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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
TCGA (cancer tissue):
Expressed in all
HPA (cell line):
Expressed in all
HPA (normal tissue):
Mixed
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expression normal tissuei
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Nuclear and cytoplasmic expression in proliferating cells.
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability descriptioni
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining consistent with RNA expression data.
Reliability score - normal tissuesi
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from.
Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
For each cancer, color-coded bars indicate the percentage of patients (maximum 12 patients) with high and medium protein expression level. The cancer types are color-coded according to which type of normal organ the cancer originates from. Low or not detected protein expression results in a white bar. Mouse-over function shows details about expression level and normal tissue of origin. The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies.
Most cancer tissues showed weak to moderate nuclear and cytoplasmic immunoreactivity. Cases of breast cancer showed strong positivity in a fraction of cells. Renal and liver cancers were negative.
A majority of cancer tissues showed moderate to strong nuclear immunoreactivity, often accompanied with cytoplasmic staining. Prostate cancers and basal cell carcinomas showed positivity in a smaller fraction of the cells.
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
CDK1 (HGNC Symbol)
Synonyms
CDC2, CDC28A
Description
Cyclin dependent kinase 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
CDK1-007
CDK1-008
CDK1-009
CDK1-013
CDK1-201
CDK1-202
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Transporters Transporter channels and pores MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000166 [nucleotide binding] GO:0000187 [activation of MAPK activity] GO:0000226 [microtubule cytoskeleton organization] GO:0000278 [mitotic cell cycle] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0000784 [nuclear chromosome, telomeric region] GO:0003682 [chromatin binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005876 [spindle microtubule] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006461 [protein complex assembly] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007049 [cell cycle] GO:0007067 [mitotic nuclear division] GO:0007077 [mitotic nuclear envelope disassembly] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0007098 [centrosome cycle] GO:0007344 [pronuclear fusion] GO:0007346 [regulation of mitotic cell cycle] GO:0007569 [cell aging] GO:0008283 [cell proliferation] GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity] GO:0009636 [response to toxic substance] GO:0010243 [response to organonitrogen compound] GO:0010468 [regulation of gene expression] GO:0010628 [positive regulation of gene expression] GO:0014038 [regulation of Schwann cell differentiation] GO:0014070 [response to organic cyclic compound] GO:0014075 [response to amine] GO:0014823 [response to activity] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016477 [cell migration] GO:0016572 [histone phosphorylation] GO:0016740 [transferase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0030261 [chromosome condensation] GO:0030332 [cyclin binding] GO:0030496 [midbody] GO:0030544 [Hsp70 protein binding] GO:0030855 [epithelial cell differentiation] GO:0031100 [animal organ regeneration] GO:0031145 [anaphase-promoting complex-dependent catabolic process] GO:0033160 [positive regulation of protein import into nucleus, translocation] GO:0034501 [protein localization to kinetochore] GO:0035173 [histone kinase activity] GO:0042493 [response to drug] GO:0042542 [response to hydrogen peroxide] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043066 [negative regulation of apoptotic process] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0044772 [mitotic cell cycle phase transition] GO:0045471 [response to ethanol] GO:0045740 [positive regulation of DNA replication] GO:0045931 [positive regulation of mitotic cell cycle] GO:0045995 [regulation of embryonic development] GO:0046686 [response to cadmium ion] GO:0046688 [response to copper ion] GO:0048678 [response to axon injury] GO:0051301 [cell division] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051445 [regulation of meiotic cell cycle] GO:0055015 [ventricular cardiac muscle cell development] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0070062 [extracellular exosome] GO:0070301 [cellular response to hydrogen peroxide] GO:0072686 [mitotic spindle] GO:0090166 [Golgi disassembly] GO:0097472 [cyclin-dependent protein kinase activity] GO:0097711 [ciliary basal body docking] GO:1900182 [positive regulation of protein localization to nucleus]
P06493 [Direct mapping] Cyclin-dependent kinase 1 A0A024QZJ8 [Target identity:100%; Query identity:100%] Cell division cycle 2, G1 to S and G2 to M, isoform CRA_c
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Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000166 [nucleotide binding] GO:0000187 [activation of MAPK activity] GO:0000226 [microtubule cytoskeleton organization] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0000784 [nuclear chromosome, telomeric region] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005876 [spindle microtubule] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007049 [cell cycle] GO:0007067 [mitotic nuclear division] GO:0007077 [mitotic nuclear envelope disassembly] GO:0007098 [centrosome cycle] GO:0007344 [pronuclear fusion] GO:0007346 [regulation of mitotic cell cycle] GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity] GO:0010468 [regulation of gene expression] GO:0014038 [regulation of Schwann cell differentiation] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016477 [cell migration] GO:0016572 [histone phosphorylation] GO:0016740 [transferase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0030332 [cyclin binding] GO:0030496 [midbody] GO:0030855 [epithelial cell differentiation] GO:0031145 [anaphase-promoting complex-dependent catabolic process] GO:0034501 [protein localization to kinetochore] GO:0035173 [histone kinase activity] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043066 [negative regulation of apoptotic process] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0044772 [mitotic cell cycle phase transition] GO:0045995 [regulation of embryonic development] GO:0051301 [cell division] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051445 [regulation of meiotic cell cycle] GO:0070062 [extracellular exosome] GO:0072686 [mitotic spindle] GO:0090166 [Golgi disassembly] GO:0097472 [cyclin-dependent protein kinase activity] GO:0097711 [ciliary basal body docking] GO:1900182 [positive regulation of protein localization to nucleus]
P06493 [Direct mapping] Cyclin-dependent kinase 1 A0A024QZJ8 [Target identity:100%; Query identity:100%] Cell division cycle 2, G1 to S and G2 to M, isoform CRA_c
Show all
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000166 [nucleotide binding] GO:0000187 [activation of MAPK activity] GO:0000226 [microtubule cytoskeleton organization] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0000784 [nuclear chromosome, telomeric region] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005876 [spindle microtubule] GO:0006260 [DNA replication] GO:0006281 [DNA repair] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007049 [cell cycle] GO:0007067 [mitotic nuclear division] GO:0007077 [mitotic nuclear envelope disassembly] GO:0007098 [centrosome cycle] GO:0007344 [pronuclear fusion] GO:0007346 [regulation of mitotic cell cycle] GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity] GO:0010468 [regulation of gene expression] GO:0014038 [regulation of Schwann cell differentiation] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016477 [cell migration] GO:0016572 [histone phosphorylation] GO:0016740 [transferase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0030332 [cyclin binding] GO:0030496 [midbody] GO:0030855 [epithelial cell differentiation] GO:0031145 [anaphase-promoting complex-dependent catabolic process] GO:0034501 [protein localization to kinetochore] GO:0035173 [histone kinase activity] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043066 [negative regulation of apoptotic process] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0044772 [mitotic cell cycle phase transition] GO:0045995 [regulation of embryonic development] GO:0051301 [cell division] GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition] GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] GO:0051445 [regulation of meiotic cell cycle] GO:0070062 [extracellular exosome] GO:0072686 [mitotic spindle] GO:0090166 [Golgi disassembly] GO:0097472 [cyclin-dependent protein kinase activity] GO:0097711 [ciliary basal body docking] GO:1900182 [positive regulation of protein localization to nucleus]
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