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MAP3K7
GENERAL INFORMATION
Gene namei MAP3K7
Gene descriptioni Mitogen-activated protein kinase kinase kinase 7
Protein classi Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted localizationi Intracellular
Number of transcriptsi 5
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HUMAN PROTEIN ATLAS INFORMATION
RNA tissue categoryi
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all
Protein evidencei Evidence at protein level
Protein expressioni Cytoplasmic expression in several tissues.

IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability
descriptioni		 Antibody staining mainly not consistent with RNA expression data.
Reliability scorei
Approved
Antibodiesi HPA007633
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RNA AND PROTEIN EXPRESSION SUMMARYi
RNA expression (TPM)i Protein expression (score)i
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis
PROTEIN EXPRESSION OVERVIEWi
Organ
Expression
Alphabetical
RNA EXPRESSION OVERVIEWi
HPA dataseti
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataseti
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataseti
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GENE INFORMATIONi
Gene name MAP3K7 (HGNC Symbol)
Synonyms MEKK7, TAK1
Description Mitogen-activated protein kinase kinase kinase 7 (HGNC Symbol)
Entrez gene summary The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Chromosome 6
Cytoband q15
Chromosome location (bp) 90513573 - 90587045
Protein evidence Evidence at protein level (all genes)
Ensembl ENSG00000135341 (version 88.38)
Entrez gene 6885
UniProt O43318 (UniProt - Evidence at protein level)
neXtProt NX_O43318
Antibodypedia MAP3K7 antibodies
PROTEIN BROWSERi
MAP3K7-001
MAP3K7-002
MAP3K7-003
MAP3K7-004
MAP3K7-006
PROTEIN INFORMATIONi
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
MAP3K7-001
ENSP00000358338
ENST00000369332
O43318 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 7
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000287 [magnesium ion binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002726 [positive regulation of T cell cytokine production]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007223 [Wnt signaling pathway, calcium modulating pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0007252 [I-kappaB phosphorylation]
GO:0007254 [JNK cascade]
GO:0008385 [IkappaB kinase complex]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016239 [positive regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016579 [protein deubiquitination]
GO:0016740 [transferase activity]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043276 [anoikis]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043966 [histone H3 acetylation]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097110 [scaffold protein binding]
Show all
 579 aa
64.2 kDa 		No 0
MAP3K7-002
ENSP00000358335
ENST00000369329
O43318 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 7
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000287 [magnesium ion binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002726 [positive regulation of T cell cytokine production]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007223 [Wnt signaling pathway, calcium modulating pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0007252 [I-kappaB phosphorylation]
GO:0007254 [JNK cascade]
GO:0008385 [IkappaB kinase complex]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016239 [positive regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016579 [protein deubiquitination]
GO:0016740 [transferase activity]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043276 [anoikis]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043966 [histone H3 acetylation]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097110 [scaffold protein binding]
Show all
 606 aa
67.2 kDa 		No 0
MAP3K7-003
ENSP00000358331
ENST00000369325
O43318 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 7
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000287 [magnesium ion binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002726 [positive regulation of T cell cytokine production]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007223 [Wnt signaling pathway, calcium modulating pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0007252 [I-kappaB phosphorylation]
GO:0007254 [JNK cascade]
GO:0008385 [IkappaB kinase complex]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016239 [positive regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016579 [protein deubiquitination]
GO:0016740 [transferase activity]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043276 [anoikis]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043966 [histone H3 acetylation]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097110 [scaffold protein binding]
Show all
 518 aa
56.7 kDa 		No 0
MAP3K7-004
ENSP00000358333
ENST00000369327
O43318 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 7
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000287 [magnesium ion binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002726 [positive regulation of T cell cytokine production]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007223 [Wnt signaling pathway, calcium modulating pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0007252 [I-kappaB phosphorylation]
GO:0007254 [JNK cascade]
GO:0008385 [IkappaB kinase complex]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016239 [positive regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016579 [protein deubiquitination]
GO:0016740 [transferase activity]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043276 [anoikis]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043966 [histone H3 acetylation]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097110 [scaffold protein binding]
Show all
 491 aa
53.7 kDa 		No 0
MAP3K7-006
ENSP00000358326
ENST00000369320
Q9UG54 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 7; Putative uncharacterized protein DKFZp586F0420
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 260 aa
28.9 kDa 		No 0

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The Human Protein Atlas

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