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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for data imported from The Genotype-Tissue Expression project (GTEX), FANTOM5 Consortium (FANTOM5) and internally generated Human Protein Atlas (HPA) data.
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expressioni
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining mainly not consistent with RNA expression data. Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability scorei
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Below is an overview of RNA and protein expression data generated in the Human Protein Atlas project. Analyzed tissues are divided into color-coded groups according to which functional features they have in common. For each group, a list of included tissues is accessed by clicking on group name, group symbol, RNA bar, or protein bar. Subsequent selection of a particular tissue in this list links to the image data page.
Images of selected tissues give a visual summary of the protein expression profile furthest to the right.
The gray human body provides links to a histology dictionary when clicking on any part of the figure.
RNA expression (TPM)i
RNA-seq results generated in HPA are reported as number of transcripts per million (TPM). Each bar represents the highest expression score found in a particular group of tissues. The assay is described more in detail in Assays & Annotation.
Protein expression (score)i
Each bar represents the highest expression score found in a particular group of tissues. Protein expression scores are based on a best estimate of the "true" protein expression from a knowledge-based annotation, described more in detail under Assays & annotation. For genes where more than one antibody has been used, a collective score is set displaying the estimated true protein expression.
Protein expression data is shown for each of the 44 tissues. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. Mouse-over function shows protein score for analyzed cell types in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation.
For genes with available protein data for which a knowledge-based annotation gave inconclusive results, no protein expression data is displayed in the protein expression data overview. However, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Organ
Expression
Alphabetical
RNA EXPRESSION OVERVIEWi
RNA expression overview shows RNA-data from three different sources: Internally generated Human Protein Atlas (HPA) RNA-seq data, RNA-seq data from the Genotype-Tissue Expression (GTEx) project and CAGE data from FANTOM5 project. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.
HPA dataseti
HPA dataset RNA-seq tissue data is reported as mean TPM (transcripts per million), corresponding to mean values of the different individual samples from each tissue. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar. The RNA-seq assay is described in detail in Assays & Annotation.
RNA tissue category HPA HPA RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataseti
GTEx dataset RNA-seq data is reported as median RPKM (reads per kilobase per million mapped reads), generated by the Genotype-Tissue Expression (GTEx) project. More information can be found in Assays & Annotation.
RNA tissue category GTEx GTEx RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataseti
FANTOM5 dataset Tissue data obtained through Cap Analysis of Gene Expression (CAGE) are reported as Tags Per Million, generated by the FANTOM5 project. More information can be found in Assays & Annotation.
RNA tissue category FANTOM5 FANTOM5 RNA tissue category (category description) is calculated based on gene expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (retina)
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
BMP4 (HGNC Symbol)
Synonyms
BMP2B
Description
Bone morphogenetic protein 4 (HGNC Symbol)
Entrez gene summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
BMP4-001
BMP4-002
BMP4-003
BMP4-004
BMP4-006
BMP4-007
BMP4-008
BMP4-201
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P12644 [Direct mapping] Bone morphogenetic protein 4 Q53XC5 [Target identity:100%; Query identity:100%] Bone morphogenetic protein 4; Bone morphogenetic protein 4, isoform CRA_a; Full-length cDNA clone CS0DC002YH22 of Neuroblastoma of Homo sapiens (human); Full-length cDNA clone CS0DI018YL16 of Placenta of Homo sapiens (human)
