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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
TCGA (cancer tissue):
Expressed in all
HPA (cell line):
Mixed
HPA (normal tissue):
Tissue enriched (esophagus)
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expression normal tissuei
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Cytoplasmic, membranous and nuclear expression at variable levels in selected tissues.
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability descriptioni
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining mainly consistent with RNA expression data.
Reliability score - normal tissuesi
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from.
Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
For each cancer, color-coded bars indicate the percentage of patients (maximum 12 patients) with high and medium protein expression level. The cancer types are color-coded according to which type of normal organ the cancer originates from. Low or not detected protein expression results in a white bar. Mouse-over function shows details about expression level and normal tissue of origin. The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies.
Thyroid cancers along with several cases of malignant melanomas, cancers of female genitalia, lung, skin and urothelia displayed moderate to strong cytoplasmic immunoreactivity, in several cases combined with membranous staining and in a few nuclear positivity. Malignant cells in general were negative. Most pancreatic and several renal cancers were moderately stained.
Squamous cell carcinomas, malignant melanomas, female genital cancers, urothelial, thyroid and pancreatic cancers displayed moderate to strong cytoplasmic immunoreactivity often combined with nuclear and membranous positivity. Remaining malignancies were in general negative.
Most malignant cells displayed moderate to strong cytoplasmic and nuclear positivity. Hepatocellular carcinomas, basal cell carcinomas, breast cancers and malignant lymphomas were mainly weakly stained or negative.
Female genital, thyroid and urothelial cancers along with some cases of malignant melanomas, lung, skin and pancreatic cancers showed strong positivity. Remaining malignancies were weakly stained or negative.
A majority of cancer tissues exhibited moderate to strong cytoplasmic and nuclear positivity with additional membranous positivity in a few cases. Lymphomas, carcinoid, breast and testicular cancers along with several cases of gliomas, colorectal, renal, stomach and liver cancers were negative.
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
ANXA1 (HGNC Symbol)
Synonyms
ANX1, LPC1
Description
Annexin A1 (HGNC Symbol)
Entrez gene summary
This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
ANXA1-002
ANXA1-003
ANXA1-004
ANXA1-006
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000733 [DNA strand renaturation] GO:0001533 [cornified envelope] GO:0001780 [neutrophil homeostasis] GO:0001891 [phagocytic cup] GO:0002250 [adaptive immune response] GO:0002376 [immune system process] GO:0002548 [monocyte chemotaxis] GO:0002685 [regulation of leukocyte migration] GO:0003697 [single-stranded DNA binding] GO:0003727 [single-stranded RNA binding] GO:0004386 [helicase activity] GO:0004859 [phospholipase inhibitor activity] GO:0005102 [receptor binding] GO:0005198 [structural molecule activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0005925 [focal adhesion] GO:0005929 [cilium] GO:0006909 [phagocytosis] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0008360 [regulation of cell shape] GO:0009725 [response to hormone] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0010165 [response to X-ray] GO:0014070 [response to organic cyclic compound] GO:0014839 [myoblast migration involved in skeletal muscle regeneration] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0016328 [lateral plasma membrane] GO:0018149 [peptide cross-linking] GO:0019834 [phospholipase A2 inhibitor activity] GO:0019898 [extrinsic component of membrane] GO:0030073 [insulin secretion] GO:0030216 [keratinocyte differentiation] GO:0030659 [cytoplasmic vesicle membrane] GO:0030674 [protein binding, bridging] GO:0030850 [prostate gland development] GO:0031018 [endocrine pancreas development] GO:0031232 [extrinsic component of external side of plasma membrane] GO:0031313 [extrinsic component of endosome membrane] GO:0031340 [positive regulation of vesicle fusion] GO:0031394 [positive regulation of prostaglandin biosynthetic process] GO:0031410 [cytoplasmic vesicle] GO:0031514 [motile cilium] GO:0031532 [actin cytoskeleton reorganization] GO:0031901 [early endosome membrane] GO:0031960 [response to corticosteroid] GO:0031966 [mitochondrial membrane] GO:0031982 [vesicle] GO:0032355 [response to estradiol] GO:0032508 [DNA duplex unwinding] GO:0032652 [regulation of interleukin-1 production] GO:0032743 [positive regulation of interleukin-2 production] GO:0033031 [positive regulation of neutrophil apoptotic process] GO:0033676 [double-stranded DNA-dependent ATPase activity] GO:0036292 [DNA rewinding] GO:0036310 [annealing helicase activity] GO:0042063 [gliogenesis] GO:0042102 [positive regulation of T cell proliferation] GO:0042127 [regulation of cell proliferation] GO:0042383 [sarcolemma] GO:0042493 [response to drug] GO:0042629 [mast cell granule] GO:0042803 [protein homodimerization activity] GO:0042995 [cell projection] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043434 [response to peptide hormone] GO:0044849 [estrous cycle] GO:0045087 [innate immune response] GO:0045627 [positive regulation of T-helper 1 cell differentiation] GO:0045629 [negative regulation of T-helper 2 cell differentiation] GO:0045920 [negative regulation of exocytosis] GO:0046632 [alpha-beta T cell differentiation] GO:0046872 [metal ion binding] GO:0046883 [regulation of hormone secretion] GO:0048306 [calcium-dependent protein binding] GO:0050482 [arachidonic acid secretion] GO:0050709 [negative regulation of protein secretion] GO:0050727 [regulation of inflammatory response] GO:0051384 [response to glucocorticoid] GO:0070062 [extracellular exosome] GO:0070301 [cellular response to hydrogen peroxide] GO:0070365 [hepatocyte differentiation] GO:0070459 [prolactin secretion] GO:0070555 [response to interleukin-1] GO:0071385 [cellular response to glucocorticoid stimulus] GO:0071621 [granulocyte chemotaxis] GO:0090303 [positive regulation of wound healing] GO:0097350 [neutrophil clearance] GO:0098609 [cell-cell adhesion] GO:0098641 [cadherin binding involved in cell-cell adhesion] GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle] GO:1900138 [negative regulation of phospholipase A2 activity] GO:2000483 [negative regulation of interleukin-8 secretion]
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