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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
TCGA (cancer tissue):
Expressed in all
HPA (cell line):
Expressed in all
HPA (normal tissue):
Expressed in all
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expression normal tissuei
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining mainly consistent with RNA expression data.
Reliability score - normal tissuesi
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from.
Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
For each cancer, color-coded bars indicate the percentage of patients (maximum 12 patients) with high and medium protein expression level. The cancer types are color-coded according to which type of normal organ the cancer originates from. Low or not detected protein expression results in a white bar. Mouse-over function shows details about expression level and normal tissue of origin. The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies.
Most of the malignant cells displayed moderate to strong membranous and cytoplasmic immunoreactivity. Malignant lymphomas along with a few cases of seminomas and renal cancers were negative or weakly stained.
Most of the malignant cells displayed moderate to strong membranous and cytoplasmic. Malignant lymphomas and cases of malignant gliomas, seminomas and renal cancers were negative or weakly stained.
Most malignant tissues displayed strong membranous and cytoplasmic positivity. Malignant lymphomas were negative.
Cases of colorectal, endometrial, gastric, prostate cancers and malignant melanomas showed moderate cytoplasmic with additional membranous positivity. Remaining malignancies were weakly stained or negative.
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
CTNNB1 (HGNC Symbol)
Synonyms
armadillo, beta-catenin, CTNNB
Description
Catenin beta 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
CTNNB1-001
CTNNB1-002
CTNNB1-003
CTNNB1-005
CTNNB1-007
CTNNB1-010
CTNNB1-011
CTNNB1-012
CTNNB1-013
CTNNB1-014
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000578 [embryonic axis specification] GO:0000904 [cell morphogenesis involved in differentiation] GO:0000922 [spindle pole] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001501 [skeletal system development] GO:0001569 [branching involved in blood vessel morphogenesis] GO:0001570 [vasculogenesis] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0001701 [in utero embryonic development] GO:0001702 [gastrulation with mouth forming second] GO:0001706 [endoderm formation] GO:0001708 [cell fate specification] GO:0001709 [cell fate determination] GO:0001711 [endodermal cell fate commitment] GO:0001764 [neuron migration] GO:0001822 [kidney development] GO:0001837 [epithelial to mesenchymal transition] GO:0001840 [neural plate development] GO:0001944 [vasculature development] GO:0002052 [positive regulation of neuroblast proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002089 [lens morphogenesis in camera-type eye] GO:0003266 [regulation of secondary heart field cardioblast proliferation] GO:0003338 [metanephros morphogenesis] GO:0003340 [negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005719 [nuclear euchromatin] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005912 [adherens junction] GO:0005913 [cell-cell adherens junction] GO:0005916 [fascia adherens] GO:0005923 [bicellular tight junction] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007223 [Wnt signaling pathway, calcium modulating pathway] GO:0007268 [chemical synaptic transmission] GO:0007398 [ectoderm development] GO:0007399 [nervous system development] GO:0007403 [glial cell fate determination] GO:0007507 [heart development] GO:0008022 [protein C-terminus binding] GO:0008134 [transcription factor binding] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0009948 [anterior/posterior axis specification] GO:0009950 [dorsal/ventral axis specification] GO:0009953 [dorsal/ventral pattern formation] GO:0009954 [proximal/distal pattern formation] GO:0009987 [cellular process] GO:0010468 [regulation of gene expression] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process] GO:0014704 [intercalated disc] GO:0016020 [membrane] GO:0016055 [Wnt signaling pathway] GO:0016323 [basolateral plasma membrane] GO:0016328 [lateral plasma membrane] GO:0016331 [morphogenesis of embryonic epithelium] GO:0016337 [single organismal cell-cell adhesion] GO:0016342 [catenin complex] GO:0016600 [flotillin complex] GO:0019827 [stem cell population maintenance] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0021819 [layer formation in cerebral cortex] GO:0022009 [central nervous system vasculogenesis] GO:0022405 [hair cycle process] GO:0030018 [Z disc] GO:0030027 [lamellipodium] GO:0030054 [cell junction] GO:0030097 [hemopoiesis] GO:0030154 [cell differentiation] GO:0030182 [neuron differentiation] GO:0030217 [T cell differentiation] GO:0030316 [osteoclast