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000186 [activation of MAPKK activity] GO:0001501 [skeletal system development] GO:0001503 [ossification] GO:0001525 [angiogenesis] GO:0001568 [blood vessel development] GO:0001649 [osteoblast differentiation] GO:0001656 [metanephros development] GO:0001657 [ureteric bud development] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0001707 [mesoderm formation] GO:0001759 [organ induction] GO:0001822 [kidney development] GO:0001823 [mesonephros development] GO:0001843 [neural tube closure] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001944 [vasculature development] GO:0001958 [endochondral ossification] GO:0002043 [blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:0002062 [chondrocyte differentiation] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0002320 [lymphoid progenitor cell differentiation] GO:0003014 [renal system process] GO:0003130 [BMP signaling pathway involved in heart induction] GO:0003139 [secondary heart field specification] GO:0003148 [outflow tract septum morphogenesis] GO:0003149 [membranous septum morphogenesis] GO:0003151 [outflow tract morphogenesis] GO:0003180 [aortic valve morphogenesis] GO:0003184 [pulmonary valve morphogenesis] GO:0003197 [endocardial cushion development] GO:0003279 [cardiac septum development] GO:0003323 [type B pancreatic cell development] GO:0003337 [mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0005125 [cytokine activity] GO:0005160 [transforming growth factor beta receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007182 [common-partner SMAD protein phosphorylation] GO:0007224 [smoothened signaling pathway] GO:0007275 [multicellular organism development] GO:0007281 [germ cell development] GO:0007492 [endoderm development] GO:0007500 [mesodermal cell fate determination] GO:0007507 [heart development] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0009791 [post-embryonic development] GO:0009888 [tissue development] GO:0009948 [anterior/posterior axis specification] GO:0010159 [specification of animal organ position] GO:0010453 [regulation of cell fate commitment] GO:0010468 [regulation of gene expression] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0010942 [positive regulation of cell death] GO:0021537 [telencephalon development] GO:0021904 [dorsal/ventral neural tube patterning] GO:0021978 [telencephalon regionalization] GO:0021983 [pituitary gland development] GO:0030154 [cell differentiation] GO:0030218 [erythrocyte differentiation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030324 [lung development] GO:0030326 [embryonic limb morphogenesis] GO:0030335 [positive regulation of cell migration] GO:0030501 [positive regulation of bone mineralization] GO:0030509 [BMP signaling pathway] GO:0030513 [positive regulation of BMP signaling pathway] GO:0030900 [forebrain development] GO:0032092 [positive regulation of protein binding] GO:0032331 [negative regulation of chondrocyte differentiation] GO:0032967 [positive regulation of collagen biosynthetic process] GO:0033085 [negative regulation of T cell differentiation in thymus] GO:0033088 [negative regulation of immature T cell proliferation in thymus] GO:0034504 [protein localization to nucleus] GO:0035116 [embryonic hindlimb morphogenesis] GO:0035990 [tendon cell differentiation] GO:0035993 [deltoid tuberosity development] GO:0039706 [co-receptor binding] GO:0042056 [chemoattractant activity] GO:0042306 [regulation of protein import into nucleus] GO:0042326 [negative regulation of phosphorylation] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0042476 [odontogenesis] GO:0042487 [regulation of odontogenesis of dentin-containing tooth] GO:0042733 [embryonic digit morphogenesis] GO:0043010 [camera-type eye development] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043407 [negative regulation of MAP kinase activity] GO:0045165 [cell fate commitment] GO:0045595 [regulation of cell differentiation] GO:0045597 [positive regulation of cell differentiation] GO:0045603 [positive regulation of endothelial cell differentiation] GO:0045606 [positive regulation of epidermal cell differentiation] GO:0045662 [negative regulation of myoblast differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045778 [positive regulation of ossification] GO:0045786 [negative regulation of cell cycle] GO:0045839 [negative regulation of mitotic nuclear division] GO:0045843 [negative regulation of striated muscle tissue development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048286 [lung alveolus development] GO:0048333 [mesodermal cell differentiation] GO:0048392 [intermediate mesodermal cell differentiation] GO:0048593 [camera-type eye morphogenesis] GO:0048598 [embryonic morphogenesis] GO:0048646 [anatomical structure formation involved in morphogenesis] GO:0048660 [regulation of smooth muscle cell