We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for data imported from The Genotype-Tissue Expression project (GTEX), FANTOM5 Consortium (FANTOM5) and internally generated Human Protein Atlas (HPA) data.
Group enriched (adrenal gland, kidney, liver, ovary, small intestine)
FANTOM5:
Group enriched (kidney, liver, small intestine)
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Reliability scorei
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Below is an overview of RNA and protein expression data generated in the Human Protein Atlas project. Analyzed tissues are divided into color-coded groups according to which functional features they have in common. For each group, a list of included tissues is accessed by clicking on group name, group symbol, RNA bar, or protein bar. Subsequent selection of a particular tissue in this list links to the image data page.
Images of selected tissues give a visual summary of the protein expression profile furthest to the right.
The gray human body provides links to a histology dictionary when clicking on any part of the figure.
RNA expression (TPM)i
RNA-seq results generated in HPA are reported as number of transcripts per million (TPM). Each bar represents the highest expression score found in a particular group of tissues. The assay is described more in detail in Assays & Annotation.
Protein expression (score)i
Each bar represents the highest expression score found in a particular group of tissues. Protein expression scores are based on a best estimate of the "true" protein expression from a knowledge-based annotation, described more in detail under Assays & annotation. For genes where more than one antibody has been used, a collective score is set displaying the estimated true protein expression.
Protein expression data is shown for each of the 44 tissues. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. Mouse-over function shows protein score for analyzed cell types in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation.
For genes with available protein data for which a knowledge-based annotation gave inconclusive results, no protein expression data is displayed in the protein expression data overview. However, all immunohistochemical images are still available and the annotation data can be found under Primary data.
Pending normal tissue annotation.
RNA EXPRESSION OVERVIEWi
RNA expression overview shows RNA-data from three different sources: Internally generated Human Protein Atlas (HPA) RNA-seq data, RNA-seq data from the Genotype-Tissue Expression (GTEx) project and CAGE data from FANTOM5 project. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.
HPA dataseti
HPA dataset RNA-seq tissue data is reported as mean TPM (transcripts per million), corresponding to mean values of the different individual samples from each tissue. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar. The RNA-seq assay is described in detail in Assays & Annotation.
RNA tissue category HPA HPA RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver, small intestine)
GTEx dataseti
GTEx dataset RNA-seq data is reported as median RPKM (reads per kilobase per million mapped reads), generated by the Genotype-Tissue Expression (GTEx) project. More information can be found in Assays & Annotation.
RNA tissue category GTEx GTEx RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, kidney, liver, ovary, small intestine)
FANTOM5 dataseti
FANTOM5 dataset Tissue data obtained through Cap Analysis of Gene Expression (CAGE) are reported as Tags Per Million, generated by the FANTOM5 project. More information can be found in Assays & Annotation.
RNA tissue category FANTOM5 FANTOM5 RNA tissue category (category description) is calculated based on gene expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (kidney, liver, small intestine)
GENE INFORMATIONi
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
NR1H4 (HGNC Symbol)
Synonyms
FXR, HRR-1, HRR1, RIP14
Description
Nuclear receptor subfamily 1 group H member 4 (HGNC Symbol)
Entrez gene summary
This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
NR1H4-001
NR1H4-002
NR1H4-003
NR1H4-005
NR1H4-006
NR1H4-007
NR1H4-008
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q96RI1 [Direct mapping] Bile acid receptor B6ZGS9 [Target identity:100%; Query identity:100%] Farnesoid X receptor; Nuclear receptor subfamily 1, group H, member 4, isoform CRA_a
Show all
