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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for data imported from The Genotype-Tissue Expression project (GTEX), FANTOM5 Consortium (FANTOM5) and internally generated Human Protein Atlas (HPA) data.
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expressioni
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining consistent with RNA expression data.
Reliability scorei
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Below is an overview of RNA and protein expression data generated in the Human Protein Atlas project. Analyzed tissues are divided into color-coded groups according to which functional features they have in common. For each group, a list of included tissues is accessed by clicking on group name, group symbol, RNA bar, or protein bar. Subsequent selection of a particular tissue in this list links to the image data page.
Images of selected tissues give a visual summary of the protein expression profile furthest to the right.
The gray human body provides links to a histology dictionary when clicking on any part of the figure.
RNA expression (TPM)i
RNA-seq results generated in HPA are reported as number of transcripts per million (TPM). Each bar represents the highest expression score found in a particular group of tissues. The assay is described more in detail in Assays & Annotation.
Protein expression (score)i
Each bar represents the highest expression score found in a particular group of tissues. Protein expression scores are based on a best estimate of the "true" protein expression from a knowledge-based annotation, described more in detail under Assays & annotation. For genes where more than one antibody has been used, a collective score is set displaying the estimated true protein expression.
Protein expression data is shown for each of the 44 tissues. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. Mouse-over function shows protein score for analyzed cell types in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation.
For genes with available protein data for which a knowledge-based annotation gave inconclusive results, no protein expression data is displayed in the protein expression data overview. However, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Organ
Expression
Alphabetical
RNA EXPRESSION OVERVIEWi
RNA expression overview shows RNA-data from three different sources: Internally generated Human Protein Atlas (HPA) RNA-seq data, RNA-seq data from the Genotype-Tissue Expression (GTEx) project and CAGE data from FANTOM5 project. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.
HPA dataseti
HPA dataset RNA-seq tissue data is reported as mean TPM (transcripts per million), corresponding to mean values of the different individual samples from each tissue. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar. The RNA-seq assay is described in detail in Assays & Annotation.
RNA tissue category HPA HPA RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataseti
GTEx dataset RNA-seq data is reported as median RPKM (reads per kilobase per million mapped reads), generated by the Genotype-Tissue Expression (GTEx) project. More information can be found in Assays & Annotation.
RNA tissue category GTEx GTEx RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataseti
FANTOM5 dataset Tissue data obtained through Cap Analysis of Gene Expression (CAGE) are reported as Tags Per Million, generated by the FANTOM5 project. More information can be found in Assays & Annotation.
RNA tissue category FANTOM5 FANTOM5 RNA tissue category (category description) is calculated based on gene expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
MDM2 (HGNC Symbol)
Synonyms
HDM2, MGC5370
Description
MDM2 proto-oncogene (HGNC Symbol)
Entrez gene summary
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001568 [blood vessel development] GO:0001974 [blood vessel remodeling] GO:0002027 [regulation of heart rate] GO:0002039 [p53 binding] GO:0003170 [heart valve development] GO:0003181 [atrioventricular valve morphogenesis] GO:0003203 [endocardial cushion morphogenesis] GO:0003281 [ventricular septum development] GO:0003283 [atrial septum development] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007089 [traversing start control point of mitotic cell cycle] GO:0007507 [heart development] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell proliferation] GO:0009636 [response to toxic substance] GO:0010039 [response to iron ion] GO:0010468 [regulation of gene expression] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010955 [negative regulation of protein processing] GO:0010977 [negative regulation of neuron projection development] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016740 [transferase activity] GO:0016874 [ligase activity] GO:0016925 [protein sumoylation] GO:0018205 [peptidyl-lysine modification] GO:0019789 [SUMO transferase activity] GO:0019899 [enzyme binding] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032026 [response to magnesium ion] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034504 [protein localization to nucleus] GO:0036369 [transcription factor catabolic process] GO:0042176 [regulation of protein catabolic process] GO:0042220 [response to cocaine] GO:0042493 [response to drug] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0042975 [peroxisome proliferator activated receptor binding] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043234 [protein complex] GO:0043278 [response to