proliferation] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0048663 [neuron fate commitment] GO:0048701 [embryonic cranial skeleton morphogenesis] GO:0048704 [embryonic skeletal system morphogenesis] GO:0048706 [embryonic skeletal system development] GO:0048745 [smooth muscle tissue development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0050918 [positive chemotaxis] GO:0051145 [smooth muscle cell differentiation] GO:0051150 [regulation of smooth muscle cell differentiation] GO:0051216 [cartilage development] GO:0055007 [cardiac muscle cell differentiation] GO:0055020 [positive regulation of cardiac muscle fiber development] GO:0060113 [inner ear receptor cell differentiation] GO:0060197 [cloacal septation] GO:0060235 [lens induction in camera-type eye] GO:0060272 [embryonic skeletal joint morphogenesis] GO:0060348 [bone development] GO:0060363 [cranial suture morphogenesis] GO:0060391 [positive regulation of SMAD protein import into nucleus] GO:0060393 [regulation of pathway-restricted SMAD protein phosphorylation] GO:0060395 [SMAD protein signal transduction] GO:0060425 [lung morphogenesis] GO:0060429 [epithelium development] GO:0060433 [bronchus development] GO:0060438 [trachea development] GO:0060440 [trachea formation] GO:0060441 [epithelial tube branching involved in lung morphogenesis] GO:0060442 [branching involved in prostate gland morphogenesis] GO:0060449 [bud elongation involved in lung branching] GO:0060502 [epithelial cell proliferation involved in lung morphogenesis] GO:0060503 [bud dilation involved in lung branching] GO:0060512 [prostate gland morphogenesis] GO:0060548 [negative regulation of cell death] GO:0060592 [mammary gland formation] GO:0060684 [epithelial-mesenchymal cell signaling] GO:0060686 [negative regulation of prostatic bud formation] GO:0060687 [regulation of branching involved in prostate gland morphogenesis] GO:0060688 [regulation of morphogenesis of a branching structure] GO:0060976 [coronary vasculature development] GO:0061035 [regulation of cartilage development] GO:0061036 [positive regulation of cartilage development] GO:0061047 [positive regulation of branching involved in lung morphogenesis] GO:0061149 [BMP signaling pathway involved in ureter morphogenesis] GO:0061151 [BMP signaling pathway involved in renal system segmentation] GO:0061155 [pulmonary artery endothelial tube morphogenesis] GO:0061312 [BMP signaling pathway involved in heart development] GO:0061626 [pharyngeal arch artery morphogenesis] GO:0070244 [negative regulation of thymocyte apoptotic process] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070700 [BMP receptor binding] GO:0071363 [cellular response to growth factor stimulus] GO:0071773 [cellular response to BMP stimulus] GO:0071893 [BMP signaling pathway involved in nephric duct formation] GO:0072001 [renal system development] GO:0072015 [glomerular visceral epithelial cell development] GO:0072097 [negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway] GO:0072101 [specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway] GO:0072104 [glomerular capillary formation] GO:0072125 [negative regulation of glomerular mesangial cell proliferation] GO:0072138 [mesenchymal cell proliferation involved in ureteric bud development] GO:0072161 [mesenchymal cell differentiation involved in kidney development] GO:0072192 [ureter epithelial cell differentiation] GO:0072193 [ureter smooth muscle cell differentiation] GO:0072198 [mesenchymal cell proliferation involved in ureter development] GO:0072200 [negative regulation of mesenchymal cell proliferation involved in ureter development] GO:0072205 [metanephric collecting duct development] GO:0090184 [positive regulation of kidney development] GO:0090191 [negative regulation of branching involved in ureteric bud morphogenesis] GO:0090194 [negative regulation of glomerulus development] GO:1901964 [positive regulation of cell proliferation involved in outflow tract morphogenesis] GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter] GO:2000005 [negative regulation of metanephric S-shaped body morphogenesis] GO:2000007 [negative regulation of metanephric comma-shaped body morphogenesis] GO:2000105 [positive regulation of DNA-dependent DNA replication] GO:2000137 [negative regulation of cell proliferation involved in heart morphogenesis] GO:2001012 [mesenchymal cell differentiation involved in renal system development] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
P12644 [Direct mapping] Bone morphogenetic protein 4 Q53XC5 [Target identity:100%; Query identity:100%] Bone morphogenetic protein 4; Bone morphogenetic protein 4, isoform CRA_a; Full-length cDNA clone CS0DC002YH22 of Neuroblastoma of Homo sapiens (human); Full-length cDNA clone CS0DI018YL16 of Placenta of Homo sapiens (human)
