. The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies.
Several colorectal cancers as well as a few cases of ovarian, liver and urothelial cancers displayed moderate immunoreactivity. Most remaining cancer tissues were weakly stained or negative.
Most cancer tissues displayed weak nuclear and cytoplasmic positivity. Thyroid cancers, few cases of carcinoid, breast and testis cancer displayed moderate staining. Majority of endometrial, liver, lung, renal, skin, stomach and pancreas cancers were negative.
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
MAPK14 (HGNC Symbol)
Synonyms
CSBP1, CSBP2, CSPB1, Mxi2, p38, PRKM14, PRKM15
Description
Mitogen-activated protein kinase 14 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
MAPK14-001
MAPK14-002
MAPK14-003
MAPK14-004
MAPK14-007
MAPK14-201
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q16539 [Direct mapping] Mitogen-activated protein kinase 14 L7RSM2 [Target identity:100%; Query identity:100%] Mitogen-activated protein kinase
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Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000077 [DNA damage checkpoint] GO:0000166 [nucleotide binding] GO:0000187 [activation of MAPK activity] GO:0000902 [cell morphogenesis] GO:0000922 [spindle pole] GO:0001502 [cartilage condensation] GO:0001525 [angiogenesis] GO:0001890 [placenta development] GO:0002062 [chondrocyte differentiation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004707 [MAP kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005623 [cell] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006006 [glucose metabolic process] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006928 [movement of cell or subcellular component] GO:0006935 [chemotaxis] GO:0006974 [cellular response to DNA damage stimulus] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway] GO:0007265 [Ras protein signal transduction] GO:0007519 [skeletal muscle tissue development] GO:0010628 [positive regulation of gene expression] GO:0010831 [positive regulation of myotube differentiation] GO:0014835 [myoblast differentiation involved in skeletal muscle regeneration] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016607 [nuclear speck] GO:0016740 [transferase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0019903 [protein phosphatase binding] GO:0030278 [regulation of ossification] GO:0030316 [osteoclast differentiation] GO:0031281 [positive regulation of cyclase activity] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0032495 [response to muramyl dipeptide] GO:0032496 [response to lipopolysaccharide] GO:0034774 [secretory granule lumen] GO:0035556 [intracellular signal transduction] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0035994 [response to muscle stretch] GO:0038066 [p38MAPK cascade] GO:0042307 [positive regulation of protein import into nucleus] GO:0042770 [signal transduction in response to DNA damage] GO:0043312 [neutrophil degranulation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045663 [positive regulation of myoblast differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046326 [positive regulation of glucose import] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] GO:0051146 [striated muscle cell differentiation] GO:0051149 [positive regulation of muscle cell differentiation] GO:0051525 [NFAT protein binding] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0070062 [extracellular exosome] GO:0070935 [3'-UTR-mediated mRNA stabilization] GO:0071222 [cellular response to lipopolysaccharide] GO:0071479 [cellular response to ionizing radiation] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0090336 [positive regulation of brown fat cell differentiation] GO:0090400 [stress-induced premature senescence] GO:0098586 [cellular response to virus] GO:1900015 [regulation of cytokine production involved in inflammatory response] GO:1901741 [positive regulation of myoblast fusion] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1904813 [ficolin-1-rich granule lumen] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2001184 [positive regulation of interleukin-12 secretion]
Q16539 [Direct mapping] Mitogen-activated protein kinase 14 A0A024RD15 [Target identity:100%; Query identity:100%] Mitogen-activated protein kinase
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Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0000187 [activation of MAPK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004707 [MAP kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006928 [movement of cell or subcellular component] GO:0006935 [chemotaxis] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007265 [Ras protein signal transduction] GO:0010628 [positive regulation of gene expression] GO:0010831 [positive regulation of myotube differentiation] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016607 [nuclear speck] GO:0016740 [transferase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0019899 [enzyme binding] GO:0019903 [protein phosphatase binding] GO:0030316 [osteoclast differentiation] GO:0031281 [positive regulation of cyclase activity] GO:0034774 [secretory granule lumen] GO:0035556 [intracellular signal transduction] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038066 [p38MAPK cascade] GO:0042770 [signal transduction in response to DNA damage] GO:0043312 [neutrophil degranulation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045663 [positive regulation of myoblast differentiation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] GO:0051149 [positive regulation of muscle cell differentiation] GO:0051525 [NFAT protein binding] GO:0070062 [extracellular exosome] GO:0070935 [3'-UTR-mediated mRNA stabilization] GO:0071222 [cellular response to lipopolysaccharide] GO:0071479 [cellular response to ionizing radiation] GO:0090400 [stress-induced premature senescence] GO:0098586 [cellular response to virus] GO:1900015 [regulation of cytokine production involved in inflammatory response] GO:1901741 [positive regulation of myoblast fusion] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1904813 [ficolin-1-rich granule lumen] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2001184 [positive regulation of interleukin-12 secretion]
Q16539 [Direct mapping] Mitogen-activated protein kinase 14
Show all
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0000187 [activation of MAPK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004707 [MAP kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006928 [movement of cell or subcellular component] GO:0006935 [chemotaxis] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007265 [Ras protein signal transduction] GO:0010628 [positive regulation of gene expression] GO:0010831 [positive regulation of myotube differentiation] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016607 [nuclear speck] GO:0016740 [transferase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0019899 [enzyme binding] GO:0019903 [protein phosphatase binding] GO:0030316 [osteoclast differentiation] GO:0031281 [positive regulation of cyclase activity] GO:0034774 [secretory granule lumen] GO:0035556 [intracellular signal transduction] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038066 [p38MAPK cascade] GO:0042770 [signal transduction in response to DNA damage] GO:0043312 [neutrophil degranulation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045663 [positive regulation of myoblast differentiation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] GO:0051149 [positive regulation of muscle cell differentiation] GO:0051525 [NFAT protein binding] GO:0070062 [extracellular exosome] GO:0070935 [3'-UTR-mediated mRNA stabilization] GO:0071222 [cellular response to lipopolysaccharide] GO:0071479 [cellular response to ionizing radiation] GO:0090400 [stress-induced premature senescence] GO:0098586 [cellular response to virus] GO:1900015 [regulation of cytokine production involved in inflammatory response] GO:1901741 [positive regulation of myoblast fusion] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1904813 [ficolin-1-rich granule lumen] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2001184 [positive regulation of interleukin-12 secretion]
The Human Protein Atlas project is funded
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