differentiation] GO:0030324 [lung development] GO:0030331 [estrogen receptor binding] GO:0030521 [androgen receptor signaling pathway] GO:0030539 [male genitalia development] GO:0030856 [regulation of epithelial cell differentiation] GO:0030858 [positive regulation of epithelial cell differentiation] GO:0030877 [beta-catenin destruction complex] GO:0030900 [forebrain development] GO:0030901 [midbrain development] GO:0030902 [hindbrain development] GO:0030997 [regulation of centriole-centriole cohesion] GO:0031016 [pancreas development] GO:0031069 [hair follicle morphogenesis] GO:0031253 [cell projection membrane] GO:0031528 [microvillus membrane] GO:0031641 [regulation of myelination] GO:0032212 [positive regulation of telomere maintenance via telomerase] GO:0032331 [negative regulation of chondrocyte differentiation] GO:0032355 [response to estradiol] GO:0032481 [positive regulation of type I interferon production] GO:0032993 [protein-DNA complex] GO:0033077 [T cell differentiation in thymus] GO:0033234 [negative regulation of protein sumoylation] GO:0034332 [adherens junction organization] GO:0034333 [adherens junction assembly] GO:0034394 [protein localization to cell surface] GO:0034613 [cellular protein localization] GO:0034750 [Scrib-APC-beta-catenin complex] GO:0035050 [embryonic heart tube development] GO:0035112 [genitalia morphogenesis] GO:0035115 [embryonic forelimb morphogenesis] GO:0035116 [embryonic hindlimb morphogenesis] GO:0035257 [nuclear hormone receptor binding] GO:0035315 [hair cell differentiation] GO:0035411 [catenin import into nucleus] GO:0035635 [entry of bacterium into host cell] GO:0036023 [embryonic skeletal limb joint morphogenesis] GO:0042127 [regulation of cell proliferation] GO:0042129 [regulation of T cell proliferation] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0042493 [response to drug] GO:0042733 [embryonic digit morphogenesis] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043234 [protein complex] GO:0043296 [apical junction complex] GO:0043410 [positive regulation of MAPK cascade] GO:0043525 [positive regulation of neuron apoptotic process] GO:0043588 [skin development] GO:0044212 [transcription regulatory region DNA binding] GO:0044325 [ion channel binding] GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition] GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process] GO:0044798 [nuclear transcription factor complex] GO:0045177 [apical part of cell] GO:0045202 [synapse] GO:0045294 [alpha-catenin binding] GO:0045296 [cadherin binding] GO:0045453 [bone resorption] GO:0045595 [regulation of cell differentiation] GO:0045596 [negative regulation of cell differentiation] GO:0045603 [positive regulation of endothelial cell differentiation] GO:0045667 [regulation of osteoblast differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045670 [regulation of osteoclast differentiation] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045743 [positive regulation of fibroblast growth factor receptor signaling pathway] GO:0045765 [regulation of angiogenesis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0045976 [negative regulation of mitotic cell cycle, embryonic] GO:0046332 [SMAD binding] GO:0046982 [protein heterodimerization activity] GO:0048096 [chromatin-mediated maintenance of transcription] GO:0048145 [regulation of fibroblast proliferation] GO:0048469 [cell maturation] GO:0048471 [perinuclear region of cytoplasm] GO:0048489 [synaptic vesicle transport] GO:0048513 [animal organ development] GO:0048538 [thymus development] GO:0048599 [oocyte development] GO:0048617 [embryonic foregut morphogenesis] GO:0048643 [positive regulation of skeletal muscle tissue development] GO:0048660 [regulation of smooth muscle cell proliferation] GO:0048715 [negative regulation of oligodendrocyte differentiation] GO:0050681 [androgen receptor binding] GO:0050767 [regulation of neurogenesis] GO:0050808 [synapse organization] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051145 [smooth muscle cell differentiation] GO:0051149 [positive regulation of muscle cell differentiation] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0051973 [positive regulation of telomerase activity] GO:0060066 [oviduct development] GO:0060070 [canonical Wnt signaling pathway] GO:0060173 [limb development] GO:0060439 [trachea morphogenesis] GO:0060440 [trachea formation] GO:0060441 [epithelial tube branching involved in lung morphogenesis] GO:0060479 [lung cell differentiation] GO:0060484 [lung-associated mesenchyme development] GO:0060492 [lung induction] GO:0060742 [epithelial cell differentiation involved in prostate gland development] GO:0060769 [positive regulation of epithelial cell proliferation involved in prostate gland development] GO:0060789 [hair follicle placode formation] GO:0060916 [mesenchymal cell proliferation involved in lung development] GO:0061047 [positive regulation of branching involved in lung morphogenesis] GO:0061154 [endothelial tube morphogenesis] GO:0061198 [fungiform papilla formation] GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation] GO:0061549 [sympathetic ganglion development] GO:0061550 [cranial ganglion development] GO:0070062 [extracellular exosome] GO:0070369 [beta-catenin-TCF7L2 complex] GO:0070411 [I-SMAD binding] GO:0070491 [repressing transcription factor binding] GO:0070602 [regulation of centromeric sister chromatid cohesion] GO:0071363 [cellular response to growth factor stimulus] GO:0071664 [catenin-TCF7L2 complex] GO:0071681 [cellular response to indole-3-methanol] GO:0071944 [cell periphery] GO:0072001 [renal system development] GO:0072033 [renal vesicle formation] GO:0072053 [renal inner medulla development] GO:0072054 [renal outer medulla development] GO:0072079 [nephron tubule formation] GO:0072182 [regulation of nephron tubule epithelial cell differentiation] GO:0090279 [regulation of calcium ion import] GO:1901215 [negative regulation of neuron death] GO:1903204 [negative regulation of oxidative stress-induced neuron death] GO:1904501 [positive regulation of chromatin-mediated maintenance of transcription] GO:1904793 [regulation of euchromatin binding] GO:1904796 [regulation of core promoter binding] GO:1904798 [positive regulation of core promoter binding] GO:1904837 [beta-catenin-TCF complex assembly] GO:1904886 [beta-catenin destruction complex disassembly] GO:1904888 [cranial skeletal system development] GO:1904948 [midbrain dopaminergic neuron differentiation] GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation] GO:1990403 [embryonic brain development] GO:1990791 [dorsal root ganglion development] GO:1990907 [beta-catenin-TCF complex] GO:1990909 [Wnt signalosome] GO:2000008 [regulation of protein localization to cell surface] GO:2000017 [positive regulation of determination of dorsal identity] GO:2000144 [positive regulation of DNA-templated transcription, initiation] GO:2001234 [negative regulation of apoptotic signaling pathway]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000922 [spindle pole] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001569 [branching involved in blood vessel morphogenesis] GO:0001837 [epithelial to mesenchymal transition] GO:0002052 [positive regulation of neuroblast proliferation] GO:0003713 [transcription coactivator activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005719 [nuclear euchromatin] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005912 [adherens junction] GO:0005913 [cell-cell adherens junction] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007155 [cell adhesion] GO:0007223 [Wnt signaling pathway, calcium modulating pathway] GO:0007399 [nervous system development] GO:0008022 [protein C-terminus binding] GO:0008134 [transcription factor binding] GO:0008285 [negative regulation of cell proliferation] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process] GO:0016020 [membrane] GO:0016055 [Wnt signaling pathway] GO:0016323 [basolateral plasma membrane] GO:0016328 [lateral plasma membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0016342 [catenin complex] GO:0019827 [stem cell population maintenance] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019903 [protein phosphatase binding] GO:0030054 [cell junction] GO:0030331 [estrogen receptor binding] GO:0030521 [androgen receptor signaling pathway] GO:0030877 [beta-catenin destruction complex] GO:0030997 [regulation of centriole-centriole cohesion] GO:0032355 [response to estradiol] GO:0032481 [positive regulation of type I interferon production] GO:0032993 [protein-DNA complex] GO:0033234 [negative regulation of protein sumoylation] GO:0034333 [adherens junction assembly] GO:0034394 [protein localization to cell surface] GO:0035257 [nuclear hormone receptor binding] GO:0035315 [hair cell differentiation] GO:0035411 [catenin import into nucleus] GO:0035635 [entry of bacterium into host cell] GO:0036023 [embryonic skeletal limb joint morphogenesis] GO:0042493 [response to drug] GO:0043065 [positive regulation of apoptotic process] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043234 [protein complex] GO:0043525 [positive regulation of neuron apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044325 [ion channel binding] GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition] GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process] GO:0045202 [synapse] GO:0045294 [alpha-catenin binding] GO:0045296 [cadherin binding] GO:0045765 [regulation of angiogenesis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0045976 [negative regulation of mitotic cell cycle, embryonic] GO:0046332 [SMAD binding] GO:0048145 [regulation of fibroblast proliferation] GO:0048471 [perinuclear region of cytoplasm] GO:0048660 [regulation of smooth muscle cell proliferation] GO:0050681 [androgen receptor binding] GO:0050767 [regulation of neurogenesis] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051149 [positive regulation of muscle cell differentiation] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0060070 [canonical Wnt signaling pathway] GO:0061154 [endothelial tube morphogenesis] GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation] GO:0061549 [sympathetic ganglion development] GO:0070062 [extracellular exosome] GO:0070369 [beta-catenin-TCF7L2 complex] GO:0070411 [I-SMAD binding] GO:0070602 [regulation of centromeric sister chromatid cohesion] GO:0071363 [cellular response to growth factor stimulus] GO:0071681 [cellular response to indole-3-methanol] GO:0071944 [cell periphery] GO:0072182 [regulation of nephron tubule epithelial cell differentiation] GO:0090279 [regulation of calcium ion import] GO:1904798 [positive regulation of core promoter binding] GO:1904837 [beta-catenin-TCF complex assembly] GO:1904886 [beta-catenin destruction complex disassembly] GO:1904948 [midbrain dopaminergic neuron differentiation] GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation] GO:1990907 [beta-catenin-TCF complex] GO:1990909 [Wnt signalosome] GO:2000008 [regulation of protein localization to cell surface] GO:2000144 [positive regulation of DNA-templated transcription, initiation]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000922 [spindle pole] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001569 [branching involved in blood vessel morphogenesis] GO:0001837 [epithelial to mesenchymal transition] GO:0002052 [positive regulation of neuroblast proliferation] GO:0003713 [transcription coactivator activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005719 [nuclear euchromatin] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005912 [adherens junction] GO:0005913 [cell-cell adherens junction] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007155 [cell adhesion] GO:0007223 [Wnt signaling pathway, calcium modulating pathway] GO:0007399 [nervous system development] GO:0008022 [protein C-terminus binding] GO:0008134 [transcription factor binding] GO:0008285 [negative regulation of cell proliferation] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process] GO:0016020 [membrane] GO:0016055 [Wnt signaling pathway] GO:0016323 [basolateral plasma membrane] GO:0016328 [lateral plasma membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0016342 [catenin complex] GO:0019827 [stem cell population maintenance] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019903 [protein phosphatase binding] GO:0030054 [cell junction] GO:0030331 [estrogen receptor binding] GO:0030521 [androgen receptor signaling pathway] GO:0030877 [beta-catenin destruction complex] GO:0030997 [regulation of centriole-centriole cohesion] GO:0032355 [response to estradiol] GO:0032481 [positive regulation of type I interferon production] GO:0032993 [protein-DNA complex] GO:0033234 [negative regulation of protein sumoylation] GO:0034333 [adherens junction assembly] GO:0034394 [protein localization to cell surface] GO:0035257 [nuclear hormone receptor binding] GO:0035315 [hair cell differentiation] GO:0035411 [catenin import into nucleus] GO:0035635 [entry of bacterium into host cell] GO:0036023 [embryonic skeletal limb joint morphogenesis] GO:0042493 [response to drug] GO:0043065 [positive regulation of apoptotic process] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043234 [protein complex] GO:0043525 [positive regulation of neuron apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044325 [ion channel binding] GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition] GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process] GO:0045202 [synapse] GO:0045294 [alpha-catenin binding] GO:0045296 [cadherin binding] GO:0045765 [regulation of angiogenesis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0045976 [negative regulation of mitotic cell cycle, embryonic] GO:0046332 [SMAD binding] GO:0048145 [regulation of fibroblast proliferation] GO:0048471 [perinuclear region of cytoplasm] GO:0048660 [regulation of smooth muscle cell proliferation] GO:0050681 [androgen receptor binding] GO:0050767 [regulation of neurogenesis] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051149 [positive regulation of muscle cell differentiation] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0060070 [canonical Wnt signaling pathway] GO:0061154 [endothelial tube morphogenesis] GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation] GO:0061549 [sympathetic ganglion development] GO:0070062 [extracellular exosome] GO:0070369 [beta-catenin-TCF7L2 complex] GO:0070411 [I-SMAD binding] GO:0070602 [regulation of centromeric sister chromatid cohesion] GO:0071363 [cellular response to growth factor stimulus] GO:0071681 [cellular response to indole-3-methanol] GO:0071944 [cell periphery] GO:0072182 [regulation of nephron tubule epithelial cell differentiation] GO:0090279 [regulation of calcium ion import] GO:1904798 [positive regulation of core promoter binding] GO:1904837 [beta-catenin-TCF complex assembly] GO:1904886 [beta-catenin destruction complex disassembly] GO:1904948 [midbrain dopaminergic neuron differentiation] GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation] GO:1990907 [beta-catenin-TCF complex] GO:1990909 [Wnt signalosome] GO:2000008 [regulation of protein localization to cell surface] GO:2000144 [positive regulation of DNA-templated transcription, initiation]
