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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
TCGA (cancer tissue):
Group enriched (breast cancer, glioma, prostate cancer, renal cancer)
HPA (cell line):
Cell line enhanced (HDLM-2, SCLC-21H, T-47d)
HPA (normal tissue):
Tissue enriched (cerebral cortex)
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expression normal tissuei
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Cytoplasmic expression mainly in CNS, peripheral nerves and renal tubules.
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability descriptioni
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining mainly consistent with RNA expression data.
Reliability score - normal tissuesi
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEWi
RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from.
RNA cancer category: Group enriched (breast cancer, glioma, prostate cancer, renal cancer)
PROTEIN EXPRESSIONi
Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
For each cancer, color-coded bars indicate the percentage of patients (maximum 12 patients) with high and medium protein expression level. The cancer types are color-coded according to which type of normal organ the cancer originates from. Low or not detected protein expression results in a white bar. Mouse-over function shows details about expression level and normal tissue of origin. The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies.
Several renal cancers together with a few melanomas and breast cancers showed moderate to strong cytoplasmic positivity. Most remaining tissues were negative.
A large subset of cancer tissues showed weak to moderate cytoplasmic positivity. Strong staining in several renal cancers and melanomas. Moderate to strong immunoreactivity in nucleoli of few melanomas, skin and testis cancers, and in luminal membranes of mainly colorectal cancers.
Moderate cytoplasmic positivity was displayed in most gliomas, carcinoids, breast and renal cancers. Most remaining cancer tissues were weakly stained or negative.
Moderate to strong cytoplasmic positivity was observed in several cases of a majority of cancers, including gliomas, breast , pancreatic and colorectal cancers. All lymphoma, testis and thryoid cancers were negative.
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P10636 [Direct mapping] Microtubule-associated protein tau
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Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
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GO:0000226 [microtubule cytoskeleton organization] GO:0001774 [microglial cell activation] GO:0003677 [DNA binding] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007613 [memory] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0010917 [negative regulation of mitochondrial membrane potential] GO:0015631 [tubulin binding] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0017124 [SH3 domain binding] GO:0019896 [axonal transport of mitochondrion] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0031122 [cytoplasmic microtubule organization] GO:0031175 [neuron projection development] GO:0032930 [positive regulation of superoxide anion generation] GO:0033673 [negative regulation of kinase activity] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0034452 [dynactin binding] GO:0034605 [cellular response to heat] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0036477 [somatodendritic compartment] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0044297 [cell body] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048018 [receptor agonist activity] GO:0048143 [astrocyte activation] GO:0048312 [intracellular distribution of mitochondria] GO:0048699 [generation of neurons] GO:0050808 [synapse organization] GO:0050848 [regulation of calcium-mediated signaling] GO:0051259 [protein oligomerization] GO:0051721 [protein phosphatase 2A binding] GO:0051879 [Hsp90 protein binding] GO:0071813 [lipoprotein particle binding] GO:0072386 [plus-end-directed organelle transport along microtubule] GO:0090140 [regulation of mitochondrial fission] GO:0090258 [negative regulation of mitochondrial fission] GO:0097418 [neurofibrillary tangle] GO:0098930 [axonal transport] GO:1900034 [regulation of cellular response to heat] GO:1901216 [positive regulation of neuron death] GO:1902474 [positive regulation of protein localization to synapse] GO:1902988 [neurofibrillary tangle assembly] GO:1903748 [negative regulation of establishment of protein localization to mitochondrion] GO:1904115 [axon cytoplasm] GO:1905689 [positive regulation of diacylglycerol kinase activity] GO:2001020 [regulation of response to DNA damage stimulus]
P10636 [Direct mapping] Microtubule-associated protein tau A0A024R9Y0 [Target identity:100%; Query identity:100%] Microtubule-associated protein
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Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
