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RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.
TCGA (cancer tissue):
Expressed in all
HPA (cell line):
Cell line enhanced (HaCaT)
HPA (normal tissue):
Mixed
Protein evidencei
Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.
Evidence at protein level
IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Reliability score - normal tissuesi
Reliability score (score description), divided into Enhanced, Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between antibody staining pattern, available RNA-Seq and gene/protein characterization data, as well as similarity between independent antibodies targeting the same protein.
Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from.
Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
DAB2IP (HGNC Symbol)
Synonyms
AF9Q34, AIP1, DIP1/2, KIAA1743
Description
DAB2 interacting protein (HGNC Symbol)
Entrez gene summary
DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
DAB2IP-001
DAB2IP-004
DAB2IP-005
DAB2IP-009
DAB2IP-010
DAB2IP-201
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q5VWQ8 [Direct mapping] Disabled homolog 2-interacting protein
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Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000185 [activation of MAPKKK activity] GO:0001525 [angiogenesis] GO:0001933 [negative regulation of protein phosphorylation] GO:0002376 [immune system process] GO:0005096 [GTPase activator activity] GO:0005123 [death receptor binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006986 [response to unfolded protein] GO:0006987 [activation of signaling protein activity involved in unfolded protein response] GO:0007049 [cell cycle] GO:0007165 [signal transduction] GO:0007252 [I-kappaB phosphorylation] GO:0007257 [activation of JUN kinase activity] GO:0007275 [multicellular organism development] GO:0008285 [negative regulation of cell proliferation] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0010596 [negative regulation of endothelial cell migration] GO:0010633 [negative regulation of epithelial cell migration] GO:0010719 [negative regulation of epithelial to mesenchymal transition] GO:0010976 [positive regulation of neuron projection development] GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016525 [negative regulation of angiogenesis] GO:0017124 [SH3 domain binding] GO:0019900 [kinase binding] GO:0019901 [protein kinase binding] GO:0021814 [cell motility involved in cerebral cortex radial glia guided migration] GO:0021819 [layer formation in cerebral cortex] GO:0030139 [endocytic vesicle] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane] GO:0031434 [mitogen-activated protein kinase kinase binding] GO:0031435 [mitogen-activated protein kinase kinase kinase binding] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032266 [phosphatidylinositol-3-phosphate binding] GO:0032403 [protein complex binding] GO:0032809 [neuronal cell body membrane] GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway] GO:0034260 [negative regulation of GTPase activity] GO:0035148 [tube formation] GO:0035414 [negative regulation of catenin import into nucleus] GO:0035591 [signaling adaptor activity] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding] GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway] GO:0038026 [reelin-mediated signaling pathway] GO:0040008 [regulation of growth] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0043065 [positive regulation of apoptotic process] GO:0043087 [regulation of GTPase activity] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043254 [regulation of protein complex assembly] GO:0043407 [negative regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0043497 [regulation of protein heterodimerization activity] GO:0043507 [positive regulation of JUN kinase activity] GO:0043547 [positive regulation of GTPase activity] GO:0043548 [phosphatidylinositol 3-kinase binding] GO:0043553 [negative regulation of phosphatidylinositol 3-kinase activity] GO:0044257 [cellular protein catabolic process] GO:0044300 [cerebellar mossy fiber] GO:0044301 [climbing fiber] GO:0045087 [innate immune response] GO:0045296 [cadherin binding] GO:0045732 [positive regulation of protein catabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046330 [positive regulation of JNK cascade] GO:0046580 [negative regulation of Ras protein signal transduction] GO:0048147 [negative regulation of fibroblast proliferation] GO:0048812 [neuron projection morphogenesis] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0051721 [protein phosphatase 2A binding] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070062 [extracellular exosome] GO:0070273 [phosphatidylinositol-4-phosphate binding] GO:0070317 [negative regulation of G0 to G1 transition] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:0071158 [positive regulation of cell cycle arrest] GO:0071222 [cellular response to lipopolysaccharide] GO:0071347 [cellular response to interleukin-1] GO:0071356 [cellular response to tumor necrosis factor] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0071889 [14-3-3 protein binding] GO:0071901 [negative regulation of protein serine/threonine kinase activity] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0072577 [endothelial cell apoptotic process] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0090129 [positive regulation of synapse maturation] GO:1900006 [positive regulation of dendrite development] GO:1900744 [regulation of p38MAPK cascade] GO:1900747 [negative regulation of vascular endothelial growth factor signaling pathway] GO:1901800 [positive regulation of proteasomal protein catabolic process] GO:1903363 [negative regulation of cellular protein catabolic process] GO:1903896 [positive regulation of IRE1-mediated unfolded protein response] GO:1990032 [parallel fiber] GO:1990597 [AIP1-IRE1 complex] GO:2001224 [positive regulation of neuron migration] GO:2001235 [positive regulation of apoptotic signaling pathway]