B4DGU4 [Direct mapping] Catenin beta-1; cDNA FLJ57878, highly similar to Beta-catenin
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Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
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GO:0000922 [spindle pole] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001569 [branching involved in blood vessel morphogenesis] GO:0001837 [epithelial to mesenchymal transition] GO:0002052 [positive regulation of neuroblast proliferation] GO:0003713 [transcription coactivator activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005719 [nuclear euchromatin] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005912 [adherens junction] GO:0005913 [cell-cell adherens junction] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007155 [cell adhesion] GO:0007223 [Wnt signaling pathway, calcium modulating pathway] GO:0007399 [nervous system development] GO:0008022 [protein C-terminus binding] GO:0008134 [transcription factor binding] GO:0008285 [negative regulation of cell proliferation] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0010909 [positive regulation of heparan sulfate proteoglycan biosynthetic process] GO:0016020 [membrane] GO:0016055 [Wnt signaling pathway] GO:0016323 [basolateral plasma membrane] GO:0016328 [lateral plasma membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0016342 [catenin complex] GO:0019827 [stem cell population maintenance] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019903 [protein phosphatase binding] GO:0030054 [cell junction] GO:0030331 [estrogen receptor binding] GO:0030521 [androgen receptor signaling pathway] GO:0030877 [beta-catenin destruction complex] GO:0030997 [regulation of centriole-centriole cohesion] GO:0032355 [response to estradiol] GO:0032481 [positive regulation of type I interferon production] GO:0032993 [protein-DNA complex] GO:0033234 [negative regulation of protein sumoylation] GO:0034333 [adherens junction assembly] GO:0034394 [protein localization to cell surface] GO:0035257 [nuclear hormone receptor binding] GO:0035315 [hair cell differentiation] GO:0035411 [catenin import into nucleus] GO:0035635 [entry of bacterium into host cell] GO:0036023 [embryonic skeletal limb joint morphogenesis] GO:0042493 [response to drug] GO:0043065 [positive regulation of apoptotic process] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043234 [protein complex] GO:0043525 [positive regulation of neuron apoptotic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044325 [ion channel binding] GO:0044334 [canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition] GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process] GO:0045202 [synapse] GO:0045294 [alpha-catenin binding] GO:0045296 [cadherin binding] GO:0045765 [regulation of angiogenesis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0045976 [negative regulation of mitotic cell cycle, embryonic] GO:0046332 [SMAD binding] GO:0048145 [regulation of fibroblast proliferation] GO:0048471 [perinuclear region of cytoplasm] GO:0048660 [regulation of smooth muscle cell proliferation] GO:0050681 [androgen receptor binding] GO:0050767 [regulation of neurogenesis] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051149 [positive regulation of muscle cell differentiation] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0060070 [canonical Wnt signaling pathway] GO:0061154 [endothelial tube morphogenesis] GO:0061324 [canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation] GO:0061549 [sympathetic ganglion development] GO:0070062 [extracellular exosome] GO:0070369 [beta-catenin-TCF7L2 complex] GO:0070411 [I-SMAD binding] GO:0070602 [regulation of centromeric sister chromatid cohesion] GO:0071363 [cellular response to growth factor stimulus] GO:0071681 [cellular response to indole-3-methanol] GO:0071944 [cell periphery] GO:0072182 [regulation of nephron tubule epithelial cell differentiation] GO:0090279 [regulation of calcium ion import] GO:1904798 [positive regulation of core promoter binding] GO:1904837 [beta-catenin-TCF complex assembly] GO:1904886 [beta-catenin destruction complex disassembly] GO:1904948 [midbrain dopaminergic neuron differentiation] GO:1904954 [canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation] GO:1990907 [beta-catenin-TCF complex] GO:1990909 [Wnt signalosome] GO:2000008 [regulation of protein localization to cell surface] GO:2000144 [positive regulation of DNA-templated transcription, initiation]
Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)