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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
TCGA (cancer tissue):
Expressed in all
HPA (cell line):
Mixed
HPA (normal tissue):
Expressed in all
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expression normal tissuei
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
General cytoplasmic and nuclear expression at variable levels.
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability descriptioni
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining mainly consistent with RNA expression data.
Reliability score - normal tissuesi
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEWi
RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from.
Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
For each cancer, color-coded bars indicate the percentage of patients (maximum 12 patients) with high and medium protein expression level. The cancer types are color-coded according to which type of normal organ the cancer originates from. Low or not detected protein expression results in a white bar. Mouse-over function shows details about expression level and normal tissue of origin. The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies.
Majority of cancer tissues showed weak to moderate cytoplasmic and nuclear staining. Few cases of squamous cell carcinoma of cervix and skin along with breast, prostate and ovarian cancers displayed strong immunoreactivity.
Cancer tissues showed weak to moderate cytoplasmic and nuclear staining. Few cases of ovarian cancers displayed strong positivity.
Cancer tissues displayed a varying staining pattern, ranging from negative to strongly stained cases within the same tumor type. Strong nuclear positivity, often accompanied with cytoplasmic staining, was observed in a few lymphomas, head & neck cancers, skin cancers and renal cancers.
Several cases of all cancers showed weak to moderate cytoplasmic and nuclear positivity. Most gliomas, lymphomas, melanomas, lung, skin, renal and pancreatic cancers were negative.
A majority of cancer tissues displayed weak to moderate cytoplasmic and nuclear positivity. Endometrial and liver cancers were mainly negative.
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
STAT3 (HGNC Symbol)
Synonyms
APRF
Description
Signal transducer and activator of transcription 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
STAT3-001
STAT3-002
STAT3-011
STAT3-012
STAT3-013
STAT3-016
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P40763 [Direct mapping] Signal transducer and activator of transcription 3
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Predicted intracellular proteins Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001659 [temperature homeostasis] GO:0001754 [eye photoreceptor cell differentiation] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004871 [signal transducer activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006606 [protein import into nucleus] GO:0006928 [movement of cell or subcellular component] GO:0006953 [acute-phase response] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0007259 [JAK-STAT cascade] GO:0007399 [nervous system development] GO:0007568 [aging] GO:0008134 [transcription factor binding] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0010033 [response to organic substance] GO:0010628 [positive regulation of gene expression] GO:0010730 [negative regulation of hydrogen peroxide biosynthetic process] GO:0014070 [response to organic cyclic compound] GO:0016032 [viral process] GO:0016310 [phosphorylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0019827 [stem cell population maintenance] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0019953 [sexual reproduction] GO:0030522 [intracellular receptor signaling pathway] GO:0031490 [chromatin DNA binding] GO:0031730 [CCR5 chemokine receptor binding] GO:0032355 [response to estradiol] GO:0032870 [cellular response to hormone stimulus] GO:0033210 [leptin-mediated signaling pathway] GO:0034097 [response to cytokine] GO:0035019 [somatic stem cell population maintenance] GO:0035259 [glucocorticoid receptor binding] GO:0035278 [miRNA mediated inhibition of translation] GO:0040014 [regulation of multicellular organism growth] GO:0042493 [response to drug] GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein] GO:0042593 [glucose homeostasis] GO:0042755 [eating behavior] GO:0042789 [mRNA transcription from RNA polymerase II promoter] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043434 [response to peptide hormone] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044320 [cellular response to leptin stimulus] GO:0044321 [response to leptin] GO:0045471 [response to ethanol] GO:0045747 [positive regulation of Notch signaling pathway] GO:0045820 [negative regulation of glycolytic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046902 [regulation of mitochondrial membrane permeability] GO:0046983 [protein dimerization activity] GO:0048708 [astrocyte differentiation] GO:0051726 [regulation of cell cycle] GO:0060019 [radial glial cell differentiation] GO:0060259 [regulation of feeding behavior] GO:0060396 [growth hormone receptor signaling pathway] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] GO:0060548 [negative regulation of cell death] GO:0070102 [interleukin-6-mediated signaling pathway] GO:0071345 [cellular response to cytokine stimulus] GO:0071407 [cellular response to organic cyclic compound] GO:0072540 [T-helper 17 cell lineage commitment] GO:0090575 [RNA polymerase II transcription factor complex] GO:0097009 [energy homeostasis] GO:1901215 [negative regulation of neuron death] GO:1902728 [positive regulation of growth factor dependent skeletal muscle satellite cell proliferation] GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter] GO:1904685 [positive regulation of metalloendopeptidase activity] GO:2000637 [positive regulation of gene silencing by miRNA] GO:2000737 [negative regulation of stem cell differentiation] GO:2001171 [positive regulation of ATP biosynthetic process] GO:2001223 [negative regulation of neuron migration]
P40763 [Direct mapping] Signal transducer and activator of transcription 3
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Predicted intracellular proteins Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001659 [temperature homeostasis] GO:0001754 [eye photoreceptor cell differentiation] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004871 [signal transducer activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006606 [protein import into nucleus] GO:0006928 [movement of cell or subcellular component] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0007259 [JAK-STAT cascade] GO:0007399 [nervous system development] GO:0008134 [transcription factor binding] GO:0010628 [positive regulation of gene expression] GO:0016032 [viral process] GO:0016310 [phosphorylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0019953 [sexual reproduction] GO:0030522 [intracellular receptor signaling pathway] GO:0031490 [chromatin DNA binding] GO:0032355 [response to estradiol] GO:0032870 [cellular response to hormone stimulus] GO:0033210 [leptin-mediated signaling pathway] GO:0035019 [somatic stem cell population maintenance] GO:0035278 [miRNA mediated inhibition of translation] GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein] GO:0042593 [glucose homeostasis] GO:0042755 [eating behavior] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044320 [cellular response to leptin stimulus] GO:0044321 [response to leptin] GO:0045747 [positive regulation of Notch signaling pathway] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046983 [protein dimerization activity] GO:0048708 [astrocyte differentiation] GO:0051726 [regulation of cell cycle] GO:0060019 [radial glial cell differentiation] GO:0060259 [regulation of feeding behavior] GO:0060396 [growth hormone receptor signaling pathway] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] GO:0070102 [interleukin-6-mediated signaling pathway] GO:0072540 [T-helper 17 cell lineage commitment] GO:0090575 [RNA polymerase II transcription factor complex] GO:0097009 [energy homeostasis] GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter] GO:1904685 [positive regulation of metalloendopeptidase activity] GO:2000637 [positive regulation of gene silencing by miRNA]
G8JLH9 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Protein evidence (Ezkurdia et al 2014)
K7EP08 [Direct mapping] Signal transducer and activator of transcription 3
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Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Protein evidence (Ezkurdia et al 2014)
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