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EGFR
GENERAL INFORMATION
Gene namei EGFR
Gene descriptioni Epidermal growth factor receptor
Protein classi Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
RAS pathway related proteins
Predicted localizationi Intracellular,Membrane,Secreted
Number of transcriptsi 8
SHOW MORE
HUMAN PROTEIN ATLAS INFORMATION
RNA categoryi
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enriched (A-431)
HPA (normal tissue):Tissue enhanced (placenta)
Protein evidencei Evidence at protein level
Protein expression
normal tissuei		 Cytoplasmic and membranous expression in several tissues, most abundant in placenta.

IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability
descriptioni		 Antibody staining mainly consistent with RNA expression data.
Reliability score -
normal tissuesi
Enhanced
Antibodiesi HPA001200 , HPA018530 , CAB000035 , CAB068186 , CAB073534
SHOW MORE
PROGNOSTIC SUMMARYi
Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001
Show all
RNA EXPRESSION OVERVIEWi
TCGA dataseti
RNA cancer category: Expressed in all
PROTEIN EXPRESSIONi
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma
PROTEIN EXPRESSION SUMMARYi
Organ
Expression
Alphabetical
HPA001200
HPA018530
CAB000035
CAB068186
CAB073534
GENE INFORMATIONi
Gene name EGFR (HGNC Symbol)
Synonyms ERBB, ERBB1
Description Epidermal growth factor receptor (HGNC Symbol)
Entrez gene summary The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]
Chromosome 7
Cytoband p11.2
Chromosome location (bp) 55019021 - 55211628
Protein evidence Evidence at protein level (all genes)
Ensembl ENSG00000146648 (version 88.38)
Entrez gene 1956
UniProt P00533 (UniProt - Evidence at protein level)
neXtProt NX_P00533
Antibodypedia EGFR antibodies
PROTEIN BROWSERi
EGFR-001
EGFR-002
EGFR-003
EGFR-004
EGFR-005
EGFR-009
EGFR-201
EGFR-202
PROTEIN INFORMATIONi
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
EGFR-001
ENSP00000275493
ENST00000275493
P00533 [Direct mapping]
Epidermal growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0000186 [activation of MAPKK activity]
GO:0000902 [cell morphogenesis]
GO:0001503 [ossification]
GO:0001889 [liver development]
GO:0001892 [embryonic placenta development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001942 [hair follicle development]
GO:0001948 [glycoprotein binding]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [signal transducer, downstream of receptor, with protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005006 [epidermal growth factor-activated receptor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005102 [receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006412 [translation]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0006970 [response to osmotic stress]
GO:0006979 [response to oxidative stress]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007275 [multicellular organism development]
GO:0007435 [salivary gland morphogenesis]
GO:0007494 [midgut development]
GO:0007611 [learning or memory]
GO:0007623 [circadian rhythm]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008544 [epidermis development]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010960 [magnesium ion homeostasis]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016101 [diterpenoid metabolic process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0021795 [cerebral cortex cell migration]
GO:0030122 [AP-2 adaptor complex]
GO:0030139 [endocytic vesicle]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0032355 [response to estradiol]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0033590 [response to cobalamin]
GO:0033594 [response to hydroxyisoflavone]
GO:0033993 [response to lipid]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0035556 [intracellular signal transduction]
GO:0035690 [cellular response to drug]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038128 [ERBB2 signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042060 [wound healing]
GO:0042127 [regulation of cell proliferation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042698 [ovulation cycle]
GO:0042743 [hydrogen peroxide metabolic process]
GO:0042802 [identical protein binding]
GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0043586 [tongue development]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045296 [cadherin binding]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0045780 [positive regulation of bone resorption]
GO:0045907 [positive regulation of vasoconstriction]
GO:0045909 [positive regulation of vasodilation]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0046982 [protein heterodimerization activity]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048143 [astrocyte activation]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048408 [epidermal growth factor binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048546 [digestive tract morphogenesis]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0048812 [neuron projection morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050729 [positive regulation of inflammatory response]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051015 [actin filament binding]
GO:0051205 [protein insertion into membrane]
GO:0051592 [response to calcium ion]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060571 [morphogenesis of an epithelial fold]
GO:0061024 [membrane organization]
GO:0061029 [eyelid development in camera-type eye]
GO:0070141 [response to UV-A]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070435 [Shc-EGFR complex]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0097421 [liver regeneration]
GO:0097489 [multivesicular body, internal vesicle lumen]
GO:1900020 [positive regulation of protein kinase C activity]
GO:1901185 [negative regulation of ERBB signaling pathway]
GO:1902722 [positive regulation of prolactin secretion]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1903800 [positive regulation of production of miRNAs involved in gene silencing by miRNA]
GO:1905208 [negative regulation of cardiocyte differentiation]
GO:2000145 [regulation of cell motility]
Show all
 1210 aa
134.3 kDa 		Yes 1
EGFR-002
ENSP00000345973
