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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
TCGA (cancer tissue):
Expressed in all
HPA (cell line):
Group enriched (HBEC3-KT, hTEC/SVTERT24-B, hTERT-HME1, TIME, U-138 MG, U-2 OS)
HPA (normal tissue):
Tissue enhanced (endometrium, gallbladder)
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Reliability score - normal tissuesi
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from.
Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
INHBA
Synonyms
Description
Inhibin beta A subunit (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
INHBA-001
INHBA-002
INHBA-004
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P08476 [Direct mapping] Inhibin beta A chain A4D1W7 [Target identity:100%; Query identity:100%] Inhibin, beta A (Activin A, activin AB alpha polypeptide); Inhibin, beta A (Activin A, activin AB alpha polypeptide), isoform CRA_a; cDNA FLJ75379, highly similar to Homo sapiens inhibin, beta A (activin A, activin AB alpha polypeptide), mRNA
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MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle] GO:0001541 [ovarian follicle development] GO:0001707 [mesoderm formation] GO:0001942 [hair follicle development] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0005102 [receptor binding] GO:0005125 [cytokine activity] GO:0005160 [transforming growth factor beta receptor binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006952 [defense response] GO:0007050 [cell cycle arrest] GO:0007166 [cell surface receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0007399 [nervous system development] GO:0008083 [growth factor activity] GO:0008285 [negative regulation of cell proliferation] GO:0008584 [male gonad development] GO:0010628 [positive regulation of gene expression] GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0017046 [peptide hormone binding] GO:0021773 [striatal medium spiny neuron differentiation] GO:0030154 [cell differentiation] GO:0030218 [erythrocyte differentiation] GO:0030308 [negative regulation of cell growth] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032924 [activin receptor signaling pathway] GO:0034711 [inhibin binding] GO:0035987 [endodermal cell differentiation] GO:0042326 [negative regulation of phosphorylation] GO:0042476 [odontogenesis] GO:0042493 [response to drug] GO:0042541 [hemoglobin biosynthetic process] GO:0042701 [progesterone secretion] GO:0042802 [identical protein binding] GO:0043408 [regulation of MAPK cascade] GO:0043509 [activin A complex] GO:0043512 [inhibin A complex] GO:0045077 [negative regulation of interferon-gamma biosynthetic process] GO:0045578 [negative regulation of B cell differentiation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045650 [negative regulation of macrophage differentiation] GO:0045786 [negative regulation of cell cycle] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046880 [regulation of follicle-stimulating hormone secretion] GO:0046881 [positive regulation of follicle-stimulating hormone secretion] GO:0046882 [negative regulation of follicle-stimulating hormone secretion] GO:0046982 [protein heterodimerization activity] GO:0048333 [mesodermal cell differentiation] GO:0048468 [cell development] GO:0048471 [perinuclear region of cytoplasm] GO:0051799 [negative regulation of hair follicle development] GO:0060021 [palate development] GO:0060279 [positive regulation of ovulation] GO:0060395 [SMAD protein signal transduction] GO:0061029 [eyelid development in camera-type eye] GO:0070699 [type II activin receptor binding] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0071397 [cellular response to cholesterol] GO:0097154 [GABAergic neuron differentiation] GO:0097191 [extrinsic apoptotic signaling pathway] GO:2001241 [positive regulation of extrinsic apoptotic signaling pathway in absence of ligand]
P08476 [Direct mapping] Inhibin beta A chain A4D1W7 [Target identity:100%; Query identity:100%] Inhibin, beta A (Activin A, activin AB alpha polypeptide); Inhibin, beta A (Activin A, activin AB alpha polypeptide), isoform CRA_a; cDNA FLJ75379, highly similar to Homo sapiens inhibin, beta A (activin A, activin AB alpha polypeptide), mRNA
Show all
