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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
TCGA (cancer tissue):
Tissue enhanced (liver cancer)
HPA (cell line):
Cell line enhanced (Hep G2, PC-3, SCLC-21H, SH-SY5Y, TIME)
HPA (normal tissue):
Tissue enhanced (liver)
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Reliability score - normal tissuesi
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEWi
RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from.
RNA cancer category: Tissue enhanced (liver cancer)
PROTEIN EXPRESSIONi
Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
RELN (HGNC Symbol)
Synonyms
PRO1598, RL
Description
Reelin (HGNC Symbol)
Entrez gene summary
This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
RELN-001
RELN-002
RELN-009
RELN-201
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000904 [cell morphogenesis involved in differentiation] GO:0001764 [neuron migration] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007155 [cell adhesion] GO:0007275 [multicellular organism development] GO:0007411 [axon guidance] GO:0007417 [central nervous system development] GO:0007420 [brain development] GO:0007612 [learning] GO:0007616 [long-term memory] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0008306 [associative learning] GO:0010001 [glial cell differentiation] GO:0010468 [regulation of gene expression] GO:0010976 [positive regulation of neuron projection development] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016358 [dendrite development] GO:0016477 [cell migration] GO:0016787 [hydrolase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0021511 [spinal cord patterning] GO:0021517 [ventral spinal cord development] GO:0021766 [hippocampus development] GO:0021800 [cerebral cortex tangential migration] GO:0021819 [layer formation in cerebral cortex] GO:0021987 [cerebral cortex development] GO:0030425 [dendrite] GO:0030900 [forebrain development] GO:0032008 [positive regulation of TOR signaling] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0035418 [protein localization to synapse] GO:0038026 [reelin-mediated signaling pathway] GO:0045860 [positive regulation of protein kinase activity] GO:0046872 [metal ion binding] GO:0048265 [response to pain] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050795 [regulation of behavior] GO:0050804 [modulation of synaptic transmission] GO:0051057 [positive regulation of small GTPase mediated signal transduction] GO:0051968 [positive regulation of synaptic transmission, glutamatergic] GO:0060291 [long-term synaptic potentiation] GO:0061003 [positive regulation of dendritic spine morphogenesis] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0070325 [lipoprotein particle receptor binding] GO:0070326 [very-low-density lipoprotein particle receptor binding] GO:0090129 [positive regulation of synapse maturation] GO:0097114 [NMDA glutamate receptor clustering] GO:0097119 [postsynaptic density protein 95 clustering] GO:0097120 [receptor localization to synapse] GO:0097477 [lateral motor column neuron migration] GO:1900273 [positive regulation of long-term synaptic potentiation] GO:1902078 [positive regulation of lateral motor column neuron migration] GO:2000310 [regulation of NMDA receptor activity] GO:2000463 [positive regulation of excitatory postsynaptic potential] GO:2000969 [positive regulation of AMPA receptor activity]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000904 [cell morphogenesis involved in differentiation] GO:0001764 [neuron migration] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007155 [cell adhesion] GO:0007275 [multicellular organism development] GO:0007411 [axon guidance] GO:0007417 [central nervous system development] GO:0007420 [brain development] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0010001 [glial cell differentiation] GO:0010976 [positive regulation of neuron projection development] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0021511 [spinal cord patterning] GO:0021766 [hippocampus development] GO:0021800 [cerebral cortex tangential migration] GO:0030425 [dendrite] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0038026 [reelin-mediated signaling pathway] GO:0045860 [positive regulation of protein kinase activity] GO:0046872 [metal ion binding] GO:0048265 [response to pain] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050795 [regulation of behavior] GO:0050804 [modulation of synaptic transmission] GO:0051057 [positive regulation of small GTPase mediated signal transduction] GO:0051968 [positive regulation of synaptic transmission, glutamatergic] GO:0061003 [positive regulation of dendritic spine morphogenesis] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0070325 [lipoprotein particle receptor binding] GO:0070326 [very-low-density lipoprotein particle receptor binding] GO:0090129 [positive regulation of synapse maturation] GO:1900273 [positive regulation of long-term synaptic potentiation] GO:2000310 [regulation of NMDA receptor activity] GO:2000463 [positive regulation of excitatory postsynaptic potential] GO:2000969 [positive regulation of AMPA receptor activity]