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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for data imported from The Genotype-Tissue Expression project (GTEX), FANTOM5 Consortium (FANTOM5) and internally generated Human Protein Atlas (HPA) data.
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expressioni
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining consistent with RNA expression data.
Reliability scorei
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Below is an overview of RNA and protein expression data generated in the Human Protein Atlas project. Analyzed tissues are divided into color-coded groups according to which functional features they have in common. For each group, a list of included tissues is accessed by clicking on group name, group symbol, RNA bar, or protein bar. Subsequent selection of a particular tissue in this list links to the image data page.
Images of selected tissues give a visual summary of the protein expression profile furthest to the right.
The gray human body provides links to a histology dictionary when clicking on any part of the figure.
RNA expression (TPM)i
RNA-seq results generated in HPA are reported as number of transcripts per million (TPM). Each bar represents the highest expression score found in a particular group of tissues. The assay is described more in detail in Assays & Annotation.
Protein expression (score)i
Each bar represents the highest expression score found in a particular group of tissues. Protein expression scores are based on a best estimate of the "true" protein expression from a knowledge-based annotation, described more in detail under Assays & annotation. For genes where more than one antibody has been used, a collective score is set displaying the estimated true protein expression.
Protein expression data is shown for each of the 44 tissues. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. Mouse-over function shows protein score for analyzed cell types in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation.
For genes with available protein data for which a knowledge-based annotation gave inconclusive results, no protein expression data is displayed in the protein expression data overview. However, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Organ
Expression
Alphabetical
RNA EXPRESSION OVERVIEWi
RNA expression overview shows RNA-data from three different sources: Internally generated Human Protein Atlas (HPA) RNA-seq data, RNA-seq data from the Genotype-Tissue Expression (GTEx) project and CAGE data from FANTOM5 project. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.
HPA dataseti
HPA dataset RNA-seq tissue data is reported as mean TPM (transcripts per million), corresponding to mean values of the different individual samples from each tissue. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar. The RNA-seq assay is described in detail in Assays & Annotation.
RNA tissue category HPA HPA RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataseti
GTEx dataset RNA-seq data is reported as median RPKM (reads per kilobase per million mapped reads), generated by the Genotype-Tissue Expression (GTEx) project. More information can be found in Assays & Annotation.
RNA tissue category GTEx GTEx RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataseti
FANTOM5 dataset Tissue data obtained through Cap Analysis of Gene Expression (CAGE) are reported as Tags Per Million, generated by the FANTOM5 project. More information can be found in Assays & Annotation.
RNA tissue category FANTOM5 FANTOM5 RNA tissue category (category description) is calculated based on gene expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
AKT1 (HGNC Symbol)
Synonyms
AKT, PKB, PRKBA, RAC
Description
AKT serine/threonine kinase 1 (HGNC Symbol)
Entrez gene summary
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
AKT1-001
AKT1-002
AKT1-003
AKT1-004
AKT1-005
AKT1-006
AKT1-010
AKT1-014
AKT1-018
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000166 [nucleotide binding] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0005977 [glycogen metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005979 [regulation of glycogen biosynthetic process] GO:0006006 [glucose metabolic process] GO:0006417 [regulation of translation] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0006469 [negative regulation of protein kinase activity] GO:0006809 [nitric oxide biosynthetic process] GO:0006810 [transport] GO:0006915 [apoptotic process] GO:0006924 [activation-induced cell death of T cells] GO:0006979 [response to oxidative stress] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008643 [carbohydrate transport] GO:0009408 [response to heat] GO:0010507 [negative regulation of autophagy] GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] GO:0010907 [positive regulation of glucose metabolic process] GO:0010951 [negative regulation of endopeptidase activity] GO:0010975 [regulation of neuron projection development] GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling] GO:0015630 [microtubule cytoskeleton] GO:0016020 [membrane] GO:0016242 [negative regulation of macroautophagy] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019899 [enzyme binding] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030307 [positive regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0031018 [endocrine pancreas development] GO:0031295 [T cell