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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for data imported from The Genotype-Tissue Expression project (GTEX), FANTOM5 Consortium (FANTOM5) and internally generated Human Protein Atlas (HPA) data.
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expressioni
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining mainly consistent with RNA expression data.
Reliability scorei
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Below is an overview of RNA and protein expression data generated in the Human Protein Atlas project. Analyzed tissues are divided into color-coded groups according to which functional features they have in common. For each group, a list of included tissues is accessed by clicking on group name, group symbol, RNA bar, or protein bar. Subsequent selection of a particular tissue in this list links to the image data page.
Images of selected tissues give a visual summary of the protein expression profile furthest to the right.
The gray human body provides links to a histology dictionary when clicking on any part of the figure.
RNA expression (TPM)i
RNA-seq results generated in HPA are reported as number of transcripts per million (TPM). Each bar represents the highest expression score found in a particular group of tissues. The assay is described more in detail in Assays & Annotation.
Protein expression (score)i
Each bar represents the highest expression score found in a particular group of tissues. Protein expression scores are based on a best estimate of the "true" protein expression from a knowledge-based annotation, described more in detail under Assays & annotation. For genes where more than one antibody has been used, a collective score is set displaying the estimated true protein expression.
Protein expression data is shown for each of the 44 tissues. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. Mouse-over function shows protein score for analyzed cell types in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation.
For genes with available protein data for which a knowledge-based annotation gave inconclusive results, no protein expression data is displayed in the protein expression data overview. However, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Organ
Expression
Alphabetical
RNA EXPRESSION OVERVIEWi
RNA expression overview shows RNA-data from three different sources: Internally generated Human Protein Atlas (HPA) RNA-seq data, RNA-seq data from the Genotype-Tissue Expression (GTEx) project and CAGE data from FANTOM5 project. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.
HPA dataseti
HPA dataset RNA-seq tissue data is reported as mean TPM (transcripts per million), corresponding to mean values of the different individual samples from each tissue. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar. The RNA-seq assay is described in detail in Assays & Annotation.
RNA tissue category HPA HPA RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataseti
GTEx dataset RNA-seq data is reported as median RPKM (reads per kilobase per million mapped reads), generated by the Genotype-Tissue Expression (GTEx) project. More information can be found in Assays & Annotation.
RNA tissue category GTEx GTEx RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataseti
FANTOM5 dataset Tissue data obtained through Cap Analysis of Gene Expression (CAGE) are reported as Tags Per Million, generated by the FANTOM5 project. More information can be found in Assays & Annotation.
RNA tissue category FANTOM5 FANTOM5 RNA tissue category (category description) is calculated based on gene expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
PTK2 (HGNC Symbol)
Synonyms
FADK, FAK, FAK1, PPP1R71
Description
Protein tyrosine kinase 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only four of them have been determined. [provided by RefSeq, Oct 2015]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0001525 [angiogenesis] GO:0001725 [stress fiber] GO:0001890 [placenta development] GO:0001932 [regulation of protein phosphorylation] GO:0001934 [positive regulation of protein phosphorylation] GO:0003007 [heart morphogenesis] GO:0003779 [actin binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0005088 [Ras guanyl-nucleotide exchange factor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006468 [protein phosphorylation] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007275 [multicellular organism development] GO:0007411 [axon guidance] GO:0008284 [positive regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0008432 [JUN kinase binding] GO:0009790 [embryo development] GO:0010594 [regulation of endothelial cell migration] GO:0010632 [regulation of epithelial cell migration] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019901 [protein kinase binding] GO:0022408 [negative regulation of cell-cell adhesion] GO:0030010 [establishment of cell polarity] GO:0030054 [cell junction] GO:0030335 [positive regulation of cell migration] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0033628 [regulation of cell adhesion mediated by integrin] GO:0038007 [netrin-activated signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043087 [regulation of GTPase activity] GO:0043547 [positive regulation of GTPase activity] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0045087 [innate immune response] GO:0045667 [regulation of osteoblast differentiation] GO:0045860 [positive regulation of protein kinase activity] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0048870 [cell motility] GO:0051493 [regulation of cytoskeleton organization] GO:0051893 [regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060396 [growth hormone receptor signaling pathway] GO:0097194 [execution phase of apoptosis] GO:1900024 [regulation of substrate adhesion-dependent cell spreading] GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000811 [negative regulation of anoikis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0000226 [microtubule cytoskeleton organization] GO:0001525 [angiogenesis] GO:0001568 [blood vessel development] GO:0001570 [vasculogenesis] GO:0001725 [stress fiber] GO:0001764 [neuron migration] GO:0001890 [placenta development] GO:0001932 [regulation of protein phosphorylation] GO:0001934 [positive regulation of protein phosphorylation] GO:0003007 [heart morphogenesis] GO:0003779 [actin binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0005088 [Ras guanyl-nucleotide exchange factor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006468 [protein phosphorylation] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007275 [multicellular organism development] GO:0007411 [axon guidance] GO:0008284 [positive regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0008432 [JUN kinase binding] GO:0009790 [embryo development] GO:0010594 [regulation of endothelial cell migration] GO:0010632 [regulation of epithelial cell migration] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016324 [apical plasma membrane] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019901 [protein kinase binding] GO:0021955 [central nervous system neuron axonogenesis] GO:0022408 [negative regulation of cell-cell adhesion] GO:0030010 [establishment of cell polarity] GO:0030027 [lamellipodium] GO:0030054 [cell junction] GO:0030198 [extracellular matrix organization] GO:0030335 [positive regulation of cell migration] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0033628 [regulation of cell adhesion mediated by integrin] GO:0038007 [netrin-activated signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0040023 [establishment of nucleus localization] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043087 [regulation of GTPase activity] GO:0043542 [endothelial cell migration] GO:0043547 [positive regulation of GTPase activity] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0045087 [innate immune response] GO:0045667 [regulation of osteoblast differentiation] GO:0045860 [positive regulation of protein kinase activity] GO:0046621 [negative regulation of organ growth] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0048870 [cell motility] GO:0050771 [negative regulation of axonogenesis] GO:0051493 [regulation of cytoskeleton organization] GO:0051893 [regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051964 [negative regulation of synapse assembly] GO:0060396 [growth hormone receptor signaling pathway] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:0097194 [execution phase of apoptosis] GO:1900024 [regulation of substrate adhesion-dependent cell spreading] GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000811 [negative regulation of anoikis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0001525 [angiogenesis] GO:0001725 [stress fiber] GO:0001890 [placenta development] GO:0001932 [regulation of protein phosphorylation] GO:0001934 [positive regulation of protein phosphorylation] GO:0003007 [heart morphogenesis] GO:0003779 [actin binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0005088 [Ras guanyl-nucleotide exchange factor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006468 [protein phosphorylation] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007275 [multicellular organism development] GO:0007411 [axon guidance] GO:0008284 [positive regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0008432 [JUN kinase binding] GO:0009790 [embryo development] GO:0010594 [regulation of endothelial cell migration] GO:0010632 [regulation of epithelial cell migration] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019901 [protein kinase binding] GO:0022408 [negative regulation of cell-cell adhesion] GO:0030010 [establishment of cell polarity] GO:0030054 [cell junction] GO:0030335 [positive regulation of cell migration] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0033628 [regulation of cell adhesion mediated by integrin] GO:0038007 [netrin-activated signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043087 [regulation of GTPase activity] GO:0043547 [positive regulation of GTPase activity] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0045087 [innate immune response] GO:0045667 [regulation of osteoblast differentiation] GO:0045860 [positive regulation of protein kinase activity] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0048870 [cell motility] GO:0051493 [regulation of cytoskeleton organization] GO:0051893 [regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060396 [growth hormone receptor signaling pathway] GO:0097194 [execution phase of apoptosis] GO:1900024 [regulation of substrate adhesion-dependent cell spreading] GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000811 [negative regulation of anoikis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0001525 [angiogenesis] GO:0001725 [stress fiber] GO:0001890 [placenta development] GO:0001932 [regulation of protein phosphorylation] GO:0001934 [positive regulation of protein phosphorylation] GO:0003007 [heart morphogenesis] GO:0003779 [actin binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004871 [signal transducer activity] GO:0005088 [Ras guanyl-nucleotide exchange factor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006468 [protein phosphorylation] GO:0007172 [signal complex assembly] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0007275 [multicellular organism development] GO:0007411 [axon guidance] GO:0008284 [positive regulation of cell proliferation] GO:0008360 [regulation of cell shape] GO:0008432 [JUN kinase binding] GO:0009790 [embryo development] GO:0010594 [regulation of endothelial cell migration] GO:0010632 [regulation of epithelial cell migration] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019901 [protein kinase binding] GO:0022408 [negative regulation of cell-cell adhesion] GO:0030010 [establishment of cell polarity] GO:0030054 [cell junction] GO:0030335 [positive regulation of cell migration] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0033628 [regulation of cell adhesion mediated by integrin] GO:0038007 [netrin-activated signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042127 [regulation of cell proliferation] GO:0042169 [SH2 domain binding] GO:0043066 [negative regulation of apoptotic process] GO:0043087 [regulation of GTPase activity] GO:0043547 [positive regulation of GTPase activity] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0045087 [innate immune response] GO:0045667 [regulation of osteoblast differentiation] GO:0045860 [positive regulation of protein kinase activity] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0048870 [cell motility] GO:0051493 [regulation of cytoskeleton organization] GO:0051893 [regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060396 [growth hormone receptor signaling pathway] GO:0097194 [execution phase of apoptosis] GO:1900024 [regulation of substrate adhesion-dependent cell spreading] GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:2000811 [negative regulation of anoikis]
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