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Protein class the gene product belongs to according to selected gene lists. List of protein classes.
Cancer-related genes Disease related genes FDA approved drug targets Plasma proteins Predicted intracellular proteins RAS pathway related proteins Transcription factors
Predicted localizationi
Protein localization predicted from several bioinformatic algorithms.
RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
TCGA (cancer tissue):
Expressed in all
HPA (cell line):
Expressed in all
HPA (normal tissue):
Expressed in all
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expression normal tissuei
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
General cytoplasmic expression. Additional nuclear expression in several tissues.
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability descriptioni
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining mainly consistent with RNA expression data.
Reliability score - normal tissuesi
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from.
Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
For each cancer, color-coded bars indicate the percentage of patients (maximum 12 patients) with high and medium protein expression level. The cancer types are color-coded according to which type of normal organ the cancer originates from. Low or not detected protein expression results in a white bar. Mouse-over function shows details about expression level and normal tissue of origin. The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies.
Weak to moderate cytoplasmic positivity was observed in a majority of cancers. Several lymphomas and a few cases of colorectal cancer were strongly stained. A majority of gliomas, testicular and renal cancers were negative.
Cancer cells were generally negative. Lymphomas and a few cases of colorectal, breast and prostate cancers were moderately stained.
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
NFKB1-001
NFKB1-002
NFKB1-003
NFKB1-004
NFKB1-005
NFKB1-007
NFKB1-011
NFKB1-013
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Immunoglobulin fold RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000975 [regulatory region DNA binding] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001818 [negative regulation of cytokine production] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0008134 [transcription factor binding] GO:0010629 [negative regulation of gene expression] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010884 [positive regulation of lipid storage] GO:0010956 [negative regulation of calcidiol 1-monooxygenase activity] GO:0010957 [negative regulation of vitamin D biosynthetic process] GO:0031293 [membrane protein intracellular domain proteolysis] GO:0032269 [negative regulation of cellular protein metabolic process] GO:0032375 [negative regulation of cholesterol transport] GO:0032481 [positive regulation of type I interferon production] GO:0033256 [I-kappaB/NF-kappaB complex] GO:0034774 [secretory granule lumen] GO:0035580 [specific granule lumen] GO:0035994 [response to muscle stretch] GO:0038061 [NIK/NF-kappaB signaling] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042805 [actinin binding] GO:0043066 [negative regulation of apoptotic process] GO:0043312 [neutrophil degranulation] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045083 [negative regulation of interleukin-12 biosynthetic process] GO:0045087 [innate immune response] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0050728 [negative regulation of inflammatory response] GO:0050852 [T cell receptor signaling pathway] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051403 [stress-activated MAPK cascade] GO:0071222 [cellular response to lipopolysaccharide] GO:0071260 [cellular response to mechanical stimulus] GO:0071316 [cellular response to nicotine] GO:0071347 [cellular response to interleukin-1] GO:0071354 [cellular response to interleukin-6] GO:0071359 [cellular response to dsRNA] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:1900127 [positive regulation of hyaluronan biosynthetic process] GO:2000630 [positive regulation of miRNA metabolic process]
THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Immunoglobulin fold RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000975 [regulatory region DNA binding] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0008134 [transcription factor binding] GO:0010629 [negative regulation of gene expression] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010884 [positive regulation of lipid storage] GO:0010956 [negative regulation of calcidiol 1-monooxygenase activity] GO:0010957 [negative regulation of vitamin D biosynthetic process] GO:0031293 [membrane protein intracellular domain proteolysis] GO:0032269 [negative regulation of cellular protein metabolic process] GO:0032375 [negative regulation of cholesterol transport] GO:0032481 [positive regulation of type I interferon production] GO:0033256 [I-kappaB/NF-kappaB complex] GO:0034774 [secretory granule lumen] GO:0035580 [specific granule lumen] GO:0038061 [NIK/NF-kappaB signaling] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0042805 [actinin binding] GO:0043066 [negative regulation of apoptotic process] GO:0043312 [neutrophil degranulation] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0050852 [T cell receptor signaling pathway] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051403 [stress-activated MAPK cascade] GO:0071222 [cellular response to lipopolysaccharide] GO:0071260 [cellular response to mechanical stimulus] GO:0071316 [cellular response to nicotine] GO:0071347 [cellular response to interleukin-1] GO:0071354 [cellular response to interleukin-6] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:1900127 [positive regulation of hyaluronan biosynthetic process] GO:2000630 [positive regulation of miRNA metabolic process]
THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Immunoglobulin fold RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000975 [regulatory region DNA binding] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0008134 [transcription factor binding] GO:0010629 [negative regulation of gene expression] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010884 [positive regulation of lipid storage] GO:0010956 [negative regulation of calcidiol 1-monooxygenase activity] GO:0010957 [negative regulation of vitamin D biosynthetic process] GO:0031293 [membrane protein intracellular domain proteolysis] GO:0032269 [negative regulation of cellular protein metabolic process] GO:0032375 [negative regulation of cholesterol transport] GO:0032481 [positive regulation of type I interferon production] GO:0033256 [I-kappaB/NF-kappaB complex] GO:0034774 [secretory granule lumen] GO:0035580 [specific granule lumen] GO:0038061 [NIK/NF-kappaB signaling] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0042805 [actinin binding] GO:0043066 [negative regulation of apoptotic process] GO:0043312 [neutrophil degranulation] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0050852 [T cell receptor signaling pathway] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051403 [stress-activated MAPK cascade] GO:0071222 [cellular response to lipopolysaccharide] GO:0071260 [cellular response to mechanical stimulus] GO:0071316 [cellular response to nicotine] GO:0071347 [cellular response to interleukin-1] GO:0071354 [cellular response to interleukin-6] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:1900127 [positive regulation of hyaluronan biosynthetic process] GO:2000630 [positive regulation of miRNA metabolic process]
THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Immunoglobulin fold RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000975 [regulatory region DNA binding] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0008134 [transcription factor binding] GO:0010629 [negative regulation of gene expression] GO:0010744 [positive regulation of macrophage derived foam cell differentiation] GO:0010884 [positive regulation of lipid storage] GO:0010956 [negative regulation of calcidiol 1-monooxygenase activity] GO:0010957 [negative regulation of vitamin D biosynthetic process] GO:0031293 [membrane protein intracellular domain proteolysis] GO:0032269 [negative regulation of cellular protein metabolic process] GO:0032375 [negative regulation of cholesterol transport] GO:0032481 [positive regulation of type I interferon production] GO:0033256 [I-kappaB/NF-kappaB complex] GO:0034774 [secretory granule lumen] GO:0035580 [specific granule lumen] GO:0038061 [NIK/NF-kappaB signaling] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042802 [identical protein binding] GO:0042805 [actinin binding] GO:0043066 [negative regulation of apoptotic process] GO:0043312 [neutrophil degranulation] GO:0044212 [transcription regulatory region DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0050852 [T cell receptor signaling pathway] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051403 [stress-activated MAPK cascade] GO:0071222 [cellular response to lipopolysaccharide] GO:0071260 [cellular response to mechanical stimulus] GO:0071316 [cellular response to nicotine] GO:0071347 [cellular response to interleukin-1] GO:0071354 [cellular response to interleukin-6] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:1900127 [positive regulation of hyaluronan biosynthetic process] GO:2000630 [positive regulation of miRNA metabolic process]
The Human Protein Atlas project is funded
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