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LEF1
GENERAL INFORMATION
Gene namei LEF1
Gene descriptioni Lymphoid enhancer binding factor 1
Protein classi Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors
Predicted localizationi Intracellular
Number of transcriptsi 6
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HUMAN PROTEIN ATLAS INFORMATION
RNA categoryi
TCGA (cancer tissue):Expressed in all
HPA (cell line):Group enriched (MOLT-4, REH)
HPA (normal tissue):Tissue enhanced (lymph node)
Protein evidencei Evidence at protein level
Protein expression
normal tissuei		 Nuclear expression in lymphoid tissue.

IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability
descriptioni		 Antibody staining mainly consistent with RNA expression data. Cytoplasmic staining observed and disregarded.
Reliability score -
normal tissuesi
Enhanced
Antibodiesi HPA002087 , CAB019405
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PROGNOSTIC SUMMARYi
Prognostic marker in renal cancer (unfavourable) and endometrial cancer (favourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEWi
TCGA dataseti
RNA cancer category: Expressed in all
PROTEIN EXPRESSIONi
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
PROTEIN EXPRESSION SUMMARYi
Organ
Expression
Alphabetical
HPA002087
CAB019405
GENE INFORMATIONi
Gene name LEF1 (HGNC Symbol)
Synonyms TCF10, TCF1ALPHA, TCF7L3
Description Lymphoid enhancer binding factor 1 (HGNC Symbol)
Entrez gene summary This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Chromosome 4
Cytoband q25
Chromosome location (bp) 108047545 - 108168956
Protein evidence Evidence at protein level (all genes)
Ensembl ENSG00000138795 (version 88.38)
Entrez gene 51176
UniProt Q9UJU2 (UniProt - Evidence at protein level)
neXtProt NX_Q9UJU2
Antibodypedia LEF1 antibodies
PROTEIN BROWSERi
LEF1-001
LEF1-003
LEF1-006
LEF1-018
LEF1-020
LEF1-201
PROTEIN INFORMATIONi
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
LEF1-001
ENSP00000265165
ENST00000265165
Q9UJU2 [Direct mapping]
Lymphoid enhancer-binding factor 1
A0A024RDI7 [Target identity:100%; Query identity:100%]
Lymphoid enhancer-binding factor 1, isoform CRA_b
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001649 [osteoblast differentiation]
GO:0001755 [neural crest cell migration]
GO:0001756 [somitogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001944 [vasculature development]
GO:0002040 [sprouting angiogenesis]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007223 [Wnt signaling pathway, calcium modulating pathway]
GO:0008013 [beta-catenin binding]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008301 [DNA binding, bending]
GO:0010628 [positive regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016055 [Wnt signaling pathway]
GO:0016202 [regulation of striated muscle tissue development]
GO:0021542 [dentate gyrus development]
GO:0021766 [hippocampus development]
GO:0021854 [hypothalamus development]
GO:0021861 [forebrain radial glial cell differentiation]
GO:0021873 [forebrain neuroblast division]
GO:0021879 [forebrain neuron differentiation]
GO:0021943 [formation of radial glial scaffolds]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0030223 [neutrophil differentiation]
GO:0030284 [estrogen receptor activity]
GO:0030307 [positive regulation of cell growth]
GO:0030326 [embryonic limb morphogenesis]
GO:0030331 [estrogen receptor binding]
GO:0030335 [positive regulation of cell migration]
GO:0030509 [BMP signaling pathway]
GO:0030854 [positive regulation of granulocyte differentiation]
GO:0030879 [mammary gland development]
GO:0032696 [negative regulation of interleukin-13 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032714 [negative regulation of interleukin-5 production]
GO:0032993 [protein-DNA complex]
GO:0033153 [T cell receptor V(D)J recombination]
GO:0035326 [enhancer binding]
GO:0042100 [B cell proliferation]
GO:0042393 [histone binding]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042826 [histone deacetylase binding]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0043586 [tongue development]
GO:0043923 [positive regulation by host of viral transcription]
GO:0043966 [histone H3 acetylation]
GO:0043967 [histone H4 acetylation]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045063 [T-helper 1 cell differentiation]
GO:0045295 [gamma-catenin binding]
GO:0045843 [negative regulation of striated muscle tissue development]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046632 [alpha-beta T cell differentiation]
GO:0048069 [eye pigmentation]
GO:0048341 [paraxial mesoderm formation]
GO:0048468 [cell development]
GO:0048747 [muscle fiber development]
GO:0050909 [sensory perception of taste]
GO:0060021 [palate development]
GO:0060033 [anatomical structure regression]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060325 [face morphogenesis]
GO:0060326 [cell chemotaxis]
GO:0060561 [apoptotic process involved in morphogenesis]
GO:0060710 [chorio-allantoic fusion]
GO:0061153 [trachea gland development]
GO:0070016 [armadillo repeat domain binding]
GO:0070742 [C2H2 zinc finger domain binding]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071353 [cellular response to interleukin-4]
