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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
TCGA (cancer tissue):
Expressed in all
HPA (cell line):
Expressed in all
HPA (normal tissue):
Expressed in all
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expression normal tissuei
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score - normal tissuesi
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from.
Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
For each cancer, color-coded bars indicate the percentage of patients (maximum 12 patients) with high and medium protein expression level. The cancer types are color-coded according to which type of normal organ the cancer originates from. Low or not detected protein expression results in a white bar. Mouse-over function shows details about expression level and normal tissue of origin. The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies.
Few cases of gliomas, melanomas, lymphomas, skin, urothelial, testicular and renal cancers showed moderate nuclear and/or cytoplasmic positivity. Other cancers tissues were in general weakly stained or negative.
Cancer cells were generally negative.
Cancer tissues showed moderate to strong cytoplasmic staining. Renal cancers displayed strong cytoplasmic and membranous positivity. Hepatocellular carcinomas and prostate cancers were mostly negative.
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
SMAD3 (HGNC Symbol)
Synonyms
HsT17436, JV15-2, MADH3
Description
SMAD family member 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P84022 [Direct mapping] Mothers against decapentaplegic homolog 3 A0A024R5Z3 [Target identity:100%; Query identity:100%] Mothers against decapentaplegic homolog
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Predicted intracellular proteins Transcription factors beta-Hairpin exposed by an alpha/beta-scaffold Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000983 [transcription factor activity, RNA polymerase II core promoter sequence-specific] GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0000988 [transcription factor activity, protein binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001501 [skeletal system development] GO:0001649 [osteoblast differentiation] GO:0001657 [ureteric bud development] GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0001707 [mesoderm formation] GO:0001756 [somitogenesis] GO:0001889 [liver development] GO:0001947 [heart looping] GO:0002076 [osteoblast development] GO:0002520 [immune system development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005160 [transforming growth factor beta receptor binding] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005637 [nuclear inner membrane] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006810 [transport] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006955 [immune response] GO:0007050 [cell cycle arrest] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007183 [SMAD protein complex assembly] GO:0007369 [gastrulation] GO:0007492 [endoderm development] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0009880 [embryonic pattern specification] GO:0010628 [positive regulation of gene expression] GO:0010694 [positive regulation of alkaline phosphatase activity] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0016202 [regulation of striated muscle tissue development] GO:0016579 [protein deubiquitination] GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway] GO:0019049 [evasion or tolerance of host defenses by virus] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0019902 [phosphatase binding] GO:0023019 [signal transduction involved in regulation of gene expression] GO:0030308 [negative regulation of cell growth] GO:0030335 [positive regulation of cell migration] GO:0030501 [positive regulation of bone mineralization] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030618 [transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity] GO:0030878 [thyroid gland development] GO:0031053 [primary miRNA processing] GO:0031490 [chromatin DNA binding] GO:0031625 [ubiquitin protein ligase binding] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0032731 [positive regulation of interleukin-1 beta production] GO:0032909 [regulation of transforming growth factor beta2 production] GO:0032916 [positive regulation of transforming growth factor beta3 production] GO:0032924 [activin receptor signaling pathway] GO:0033689 [negative regulation of osteoblast proliferation] GO:0035326 [enhancer binding] GO:0035413 [positive regulation of catenin import into nucleus] GO:0038092 [nodal signaling pathway] GO:0042060 [wound healing] GO:0042110 [T cell activation] GO:0042177 [negative regulation of protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042993 [positive regulation of transcription factor import into nucleus] GO:0043066 [negative regulation of apoptotic process] GO:0043130 [ubiquitin binding] GO:0043234 [protein complex] GO:0043235 [receptor complex] GO:0043425 [bHLH transcription factor binding] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045216 [cell-cell junction organization] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045599 [negative regulation of fat cell differentiation] GO:0045668 [negative regulation of osteoblast differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046332 [SMAD binding] GO:0046872 [metal ion binding] GO:0046982 [protein heterodimerization activity] GO:0048340 [paraxial mesoderm morphogenesis] GO:0048589 [developmental growth] GO:0048617 [embryonic foregut morphogenesis] GO:0048701 [embryonic cranial skeleton morphogenesis] GO:0050678 [regulation of epithelial cell proliferation] GO:0050728 [negative regulation of inflammatory response] GO:0050776 [regulation of immune response] GO:0050821 [protein stabilization] GO:0050927 [positive regulation of positive chemotaxis] GO:0051098 [regulation of binding] GO:0051481 [negative regulation of cytosolic calcium ion concentration] GO:0051496 [positive regulation of stress fiber assembly] GO:0051894 [positive regulation of focal adhesion assembly] GO:0060039 [pericardium development] GO:0060070 [canonical Wnt signaling pathway] GO:0060290 [transdifferentiation] GO:0060395 [SMAD protein signal transduction] GO:0061045 [negative regulation of wound healing] GO:0061767 [negative regulation of lung blood pressure] GO:0070306 [lens fiber cell differentiation] GO:0070410 [co-SMAD binding] GO:0070412 [R-SMAD binding] GO:0071141 [SMAD protein complex] GO:0071144 [SMAD2-SMAD3 protein complex] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:1901203 [positive regulation of extracellular matrix assembly] GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter] GO:1903243 [negative regulation of cardiac muscle hypertrophy in response to stress]
P84022 [Direct mapping] Mothers against decapentaplegic homolog 3
