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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
TCGA (cancer tissue):
Expressed in all
HPA (cell line):
Mixed
HPA (normal tissue):
Mixed
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expression normal tissuei
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
General nuclear expression, distinct expression in epididymis, testis and lymphoid tissue.
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability descriptioni
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining mainly consistent with RNA expression data.
Reliability score - normal tissuesi
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from.
Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
For each cancer, color-coded bars indicate the percentage of patients (maximum 12 patients) with high and medium protein expression level. The cancer types are color-coded according to which type of normal organ the cancer originates from. Low or not detected protein expression results in a white bar. Mouse-over function shows details about expression level and normal tissue of origin. The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies.
Most malignant cells showed moderate to strong nuclear and cytoplasmic positivity.
Moderate to strong nuclear immunoreactivity was observed in most malignant tissues. A majority of liver- and renal cancers were negative.
Most malignancies displayed weak to moderate nuclear positivity.
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
DAXX (HGNC Symbol)
Synonyms
DAP6
Description
Death domain associated protein (HGNC Symbol)
Entrez gene summary
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
DAXX-001
DAXX-002
DAXX-005
DAXX-007
DAXX-011
DAXX-201
DAXX-202
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q9UER7 [Direct mapping] Death domain-associated protein 6 A0A024RCS3 [Target identity:100%; Query identity:100%] Death-associated protein 6, isoform CRA_a
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Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000775 [chromosome, centromeric region] GO:0001934 [positive regulation of protein phosphorylation] GO:0002039 [p53 binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0005057 [signal transducer activity, downstream of receptor] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006334 [nucleosome assembly] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0007257 [activation of JUN kinase activity] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0016032 [viral process] GO:0016569 [covalent chromatin modification] GO:0016604 [nuclear body] GO:0016605 [PML body] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0030295 [protein kinase activator activity] GO:0030521 [androgen receptor signaling pathway] GO:0031072 [heat shock protein binding] GO:0031396 [regulation of protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0034605 [cellular response to heat] GO:0034620 [cellular response to unfolded protein] GO:0042393 [histone binding] GO:0045860 [positive regulation of protein kinase activity] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0047485 [protein N-terminus binding] GO:0050681 [androgen receptor binding] GO:0070603 [SWI/SNF superfamily-type complex] GO:0071276 [cellular response to cadmium ion] GO:0071280 [cellular response to copper ion] GO:0072738 [cellular response to diamide] GO:1901216 [positive regulation of neuron death] GO:1903936 [cellular response to sodium arsenite]
Q9UER7 [Direct mapping] Death domain-associated protein 6
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Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000775 [chromosome, centromeric region] GO:0001934 [positive regulation of protein phosphorylation] GO:0002039 [p53 binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0005057 [signal transducer activity, downstream of receptor] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006334 [nucleosome assembly] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0007257 [activation of JUN kinase activity] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0016032 [viral process] GO:0016569 [covalent chromatin modification] GO:0016604 [nuclear body] GO:0016605 [PML body] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0030295 [protein kinase activator activity] GO:0030521 [androgen receptor signaling pathway] GO:0031072 [heat shock protein binding] GO:0031396 [regulation of protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0034605 [cellular response to heat] GO:0034620 [cellular response to unfolded protein] GO:0042393 [histone binding] GO:0045860 [positive regulation of protein kinase activity] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0047485 [protein N-terminus binding] GO:0050681 [androgen receptor binding] GO:0070603 [SWI/SNF superfamily-type complex] GO:0071276 [cellular response to cadmium ion] GO:0071280 [cellular response to copper ion] GO:0072738 [cellular response to diamide] GO:1901216 [positive regulation of neuron death] GO:1903936 [cellular response to sodium arsenite]
The Human Protein Atlas project is funded
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