costimulation] GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] GO:0031929 [TOR signaling] GO:0031982 [vesicle] GO:0031999 [negative regulation of fatty acid beta-oxidation] GO:0032079 [positive regulation of endodeoxyribonuclease activity] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032869 [cellular response to insulin stimulus] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034405 [response to fluid shear stress] GO:0035556 [intracellular signal transduction] GO:0035655 [interleukin-18-mediated signaling pathway] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043276 [anoikis] GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding] GO:0043488 [regulation of mRNA stability] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway] GO:0045861 [negative regulation of proteolysis] GO:0046326 [positive regulation of glucose import] GO:0046777 [protein autophosphorylation] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060416 [response to growth hormone] GO:0060644 [mammary gland epithelial cell differentiation] GO:0061024 [membrane organization] GO:0070141 [response to UV-A] GO:0071889 [14-3-3 protein binding] GO:0072655 [establishment of protein localization to mitochondrion] GO:0072656 [maintenance of protein location in mitochondrion] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0098794 [postsynapse] GO:0099565 [chemical synaptic transmission, postsynaptic] GO:0100002 [negative regulation of protein kinase activity by protein phosphorylation] GO:1900182 [positive regulation of protein localization to nucleus] GO:1901215 [negative regulation of neuron death] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1901976 [regulation of cell cycle checkpoint] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1990090 [cellular response to nerve growth factor stimulus] GO:1990418 [response to insulin-like growth factor stimulus] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000166 [nucleotide binding] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0005977 [glycogen metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005979 [regulation of glycogen biosynthetic process] GO:0006006 [glucose metabolic process] GO:0006417 [regulation of translation] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0006469 [negative regulation of protein kinase activity] GO:0006809 [nitric oxide biosynthetic process] GO:0006810 [transport] GO:0006915 [apoptotic process] GO:0006924 [activation-induced cell death of T cells] GO:0006979 [response to oxidative stress] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008643 [carbohydrate transport] GO:0009408 [response to heat] GO:0010507 [negative regulation of autophagy] GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] GO:0010907 [positive regulation of glucose metabolic process] GO:0010951 [negative regulation of endopeptidase activity] GO:0010975 [regulation of neuron projection development] GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling] GO:0015630 [microtubule cytoskeleton] GO:0016020 [membrane] GO:0016242 [negative regulation of macroautophagy] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019899 [enzyme binding] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030307 [positive regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0031018 [endocrine pancreas development] GO:0031295 [T cell costimulation] GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] GO:0031929 [TOR signaling] GO:0031982 [vesicle] GO:0031999 [negative regulation of fatty acid beta-oxidation] GO:0032079 [positive regulation of endodeoxyribonuclease activity] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032869 [cellular response to insulin stimulus] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034405 [response to fluid shear stress] GO:0035556 [intracellular signal transduction] GO:0035655 [interleukin-18-mediated signaling pathway] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043276 [anoikis] GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding] GO:0043488 [regulation of mRNA stability] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway] GO:0045861 [negative regulation of proteolysis] GO:0046326 [positive regulation of glucose import] GO:0046777 [protein autophosphorylation] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060416 [response to growth hormone] GO:0060644 [mammary gland epithelial cell differentiation] GO:0061024 [membrane organization] GO:0070141 [response to UV-A] GO:0071889 [14-3-3 protein binding] GO:0072655 [establishment of protein localization to mitochondrion] GO:0072656 [maintenance of protein location in mitochondrion] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0098794 [postsynapse] GO:0099565 [chemical synaptic transmission, postsynaptic] GO:0100002 [negative regulation of protein kinase activity by protein phosphorylation] GO:1900182 [positive regulation of protein localization to nucleus] GO:1901215 [negative regulation of neuron death] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1901976 [regulation of cell cycle checkpoint] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1990090 [cellular response to nerve growth factor stimulus] GO:1990418 [response to insulin-like growth factor stimulus] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000166 [nucleotide binding] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0005977 [glycogen metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005979 [regulation of glycogen biosynthetic