Nuclear receptors Transporters Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001080 [nitrogen catabolite activation of transcription from RNA polymerase II promoter] GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding] GO:0002376 [immune system process] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0004887 [thyroid hormone receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005719 [nuclear euchromatin] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010988 [regulation of low-density lipoprotein particle clearance] GO:0015721 [bile acid and bile salt transport] GO:0016922 [ligand-dependent nuclear receptor binding] GO:0030522 [intracellular receptor signaling pathway] GO:0032052 [bile acid binding] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034255 [regulation of urea metabolic process] GO:0034971 [histone H3-R17 methylation] GO:0035356 [cellular triglyceride homeostasis] GO:0038181 [bile acid receptor activity] GO:0038183 [bile acid signaling pathway] GO:0038185 [intracellular bile acid receptor signaling pathway] GO:0043066 [negative regulation of apoptotic process] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045087 [innate immune response] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070857 [regulation of bile acid biosynthetic process] GO:0070858 [negative regulation of bile acid biosynthetic process] GO:0071398 [cellular response to fatty acid] GO:0071417 [cellular response to organonitrogen compound] GO:0072615 [interleukin-17 secretion] GO:0090181 [regulation of cholesterol metabolic process] GO:1902122 [chenodeoxycholic acid binding] GO:1902714 [negative regulation of interferon-gamma secretion] GO:1904468 [negative regulation of tumor necrosis factor secretion] GO:1905695 [positive regulation of phosphatidic acid biosynthetic process] GO:2000213 [positive regulation of glutamate metabolic process]
Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001080 [nitrogen catabolite activation of transcription from RNA polymerase II promoter] GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding] GO:0002376 [immune system process] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0004887 [thyroid hormone receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005719 [nuclear euchromatin] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010988 [regulation of low-density lipoprotein particle clearance] GO:0015721 [bile acid and bile salt transport] GO:0016922 [ligand-dependent nuclear receptor binding] GO:0030522 [intracellular receptor signaling pathway] GO:0032052 [bile acid binding] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034255 [regulation of urea metabolic process] GO:0034971 [histone H3-R17 methylation] GO:0035356 [cellular triglyceride homeostasis] GO:0038181 [bile acid receptor activity] GO:0038183 [bile acid signaling pathway] GO:0038185 [intracellular bile acid receptor signaling pathway] GO:0043066 [negative regulation of apoptotic process] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045087 [innate immune response] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070857 [regulation of bile acid biosynthetic process] GO:0070858 [negative regulation of bile acid biosynthetic process] GO:0071398 [cellular response to fatty acid] GO:0071417 [cellular response to organonitrogen compound] GO:0072615 [interleukin-17 secretion] GO:0090181 [regulation of cholesterol metabolic process] GO:1902122 [chenodeoxycholic acid binding] GO:1902714 [negative regulation of interferon-gamma secretion] GO:1904468 [negative regulation of tumor necrosis factor secretion] GO:1905695 [positive regulation of phosphatidic acid biosynthetic process] GO:2000213 [positive regulation of glutamate metabolic process]
Q96RI1 [Direct mapping] Bile acid receptor F1DAL1 [Target identity:100%; Query identity:100%] Farnesoid X nuclear receptor; Nuclear receptor subfamily 1, group H, member 4, isoform CRA_b
Show all
Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001080 [nitrogen catabolite activation of transcription from RNA polymerase II promoter] GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding] GO:0002376 [immune system process] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0004887 [thyroid hormone receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005719 [nuclear euchromatin] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010988 [regulation of low-density lipoprotein particle clearance] GO:0015721 [bile acid and bile salt transport] GO:0016922 [ligand-dependent nuclear receptor binding] GO:0030522 [intracellular receptor signaling pathway] GO:0032052 [bile acid binding] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034255 [regulation of urea metabolic process] GO:0034971 [histone H3-R17 methylation] GO:0035356 [cellular triglyceride homeostasis] GO:0038181 [bile acid receptor activity] GO:0038183 [bile acid signaling pathway] GO:0038185 [intracellular bile acid receptor signaling pathway] GO:0043066 [negative regulation of apoptotic process] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045087 [innate immune response] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070857 [regulation of bile acid biosynthetic process] GO:0070858 [negative regulation of bile acid biosynthetic process] GO:0071398 [cellular response to fatty acid] GO:0071417 [cellular response to organonitrogen compound] GO:0072615 [interleukin-17 secretion] GO:0090181 [regulation of cholesterol metabolic process] GO:1902122 [chenodeoxycholic acid binding] GO:1902714 [negative regulation of interferon-gamma secretion] GO:1904468 [negative regulation of tumor necrosis factor secretion] GO:1905695 [positive regulation of phosphatidic acid biosynthetic process] GO:2000213 [positive regulation of glutamate metabolic process]
Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001080 [nitrogen catabolite activation of transcription from RNA polymerase II promoter] GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding] GO:0002376 [immune system process] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0004887 [thyroid hormone receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005719 [nuclear euchromatin] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010988 [regulation of low-density lipoprotein particle clearance] GO:0015721 [bile acid and bile salt transport] GO:0016922 [ligand-dependent nuclear receptor binding] GO:0030522 [intracellular receptor signaling pathway] GO:0032052 [bile acid binding] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034255 [regulation of urea metabolic process] GO:0034971 [histone H3-R17 methylation] GO:0035356 [cellular triglyceride homeostasis] GO:0038181 [bile acid receptor activity] GO:0038183 [bile acid signaling pathway] GO:0038185 [intracellular bile acid receptor signaling pathway] GO:0043066 [negative regulation of apoptotic process] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045087 [innate immune response] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070857 [regulation of bile acid biosynthetic process] GO:0070858 [negative regulation of bile acid biosynthetic process] GO:0071398 [cellular response to fatty acid] GO:0071417 [cellular response to organonitrogen compound] GO:0072615 [interleukin-17 secretion] GO:0090181 [regulation of cholesterol metabolic process] GO:1902122 [chenodeoxycholic acid binding] GO:1902714 [negative regulation of interferon-gamma secretion] GO:1904468 [negative regulation of tumor necrosis factor secretion] GO:1905695 [positive regulation of phosphatidic acid biosynthetic process] GO:2000213 [positive regulation of glutamate metabolic process]
Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001080 [nitrogen catabolite activation of transcription from RNA polymerase II promoter] GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding] GO:0002376 [immune system process] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0004887 [thyroid hormone receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005719 [nuclear euchromatin] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0007043 [cell-cell junction assembly] GO:0007165 [signal transduction] GO:0007219 [Notch signaling pathway] GO:0008206 [bile acid metabolic process] GO:0008270 [zinc ion binding] GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0010988 [regulation of low-density lipoprotein particle clearance] GO:0015721 [bile acid and bile salt transport] GO:0016922 [ligand-dependent nuclear receptor binding] GO:0030522 [intracellular receptor signaling pathway] GO:0032052 [bile acid binding] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032689 [negative regulation of interferon-gamma production] GO:0032692 [negative regulation of interleukin-1 production] GO:0032703 [negative regulation of interleukin-2 production] GO:0032715 [negative regulation of interleukin-6 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034255 [regulation of urea metabolic process] GO:0034971 [histone H3-R17 methylation] GO:0035356 [cellular triglyceride homeostasis] GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0038181 [bile acid receptor activity] GO:0038183 [bile acid signaling pathway] GO:0038185 [intracellular bile acid receptor signaling pathway] GO:0042593 [glucose homeostasis] GO:0042742 [defense response to bacterium] GO:0043066 [negative regulation of apoptotic process] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045087 [innate immune response] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046628 [positive regulation of insulin receptor signaling pathway] GO:0046872 [metal ion binding] GO:0046965 [retinoid X receptor binding] GO:0050728 [negative regulation of inflammatory response] GO:0055089 [fatty acid homeostasis] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070328 [triglyceride homeostasis] GO:0070857 [regulation of bile acid biosynthetic process] GO:0070858 [negative regulation of bile acid biosynthetic process] GO:0071222 [cellular response to lipopolysaccharide] GO:0071398 [cellular response to fatty acid] GO:0071417 [cellular response to organonitrogen compound] GO:0071638 [negative regulation of monocyte chemotactic protein-1 production] GO:0072615 [interleukin-17 secretion] GO:0090181 [regulation of cholesterol metabolic process] GO:1902122 [chenodeoxycholic acid binding] GO:1902714 [negative regulation of interferon-gamma secretion] GO:1904179 [positive regulation of adipose tissue development] GO:1904468 [negative regulation of tumor necrosis factor secretion] GO:1905695 [positive regulation of phosphatidic acid biosynthetic process] GO:2000188 [regulation of cholesterol homeostasis] GO:2000213 [positive regulation of glutamate metabolic process] GO:2001250 [positive regulation of ammonia assimilation cycle] GO:2001275 [positive regulation of glucose import in response to insulin stimulus]
The Human Protein Atlas project is funded
MENU