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000186 [activation of MAPKK activity] GO:0001503 [ossification] GO:0001649 [osteoblast differentiation] GO:0001657 [ureteric bud development] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0001822 [kidney development] GO:0001823 [mesonephros development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001958 [endochondral ossification] GO:0002043 [blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:0002062 [chondrocyte differentiation] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0002320 [lymphoid progenitor cell differentiation] GO:0003130 [BMP signaling pathway involved in heart induction] GO:0003139 [secondary heart field specification] GO:0003148 [outflow tract septum morphogenesis] GO:0003149 [membranous septum morphogenesis] GO:0003180 [aortic valve morphogenesis] GO:0003184 [pulmonary valve morphogenesis] GO:0003197 [endocardial cushion development] GO:0003279 [cardiac septum development] GO:0003323 [type B pancreatic cell development] GO:0003337 [mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0005125 [cytokine activity] GO:0005160 [transforming growth factor beta receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007182 [common-partner SMAD protein phosphorylation] GO:0007224 [smoothened signaling pathway] GO:0007275 [multicellular organism development] GO:0008083 [growth factor activity] GO:0008285 [negative regulation of cell proliferation] GO:0009791 [post-embryonic development] GO:0010453 [regulation of cell fate commitment] GO:0010595 [positive regulation of endothelial cell migration] GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0010942 [positive regulation of cell death] GO:0021537 [telencephalon development] GO:0030154 [cell differentiation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030501 [positive regulation of bone mineralization] GO:0030509 [BMP signaling pathway] GO:0030513 [positive regulation of BMP signaling pathway] GO:0032092 [positive regulation of protein binding] GO:0032967 [positive regulation of collagen biosynthetic process] GO:0033085 [negative regulation of T cell differentiation in thymus] GO:0033088 [negative regulation of immature T cell proliferation in thymus] GO:0034504 [protein localization to nucleus] GO:0035990 [tendon cell differentiation] GO:0035993 [deltoid tuberosity development] GO:0039706 [co-receptor binding] GO:0042056 [chemoattractant activity] GO:0042306 [regulation of protein import into nucleus] GO:0042326 [negative regulation of phosphorylation] GO:0042476 [odontogenesis] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043407 [negative regulation of MAP kinase activity] GO:0045606 [positive regulation of epidermal cell differentiation] GO:0045662 [negative regulation of myoblast differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045778 [positive regulation of ossification] GO:0045786 [negative regulation of cell cycle] GO:0045839 [negative regulation of mitotic nuclear division] GO:0045843 [negative regulation of striated muscle tissue development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048286 [lung alveolus development] GO:0048392 [intermediate mesodermal cell differentiation] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0048745 [smooth muscle tissue development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050918 [positive chemotaxis] GO:0051216 [cartilage development] GO:0055020 [positive regulation of cardiac muscle fiber development] GO:0060391 [positive regulation of SMAD protein import into nucleus] GO:0060393 [regulation of pathway-restricted SMAD protein phosphorylation] GO:0060395 [SMAD protein signal transduction] GO:0060425 [lung morphogenesis] GO:0060433 [bronchus development] GO:0060438 [trachea development] GO:0060441 [epithelial tube branching involved in lung morphogenesis] GO:0060502 [epithelial cell proliferation involved in lung morphogenesis] GO:0060503 [bud dilation involved in lung branching] GO:0060548 [negative regulation of cell death] GO:0060976 [coronary vasculature development] GO:0061036 [positive regulation of cartilage development] GO:0061047 [positive regulation of branching involved in lung morphogenesis] GO:0061149 [BMP signaling pathway involved in ureter morphogenesis] GO:0061151 [BMP signaling pathway involved in renal system segmentation] GO:0061155 [pulmonary artery endothelial tube morphogenesis] GO:0061312 [BMP signaling pathway involved in heart development] GO:0061626 [pharyngeal arch artery morphogenesis] GO:0070244 [negative