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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
TCGA (cancer tissue):
Expressed in all
HPA (cell line):
Expressed in all
HPA (normal tissue):
Expressed in all
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expression normal tissuei
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining consistent with RNA expression data.
Reliability score - normal tissuesi
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from.
Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
For each cancer, color-coded bars indicate the percentage of patients (maximum 12 patients) with high and medium protein expression level. The cancer types are color-coded according to which type of normal organ the cancer originates from. Low or not detected protein expression results in a white bar. Mouse-over function shows details about expression level and normal tissue of origin. The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies.
Most cancer cells displayed strong nuclear immunoreactivity. One case of seminoma and a few hepatocellular carcinoma cases were negative.
Cancer cells generally showed strong nuclear positivity. Most hepatocellular carcinomas were negative.
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
CREB1
Synonyms
Description
CAMP responsive element binding protein 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
CREB1-001
CREB1-002
CREB1-003
CREB1-005
CREB1-006
CREB1-007
CREB1-009
CREB1-010
CREB1-011
CREB1-016
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P16220 [Direct mapping] Cyclic AMP-responsive element-binding protein 1 Q5U0J5 [Target identity:100%; Query identity:100%] cAMP responsive element binding protein 1; cAMP responsive element binding protein 1, isoform CRA_a; cDNA, FLJ93156, Homo sapiens cAMP responsive element binding protein 1 (CREB1),transcript variant B, mRNA
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Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785 [chromatin] GO:0000790 [nuclear chromatin] GO:0000975 [regulatory region DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding] GO:0001666 [response to hypoxia] GO:0003677 [DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005719 [nuclear euchromatin] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007409 [axonogenesis] GO:0007411 [axon guidance] GO:0007568 [aging] GO:0007595 [lactation] GO:0007613 [memory] GO:0007623 [circadian rhythm] GO:0008134 [transcription factor binding] GO:0008361 [regulation of cell size] GO:0008542 [visual learning] GO:0010033 [response to organic substance] GO:0010629 [negative regulation of gene expression] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0014823 [response to activity] GO:0016032 [viral process] GO:0019899 [enzyme binding] GO:0021983 [pituitary gland development] GO:0030154 [cell differentiation] GO:0030424 [axon] GO:0030544 [Hsp70 protein binding] GO:0030879 [mammary gland development] GO:0032916 [positive regulation of transforming growth factor beta3 production] GO:0033363 [secretory granule organization] GO:0033762 [response to glucagon] GO:0034670 [chemotaxis to arachidonic acid] GO:0035035 [histone acetyltransferase binding] GO:0035094 [response to nicotine] GO:0035497 [cAMP response element binding] GO:0035729 [cellular response to hepatocyte growth factor stimulus] GO:0036120 [cellular response to platelet-derived growth factor stimulus] GO:0040018 [positive regulation of multicellular organism growth] GO:0042493 [response to drug] GO:0042752 [regulation of circadian rhythm] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045600 [positive regulation of fat cell differentiation] GO:0045672 [positive regulation of osteoclast differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045899 [positive regulation of RNA polymerase II transcriptional preinitiation complex assembly] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046887 [positive regulation of hormone secretion] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048145 [regulation of fibroblast proliferation] GO:0048511 [rhythmic process] GO:0050821 [protein stabilization] GO:0055025 [positive regulation of cardiac muscle tissue development] GO:0060251 [regulation of glial cell proliferation] GO:0060428 [lung epithelium development] GO:0060430 [lung saccule development] GO:0060509 [Type I pneumocyte differentiation] GO:0071294 [cellular response to zinc ion] GO:0071363 [cellular response to growth factor stimulus] GO:0071398 [cellular response to fatty acid] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:1900273 [positive regulation of long-term synaptic potentiation] GO:1901215 [negative regulation of neuron death] GO:1902065 [response to L-glutamate] GO:1990090 [cellular response to nerve growth factor stimulus] GO:1990314 [cellular response to insulin-like growth factor stimulus] GO:1990589 [ATF4-CREB1 transcription factor complex] GO:1990763 [arrestin family protein binding]
P16220 [Direct mapping] Cyclic AMP-responsive element-binding protein 1 Q53X93 [Target identity:100%; Query identity:100%] CREB1 protein; cAMP responsive element binding protein 1; cAMP responsive element binding protein 1, isoform CRA_b; cDNA, FLJ96224, Homo sapiens cAMP responsive element binding protein 1 (CREB1),transcript variant A, mRNA
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Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005719 [nuclear euchromatin] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007411 [axon guidance] GO:0007623 [circadian rhythm] GO:0010033 [response to organic substance] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016032 [viral process] GO:0019899 [enzyme binding] GO:0030154 [cell differentiation] GO:0033762 [response to glucagon] GO:0035497 [cAMP response element binding] GO:0042802 [identical protein binding] GO:0043565 [sequence-specific DNA binding] GO:0045600 [positive regulation of fat cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048511 [rhythmic process] GO:0050821 [protein stabilization] GO:1990589 [ATF4-CREB1 transcription factor complex]
P16220 [Direct mapping] Cyclic AMP-responsive element-binding protein 1 Q53X93 [Target identity:100%; Query identity:100%] CREB1 protein; cAMP responsive element binding protein 1; cAMP responsive element binding protein 1, isoform CRA_b; cDNA, FLJ96224, Homo sapiens cAMP responsive element binding protein 1 (CREB1),transcript variant A, mRNA
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Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005719 [nuclear euchromatin] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0007411 [axon guidance] GO:0007623 [circadian rhythm] GO:0010033 [response to organic substance] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016032 [viral process] GO:0019899 [enzyme binding] GO:0030154 [cell differentiation] GO:0033762 [response to glucagon] GO:0035497 [cAMP response element binding] GO:0042802 [identical protein binding] GO:0043565 [sequence-specific DNA binding] GO:0045600 [positive regulation of fat cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046889 [positive regulation of lipid biosynthetic process] GO:0048511 [rhythmic process] GO:0050821 [protein stabilization] GO:1990589 [ATF4-CREB1 transcription factor complex]
E7EWP8 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated]
C9J276 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0006355 [regulation of transcription, DNA-templated]
C9JBT4 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated]
C9JCI4 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
C9J4L5 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated]
C9J896 [Direct mapping] Cyclic AMP-responsive element-binding protein 1
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Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding]
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