ENST00000344576
P00533 [Direct mapping]
Epidermal growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0001503 [ossification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [signal transducer, downstream of receptor, with protein tyrosine kinase activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005006 [epidermal growth factor-activated receptor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007275 [multicellular organism development]
GO:0007611 [learning or memory]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0030122 [AP-2 adaptor complex]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030335 [positive regulation of cell migration]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038128 [ERBB2 signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045121 [membrane raft]
GO:0045296 [cadherin binding]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0046982 [protein heterodimerization activity]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051015 [actin filament binding]
GO:0051205 [protein insertion into membrane]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0061024 [membrane organization]
GO:0070141 [response to UV-A]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070435 [Shc-EGFR complex]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0097489 [multivesicular body, internal vesicle lumen]
GO:1900020 [positive regulation of protein kinase C activity]
GO:1901185 [negative regulation of ERBB signaling pathway]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1903800 [positive regulation of production of miRNAs involved in gene silencing by miRNA]
GO:1905208 [negative regulation of cardiocyte differentiation]
GO:2000145 [regulation of cell motility]
Show all
 705 aa
77.3 kDa 		Yes 0
EGFR-003
ENSP00000342376
ENST00000342916
P00533 [Direct mapping]
Epidermal growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0001503 [ossification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [signal transducer, downstream of receptor, with protein tyrosine kinase activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005006 [epidermal growth factor-activated receptor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007275 [multicellular organism development]
GO:0007611 [learning or memory]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0030122 [AP-2 adaptor complex]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030335 [positive regulation of cell migration]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038128 [ERBB2 signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045121 [membrane raft]
GO:0045296 [cadherin binding]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0046982 [protein heterodimerization activity]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051015 [actin filament binding]
GO:0051205 [protein insertion into membrane]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0061024 [membrane organization]
GO:0070141 [response to UV-A]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070435 [Shc-EGFR complex]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0097489 [multivesicular body, internal vesicle lumen]
GO:1900020 [positive regulation of protein kinase C activity]
GO:1901185 [negative regulation of ERBB signaling pathway]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1903800 [positive regulation of production of miRNAs involved in gene silencing by miRNA]
GO:1905208 [negative regulation of cardiocyte differentiation]
GO:2000145 [regulation of cell motility]
Show all
 628 aa
69.2 kDa 		Yes 0
EGFR-004
ENSP00000415559
ENST00000455089
Q504U8 [Direct mapping]
Receptor protein-tyrosine kinase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0006898 [receptor-mediated endocytosis]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 1091 aa
120.7 kDa 		Yes 1
EGFR-005
ENSP00000413843
ENST00000420316
P00533 [Direct mapping]
Epidermal growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0001503 [ossification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [signal transducer, downstream of receptor, with protein tyrosine kinase activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005006 [epidermal growth factor-activated receptor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007275 [multicellular organism development]
GO:0007611 [learning or memory]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0030122 [AP-2 adaptor complex]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030307 [positive regulation of cell growth]
GO:0030335 [positive regulation of cell migration]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038128 [ERBB2 signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045121 [membrane raft]
GO:0045296 [cadherin binding]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0046982 [protein heterodimerization activity]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051015 [actin filament binding]
GO:0051205 [protein insertion into membrane]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0061024 [membrane organization]
GO:0070141 [response to UV-A]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070435 [Shc-EGFR complex]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0097489 [multivesicular body, internal vesicle lumen]
GO:1900020 [positive regulation of protein kinase C activity]
GO:1901185 [negative regulation of ERBB signaling pathway]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1903800 [positive regulation of production of miRNAs involved in gene silencing by miRNA]
GO:1905208 [negative regulation of cardiocyte differentiation]
GO:2000145 [regulation of cell motility]
Show all
 405 aa
44.7 kDa 		Yes 0
EGFR-009
ENSP00000413354
ENST00000450046
C9JYS6 [Direct mapping]
Epidermal growth factor receptor
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 128 aa
14.7 kDa 		No 0
EGFR-201
ENSP00000395243
ENST00000454757
E9PFD7 [Direct mapping]
Receptor protein-tyrosine kinase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 1165 aa
129.2 kDa 		Yes 1
EGFR-202
ENSP00000492462
ENST00000638463
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 464 aa
50.5 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.