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GO:0000226 [microtubule cytoskeleton organization] GO:0001774 [microglial cell activation] GO:0003677 [DNA binding] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007613 [memory] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0010917 [negative regulation of mitochondrial membrane potential] GO:0015631 [tubulin binding] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0017124 [SH3 domain binding] GO:0019896 [axonal transport of mitochondrion] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0031122 [cytoplasmic microtubule organization] GO:0031175 [neuron projection development] GO:0032930 [positive regulation of superoxide anion generation] GO:0033673 [negative regulation of kinase activity] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0034452 [dynactin binding] GO:0034605 [cellular response to heat] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0036477 [somatodendritic compartment] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0044297 [cell body] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048018 [receptor agonist activity] GO:0048143 [astrocyte activation] GO:0048312 [intracellular distribution of mitochondria] GO:0048699 [generation of neurons] GO:0050808 [synapse organization] GO:0050848 [regulation of calcium-mediated signaling] GO:0051259 [protein oligomerization] GO:0051721 [protein phosphatase 2A binding] GO:0051879 [Hsp90 protein binding] GO:0071813 [lipoprotein particle binding] GO:0072386 [plus-end-directed organelle transport along microtubule] GO:0090140 [regulation of mitochondrial fission] GO:0090258 [negative regulation of mitochondrial fission] GO:0097418 [neurofibrillary tangle] GO:0098930 [axonal transport] GO:1900034 [regulation of cellular response to heat] GO:1901216 [positive regulation of neuron death] GO:1902474 [positive regulation of protein localization to synapse] GO:1902988 [neurofibrillary tangle assembly] GO:1903748 [negative regulation of establishment of protein localization to mitochondrion] GO:1904115 [axon cytoplasm] GO:1905689 [positive regulation of diacylglycerol kinase activity] GO:2001020 [regulation of response to DNA damage stimulus]
P10636 [Direct mapping] Microtubule-associated protein tau
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Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization] GO:0001774 [microglial cell activation] GO:0003677 [DNA binding] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007613 [memory] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0010917 [negative regulation of mitochondrial membrane potential] GO:0015631 [tubulin binding] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0017124 [SH3 domain binding] GO:0019896 [axonal transport of mitochondrion] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0031122 [cytoplasmic microtubule organization] GO:0031175 [neuron projection development] GO:0032930 [positive regulation of superoxide anion generation] GO:0033673 [negative regulation of kinase activity] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0034452 [dynactin binding] GO:0034605 [cellular response to heat] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0036477 [somatodendritic compartment] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0044297 [cell body] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048018 [receptor agonist activity] GO:0048143 [astrocyte activation] GO:0048312 [intracellular distribution of mitochondria] GO:0048699 [generation of neurons] GO:0050808 [synapse organization] GO:0050848 [regulation of calcium-mediated signaling] GO:0051259 [protein oligomerization] GO:0051721 [protein phosphatase 2A binding] GO:0051879 [Hsp90 protein binding] GO:0071813 [lipoprotein particle binding] GO:0072386 [plus-end-directed organelle transport along microtubule] GO:0090140 [regulation of mitochondrial fission] GO:0090258 [negative regulation of mitochondrial fission] GO:0097418 [neurofibrillary tangle] GO:0098930 [axonal transport] GO:1900034 [regulation of cellular response to heat] GO:1901216 [positive regulation of neuron death] GO:1902474 [positive regulation of protein localization to synapse] GO:1902988 [neurofibrillary tangle assembly] GO:1903748 [negative regulation of establishment of protein localization to mitochondrion] GO:1904115 [axon cytoplasm] GO:1905689 [positive regulation of diacylglycerol kinase activity] GO:2001020 [regulation of response to DNA damage stimulus]
P10636 [Direct mapping] Microtubule-associated protein tau
Show all
Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization] GO:0001774 [microglial cell activation] GO:0003677 [DNA binding] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007613 [memory] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0010917 [negative regulation of mitochondrial membrane potential] GO:0015631 [tubulin binding] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0017124 [SH3 domain binding] GO:0019896 [axonal transport of mitochondrion] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0031122 [cytoplasmic microtubule organization] GO:0031175 [neuron projection development] GO:0032930 [positive regulation of superoxide anion generation] GO:0033673 [negative regulation of kinase activity] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0034452 [dynactin binding] GO:0034605 [cellular response to heat] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0036477 [somatodendritic compartment] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0044297 [cell body] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048018 [receptor agonist activity] GO:0048143 [astrocyte activation] GO:0048312 [intracellular distribution of mitochondria] GO:0048699 [generation of neurons] GO:0050808 [synapse organization] GO:0050848 [regulation of calcium-mediated signaling] GO:0051259 [protein oligomerization] GO:0051721 [protein phosphatase 2A binding] GO:0051879 [Hsp90 protein binding] GO:0071813 [lipoprotein particle binding] GO:0072386 [plus-end-directed organelle transport along microtubule] GO:0090140 [regulation of mitochondrial fission] GO:0090258 [negative regulation of mitochondrial fission] GO:0097418 [neurofibrillary tangle] GO:0098930 [axonal transport] GO:1900034 [regulation of cellular response to heat] GO:1901216 [positive regulation of neuron death] GO:1902474 [positive regulation of protein localization to synapse] GO:1902988 [neurofibrillary tangle assembly] GO:1903748 [negative regulation of establishment of protein localization to mitochondrion] GO:1904115 [axon cytoplasm] GO:1905689 [positive regulation of diacylglycerol kinase activity] GO:2001020 [regulation of response to DNA damage stimulus]
P10636 [Direct mapping] Microtubule-associated protein tau
Show all
Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization] GO:0001774 [microglial cell activation] GO:0003677 [DNA binding] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007613 [memory] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0010917 [negative regulation of mitochondrial membrane potential] GO:0015631 [tubulin binding] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0017124 [SH3 domain binding] GO:0019896 [axonal transport of mitochondrion] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0031122 [cytoplasmic microtubule organization] GO:0031175 [neuron projection development] GO:0032930 [positive regulation of superoxide anion generation] GO:0033673 [negative regulation of kinase activity] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0034452 [dynactin binding] GO:0034605 [cellular response to heat] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0036477 [somatodendritic compartment] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0044297 [cell body] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048018 [receptor agonist activity] GO:0048143 [astrocyte activation] GO:0048312 [intracellular distribution of mitochondria] GO:0048699 [generation of neurons] GO:0050808 [synapse organization] GO:0050848 [regulation of calcium-mediated signaling] GO:0051259 [protein oligomerization] GO:0051721 [protein phosphatase 2A binding] GO:0051879 [Hsp90 protein binding] GO:0071813 [lipoprotein particle binding] GO:0072386 [plus-end-directed organelle transport along microtubule] GO:0090140 [regulation of mitochondrial fission] GO:0090258 [negative regulation of mitochondrial fission] GO:0097418 [neurofibrillary tangle] GO:0098930 [axonal transport] GO:1900034 [regulation of cellular response to heat] GO:1901216 [positive regulation of neuron death] GO:1902474 [positive regulation of protein localization to synapse] GO:1902988 [neurofibrillary tangle assembly] GO:1903748 [negative regulation of establishment of protein localization to mitochondrion] GO:1904115 [axon cytoplasm] GO:1905689 [positive regulation of diacylglycerol kinase activity] GO:2001020 [regulation of response to DNA damage stimulus]
P10636 [Direct mapping] Microtubule-associated protein tau A0A024RA17 [Target identity:100%; Query identity:100%] Microtubule-associated protein
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Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
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GO:0000226 [microtubule cytoskeleton organization] GO:0001774 [microglial cell activation] GO:0003677 [DNA binding] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007613 [memory] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0010917 [negative regulation of mitochondrial membrane potential] GO:0015631 [tubulin binding] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0017124 [SH3 domain binding] GO:0019896 [axonal transport of mitochondrion] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0031122 [cytoplasmic microtubule organization] GO:0031175 [neuron projection development] GO:0032930 [positive regulation of superoxide anion generation] GO:0033673 [negative regulation of kinase activity] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0034452 [dynactin binding] GO:0034605 [cellular response to heat] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0036477 [somatodendritic compartment] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0044297 [cell body] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048018 [receptor agonist activity] GO:0048143 [astrocyte activation] GO:0048312 [intracellular distribution of mitochondria] GO:0048699 [generation of neurons] GO:0050808 [synapse organization] GO:0050848 [regulation of calcium-mediated signaling] GO:0051259 [protein oligomerization] GO:0051721 [protein phosphatase 2A binding] GO:0051879 [Hsp90 protein binding] GO:0071813 [lipoprotein particle binding] GO:0072386 [plus-end-directed organelle transport along microtubule] GO:0090140 [regulation of mitochondrial fission] GO:0090258 [negative regulation of mitochondrial fission] GO:0097418 [neurofibrillary tangle] GO:0098930 [axonal transport] GO:1900034 [regulation of cellular response to heat] GO:1901216 [positive regulation of neuron death] GO:1902474 [positive regulation of protein localization to synapse] GO:1902988 [neurofibrillary tangle assembly] GO:1903748 [negative regulation of establishment of protein localization to mitochondrion] GO:1904115 [axon cytoplasm] GO:1905689 [positive regulation of diacylglycerol kinase activity] GO:2001020 [regulation of response to DNA damage stimulus]
P10636 [Direct mapping] Microtubule-associated protein tau A0A024R9Y1 [Target identity:100%; Query identity:100%] Microtubule-associated protein
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Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
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GO:0000226 [microtubule cytoskeleton organization] GO:0001774 [microglial cell activation] GO:0003677 [DNA binding] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007613 [memory] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0010917 [negative regulation of mitochondrial membrane potential] GO:0015631 [tubulin binding] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0017124 [SH3 domain binding] GO:0019896 [axonal transport of mitochondrion] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0031122 [cytoplasmic microtubule organization] GO:0031175 [neuron projection development] GO:0032930 [positive regulation of superoxide anion generation] GO:0033673 [negative regulation of kinase activity] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0034452 [dynactin binding] GO:0034605 [cellular response to heat] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0036477 [somatodendritic compartment] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0044297 [cell body] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048018 [receptor agonist activity] GO:0048143 [astrocyte activation] GO:0048312 [intracellular distribution of mitochondria] GO:0048699 [generation of neurons] GO:0050808 [synapse organization] GO:0050848 [regulation of calcium-mediated signaling] GO:0051259 [protein oligomerization] GO:0051721 [protein phosphatase 2A binding] GO:0051879 [Hsp90 protein binding] GO:0071813 [lipoprotein particle binding] GO:0072386 [plus-end-directed organelle transport along microtubule] GO:0090140 [regulation of mitochondrial fission] GO:0090258 [negative regulation of mitochondrial fission] GO:0097418 [neurofibrillary tangle] GO:0098930 [axonal transport] GO:1900034 [regulation of cellular response to heat] GO:1901216 [positive regulation of neuron death] GO:1902474 [positive regulation of protein localization to synapse] GO:1902988 [neurofibrillary tangle assembly] GO:1903748 [negative regulation of establishment of protein localization to mitochondrion] GO:1904115 [axon cytoplasm] GO:1905689 [positive regulation of diacylglycerol kinase activity] GO:2001020 [regulation of response to DNA damage stimulus]
P10636 [Direct mapping] Microtubule-associated protein tau A0A024R9Y1 [Target identity:100%; Query identity:100%] Microtubule-associated protein
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Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000226 [microtubule cytoskeleton organization] GO:0001774 [microglial cell activation] GO:0003677 [DNA binding] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007613 [memory] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0010917 [negative regulation of mitochondrial membrane potential] GO:0015631 [tubulin binding] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0017124 [SH3 domain binding] GO:0019896 [axonal transport of mitochondrion] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0031122 [cytoplasmic microtubule organization] GO:0031175 [neuron projection development] GO:0032930 [positive regulation of superoxide anion generation] GO:0033673 [negative regulation of kinase activity] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0034452 [dynactin binding] GO:0034605 [cellular response to heat] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0036477 [somatodendritic compartment] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0044297 [cell body] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048018 [receptor agonist activity] GO:0048143 [astrocyte activation] GO:0048312 [intracellular distribution of mitochondria] GO:0048699 [generation of neurons] GO:0050808 [synapse organization] GO:0050848 [regulation of calcium-mediated signaling] GO:0051259 [protein oligomerization] GO:0051721 [protein phosphatase 2A binding] GO:0051879 [Hsp90 protein binding] GO:0071813 [lipoprotein particle binding] GO:0072386 [plus-end-directed organelle transport along microtubule] GO:0090140 [regulation of mitochondrial fission] GO:0090258 [negative regulation of mitochondrial fission] GO:0097418 [neurofibrillary tangle] GO:0098930 [axonal transport] GO:1900034 [regulation of cellular response to heat] GO:1901216 [positive regulation of neuron death] GO:1902474 [positive regulation of protein localization to synapse] GO:1902988 [neurofibrillary tangle assembly] GO:1903748 [negative regulation of establishment of protein localization to mitochondrion] GO:1904115 [axon cytoplasm] GO:1905689 [positive regulation of diacylglycerol kinase activity] GO:2001020 [regulation of response to DNA damage stimulus]
P10636 [Direct mapping] Microtubule-associated protein tau
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Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization] GO:0001774 [microglial cell activation] GO:0003677 [DNA binding] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007613 [memory] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0010917 [negative regulation of mitochondrial membrane potential] GO:0015631 [tubulin binding] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0017124 [SH3 domain binding] GO:0019896 [axonal transport of mitochondrion] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0031122 [cytoplasmic microtubule organization] GO:0031175 [neuron projection development] GO:0032930 [positive regulation of superoxide anion generation] GO:0033673 [negative regulation of kinase activity] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0034452 [dynactin binding] GO:0034605 [cellular response to heat] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0036477 [somatodendritic compartment] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0044297 [cell body] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048018 [receptor agonist activity] GO:0048143 [astrocyte activation] GO:0048312 [intracellular distribution of mitochondria] GO:0048699 [generation of neurons] GO:0050808 [synapse organization] GO:0050848 [regulation of calcium-mediated signaling] GO:0051259 [protein oligomerization] GO:0051721 [protein phosphatase 2A binding] GO:0051879 [Hsp90 protein binding] GO:0071813 [lipoprotein particle binding] GO:0072386 [plus-end-directed organelle transport along microtubule] GO:0090140 [regulation of mitochondrial fission] GO:0090258 [negative regulation of mitochondrial fission] GO:0097418 [neurofibrillary tangle] GO:0098930 [axonal transport] GO:1900034 [regulation of cellular response to heat] GO:1901216 [positive regulation of neuron death] GO:1902474 [positive regulation of protein localization to synapse] GO:1902988 [neurofibrillary tangle assembly] GO:1903748 [negative regulation of establishment of protein localization to mitochondrion] GO:1904115 [axon cytoplasm] GO:1905689 [positive regulation of diacylglycerol kinase activity] GO:2001020 [regulation of response to DNA damage stimulus]
P10636 [Direct mapping] Microtubule-associated protein tau
Show all
Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization] GO:0001774 [microglial cell activation] GO:0003677 [DNA binding] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007613 [memory] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0010917 [negative regulation of mitochondrial membrane potential] GO:0015631 [tubulin binding] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0017124 [SH3 domain binding] GO:0019896 [axonal transport of mitochondrion] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0031122 [cytoplasmic microtubule organization] GO:0031175 [neuron projection development] GO:0032930 [positive regulation of superoxide anion generation] GO:0033673 [negative regulation of kinase activity] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0034452 [dynactin binding] GO:0034605 [cellular response to heat] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0036477 [somatodendritic compartment] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0044297 [cell body] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048018 [receptor agonist activity] GO:0048143 [astrocyte activation] GO:0048312 [intracellular distribution of mitochondria] GO:0048699 [generation of neurons] GO:0050808 [synapse organization] GO:0050848 [regulation of calcium-mediated signaling] GO:0051259 [protein oligomerization] GO:0051721 [protein phosphatase 2A binding] GO:0051879 [Hsp90 protein binding] GO:0071813 [lipoprotein particle binding] GO:0072386 [plus-end-directed organelle transport along microtubule] GO:0090140 [regulation of mitochondrial fission] GO:0090258 [negative regulation of mitochondrial fission] GO:0097418 [neurofibrillary tangle] GO:0098930 [axonal transport] GO:1900034 [regulation of cellular response to heat] GO:1901216 [positive regulation of neuron death] GO:1902474 [positive regulation of protein localization to synapse] GO:1902988 [neurofibrillary tangle assembly] GO:1903748 [negative regulation of establishment of protein localization to mitochondrion] GO:1904115 [axon cytoplasm] GO:1905689 [positive regulation of diacylglycerol kinase activity] GO:2001020 [regulation of response to DNA damage stimulus]