GO:0071864 [positive regulation of cell proliferation in bone marrow]
GO:0071866 [negative regulation of apoptotic process in bone marrow]
GO:0071895 [odontoblast differentiation]
GO:0071899 [negative regulation of estrogen receptor binding]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:1902262 [apoptotic process involved in blood vessel morphogenesis]
GO:1904837 [beta-catenin-TCF complex assembly]
GO:1990907 [beta-catenin-TCF complex]
Show all
 399 aa
44.2 kDa 		No 0
LEF1-003
ENSP00000422801
ENST00000515500
D6RAB1 [Direct mapping]
Lymphoid enhancer-binding factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0016055 [Wnt signaling pathway]
Show all
 173 aa
18.8 kDa 		No 0
LEF1-006
ENSP00000427365
ENST00000512172
D6RIV1 [Direct mapping]
Lymphoid enhancer-binding factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008013 [beta-catenin binding]
GO:0016055 [Wnt signaling pathway]
Show all
 145 aa
15.8 kDa 		No 0
LEF1-018
ENSP00000422840
ENST00000510624
Q9UJU2 [Direct mapping]
Lymphoid enhancer-binding factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001649 [osteoblast differentiation]
GO:0001755 [neural crest cell migration]
GO:0001756 [somitogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002040 [sprouting angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007223 [Wnt signaling pathway, calcium modulating pathway]
GO:0008013 [beta-catenin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008301 [DNA binding, bending]
GO:0010628 [positive regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016055 [Wnt signaling pathway]
GO:0016202 [regulation of striated muscle tissue development]
GO:0021542 [dentate gyrus development]
GO:0021854 [hypothalamus development]
GO:0021861 [forebrain radial glial cell differentiation]
GO:0021873 [forebrain neuroblast division]
GO:0021879 [forebrain neuron differentiation]
GO:0021943 [formation of radial glial scaffolds]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030223 [neutrophil differentiation]
GO:0030284 [estrogen receptor activity]
GO:0030307 [positive regulation of cell growth]
GO:0030326 [embryonic limb morphogenesis]
GO:0030331 [estrogen receptor binding]
GO:0030335 [positive regulation of cell migration]
GO:0030509 [BMP signaling pathway]
GO:0030854 [positive regulation of granulocyte differentiation]
GO:0030879 [mammary gland development]
GO:0032696 [negative regulation of interleukin-13 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032714 [negative regulation of interleukin-5 production]
GO:0032993 [protein-DNA complex]
GO:0035326 [enhancer binding]
GO:0042100 [B cell proliferation]
GO:0042393 [histone binding]
GO:0042826 [histone deacetylase binding]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0043923 [positive regulation by host of viral transcription]
GO:0043966 [histone H3 acetylation]
GO:0043967 [histone H4 acetylation]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045063 [T-helper 1 cell differentiation]
GO:0045295 [gamma-catenin binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046632 [alpha-beta T cell differentiation]
GO:0048069 [eye pigmentation]
GO:0048341 [paraxial mesoderm formation]
GO:0048747 [muscle fiber development]
GO:0060021 [palate development]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060325 [face morphogenesis]
GO:0060326 [cell chemotaxis]
GO:0060561 [apoptotic process involved in morphogenesis]
GO:0060710 [chorio-allantoic fusion]
GO:0061153 [trachea gland development]
GO:0070016 [armadillo repeat domain binding]
GO:0070742 [C2H2 zinc finger domain binding]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071353 [cellular response to interleukin-4]
GO:0071864 [positive regulation of cell proliferation in bone marrow]
GO:0071866 [negative regulation of apoptotic process in bone marrow]
GO:0071895 [odontoblast differentiation]
GO:0071899 [negative regulation of estrogen receptor binding]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:1904837 [beta-catenin-TCF complex assembly]
GO:1990907 [beta-catenin-TCF complex]
Show all
 303 aa
34.1 kDa 		No 0
LEF1-020
ENSP00000406176
ENST00000438313
Q9UJU2 [Direct mapping]
Lymphoid enhancer-binding factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001649 [osteoblast differentiation]
GO:0001755 [neural crest cell migration]
GO:0001756 [somitogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002040 [sprouting angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007223 [Wnt signaling pathway, calcium modulating pathway]
GO:0008013 [beta-catenin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008301 [DNA binding, bending]
GO:0010628 [positive regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016055 [Wnt signaling pathway]
GO:0016202 [regulation of striated muscle tissue development]
GO:0021542 [dentate gyrus development]
GO:0021854 [hypothalamus development]
GO:0021861 [forebrain radial glial cell differentiation]
GO:0021873 [forebrain neuroblast division]
GO:0021879 [forebrain neuron differentiation]
GO:0021943 [formation of radial glial scaffolds]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030223 [neutrophil differentiation]
GO:0030284 [estrogen receptor activity]
