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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
TCGA (cancer tissue):
Expressed in all
HPA (cell line):
Expressed in all
HPA (normal tissue):
Expressed in all
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
Protein expression normal tissuei
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
Cytoplasmic and membranous expression in most tissues.
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability descriptioni
Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.
Antibody staining consistent with RNA expression data.
Reliability score - normal tissuesi
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from.
Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
For each cancer, color-coded bars indicate the percentage of patients (maximum 12 patients) with high and medium protein expression level. The cancer types are color-coded according to which type of normal organ the cancer originates from. Low or not detected protein expression results in a white bar. Mouse-over function shows details about expression level and normal tissue of origin. The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies.
Most cancer cells showed moderate to strong cytoplasmic and occasional membranous immunoreactivity. Hepatocellular carcinomas were negative.
Most cancer cells displayed moderate to strong cytoplasmic and membranous immunoreactivity. Strongest staining was observed in lymphomas and breast cancers.
Most cancer cells displayed moderate to strong cytoplasmic immunoreactivity with additional membranous staining in several cases. Several cases of glioma were negative.
Strong to moderate cytoplasmic positivity was observed in most cancers.
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
EZR (HGNC Symbol)
Synonyms
VIL2
Description
Ezrin (HGNC Symbol)
Entrez gene summary
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
EZR-001
EZR-002
EZR-201
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001650 [fibrillar center] GO:0001726 [ruffle] GO:0001772 [immunological synapse] GO:0001931 [uropod] GO:0001951 [intestinal D-glucose absorption] GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0003723 [RNA binding] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005884 [actin filament] GO:0005886 [plasma membrane] GO:0005902 [microvillus] GO:0005903 [brush border] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0007016 [cytoskeletal anchoring at plasma membrane] GO:0007159 [leukocyte cell-cell adhesion] GO:0007411 [axon guidance] GO:0008017 [microtubule binding] GO:0008092 [cytoskeletal protein binding] GO:0008360 [regulation of cell shape] GO:0010628 [positive regulation of gene expression] GO:0010737 [protein kinase A signaling] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0019898 [extrinsic component of membrane] GO:0019904 [protein domain specific binding] GO:0022614 [membrane to membrane docking] GO:0030033 [microvillus assembly] GO:0030175 [filopodium] GO:0030315 [T-tubule] GO:0030855 [epithelial cell differentiation] GO:0030863 [cortical cytoskeleton] GO:0030953 [astral microtubule organization] GO:0031528 [microvillus membrane] GO:0031532 [actin cytoskeleton reorganization] GO:0031623 [receptor internalization] GO:0031982 [vesicle] GO:0032403 [protein complex binding] GO:0032532 [regulation of microvillus length] GO:0032587 [ruffle membrane] GO:0034236 [protein kinase A catalytic subunit binding] GO:0034237 [protein kinase A regulatory subunit binding] GO:0034629 [cellular protein complex localization] GO:0035088 [establishment or maintenance of apical/basal cell polarity] GO:0036064 [ciliary basal body] GO:0040018 [positive regulation of multicellular organism growth] GO:0042995 [cell projection] GO:0043209 [myelin sheath] GO:0043622 [cortical microtubule organization] GO:0044297 [cell body] GO:0044393 [microspike] GO:0044548 [S100 protein binding] GO:0044853 [plasma membrane raft] GO:0045121 [membrane raft] GO:0045177 [apical part of cell] GO:0045296 [cadherin binding] GO:0046847 [filopodium assembly] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048471 [perinuclear region of cytoplasm] GO:0050714 [positive regulation of protein secretion] GO:0050839 [cell adhesion molecule binding] GO:0050860 [negative regulation of T cell receptor signaling pathway] GO:0051015 [actin filament binding] GO:0051017 [actin filament bundle assembly] GO:0051117 [ATPase binding] GO:0051286 [cell tip] GO:0051660 [establishment of centrosome localization] GO:0061028 [establishment of endothelial barrier] GO:0070062 [extracellular exosome] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:0071320 [cellular response to cAMP] GO:0071944 [cell periphery] GO:0072697 [protein localization to cell cortex] GO:0090002 [establishment of protein localization to plasma membrane] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:0097449 [astrocyte projection] GO:0097454 [Schwann cell microvillus] GO:0098592 [cytoplasmic side of apical plasma membrane] GO:1900041 [negative regulation of interleukin-2 secretion] GO:1902115 [regulation of organelle assembly] GO:1902896 [terminal web assembly] GO:1902966 [positive regulation of protein localization to early endosome] GO:1903364 [positive regulation of cellular protein catabolic process] GO:1903753 [negative regulation of p38MAPK cascade] GO:2000643 [positive regulation of early endosome to late endosome transport]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001650 [fibrillar center] GO:0001726 [ruffle] GO:0001772 [immunological synapse] GO:0003376 [sphingosine-1-phosphate signaling pathway] GO:0003723 [RNA binding] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005884 [actin filament] GO:0005886 [plasma membrane] GO:0005902 [microvillus] GO:0005903 [brush border] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0007016 [cytoskeletal anchoring at plasma membrane] GO:0007159 [leukocyte cell-cell adhesion] GO:0007411 [axon guidance] GO:0008017 [microtubule binding] GO:0008092 [cytoskeletal protein binding] GO:0008360 [regulation of cell shape] GO:0010628 [positive regulation of gene expression] GO:0010737 [protein kinase A signaling] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0019898 [extrinsic component of membrane] GO:0019904 [protein domain specific binding] GO:0022614 [membrane to membrane docking] GO:0030033 [microvillus assembly] GO:0030175 [filopodium] GO:0030863 [cortical cytoskeleton] GO:0030953 [astral microtubule organization] GO:0031528 [microvillus membrane] GO:0031532 [actin cytoskeleton reorganization] GO:0031982 [vesicle] GO:0032587 [ruffle membrane] GO:0034236 [protein kinase A catalytic subunit binding] GO:0034237 [protein kinase A regulatory subunit binding] GO:0034629 [cellular protein complex localization] GO:0042995 [cell projection] GO:0043622 [cortical microtubule organization] GO:0044548 [S100 protein binding] GO:0044853 [plasma membrane raft] GO:0045177 [apical part of cell] GO:0045296 [cadherin binding] GO:0046847 [filopodium assembly] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048471 [perinuclear region of cytoplasm] GO:0050714 [positive regulation of protein secretion] GO:0050839 [cell adhesion molecule binding] GO:0050860 [negative regulation of T cell receptor signaling pathway] GO:0051015 [actin filament binding] GO:0051017 [actin filament bundle assembly] GO:0051117 [ATPase binding] GO:0051660 [establishment of centrosome localization] GO:0061028 [establishment of endothelial barrier] GO:0070062 [extracellular exosome] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:0071320 [cellular response to cAMP] GO:0071944 [cell periphery] GO:0072697 [protein localization to cell cortex] GO:0090002 [establishment of protein localization to plasma membrane] GO:0098592 [cytoplasmic side of apical plasma membrane] GO:1900041 [negative regulation of interleukin-2 secretion] GO:1902115 [regulation of organelle assembly] GO:1902966 [positive regulation of protein localization to early endosome] GO:1903364 [positive regulation of cellular protein catabolic process] GO:1903753 [negative regulation of p38MAPK cascade] GO:2000643 [positive regulation of early endosome to late endosome transport]
Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
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