morphine] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045184 [establishment of protein localization] GO:0045202 [synapse] GO:0045472 [response to ether] GO:0045787 [positive regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0046677 [response to antibiotic] GO:0046827 [positive regulation of protein export from nucleus] GO:0046872 [metal ion binding] GO:0048545 [response to steroid hormone] GO:0051865 [protein autoubiquitination] GO:0060411 [cardiac septum morphogenesis] GO:0061630 [ubiquitin protein ligase activity] GO:0070301 [cellular response to hydrogen peroxide] GO:0071157 [negative regulation of cell cycle arrest] GO:0071236 [cellular response to antibiotic] GO:0071301 [cellular response to vitamin B1] GO:0071310 [cellular response to organic substance] GO:0071312 [cellular response to alkaloid] GO:0071363 [cellular response to growth factor stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071391 [cellular response to estrogen stimulus] GO:0071407 [cellular response to organic cyclic compound] GO:0071456 [cellular response to hypoxia] GO:0071494 [cellular response to UV-C] GO:0097110 [scaffold protein binding] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1901797 [negative regulation of signal transduction by p53 class mediator] GO:1904404 [response to formaldehyde] GO:1904707 [positive regulation of vascular smooth muscle cell proliferation] GO:1904754 [positive regulation of vascular associated smooth muscle cell migration] GO:1990785 [response to water-immersion restraint stress]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0071157 [negative regulation of cell cycle arrest]
Q9H4C5 [Direct mapping] E3 ubiquitin-protein ligase Mdm2; p53-binding protein
Show all
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0046872 [metal ion binding]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002039 [p53 binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell proliferation] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016740 [transferase activity] GO:0016874 [ligase activity] GO:0016925 [protein sumoylation] GO:0018205 [peptidyl-lysine modification] GO:0019789 [SUMO transferase activity] GO:0019899 [enzyme binding] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034504 [protein localization to nucleus] GO:0036369 [transcription factor catabolic process] GO:0042176 [regulation of protein catabolic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045184 [establishment of protein localization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0046677 [response to antibiotic] GO:0046872 [metal ion binding] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1901797 [negative regulation of signal transduction by p53 class mediator]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002039 [p53 binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell proliferation] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016740 [transferase activity] GO:0016874 [ligase activity] GO:0016925 [protein sumoylation] GO:0018205 [peptidyl-lysine modification] GO:0019789 [SUMO transferase activity] GO:0019899 [enzyme binding] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034504 [protein localization to nucleus] GO:0036369 [transcription factor catabolic process] GO:0042176 [regulation of protein catabolic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045184 [establishment of protein localization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0046677 [response to antibiotic] GO:0046872 [metal ion binding] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1901797 [negative regulation of signal transduction by p53 class mediator]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0046872 [metal ion binding]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0016567 [protein ubiquitination] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination]
Q9H4C3 [Direct mapping] E3 ubiquitin-protein ligase Mdm2; p53 binding protein
Show all
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005634 [nucleus] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0016567 [protein ubiquitination]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0016567 [protein ubiquitination]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002039 [p53 binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell proliferation] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016740 [transferase activity] GO:0016874 [ligase activity] GO:0016925 [protein sumoylation] GO:0018205 [peptidyl-lysine modification] GO:0019789 [SUMO transferase activity] GO:0019899 [enzyme binding] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034504 [protein localization to nucleus] GO:0036369 [transcription factor catabolic process] GO:0042176 [regulation of protein catabolic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045184 [establishment of protein localization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0046677 [response to antibiotic] GO:0046872 [metal ion binding] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1901797 [negative regulation of signal transduction by p53 class mediator]
J3KN53 [Direct mapping] E3 ubiquitin-protein ligase Mdm2; MDM2 protein
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0071157 [negative regulation of cell cycle arrest]
Q9H4C5 [Direct mapping] E3 ubiquitin-protein ligase Mdm2; p53-binding protein
Show all
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0046872 [metal ion binding]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination]
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