process] GO:0006006 [glucose metabolic process] GO:0006417 [regulation of translation] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0006469 [negative regulation of protein kinase activity] GO:0006809 [nitric oxide biosynthetic process] GO:0006810 [transport] GO:0006915 [apoptotic process] GO:0006924 [activation-induced cell death of T cells] GO:0006979 [response to oxidative stress] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008643 [carbohydrate transport] GO:0009408 [response to heat] GO:0010507 [negative regulation of autophagy] GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] GO:0010907 [positive regulation of glucose metabolic process] GO:0010951 [negative regulation of endopeptidase activity] GO:0010975 [regulation of neuron projection development] GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling] GO:0015630 [microtubule cytoskeleton] GO:0016020 [membrane] GO:0016242 [negative regulation of macroautophagy] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019899 [enzyme binding] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030307 [positive regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0031018 [endocrine pancreas development] GO:0031295 [T cell costimulation] GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] GO:0031929 [TOR signaling] GO:0031982 [vesicle] GO:0031999 [negative regulation of fatty acid beta-oxidation] GO:0032079 [positive regulation of endodeoxyribonuclease activity] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032869 [cellular response to insulin stimulus] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034405 [response to fluid shear stress] GO:0035556 [intracellular signal transduction] GO:0035655 [interleukin-18-mediated signaling pathway] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043276 [anoikis] GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding] GO:0043488 [regulation of mRNA stability] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway] GO:0045861 [negative regulation of proteolysis] GO:0046326 [positive regulation of glucose import] GO:0046777 [protein autophosphorylation] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060416 [response to growth hormone] GO:0060644 [mammary gland epithelial cell differentiation] GO:0061024 [membrane organization] GO:0070141 [response to UV-A] GO:0071889 [14-3-3 protein binding] GO:0072655 [establishment of protein localization to mitochondrion] GO:0072656 [maintenance of protein location in mitochondrion] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0098794 [postsynapse] GO:0099565 [chemical synaptic transmission, postsynaptic] GO:0100002 [negative regulation of protein kinase activity by protein phosphorylation] GO:1900182 [positive regulation of protein localization to nucleus] GO:1901215 [negative regulation of neuron death] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1901976 [regulation of cell cycle checkpoint] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1990090 [cellular response to nerve growth factor stimulus] GO:1990418 [response to insulin-like growth factor stimulus] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000166 [nucleotide binding] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0005977 [glycogen metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005979 [regulation of glycogen biosynthetic process] GO:0006006 [glucose metabolic process] GO:0006417 [regulation of translation] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0006469 [negative regulation of protein kinase activity] GO:0006809 [nitric oxide biosynthetic process] GO:0006810 [transport] GO:0006915 [apoptotic process] GO:0006924 [activation-induced cell death of T cells] GO:0006979 [response to oxidative stress] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008643 [carbohydrate transport] GO:0009408 [response to heat] GO:0010507 [negative regulation of autophagy] GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] GO:0010907 [positive regulation of glucose metabolic process] GO:0010951 [negative regulation of endopeptidase activity] GO:0010975 [regulation of neuron projection development] GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling] GO:0015630 [microtubule cytoskeleton] GO:0016020 [membrane] GO:0016242 [negative regulation of macroautophagy] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019899 [enzyme binding] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030307 [positive regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0031018 [endocrine pancreas development] GO:0031295 [T cell costimulation] GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] GO:0031929 [TOR signaling] GO:0031982 [vesicle] GO:0031999 [negative regulation of fatty acid beta-oxidation] GO:0032079 [positive regulation of endodeoxyribonuclease activity] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032869 [cellular response to insulin stimulus] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034405 [response to fluid shear stress] GO:0035556 [intracellular signal transduction] GO:0035655 [interleukin-18-mediated signaling pathway] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043276 [anoikis] GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding] GO:0043488 [regulation of mRNA stability] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway] GO:0045861 [negative regulation of proteolysis] GO:0046326 [positive regulation of glucose import] GO:0046777 [protein