GO:0030307 [positive regulation of cell growth]
GO:0030326 [embryonic limb morphogenesis]
GO:0030331 [estrogen receptor binding]
GO:0030335 [positive regulation of cell migration]
GO:0030509 [BMP signaling pathway]
GO:0030854 [positive regulation of granulocyte differentiation]
GO:0030879 [mammary gland development]
GO:0032696 [negative regulation of interleukin-13 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032714 [negative regulation of interleukin-5 production]
GO:0032993 [protein-DNA complex]
GO:0035326 [enhancer binding]
GO:0042100 [B cell proliferation]
GO:0042393 [histone binding]
GO:0042826 [histone deacetylase binding]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0043923 [positive regulation by host of viral transcription]
GO:0043966 [histone H3 acetylation]
GO:0043967 [histone H4 acetylation]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045063 [T-helper 1 cell differentiation]
GO:0045295 [gamma-catenin binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046632 [alpha-beta T cell differentiation]
GO:0048069 [eye pigmentation]
GO:0048341 [paraxial mesoderm formation]
GO:0048747 [muscle fiber development]
GO:0060021 [palate development]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060325 [face morphogenesis]
GO:0060326 [cell chemotaxis]
GO:0060561 [apoptotic process involved in morphogenesis]
GO:0060710 [chorio-allantoic fusion]
GO:0061153 [trachea gland development]
GO:0070016 [armadillo repeat domain binding]
GO:0070742 [C2H2 zinc finger domain binding]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071353 [cellular response to interleukin-4]
GO:0071864 [positive regulation of cell proliferation in bone marrow]
GO:0071866 [negative regulation of apoptotic process in bone marrow]
GO:0071895 [odontoblast differentiation]
GO:0071899 [negative regulation of estrogen receptor binding]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:1904837 [beta-catenin-TCF complex assembly]
GO:1990907 [beta-catenin-TCF complex]
Show all
 371 aa
41.2 kDa 		No 0
LEF1-201
ENSP00000369284
ENST00000379951
Q9UJU2 [Direct mapping]
Lymphoid enhancer-binding factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001649 [osteoblast differentiation]
GO:0001755 [neural crest cell migration]
GO:0001756 [somitogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002040 [sprouting angiogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007223 [Wnt signaling pathway, calcium modulating pathway]
GO:0008013 [beta-catenin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008301 [DNA binding, bending]
GO:0010628 [positive regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0016055 [Wnt signaling pathway]
GO:0016202 [regulation of striated muscle tissue development]
GO:0021542 [dentate gyrus development]
GO:0021854 [hypothalamus development]
GO:0021861 [forebrain radial glial cell differentiation]
GO:0021873 [forebrain neuroblast division]
GO:0021879 [forebrain neuron differentiation]
GO:0021943 [formation of radial glial scaffolds]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030223 [neutrophil differentiation]
GO:0030284 [estrogen receptor activity]
GO:0030307 [positive regulation of cell growth]
GO:0030326 [embryonic limb morphogenesis]
GO:0030331 [estrogen receptor binding]
GO:0030335 [positive regulation of cell migration]
GO:0030509 [BMP signaling pathway]
GO:0030854 [positive regulation of granulocyte differentiation]
GO:0030879 [mammary gland development]
GO:0032696 [negative regulation of interleukin-13 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032714 [negative regulation of interleukin-5 production]
GO:0032993 [protein-DNA complex]
GO:0035326 [enhancer binding]
GO:0042100 [B cell proliferation]
GO:0042393 [histone binding]
GO:0042826 [histone deacetylase binding]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0043923 [positive regulation by host of viral transcription]
GO:0043966 [histone H3 acetylation]
GO:0043967 [histone H4 acetylation]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045063 [T-helper 1 cell differentiation]
GO:0045295 [gamma-catenin binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046632 [alpha-beta T cell differentiation]
GO:0048069 [eye pigmentation]
GO:0048341 [paraxial mesoderm formation]
GO:0048747 [muscle fiber development]
GO:0060021 [palate development]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060325 [face morphogenesis]
GO:0060326 [cell chemotaxis]
GO:0060561 [apoptotic process involved in morphogenesis]
GO:0060710 [chorio-allantoic fusion]
GO:0061153 [trachea gland development]
GO:0070016 [armadillo repeat domain binding]
GO:0070742 [C2H2 zinc finger domain binding]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071353 [cellular response to interleukin-4]
GO:0071864 [positive regulation of cell proliferation in bone marrow]
GO:0071866 [negative regulation of apoptotic process in bone marrow]
GO:0071895 [odontoblast differentiation]
GO:0071899 [negative regulation of estrogen receptor binding]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:1904837 [beta-catenin-TCF complex assembly]
GO:1990907 [beta-catenin-TCF complex]
Show all
 386 aa
42.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.