regulation of thymocyte apoptotic process] GO:0070700 [BMP receptor binding] GO:0071773 [cellular response to BMP stimulus] GO:0071893 [BMP signaling pathway involved in nephric duct formation] GO:0072001 [renal system development] GO:0072097 [negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway] GO:0072101 [specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway] GO:0072104 [glomerular capillary formation] GO:0072125 [negative regulation of glomerular mesangial cell proliferation] GO:0072192 [ureter epithelial cell differentiation] GO:0072193 [ureter smooth muscle cell differentiation] GO:0072200 [negative regulation of mesenchymal cell proliferation involved in ureter development] GO:0072205 [metanephric collecting duct development] GO:0090184 [positive regulation of kidney development] GO:0090191 [negative regulation of branching involved in ureteric bud morphogenesis] GO:0090194 [negative regulation of glomerulus development] GO:1901964 [positive regulation of cell proliferation involved in outflow tract morphogenesis] GO:2000005 [negative regulation of metanephric S-shaped body morphogenesis] GO:2000007 [negative regulation of metanephric comma-shaped body morphogenesis] GO:2000105 [positive regulation of DNA-dependent DNA replication] GO:2000137 [negative regulation of cell proliferation involved in heart morphogenesis] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
P12644 [Direct mapping] Bone morphogenetic protein 4 Q53XC5 [Target identity:100%; Query identity:100%] Bone morphogenetic protein 4; Bone morphogenetic protein 4, isoform CRA_a; Full-length cDNA clone CS0DC002YH22 of Neuroblastoma of Homo sapiens (human); Full-length cDNA clone CS0DI018YL16 of Placenta of Homo sapiens (human)
Show all
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000186 [activation of MAPKK activity] GO:0001503 [ossification] GO:0001649 [osteoblast differentiation] GO:0001657 [ureteric bud development] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0001822 [kidney development] GO:0001823 [mesonephros development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001958 [endochondral ossification] GO:0002043 [blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:0002062 [chondrocyte differentiation] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0002320 [lymphoid progenitor cell differentiation] GO:0003130 [BMP signaling pathway involved in heart induction] GO:0003139 [secondary heart field specification] GO:0003148 [outflow tract septum morphogenesis] GO:0003149 [membranous septum morphogenesis] GO:0003180 [aortic valve morphogenesis] GO:0003184 [pulmonary valve morphogenesis] GO:0003197 [endocardial cushion development] GO:0003279 [cardiac septum development] GO:0003323 [type B pancreatic cell development] GO:0003337 [mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0005125 [cytokine activity] GO:0005160 [transforming growth factor beta receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007182 [common-partner SMAD protein phosphorylation] GO:0007224 [smoothened signaling pathway] GO:0007275 [multicellular organism development] GO:0008083 [growth factor activity] GO:0008285 [negative regulation of cell proliferation] GO:0009791 [post-embryonic development] GO:0010453 [regulation of cell fate commitment] GO:0010595 [positive regulation of endothelial cell migration] GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0010942 [positive regulation of cell death] GO:0021537 [telencephalon development] GO:0030154 [cell differentiation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030501 [positive regulation of bone mineralization] GO:0030509 [BMP signaling pathway] GO:0030513 [positive regulation of BMP signaling pathway] GO:0032092 [positive regulation of protein binding] GO:0032967 [positive regulation of collagen biosynthetic process] GO:0033085 [negative regulation of T cell differentiation in thymus] GO:0033088 [negative regulation of immature T cell proliferation in thymus] GO:0034504 [protein localization to nucleus] GO:0035990 [tendon cell differentiation] GO:0035993 [deltoid tuberosity development] GO:0039706 [co-receptor binding] GO:0042056 [chemoattractant activity] GO:0042306 [regulation of protein import into nucleus] GO:0042326 [negative regulation of phosphorylation] GO:0042476 [odontogenesis] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043407 [negative regulation of MAP kinase activity] GO:0045606 [positive regulation of epidermal cell differentiation] GO:0045662 [negative regulation of myoblast differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045778 [positive regulation of ossification] GO:0045786 [negative