Q5VWQ8 [Direct mapping] Disabled homolog 2-interacting protein
Show all
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000185 [activation of MAPKKK activity] GO:0001525 [angiogenesis] GO:0001933 [negative regulation of protein phosphorylation] GO:0002376 [immune system process] GO:0005096 [GTPase activator activity] GO:0005123 [death receptor binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006986 [response to unfolded protein] GO:0006987 [activation of signaling protein activity involved in unfolded protein response] GO:0007049 [cell cycle] GO:0007165 [signal transduction] GO:0007252 [I-kappaB phosphorylation] GO:0007257 [activation of JUN kinase activity] GO:0007275 [multicellular organism development] GO:0008285 [negative regulation of cell proliferation] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0010596 [negative regulation of endothelial cell migration] GO:0010633 [negative regulation of epithelial cell migration] GO:0010719 [negative regulation of epithelial to mesenchymal transition] GO:0010976 [positive regulation of neuron projection development] GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016525 [negative regulation of angiogenesis] GO:0017124 [SH3 domain binding] GO:0019900 [kinase binding] GO:0019901 [protein kinase binding] GO:0021814 [cell motility involved in cerebral cortex radial glia guided migration] GO:0021819 [layer formation in cerebral cortex] GO:0030139 [endocytic vesicle] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane] GO:0031434 [mitogen-activated protein kinase kinase binding] GO:0031435 [mitogen-activated protein kinase kinase kinase binding] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032266 [phosphatidylinositol-3-phosphate binding] GO:0032403 [protein complex binding] GO:0032809 [neuronal cell body membrane] GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway] GO:0034260 [negative regulation of GTPase activity] GO:0035148 [tube formation] GO:0035414 [negative regulation of catenin import into nucleus] GO:0035591 [signaling adaptor activity] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding] GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway] GO:0038026 [reelin-mediated signaling pathway] GO:0040008 [regulation of growth] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0043065 [positive regulation of apoptotic process] GO:0043087 [regulation of GTPase activity] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043254 [regulation of protein complex assembly] GO:0043407 [negative regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0043497 [regulation of protein heterodimerization activity] GO:0043507 [positive regulation of JUN kinase activity] GO:0043547 [positive regulation of GTPase activity] GO:0043548 [phosphatidylinositol 3-kinase binding] GO:0043553 [negative regulation of phosphatidylinositol 3-kinase activity] GO:0044257 [cellular protein catabolic process] GO:0044300 [cerebellar mossy fiber] GO:0044301 [climbing fiber] GO:0045087 [innate immune response] GO:0045296 [cadherin binding] GO:0045732 [positive regulation of protein catabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046330 [positive regulation of JNK cascade] GO:0046580 [negative regulation of Ras protein signal transduction] GO:0048147 [negative regulation of fibroblast proliferation] GO:0048812 [neuron projection morphogenesis] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0051721 [protein phosphatase 2A binding] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070062 [extracellular exosome] GO:0070273 [phosphatidylinositol-4-phosphate binding] GO:0070317 [negative regulation of G0 to G1 transition] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:0071158 [positive regulation of cell cycle arrest] GO:0071222 [cellular response to lipopolysaccharide] GO:0071347 [cellular response to interleukin-1] GO:0071356 [cellular response to tumor necrosis factor] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0071889 [14-3-3 protein binding] GO:0071901 [negative regulation of protein serine/threonine kinase activity] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0072577 [endothelial cell apoptotic process] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0090129 [positive regulation of synapse maturation] GO:1900006 [positive regulation of dendrite development] GO:1900744 [regulation of p38MAPK cascade] GO:1900747 [negative regulation of vascular endothelial growth factor signaling pathway] GO:1901800 [positive regulation of proteasomal protein catabolic process] GO:1903363 [negative regulation of cellular protein catabolic process] GO:1903896 [positive regulation of IRE1-mediated unfolded protein response] GO:1990032 [parallel fiber] GO:1990597 [AIP1-IRE1 complex] GO:2001224 [positive regulation of neuron migration] GO:2001235 [positive regulation of apoptotic signaling pathway]