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle] GO:0001541 [ovarian follicle development] GO:0001942 [hair follicle development] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0005125 [cytokine activity] GO:0005160 [transforming growth factor beta receptor binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006952 [defense response] GO:0007050 [cell cycle arrest] GO:0007166 [cell surface receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0007399 [nervous system development] GO:0008083 [growth factor activity] GO:0008285 [negative regulation of cell proliferation] GO:0008584 [male gonad development] GO:0010628 [positive regulation of gene expression] GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0017046 [peptide hormone binding] GO:0021773 [striatal medium spiny neuron differentiation] GO:0030154 [cell differentiation] GO:0030218 [erythrocyte differentiation] GO:0030308 [negative regulation of cell growth] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032924 [activin receptor signaling pathway] GO:0035987 [endodermal cell differentiation] GO:0042326 [negative regulation of phosphorylation] GO:0042476 [odontogenesis] GO:0042493 [response to drug] GO:0042541 [hemoglobin biosynthetic process] GO:0042701 [progesterone secretion] GO:0042802 [identical protein binding] GO:0043408 [regulation of MAPK cascade] GO:0043509 [activin A complex] GO:0043512 [inhibin A complex] GO:0045077 [negative regulation of interferon-gamma biosynthetic process] GO:0045578 [negative regulation of B cell differentiation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045650 [negative regulation of macrophage differentiation] GO:0045786 [negative regulation of cell cycle] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046880 [regulation of follicle-stimulating hormone secretion] GO:0046881 [positive regulation of follicle-stimulating hormone secretion] GO:0046882 [negative regulation of follicle-stimulating hormone secretion] GO:0048468 [cell development] GO:0051799 [negative regulation of hair follicle development] GO:0060021 [palate development] GO:0060279 [positive regulation of ovulation] GO:0060395 [SMAD protein signal transduction] GO:0061029 [eyelid development in camera-type eye] GO:0070699 [type II activin receptor binding] GO:0097154 [GABAergic neuron differentiation] GO:0097191 [extrinsic apoptotic signaling pathway] GO:2001241 [positive regulation of extrinsic apoptotic signaling pathway in absence of ligand]
P08476 [Direct mapping] Inhibin beta A chain A4D1W7 [Target identity:100%; Query identity:100%] Inhibin, beta A (Activin A, activin AB alpha polypeptide); Inhibin, beta A (Activin A, activin AB alpha polypeptide), isoform CRA_a; cDNA FLJ75379, highly similar to Homo sapiens inhibin, beta A (activin A, activin AB alpha polypeptide), mRNA
Show all
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle] GO:0001541 [ovarian follicle development] GO:0001942 [hair follicle development] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0005125 [cytokine activity] GO:0005160 [transforming growth factor beta receptor binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006952 [defense response] GO:0007050 [cell cycle arrest] GO:0007166 [cell surface receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0007399 [nervous system development] GO:0008083 [growth factor activity] GO:0008285 [negative regulation of cell proliferation] GO:0008584 [male gonad development] GO:0010628 [positive regulation of gene expression] GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation] GO:0017046 [peptide hormone binding] GO:0021773 [striatal medium spiny neuron differentiation] GO:0030154 [cell differentiation] GO:0030218 [erythrocyte differentiation] GO:0030308 [negative regulation of cell growth] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032924 [activin receptor signaling pathway] GO:0035987 [endodermal cell differentiation] GO:0042326 [negative regulation of phosphorylation] GO:0042476 [odontogenesis] GO:0042493 [response to drug] GO:0042541 [hemoglobin biosynthetic process] GO:0042701 [progesterone secretion] GO:0042802 [identical protein binding] GO:0043408 [regulation of MAPK cascade] GO:0043509 [activin A complex] GO:0043512 [inhibin A complex] GO:0045077 [negative regulation of interferon-gamma biosynthetic process] GO:0045578 [negative regulation of B cell differentiation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045650 [negative regulation of macrophage differentiation] GO:0045786 [negative regulation of cell cycle] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046880 [regulation of follicle-stimulating hormone secretion] GO:0046881 [positive regulation of follicle-stimulating hormone secretion] GO:0046882 [negative regulation of follicle-stimulating hormone secretion] GO:0048468 [cell development] GO:0051799 [negative regulation of hair follicle development] GO:0060021 [palate development] GO:0060279 [positive regulation of ovulation] GO:0060395 [SMAD protein signal transduction] GO:0061029 [eyelid development in camera-type eye] GO:0070699 [type II activin receptor binding] GO:0097154 [GABAergic neuron differentiation] GO:0097191 [extrinsic apoptotic signaling pathway] GO:2001241 [positive regulation of extrinsic apoptotic signaling pathway in absence of ligand]
The Human Protein Atlas project is funded
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