regulation of cell cycle] GO:0045839 [negative regulation of mitotic nuclear division] GO:0045843 [negative regulation of striated muscle tissue development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048286 [lung alveolus development] GO:0048392 [intermediate mesodermal cell differentiation] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0048745 [smooth muscle tissue development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050918 [positive chemotaxis] GO:0051216 [cartilage development] GO:0055020 [positive regulation of cardiac muscle fiber development] GO:0060391 [positive regulation of SMAD protein import into nucleus] GO:0060393 [regulation of pathway-restricted SMAD protein phosphorylation] GO:0060395 [SMAD protein signal transduction] GO:0060425 [lung morphogenesis] GO:0060433 [bronchus development] GO:0060438 [trachea development] GO:0060441 [epithelial tube branching involved in lung morphogenesis] GO:0060502 [epithelial cell proliferation involved in lung morphogenesis] GO:0060503 [bud dilation involved in lung branching] GO:0060548 [negative regulation of cell death] GO:0060976 [coronary vasculature development] GO:0061036 [positive regulation of cartilage development] GO:0061047 [positive regulation of branching involved in lung morphogenesis] GO:0061149 [BMP signaling pathway involved in ureter morphogenesis] GO:0061151 [BMP signaling pathway involved in renal system segmentation] GO:0061155 [pulmonary artery endothelial tube morphogenesis] GO:0061312 [BMP signaling pathway involved in heart development] GO:0061626 [pharyngeal arch artery morphogenesis] GO:0070244 [negative regulation of thymocyte apoptotic process] GO:0070700 [BMP receptor binding] GO:0071773 [cellular response to BMP stimulus] GO:0071893 [BMP signaling pathway involved in nephric duct formation] GO:0072001 [renal system development] GO:0072097 [negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway] GO:0072101 [specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway] GO:0072104 [glomerular capillary formation] GO:0072125 [negative regulation of glomerular mesangial cell proliferation] GO:0072192 [ureter epithelial cell differentiation] GO:0072193 [ureter smooth muscle cell differentiation] GO:0072200 [negative regulation of mesenchymal cell proliferation involved in ureter development] GO:0072205 [metanephric collecting duct development] GO:0090184 [positive regulation of kidney development] GO:0090191 [negative regulation of branching involved in ureteric bud morphogenesis] GO:0090194 [negative regulation of glomerulus development] GO:1901964 [positive regulation of cell proliferation involved in outflow tract morphogenesis] GO:2000005 [negative regulation of metanephric S-shaped body morphogenesis] GO:2000007 [negative regulation of metanephric comma-shaped body morphogenesis] GO:2000105 [positive regulation of DNA-dependent DNA replication] GO:2000137 [negative regulation of cell proliferation involved in heart morphogenesis] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
P12644 [Direct mapping] Bone morphogenetic protein 4 Q53XC5 [Target identity:100%; Query identity:100%] Bone morphogenetic protein 4; Bone morphogenetic protein 4, isoform CRA_a; Full-length cDNA clone CS0DC002YH22 of Neuroblastoma of Homo sapiens (human); Full-length cDNA clone CS0DI018YL16 of Placenta of Homo sapiens (human)
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000186 [activation of MAPKK activity] GO:0001503 [ossification] GO:0001649 [osteoblast differentiation] GO:0001657 [ureteric bud development] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0001822 [kidney development] GO:0001823 [mesonephros development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001958 [endochondral ossification] GO:0002043 [blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:0002062 [chondrocyte differentiation] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0002320 [lymphoid progenitor cell differentiation] GO:0003130 [BMP signaling pathway involved in heart induction] GO:0003139 [secondary heart field specification] GO:0003148 [outflow tract septum morphogenesis] GO:0003149 [membranous septum morphogenesis] GO:0003180 [aortic valve morphogenesis] GO:0003184 [pulmonary valve morphogenesis] GO:0003197 [endocardial cushion development] GO:0003279 [cardiac septum development] GO:0003323 [type B pancreatic cell development] GO:0003337 [mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0005125 [cytokine activity] GO:0005160 [transforming growth factor beta receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007182 [common-partner SMAD protein phosphorylation] GO:0007224 [smoothened signaling pathway] GO:0007275 [multicellular organism development] GO:0008083 [growth factor activity] GO:0008285 [negative regulation of cell proliferation] GO:0009791 [post-embryonic development] GO:0010453 [regulation of cell fate commitment] GO:0010595 [positive regulation of endothelial cell migration] GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0010942 [positive regulation of cell death] GO:0021537 [telencephalon development] GO:0030154 [cell differentiation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030501 [positive regulation of bone mineralization] GO:0030509 [BMP signaling pathway] GO:0030513 [positive regulation of BMP signaling pathway] GO:0032092 [positive regulation of protein binding] GO:0032967 [positive regulation of collagen biosynthetic process] GO:0033085 [negative regulation of T cell differentiation in thymus] GO:0033088 [negative regulation of immature T cell proliferation in thymus] GO:0034504 [protein localization to nucleus] GO:0035990 [tendon cell differentiation] GO:0035993 [deltoid tuberosity development] GO:0039706 [co-receptor binding] GO:0042056 [chemoattractant activity] GO:0042306 [regulation of protein import into nucleus] GO:0042326 [negative regulation of phosphorylation] GO:0042476 [odontogenesis] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043407 [negative regulation of MAP kinase activity] GO:0045606 [positive regulation of epidermal cell differentiation] GO:0045662 [negative regulation of myoblast differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045778 [positive regulation of ossification] GO:0045786 [negative regulation of cell cycle] GO:0045839 [negative regulation of mitotic nuclear division] GO:0045843 [negative regulation of striated muscle tissue development] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048286 [lung alveolus development] GO:0048392 [intermediate mesodermal cell differentiation] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0048745 [smooth muscle tissue development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050918 [positive chemotaxis] GO:0051216 [cartilage development] GO:0055020 [positive regulation of cardiac muscle fiber development] GO:0060391 [positive regulation of SMAD protein import into nucleus] GO:0060393 [regulation of pathway-restricted SMAD protein phosphorylation] GO:0060395 [SMAD protein signal transduction] GO:0060425 [lung morphogenesis] GO:0060433 [bronchus development] GO:0060438 [trachea development] GO:0060441 [epithelial tube branching involved in lung morphogenesis] GO:0060502 [epithelial cell proliferation involved in lung morphogenesis] GO:0060503 [bud dilation involved in lung branching] GO:0060548 [negative regulation of cell death] GO:0060976 [coronary vasculature development] GO:0061036 [positive regulation of cartilage development] GO:0061047 [positive regulation of branching involved in lung morphogenesis] GO:0061149 [BMP signaling pathway involved in ureter morphogenesis] GO:0061151 [BMP signaling pathway involved in renal system segmentation] GO:0061155 [pulmonary artery endothelial tube morphogenesis] GO:0061312 [BMP signaling pathway involved in heart development] GO:0061626 [pharyngeal arch artery morphogenesis] GO:0070244 [negative regulation of thymocyte apoptotic process] GO:0070700 [BMP receptor binding] GO:0071773 [cellular response to BMP stimulus] GO:0071893 [BMP signaling pathway involved in nephric duct formation] GO:0072001 [renal system development] GO:0072097 [negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway] GO:0072101 [specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway] GO:0072104 [glomerular capillary formation] GO:0072125 [negative regulation of glomerular mesangial cell proliferation] GO:0072192 [ureter epithelial cell differentiation] GO:0072193 [ureter smooth muscle cell differentiation] GO:0072200 [negative regulation of mesenchymal cell proliferation involved in ureter development] GO:0072205 [metanephric collecting duct development] GO:0090184 [positive regulation of kidney development] GO:0090191 [negative regulation of branching involved in ureteric bud morphogenesis] GO:0090194 [negative regulation of glomerulus development] GO:1901964 [positive regulation of cell proliferation involved in outflow tract morphogenesis] GO:2000005 [negative regulation of metanephric S-shaped body morphogenesis] GO:2000007 [negative regulation of metanephric comma-shaped body morphogenesis] GO:2000105 [positive regulation of DNA-dependent DNA replication] GO:2000137 [negative regulation of cell proliferation involved in heart morphogenesis] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]