autophosphorylation] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060416 [response to growth hormone] GO:0060644 [mammary gland epithelial cell differentiation] GO:0061024 [membrane organization] GO:0070141 [response to UV-A] GO:0071889 [14-3-3 protein binding] GO:0072655 [establishment of protein localization to mitochondrion] GO:0072656 [maintenance of protein location in mitochondrion] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0098794 [postsynapse] GO:0099565 [chemical synaptic transmission, postsynaptic] GO:0100002 [negative regulation of protein kinase activity by protein phosphorylation] GO:1900182 [positive regulation of protein localization to nucleus] GO:1901215 [negative regulation of neuron death] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1901976 [regulation of cell cycle checkpoint] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1990090 [cellular response to nerve growth factor stimulus] GO:1990418 [response to insulin-like growth factor stimulus] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
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GO:0000060 [protein import into nucleus, translocation] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000166 [nucleotide binding] GO:0001649 [osteoblast differentiation] GO:0001893 [maternal placenta development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005080 [protein kinase C binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005975 [carbohydrate metabolic process] GO:0005977 [glycogen metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005979 [regulation of glycogen biosynthetic process] GO:0006006 [glucose metabolic process] GO:0006412 [translation] GO:0006417 [regulation of translation] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0006469 [negative regulation of protein kinase activity] GO:0006809 [nitric oxide biosynthetic process] GO:0006810 [transport] GO:0006915 [apoptotic process] GO:0006924 [activation-induced cell death of T cells] GO:0006954 [inflammatory response] GO:0006974 [cellular response to DNA damage stimulus] GO:0006979 [response to oxidative stress] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007275 [multicellular organism development] GO:0007281 [germ cell development] GO:0007399 [nervous system development] GO:0007568 [aging] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008637 [apoptotic mitochondrial changes] GO:0008643 [carbohydrate transport] GO:0009408 [response to heat] GO:0009725 [response to hormone] GO:0010033 [response to organic substance] GO:0010507 [negative regulation of autophagy] GO:0010629 [negative regulation of gene expression] GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] GO:0010763 [positive regulation of fibroblast migration] GO:0010765 [positive regulation of sodium ion transport] GO:0010907 [positive regulation of glucose metabolic process] GO:0010951 [negative regulation of endopeptidase activity] GO:0010975 [regulation of neuron projection development] GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling] GO:0015630 [microtubule cytoskeleton] GO:0015758 [glucose transport] GO:0016020 [membrane] GO:0016242 [negative regulation of macroautophagy] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016567 [protein ubiquitination] GO:0016740 [transferase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0021510 [spinal cord development] GO:0030030 [cell projection organization] GO:0030154 [cell differentiation] GO:0030163 [protein catabolic process] GO:0030168 [platelet activation] GO:0030212 [hyaluronan metabolic process] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030307 [positive regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0031018 [endocrine pancreas development] GO:0031295 [T cell costimulation] GO:0031641 [regulation of myelination] GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0031929 [TOR signaling] GO:0031982 [vesicle] GO:0031999 [negative regulation of fatty acid beta-oxidation] GO:0032079 [positive regulation of endodeoxyribonuclease activity] GO:0032094 [response to food] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032287 [peripheral nervous system myelin maintenance] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032794 [GTPase activating protein binding] GO:0032869 [cellular response to insulin stimulus] GO:0032880 [regulation of protein localization] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034405 [response to fluid shear stress] GO:0035556 [intracellular signal transduction] GO:0035655 [interleukin-18-mediated signaling pathway] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036064 [ciliary basal body] GO:0036294 [cellular response to decreased oxygen levels] GO:0042593 [glucose homeostasis] GO:0042802 [identical protein binding] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043234 [protein complex] GO:0043276 [anoikis] GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding] GO:0043488 [regulation of mRNA stability] GO:0043491 [protein kinase B signaling] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway] GO:0045792 [negative regulation of cell size] GO:0045861 [negative regulation of proteolysis] GO:0045907 [positive regulation of vasoconstriction] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046326 [positive regulation of glucose import] GO:0046329 [negative regulation of JNK cascade] GO:0046622 [positive regulation of organ growth] GO:0046777 [protein