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Predicted intracellular proteins Transcription factors beta-Hairpin exposed by an alpha/beta-scaffold Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000983 [transcription factor activity, RNA polymerase II core promoter sequence-specific] GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0000988 [transcription factor activity, protein binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001666 [response to hypoxia] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005160 [transforming growth factor beta receptor binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005637 [nuclear inner membrane] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006810 [transport] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006955 [immune response] GO:0007050 [cell cycle arrest] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007183 [SMAD protein complex assembly] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0010628 [positive regulation of gene expression] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0016579 [protein deubiquitination] GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway] GO:0019049 [evasion or tolerance of host defenses by virus] GO:0019901 [protein kinase binding] GO:0019902 [phosphatase binding] GO:0030308 [negative regulation of cell growth] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030618 [transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity] GO:0031053 [primary miRNA processing] GO:0031625 [ubiquitin protein ligase binding] GO:0032909 [regulation of transforming growth factor beta2 production] GO:0032924 [activin receptor signaling pathway] GO:0035326 [enhancer binding] GO:0038092 [nodal signaling pathway] GO:0042060 [wound healing] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042993 [positive regulation of transcription factor import into nucleus] GO:0043130 [ubiquitin binding] GO:0043235 [receptor complex] GO:0043425 [bHLH transcription factor binding] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045216 [cell-cell junction organization] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045599 [negative regulation of fat cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0051481 [negative regulation of cytosolic calcium ion concentration] GO:0070410 [co-SMAD binding] GO:0070412 [R-SMAD binding] GO:0071141 [SMAD protein complex] GO:0071144 [SMAD2-SMAD3 protein complex] GO:0097191 [extrinsic apoptotic signaling pathway] GO:1901203 [positive regulation of extracellular matrix assembly] GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
P84022 [Direct mapping] Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins Transcription factors beta-Hairpin exposed by an alpha/beta-scaffold Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000983 [transcription factor activity, RNA polymerase II core promoter sequence-specific] GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0000988 [transcription factor activity, protein binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001666 [response to hypoxia] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005160 [transforming growth factor beta receptor binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005637 [nuclear inner membrane] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006810 [transport] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006955 [immune response] GO:0007050 [cell cycle arrest] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007183 [SMAD protein complex assembly] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0010628 [positive regulation of gene expression] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0016579 [protein deubiquitination] GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway] GO:0019049 [evasion or tolerance of host defenses by virus] GO:0019901 [protein kinase binding] GO:0019902 [phosphatase binding] GO:0030308 [negative regulation of cell growth] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030618 [transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity] GO:0031053 [primary miRNA processing] GO:0031625 [ubiquitin protein ligase binding] GO:0032909 [regulation of transforming growth factor beta2 production] GO:0032924 [activin receptor signaling pathway] GO:0035326 [enhancer binding] GO:0038092 [nodal signaling pathway] GO:0042060 [wound healing] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042993 [positive regulation of transcription factor import into nucleus] GO:0043130 [ubiquitin binding] GO:0043235 [receptor complex] GO:0043425 [bHLH transcription factor binding] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045216 [cell-cell junction organization] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045599 [negative regulation of fat cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0051481 [negative regulation of cytosolic calcium ion concentration] GO:0070410 [co-SMAD binding] GO:0070412 [R-SMAD binding] GO:0071141 [SMAD protein complex] GO:0071144 [SMAD2-SMAD3 protein complex] GO:0097191 [extrinsic apoptotic signaling pathway] GO:1901203 [positive regulation of extracellular matrix assembly] GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
P84022 [Direct mapping] Mothers against decapentaplegic homolog 3
Show all
Predicted intracellular proteins Transcription factors beta-Hairpin exposed by an alpha/beta-scaffold Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000983 [transcription factor activity, RNA polymerase II core promoter sequence-specific] GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0000988 [transcription factor activity, protein binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001666 [response to hypoxia] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005160 [transforming growth factor beta receptor binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005637 [nuclear inner membrane] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006810 [transport] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006955 [immune response] GO:0007050 [cell cycle arrest] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007183 [SMAD protein complex assembly] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0010628 [positive regulation of gene expression] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0016579 [protein deubiquitination] GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway] GO:0019049 [evasion or tolerance of host defenses by virus] GO:0019901 [protein kinase binding] GO:0019902 [phosphatase binding] GO:0030308 [negative regulation of cell growth] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030618 [transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity] GO:0031053 [primary miRNA processing] GO:0031625 [ubiquitin protein ligase binding] GO:0032909 [regulation of transforming growth factor beta2 production] GO:0032924 [activin receptor signaling pathway] GO:0035326 [enhancer binding] GO:0038092 [nodal signaling pathway] GO:0042060 [wound healing] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042993 [positive regulation of transcription factor import into nucleus] GO:0043130 [ubiquitin binding] GO:0043235 [receptor complex] GO:0043425 [bHLH transcription factor binding] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045216 [cell-cell junction organization] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045599 [negative regulation of fat cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0051481 [negative regulation of cytosolic calcium ion concentration] GO:0070410 [co-SMAD binding] GO:0070412 [R-SMAD binding] GO:0071141 [SMAD protein complex] GO:0071144 [SMAD2-SMAD3 protein complex] GO:0097191 [extrinsic apoptotic signaling pathway] GO:1901203 [positive regulation of extracellular matrix assembly] GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
H0YKE2 [Direct mapping] Mothers against decapentaplegic homolog 3
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
H0YNV1 [Direct mapping] Mothers against decapentaplegic homolog 3
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
H0YL71 [Direct mapping] Mothers against decapentaplegic homolog 3
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
H3BVD1 [Direct mapping] Mothers against decapentaplegic homolog
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
H0YMP2 [Direct mapping] Mothers against decapentaplegic homolog 3
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
H0YMY0 [Direct mapping] Mothers against decapentaplegic homolog 3
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
H3BP09 [Direct mapping] Mothers against decapentaplegic homolog 3
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
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