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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
TCGA (cancer tissue):
Expressed in all
HPA (cell line):
Mixed
HPA (normal tissue):
Expressed in all
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expression normal tissuei
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Cytoplasmic and nuclear expression at variable levels in most cells.
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability descriptioni
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining mainly consistent with RNA expression data.
Reliability score - normal tissuesi
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEWi
RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from.
Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
For each cancer, color-coded bars indicate the percentage of patients (maximum 12 patients) with high and medium protein expression level. The cancer types are color-coded according to which type of normal organ the cancer originates from. Low or not detected protein expression results in a white bar. Mouse-over function shows details about expression level and normal tissue of origin. The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies.
Moderate to strong cytoplasmic and/or nuclear positivity was observed in thyroid, prostate and breast cancers along with several malignant gliomas, colorectal, lung and renal cancers. Remaining malignancies were in general weakly stained or negative.
Most malignancies were weakly stained or negative. Malignant gliomas, lymphomas, melanomas, lung, colorectal, breast and urothelial cancers displayed moderate to strong immunoreactivity.
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
BIRC2 (HGNC Symbol)
Synonyms
API1, c-IAP1, cIAP1, hiap-2, MIHB, RNF48
Description
Baculoviral IAP repeat containing 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
BIRC2-001
BIRC2-002
BIRC2-003
BIRC2-006
BIRC2-008
BIRC2-009
BIRC2-010
BIRC2-201
BIRC2-202
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q13490 [Direct mapping] Baculoviral IAP repeat-containing protein 2
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Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000209 [protein polyubiquitination] GO:0003713 [transcription coactivator activity] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0008270 [zinc ion binding] GO:0009898 [cytoplasmic side of plasma membrane] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016579 [protein deubiquitination] GO:0016740 [transferase activity] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034121 [regulation of toll-like receptor signaling pathway] GO:0035631 [CD40 receptor complex] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038061 [NIK/NF-kappaB signaling] GO:0039535 [regulation of RIG-I signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045088 [regulation of innate immune response] GO:0045595 [regulation of cell differentiation] GO:0046872 [metal ion binding] GO:0047485 [protein N-terminus binding] GO:0050727 [regulation of inflammatory response] GO:0051087 [chaperone binding] GO:0051726 [regulation of cell cycle] GO:0060544 [regulation of necroptotic process] GO:0060546 [negative regulation of necroptotic process] GO:0070424 [regulation of nucleotide-binding oligomerization domain containing signaling pathway] GO:0097194 [execution phase of apoptosis] GO:0098770 [FBXO family protein binding] GO:1902523 [positive regulation of protein K63-linked ubiquitination] GO:1902524 [positive regulation of protein K48-linked ubiquitination] GO:1902527 [positive regulation of protein monoubiquitination] GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process] GO:2000116 [regulation of cysteine-type endopeptidase activity]
Q13490 [Direct mapping] Baculoviral IAP repeat-containing protein 2
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Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)
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GO:0000209 [protein polyubiquitination] GO:0003713 [transcription coactivator activity] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0008270 [zinc ion binding] GO:0009898 [cytoplasmic side of plasma membrane] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016579 [protein deubiquitination] GO:0016740 [transferase activity] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034121 [regulation of toll-like receptor signaling pathway] GO:0035631 [CD40 receptor complex] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038061 [NIK/NF-kappaB signaling] GO:0039535 [regulation of RIG-I signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045088 [regulation of innate immune response] GO:0045595 [regulation of cell differentiation] GO:0046872 [metal ion binding] GO:0047485 [protein N-terminus binding] GO:0050727 [regulation of inflammatory response] GO:0051087 [chaperone binding] GO:0051726 [regulation of cell cycle] GO:0060544 [regulation of necroptotic process] GO:0060546 [negative regulation of necroptotic process] GO:0070424 [regulation of nucleotide-binding oligomerization domain containing signaling pathway] GO:0097194 [execution phase of apoptosis] GO:0098770 [FBXO family protein binding] GO:1902523 [positive regulation of protein K63-linked ubiquitination] GO:1902524 [positive regulation of protein K48-linked ubiquitination] GO:1902527 [positive regulation of protein monoubiquitination] GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process] GO:2000116 [regulation of cysteine-type endopeptidase activity]
Q13490 [Direct mapping] Baculoviral IAP repeat-containing protein 2
Show all
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination] GO:0001666 [response to hypoxia] GO:0001741 [XY body] GO:0001890 [placenta development] GO:0003713 [transcription coactivator activity] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0008270 [zinc ion binding] GO:0009898 [cytoplasmic side of plasma membrane] GO:0010243 [response to organonitrogen compound] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0014070 [response to organic cyclic compound] GO:0016579 [protein deubiquitination] GO:0016740 [transferase activity] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034121 [regulation of toll-like receptor signaling pathway] GO:0035631 [CD40 receptor complex] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038061 [NIK/NF-kappaB signaling] GO:0039535 [regulation of RIG-I signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042981 [regulation of apoptotic process] GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043234 [protein complex] GO:0045088 [regulation of innate immune response] GO:0045121 [membrane raft] GO:0045471 [response to ethanol] GO:0045595 [regulation of cell differentiation] GO:0046872 [metal ion binding] GO:0047485 [protein N-terminus binding] GO:0050727 [regulation of inflammatory response] GO:0051087 [chaperone binding] GO:0051291 [protein heterooligomerization] GO:0051591 [response to cAMP] GO:0051726 [regulation of cell cycle] GO:0060544 [regulation of necroptotic process] GO:0060546 [negative regulation of necroptotic process] GO:0070266 [necroptotic process] GO:0070424 [regulation of nucleotide-binding oligomerization domain containing signaling pathway] GO:0071356 [cellular response to tumor necrosis factor] GO:0097194 [execution phase of apoptosis] GO:0098770 [FBXO family protein binding] GO:1901222 [regulation of NIK/NF-kappaB signaling] GO:1902443 [negative regulation of ripoptosome assembly involved in necroptotic process] GO:1902523 [positive regulation of protein K63-linked ubiquitination] GO:1902524 [positive regulation of protein K48-linked ubiquitination] GO:1902527 [positive regulation of protein monoubiquitination] GO:1902916 [positive regulation of protein polyubiquitination] GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process] GO:2000116 [regulation of cysteine-type endopeptidase activity] GO:2000377 [regulation of reactive oxygen species metabolic process]
The Human Protein Atlas project is funded
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