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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
TCGA (cancer tissue):
Mixed
HPA (cell line):
Cell line enhanced (BJ hTERT+, HBEC3-KT, HMC-1, hTEC/SVTERT24-B, U-87 MG)
HPA (normal tissue):
Tissue enhanced (appendix, bone marrow)
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Reliability score - normal tissuesi
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from.
Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
IL1B (HGNC Symbol)
Synonyms
IL-1B, IL1-BETA, IL1F2
Description
Interleukin 1 beta (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
IL1B-001
IL1B-003
IL1B-006
IL1B-007
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000187 [activation of MAPK activity] GO:0001660 [fever generation] GO:0001934 [positive regulation of protein phosphorylation] GO:0002711 [positive regulation of T cell mediated immunity] GO:0005125 [cytokine activity] GO:0005149 [interleukin-1 receptor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0007566 [embryo implantation] GO:0008285 [negative regulation of cell proliferation] GO:0009743 [response to carbohydrate] GO:0010575 [positive regulation of vascular endothelial growth factor production] GO:0010628 [positive regulation of gene expression] GO:0010829 [negative regulation of glucose transport] GO:0014805 [smooth muscle adaptation] GO:0019221 [cytokine-mediated signaling pathway] GO:0019904 [protein domain specific binding] GO:0030141 [secretory granule] GO:0030213 [hyaluronan biosynthetic process] GO:0030593 [neutrophil chemotaxis] GO:0030730 [sequestering of triglyceride] GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031622 [positive regulation of fever generation] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0031982 [vesicle] GO:0032308 [positive regulation of prostaglandin secretion] GO:0032496 [response to lipopolysaccharide] GO:0032611 [interleukin-1 beta production] GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production] GO:0032729 [positive regulation of interferon-gamma production] GO:0032755 [positive regulation of interleukin-6 production] GO:0032757 [positive regulation of interleukin-8 production] GO:0033129 [positive regulation of histone phosphorylation] GO:0033198 [response to ATP] GO:0034116 [positive regulation of heterotypic cell-cell adhesion] GO:0035066 [positive regulation of histone acetylation] GO:0035234 [ectopic germ cell programmed cell death] GO:0035505 [positive regulation of myosin light chain kinase activity] GO:0035690 [cellular response to drug] GO:0042102 [positive regulation of T cell proliferation] GO:0042346 [positive regulation of NF-kappaB import into nucleus] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043407 [negative regulation of MAP kinase activity] GO:0043491 [protein kinase B signaling] GO:0045080 [positive regulation of chemokine biosynthetic process] GO:0045086 [positive regulation of interleukin-2 biosynthetic process] GO:0045410 [positive regulation of interleukin-6 biosynthetic process] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045833 [negative regulation of lipid metabolic process] GO:0045840 [positive regulation of mitotic nuclear division] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046330 [positive regulation of JNK cascade] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0046827 [positive regulation of protein export from nucleus] GO:0050766 [positive regulation of phagocytosis] GO:0050796 [regulation of insulin secretion] GO:0050900 [leukocyte migration] GO:0050995 [negative regulation of lipid catabolic process] GO:0050996 [positive regulation of lipid catabolic process] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051044 [positive regulation of membrane protein ectodomain proteolysis] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051781 [positive regulation of cell division] GO:0060355 [positive regulation of cell adhesion molecule production] GO:0060559 [positive regulation of calcidiol 1-monooxygenase activity] GO:0070062 [extracellular exosome] GO:0070164 [negative regulation of adiponectin secretion] GO:0070487 [monocyte aggregation] GO:0071260 [cellular response to mechanical stimulus] GO:0071310 [cellular response to organic substance] GO:0071407 [cellular response to organic cyclic compound] GO:0071639 [positive regulation of monocyte chemotactic protein-1 production] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:1903140 [regulation of establishment of endothelial barrier] GO:2000778 [positive regulation of interleukin-6 secretion] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
The Human Protein Atlas project is funded
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