Q5VWQ8 [Direct mapping] Disabled homolog 2-interacting protein
Show all
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000165 [MAPK cascade] GO:0000185 [activation of MAPKKK activity] GO:0001525 [angiogenesis] GO:0001933 [negative regulation of protein phosphorylation] GO:0002376 [immune system process] GO:0005096 [GTPase activator activity] GO:0005123 [death receptor binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006986 [response to unfolded protein] GO:0006987 [activation of signaling protein activity involved in unfolded protein response] GO:0007049 [cell cycle] GO:0007165 [signal transduction] GO:0007252 [I-kappaB phosphorylation] GO:0007257 [activation of JUN kinase activity] GO:0007275 [multicellular organism development] GO:0008285 [negative regulation of cell proliferation] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0010596 [negative regulation of endothelial cell migration] GO:0010633 [negative regulation of epithelial cell migration] GO:0010719 [negative regulation of epithelial to mesenchymal transition] GO:0010976 [positive regulation of neuron projection development] GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016525 [negative regulation of angiogenesis] GO:0017124 [SH3 domain binding] GO:0019900 [kinase binding] GO:0019901 [protein kinase binding] GO:0021814 [cell motility involved in cerebral cortex radial glia guided migration] GO:0021819 [layer formation in cerebral cortex] GO:0030139 [endocytic vesicle] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane] GO:0031434 [mitogen-activated protein kinase kinase binding] GO:0031435 [mitogen-activated protein kinase kinase kinase binding] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032266 [phosphatidylinositol-3-phosphate binding] GO:0032403 [protein complex binding] GO:0032809 [neuronal cell body membrane] GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway] GO:0034260 [negative regulation of GTPase activity] GO:0035148 [tube formation] GO:0035414 [negative regulation of catenin import into nucleus] GO:0035591 [signaling adaptor activity] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding] GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway] GO:0038026 [reelin-mediated signaling pathway] GO:0040008 [regulation of growth] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0043065 [positive regulation of apoptotic process] GO:0043087 [regulation of GTPase activity] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043254 [regulation of protein complex assembly] GO:0043407 [negative regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0043497 [regulation of protein heterodimerization activity] GO:0043507 [positive regulation of JUN kinase activity] GO:0043547 [positive regulation of GTPase activity] GO:0043548 [phosphatidylinositol 3-kinase binding] GO:0043553 [negative regulation of phosphatidylinositol 3-kinase activity] GO:0044257 [cellular protein catabolic process] GO:0044300 [cerebellar mossy fiber] GO:0044301 [climbing fiber] GO:0045087 [innate immune response] GO:0045296 [cadherin binding] GO:0045732 [positive regulation of protein catabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046330 [positive regulation of JNK cascade] GO:0046580 [negative regulation of Ras protein signal transduction] GO:0048147 [negative regulation of fibroblast proliferation] GO:0048812 [neuron projection morphogenesis] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0051721 [protein phosphatase 2A binding] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070062 [extracellular exosome] GO:0070273 [phosphatidylinositol-4-phosphate binding] GO:0070317 [negative regulation of G0 to G1 transition] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:0071158 [positive regulation of cell cycle arrest] GO:0071222 [cellular response to lipopolysaccharide] GO:0071347 [cellular response to interleukin-1] GO:0071356 [cellular response to tumor necrosis factor] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0071889 [14-3-3 protein binding] GO:0071901 [negative regulation of protein serine/threonine kinase activity] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0072577 [endothelial cell apoptotic process] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0090129 [positive regulation of synapse maturation] GO:1900006 [positive regulation of dendrite development] GO:1900744 [regulation of p38MAPK cascade] GO:1900747 [negative regulation of vascular endothelial growth factor signaling pathway] GO:1901800 [positive regulation of proteasomal protein catabolic process] GO:1903363 [negative regulation of cellular protein catabolic process] GO:1903896 [positive regulation of IRE1-mediated unfolded protein response] GO:1990032 [parallel fiber] GO:1990597 [AIP1-IRE1 complex] GO:2001224 [positive regulation of neuron migration] GO:2001235 [positive regulation of apoptotic signaling pathway]