autophosphorylation] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051146 [striated muscle cell differentiation] GO:0051721 [protein phosphatase 2A binding] GO:0060416 [response to growth hormone] GO:0060644 [mammary gland epithelial cell differentiation] GO:0060709 [glycogen cell differentiation involved in embryonic placenta development] GO:0060716 [labyrinthine layer blood vessel development] GO:0061024 [membrane organization] GO:0070141 [response to UV-A] GO:0071260 [cellular response to mechanical stimulus] GO:0071363 [cellular response to growth factor stimulus] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0071380 [cellular response to prostaglandin E stimulus] GO:0071407 [cellular response to organic cyclic compound] GO:0071456 [cellular response to hypoxia] GO:0071889 [14-3-3 protein binding] GO:0072655 [establishment of protein localization to mitochondrion] GO:0072656 [maintenance of protein location in mitochondrion] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0097011 [cellular response to granulocyte macrophage colony-stimulating factor stimulus] GO:0097194 [execution phase of apoptosis] GO:0098794 [postsynapse] GO:0099565 [chemical synaptic transmission, postsynaptic] GO:0100002 [negative regulation of protein kinase activity by protein phosphorylation] GO:1900182 [positive regulation of protein localization to nucleus] GO:1901215 [negative regulation of neuron death] GO:1901653 [cellular response to peptide] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1901976 [regulation of cell cycle checkpoint] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1990090 [cellular response to nerve growth factor stimulus] GO:1990418 [response to insulin-like growth factor stimulus] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000060 [protein import into nucleus, translocation] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000166 [nucleotide binding] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0005977 [glycogen metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0005979 [regulation of glycogen biosynthetic process] GO:0006006 [glucose metabolic process] GO:0006417 [regulation of translation] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0006469 [negative regulation of protein kinase activity] GO:0006809 [nitric oxide biosynthetic process] GO:0006810 [transport] GO:0006915 [apoptotic process] GO:0006924 [activation-induced cell death of T cells] GO:0006979 [response to oxidative stress] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008643 [carbohydrate transport] GO:0009408 [response to heat] GO:0010507 [negative regulation of autophagy] GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] GO:0010907 [positive regulation of glucose metabolic process] GO:0010951 [negative regulation of endopeptidase activity] GO:0010975 [regulation of neuron projection development] GO:0014066 [regulation of phosphatidylinositol 3-kinase signaling] GO:0015630 [microtubule cytoskeleton] GO:0016020 [membrane] GO:0016242 [negative regulation of macroautophagy] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019899 [enzyme binding] GO:0030154 [cell differentiation] GO:0030168 [platelet activation] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030307 [positive regulation of cell growth] GO:0030334 [regulation of cell migration] GO:0031018 [endocrine pancreas development] GO:0031295 [T cell costimulation] GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] GO:0031929 [TOR signaling] GO:0031982 [vesicle] GO:0031999 [negative regulation of fatty acid beta-oxidation] GO:0032079 [positive regulation of endodeoxyribonuclease activity] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032869 [cellular response to insulin stimulus] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034405 [response to fluid shear stress] GO:0035556 [intracellular signal transduction] GO:0035655 [interleukin-18-mediated signaling pathway] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043276 [anoikis] GO:0043325 [phosphatidylinositol-3,4-bisphosphate binding] GO:0043488 [regulation of mRNA stability] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045600 [positive regulation of fat cell differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway] GO:0045861 [negative regulation of proteolysis] GO:0046326 [positive regulation of glucose import] GO:0046777 [protein autophosphorylation] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060416 [response to growth hormone] GO:0060644 [mammary gland epithelial cell differentiation] GO:0061024 [membrane organization] GO:0070141 [response to UV-A] GO:0071889 [14-3-3 protein binding] GO:0072655 [establishment of protein localization to mitochondrion] GO:0072656 [maintenance of protein location in mitochondrion] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0098794 [postsynapse] GO:0099565 [chemical synaptic transmission, postsynaptic] GO:0100002 [negative regulation of protein kinase activity by protein phosphorylation] GO:1900182 [positive regulation of protein localization to nucleus] GO:1901215 [negative regulation of neuron death] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1901976 [regulation of cell cycle checkpoint] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1990090 [cellular response to nerve growth factor stimulus] GO:1990418 [response to insulin-like growth factor stimulus] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
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