P10636 [Direct mapping] Microtubule-associated protein tau A0A024RA17 [Target identity:100%; Query identity:100%] Microtubule-associated protein
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Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization] GO:0001774 [microglial cell activation] GO:0003677 [DNA binding] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007613 [memory] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0010917 [negative regulation of mitochondrial membrane potential] GO:0015631 [tubulin binding] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0017124 [SH3 domain binding] GO:0019896 [axonal transport of mitochondrion] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0031122 [cytoplasmic microtubule organization] GO:0031175 [neuron projection development] GO:0032930 [positive regulation of superoxide anion generation] GO:0033673 [negative regulation of kinase activity] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0034452 [dynactin binding] GO:0034605 [cellular response to heat] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0036477 [somatodendritic compartment] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0044297 [cell body] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048018 [receptor agonist activity] GO:0048143 [astrocyte activation] GO:0048312 [intracellular distribution of mitochondria] GO:0048699 [generation of neurons] GO:0050808 [synapse organization] GO:0050848 [regulation of calcium-mediated signaling] GO:0051259 [protein oligomerization] GO:0051721 [protein phosphatase 2A binding] GO:0051879 [Hsp90 protein binding] GO:0071813 [lipoprotein particle binding] GO:0072386 [plus-end-directed organelle transport along microtubule] GO:0090140 [regulation of mitochondrial fission] GO:0090258 [negative regulation of mitochondrial fission] GO:0097418 [neurofibrillary tangle] GO:0098930 [axonal transport] GO:1900034 [regulation of cellular response to heat] GO:1901216 [positive regulation of neuron death] GO:1902474 [positive regulation of protein localization to synapse] GO:1902988 [neurofibrillary tangle assembly] GO:1903748 [negative regulation of establishment of protein localization to mitochondrion] GO:1904115 [axon cytoplasm] GO:1905689 [positive regulation of diacylglycerol kinase activity] GO:2001020 [regulation of response to DNA damage stimulus]
P10636 [Direct mapping] Microtubule-associated protein tau
Show all
Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization] GO:0001774 [microglial cell activation] GO:0003677 [DNA binding] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0005886 [plasma membrane] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007165 [signal transduction] GO:0007613 [memory] GO:0008017 [microtubule binding] GO:0010506 [regulation of autophagy] GO:0010917 [negative regulation of mitochondrial membrane potential] GO:0015631 [tubulin binding] GO:0016020 [membrane] GO:0016607 [nuclear speck] GO:0017124 [SH3 domain binding] GO:0019896 [axonal transport of mitochondrion] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0031113 [regulation of microtubule polymerization] GO:0031116 [positive regulation of microtubule polymerization] GO:0031122 [cytoplasmic microtubule organization] GO:0031175 [neuron projection development] GO:0032930 [positive regulation of superoxide anion generation] GO:0033673 [negative regulation of kinase activity] GO:0034185 [apolipoprotein binding] GO:0034399 [nuclear periphery] GO:0034452 [dynactin binding] GO:0034605 [cellular response to heat] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0036477 [somatodendritic compartment] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0044297 [cell body] GO:0045298 [tubulin complex] GO:0045773 [positive regulation of axon extension] GO:0048018 [receptor agonist activity] GO:0048143 [astrocyte activation] GO:0048312 [intracellular distribution of mitochondria] GO:0048699 [generation of neurons] GO:0050808 [synapse organization] GO:0050848 [regulation of calcium-mediated signaling] GO:0051259 [protein oligomerization] GO:0051721 [protein phosphatase 2A binding] GO:0051879 [Hsp90 protein binding] GO:0071813 [lipoprotein particle binding] GO:0072386 [plus-end-directed organelle transport along microtubule] GO:0090140 [regulation of mitochondrial fission] GO:0090258 [negative regulation of mitochondrial fission] GO:0097418 [neurofibrillary tangle] GO:0098930 [axonal transport] GO:1900034 [regulation of cellular response to heat] GO:1901216 [positive regulation of neuron death] GO:1902474 [positive regulation of protein localization to synapse] GO:1902988 [neurofibrillary tangle assembly] GO:1903748 [negative regulation of establishment of protein localization to mitochondrion] GO:1904115 [axon cytoplasm] GO:1905689 [positive regulation of diacylglycerol kinase activity] GO:2001020 [regulation of response to DNA damage stimulus]
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