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NTRK1
GENERAL INFORMATION
Gene namei NTRK1
Gene descriptioni Neurotrophic receptor tyrosine kinase 1
Protein classi Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Predicted membrane proteins
Predicted localizationi Membrane
Number of transcriptsi 4
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HUMAN PROTEIN ATLAS INFORMATION
RNA categoryi
TCGA (cancer tissue):Tissue enhanced (glioma)
HPA (cell line):Cell line enhanced (HDLM-2, HEL, HMC-1, SH-SY5Y)
HPA (normal tissue):Tissue enriched (adrenal gland)
Protein evidencei Evidence at protein level
Protein expression
normal tissuei		 Cytoplasmic expression in several tissues, including neuronal cells in CNS.

IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability
descriptioni		 Antibody staining not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score -
normal tissuesi
Approved
Antibodiesi HPA035799 , CAB004606
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PROGNOSTIC SUMMARYi
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEWi
TCGA dataseti
RNA cancer category: Tissue enhanced (glioma)
PROTEIN EXPRESSIONi
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer
PROTEIN EXPRESSION SUMMARYi
Organ
Expression
Alphabetical
HPA035799
CAB004606
GENE INFORMATIONi
Gene name NTRK1 (HGNC Symbol)
Synonyms MTC, TRK, TRKA
Description Neurotrophic receptor tyrosine kinase 1 (HGNC Symbol)
Entrez gene summary This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
Chromosome 1
Cytoband q23.1
Chromosome location (bp) 156815640 - 156881850
Protein evidence Evidence at protein level (all genes)
Ensembl ENSG00000198400 (version 88.38)
Entrez gene 4914
UniProt P04629 (UniProt - Evidence at protein level)
neXtProt NX_P04629
Antibodypedia NTRK1 antibodies
PROTEIN BROWSERi
NTRK1-001
NTRK1-004
NTRK1-006
NTRK1-007
PROTEIN INFORMATIONi
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
NTRK1-001
ENSP00000357179
ENST00000368196
P04629 [Direct mapping]
High affinity nerve growth factor receptor
X5DR71 [Target identity:100%; Query identity:100%]
Tyrosine-protein kinase receptor
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000186 [activation of MAPKK activity]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005030 [neurotrophin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007018 [microtubule-based movement]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007275 [multicellular organism development]
GO:0007399 [nervous system development]
GO:0008285 [negative regulation of cell proliferation]
GO:0010465 [nerve growth factor receptor activity]
GO:0010623 [programmed cell death involved in cell development]
GO:0010976 [positive regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030154 [cell differentiation]
GO:0031901 [early endosome membrane]
GO:0031902 [late endosome membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038179 [neurotrophin signaling pathway]
GO:0038180 [nerve growth factor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043068 [positive regulation of programmed cell death]
GO:0043121 [neurotrophin binding]
GO:0043234 [protein complex]
GO:0043235 [receptor complex]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0046777 [protein autophosphorylation]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048406 [nerve growth factor binding]
GO:0048485 [sympathetic nervous system development]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060385 [axonogenesis involved in innervation]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:1990090 [cellular response to nerve growth factor stimulus]
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 790 aa
86.9 kDa 		Yes 1
NTRK1-004
ENSP00000376120
ENST00000392302
P04629 [Direct mapping]
High affinity nerve growth factor receptor
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000186 [activation of MAPKK activity]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005030 [neurotrophin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007018 [microtubule-based movement]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007275 [multicellular organism development]
GO:0007399 [nervous system development]
GO:0008285 [negative regulation of cell proliferation]
GO:0010465 [nerve growth factor receptor activity]
GO:0010623 [programmed cell death involved in cell development]
GO:0010976 [positive regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030154 [cell differentiation]
GO:0031901 [early endosome membrane]
GO:0031902 [late endosome membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038180 [nerve growth factor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043068 [positive regulation of programmed cell death]
GO:0043121 [neurotrophin binding]
GO:0043234 [protein complex]
GO:0043235 [receptor complex]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0046777 [protein autophosphorylation]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048406 [nerve growth factor binding]
GO:0048485 [sympathetic nervous system development]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060385 [axonogenesis involved in innervation]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:1990090 [cellular response to nerve growth factor stimulus]
Show all
 760 aa
84 kDa 		Yes 1
NTRK1-006
ENSP00000351486
ENST00000358660
J3KP20 [Direct mapping]
Tyrosine-protein kinase receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005030 [neurotrophin receptor activity]
GO:0005524 [ATP binding]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0038179 [neurotrophin signaling pathway]
Show all
 793 aa
87.1 kDa 		Yes 1
NTRK1-007
ENSP00000431418
ENST00000524377
P04629 [Direct mapping]
High affinity nerve growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000186 [activation of MAPKK activity]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005004 [GPI-linked ephrin receptor activity]
GO:0005030 [neurotrophin receptor activity]
GO:0005166 [neurotrophin p75 receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007018 [microtubule-based movement]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007275 [multicellular organism development]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007568 [aging]
GO:0007611 [learning or memory]
GO:0007623 [circadian rhythm]
GO:0008285 [negative regulation of cell proliferation]
GO:0009314 [response to radiation]
GO:0009986 [cell surface]
GO:0010465 [nerve growth factor receptor activity]
GO:0010623 [programmed cell death involved in cell development]
GO:0010976 [positive regulation of neuron projection development]
GO:0014823 [response to activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019233 [sensory perception of pain]
GO:0019900 [kinase binding]
GO:0021553 [olfactory nerve development]
GO:0030154 [cell differentiation]
GO:0030183 [B cell differentiation]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031410 [cytoplasmic vesicle]
GO:0031667 [response to nutrient levels]
GO:0031901 [early endosome membrane]
GO:0031902 [late endosome membrane]
GO:0035094 [response to nicotine]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038180 [nerve growth factor signaling pathway]
GO:0042490 [mechanoreceptor differentiation]
GO:0042493 [response to drug]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0043068 [positive regulation of programmed cell death]
GO:0043121 [neurotrophin binding]
GO:0043234 [protein complex]
GO:0043235 [receptor complex]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045471 [response to ethanol]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0046777 [protein autophosphorylation]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048406 [nerve growth factor binding]
GO:0048485 [sympathetic nervous system development]
GO:0048678 [response to axon injury]
GO:0050965 [detection of temperature stimulus involved in sensory perception of pain]
GO:0050966 [detection of mechanical stimulus involved in sensory perception of pain]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051599 [response to hydrostatic pressure]
GO:0051602 [response to electrical stimulus]
GO:0051965 [positive regulation of synapse assembly]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060009 [Sertoli cell development]
GO:0060384 [innervation]
GO:0060385 [axonogenesis involved in innervation]
GO:0061368 [behavioral response to formalin induced pain]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071316 [cellular response to nicotine]
GO:0071363 [cellular response to growth factor stimulus]
GO:1901215 [negative regulation of neuron death]
GO:1990090 [cellular response to nerve growth factor stimulus]
Show all
 796 aa
87.5 kDa 		Yes 1

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.